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The map label for this gene is fabD [H]

Identifier: 83591755

GI number: 83591755

Start: 491531

End: 492469

Strand: Direct

Name: fabD [H]

Synonym: Rru_A0415

Alternate gene names: 83591755

Gene position: 491531-492469 (Clockwise)

Preceding gene: 83591742

Following gene: 83591756

Centisome position: 11.29

GC content: 68.9

Gene sequence:

>939_bases
ATGACACGCGCTTTCGTCTTCCCCGGTCAAGGGTCCCAGGCCGTCGGCATGGGCAAAGAACTGGCCGACGCCTTTCCGGC
GGCCCGCGATGTTTTCCAAGAAGTCGACGACGCCCTGTCGCAAAAGCTTTTCGCCTTGATGGTCGAGGGTCCGGCCGACG
AGCTAACCCTGACCCAGAACGCCCAGCCGGCGCTGATGGCGGTTTCGATGGCCGTGGTCCGCGTGCTTGAAACCGGCGGC
GTGCGTCTGGCCGCCCATGCCGATCTGGTCGCCGGGCATTCCCTGGGCGAATATTCGGCCCTGGCCGCCGCCGGGGCGCT
GGGGCTGGCCGATACCGCCCGCCTGCTGCGCATCCGCGGCGAAGCGATGCAAAAGGCCGTGCCCGTTGGCCTGGGGGCGA
TGGCCGCCCTGATCGGCCTGAGCCTTGAGGACGCCCGCTCTGTTGCCGCCGAGGCGGCCGAGGGCGAGATTTGCGAAGCC
GCCAACGACAACGCCCCCGGGCAGGTGGTGATCAGCGGTCATCGCACCGCCATCGAGCGGGCGATCGTTCTGGCCAAGGC
CAAGGGCTGCAAGCGCGCCCTGCCGCTGCCCGTCAGCGCGCCGTTCCATTGCGCCCTGATGGCGCCGGCGGCCGAGGTCA
TGGCCGAGGCGTTGGAGCGGGTGACCTTCAAGGCGCCGGCGGTGCCGCTGGTGGCCAATGTGACCGCCTCGGCGGTCAGC
GATCCCTTGGAAATCCGCCGACTGCTGGTCGAGCAGGTGACGGGCGCGGTGCGCTGGCGCGAGAGCGTGCTTTATATGGT
CGACGCCGGGGTGAGCGAATTGGTCGAGCTGGGGGCCGGCAAGGTGCTGGGCGGGCTGGCCAAGCGCATCCATGGCGATC
TTGGCGCTCGCTCGATCCAGGGCCCGGCCGATATCGACGCCTTCATCAAGGGGATTTAG

Upstream 100 bases:

>100_bases
CACTCCAGGCGGTCCGGGCCGTGATCGCTGCGCGCCAAGCGCGCGGGCGGTCGGGTCGTTCGGCCCCGACTCCGCGTCCT
CCCAGCTATCGGATCAGGTC

Downstream 100 bases:

>100_bases
GTCCCGTTTATCACTGGGGGGCCGGATCCGCCGGTCCCCGGATTCTAAAGATAAAGCAAATCATGAGAAAGGACGGCTGG
GCCGATCCTTCCATCAGGAG

Product: [Acyl-carrier-protein] S-malonyltransferase

Products: NA

Alternate protein names: MCT [H]

Number of amino acids: Translated: 312; Mature: 311

Protein sequence:

>312_residues
MTRAFVFPGQGSQAVGMGKELADAFPAARDVFQEVDDALSQKLFALMVEGPADELTLTQNAQPALMAVSMAVVRVLETGG
VRLAAHADLVAGHSLGEYSALAAAGALGLADTARLLRIRGEAMQKAVPVGLGAMAALIGLSLEDARSVAAEAAEGEICEA
ANDNAPGQVVISGHRTAIERAIVLAKAKGCKRALPLPVSAPFHCALMAPAAEVMAEALERVTFKAPAVPLVANVTASAVS
DPLEIRRLLVEQVTGAVRWRESVLYMVDAGVSELVELGAGKVLGGLAKRIHGDLGARSIQGPADIDAFIKGI

Sequences:

>Translated_312_residues
MTRAFVFPGQGSQAVGMGKELADAFPAARDVFQEVDDALSQKLFALMVEGPADELTLTQNAQPALMAVSMAVVRVLETGG
VRLAAHADLVAGHSLGEYSALAAAGALGLADTARLLRIRGEAMQKAVPVGLGAMAALIGLSLEDARSVAAEAAEGEICEA
ANDNAPGQVVISGHRTAIERAIVLAKAKGCKRALPLPVSAPFHCALMAPAAEVMAEALERVTFKAPAVPLVANVTASAVS
DPLEIRRLLVEQVTGAVRWRESVLYMVDAGVSELVELGAGKVLGGLAKRIHGDLGARSIQGPADIDAFIKGI
>Mature_311_residues
TRAFVFPGQGSQAVGMGKELADAFPAARDVFQEVDDALSQKLFALMVEGPADELTLTQNAQPALMAVSMAVVRVLETGGV
RLAAHADLVAGHSLGEYSALAAAGALGLADTARLLRIRGEAMQKAVPVGLGAMAALIGLSLEDARSVAAEAAEGEICEAA
NDNAPGQVVISGHRTAIERAIVLAKAKGCKRALPLPVSAPFHCALMAPAAEVMAEALERVTFKAPAVPLVANVTASAVSD
PLEIRRLLVEQVTGAVRWRESVLYMVDAGVSELVELGAGKVLGGLAKRIHGDLGARSIQGPADIDAFIKGI

Specific function: Fatty acid biosynthesis. [C]

COG id: COG0331

COG function: function code I; (acyl-carrier-protein) S-malonyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabD family [H]

Homologues:

Organism=Homo sapiens, GI51243059, Length=296, Percent_Identity=33.445945945946, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI27477045, Length=107, Percent_Identity=36.4485981308411, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1787334, Length=304, Percent_Identity=50, Blast_Score=263, Evalue=1e-71,
Organism=Caenorhabditis elegans, GI71984332, Length=290, Percent_Identity=31.0344827586207, Blast_Score=126, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17550940, Length=294, Percent_Identity=28.2312925170068, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24665753, Length=302, Percent_Identity=32.4503311258278, Blast_Score=123, Evalue=1e-28,

Paralogues:

None

Copy number: 500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001227
- InterPro:   IPR014043
- InterPro:   IPR016035
- InterPro:   IPR004410
- InterPro:   IPR016036 [H]

Pfam domain/function: PF00698 Acyl_transf_1 [H]

EC number: =2.3.1.39 [H]

Molecular weight: Translated: 32139; Mature: 32007

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRAFVFPGQGSQAVGMGKELADAFPAARDVFQEVDDALSQKLFALMVEGPADELTLTQN
CCCEEEECCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECC
AQPALMAVSMAVVRVLETGGVRLAAHADLVAGHSLGEYSALAAAGALGLADTARLLRIRG
CCHHHHHHHHHHHHHHHCCCEEEEEHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EAMQKAVPVGLGAMAALIGLSLEDARSVAAEAAEGEICEAANDNAPGQVVISGHRTAIER
HHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHCCCCHHHCCCCCCCCEEEEECCHHHHHH
AIVLAKAKGCKRALPLPVSAPFHCALMAPAAEVMAEALERVTFKAPAVPLVANVTASAVS
HHHHHHCCCCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHC
DPLEIRRLLVEQVTGAVRWRESVLYMVDAGVSELVELGAGKVLGGLAKRIHGDLGARSIQ
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHCCCCCCCC
GPADIDAFIKGI
CCHHHHHHHCCC
>Mature Secondary Structure 
TRAFVFPGQGSQAVGMGKELADAFPAARDVFQEVDDALSQKLFALMVEGPADELTLTQN
CCEEEECCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECC
AQPALMAVSMAVVRVLETGGVRLAAHADLVAGHSLGEYSALAAAGALGLADTARLLRIRG
CCHHHHHHHHHHHHHHHCCCEEEEEHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EAMQKAVPVGLGAMAALIGLSLEDARSVAAEAAEGEICEAANDNAPGQVVISGHRTAIER
HHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHCCCCHHHCCCCCCCCEEEEECCHHHHHH
AIVLAKAKGCKRALPLPVSAPFHCALMAPAAEVMAEALERVTFKAPAVPLVANVTASAVS
HHHHHHCCCCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHC
DPLEIRRLLVEQVTGAVRWRESVLYMVDAGVSELVELGAGKVLGGLAKRIHGDLGARSIQ
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHCCCCCCCC
GPADIDAFIKGI
CCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8759840; 9534248; 9384377 [H]