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The map label for this gene is ggt [H]

Identifier: 83591725

GI number: 83591725

Start: 462542

End: 464272

Strand: Direct

Name: ggt [H]

Synonym: Rru_A0385

Alternate gene names: 83591725

Gene position: 462542-464272 (Clockwise)

Preceding gene: 83591724

Following gene: 83591727

Centisome position: 10.63

GC content: 65.74

Gene sequence:

>1731_bases
ATGGGGGTGTTGAAGGTCGTCGTCACCACGGGTCTGGCCTTCGCGGCGCTGACCTTGCCGAGCATGGCCCAGGAAAAAGC
CATCTTCGACCCGATGGACCGCATCCATCCGGTGTGGGCCGAGCATGGCATGGTCGCCGCCCAAGAACGGCTGGCCGCTG
AAATCGGCCGCGACATTCTGGCCAAGGGCGGCAACGCCGTTGACGCCGGCGTCGCCGTCGCCTTCGCCCTGGCGGTGACG
CTGCCCCAGGCCGGCAATATCGGCGGCGGCGGCTTCATGATCGTCCATGACGGCCCAACCGGCAAAACCGTCGCCATCGA
CTATCGCGAAAAGGCCCCCGCCGGCGCCAGCCGCGACATGTTCCTTGATGCCCAGGGGAATGCCGACAGCGGAAAGTCGC
TCTACAGCGGCGCGGCCTCGGGCGTCCCGGGCACGGTCGCCGGGATGAAGGCGGCGCTCGATGCTTTCGGCTCGATGGAC
TGGGCCGAGGTCATCGCCCCGGCCATCCGTTTGGCCGAAGGCGGCATCGTCGTCACGCCCAAGCTGGCCGACAGCCTGAA
GGACGCCCGCAAGCAGCTTGAGGCGTTTCCGTCGTCCGCCCGCATCTTTTTGAAAGAGGGCGGGGCCGATTATCGCCCCG
GCGATAGGCTGGTGCAGGCCGATCTGGCGGCAACGCTGAAGACGATCGCCGCCGAAGGCCCCGACGGCTTTTACAAGGGC
GCGGTCGCCGAAAAAATCTCGGCCGCCGTACAGGCGGCGGGTGGGCTTATCACCCCCCAGGATATGGCCGATTACACGGT
CGTGATGCGCGAGCCGGTGCGCGGCGGCTATCGCGGCTATGAGATCGTCTCCATGCCGCCGCCCTCCTCGGGGGGCGTGC
ATCTGGTCCAGATCCTCAATGCGCTAGAGGGCTATCCGATCGGCGCCCTTGGCCAGAACACGGGACAGACCCTTCATCTG
ATGGCCGAAACCATGAAGCTGGCTTACGCCGACCGCGCGCATTATCTGGGCGATCCGGATTTCACGGCGGTGCCGGTGGC
GGCGCTGACGAGCAAGGATTACGCGGCGGCCATGCGCGAGACGATCAGCGCCGATTTCGCCCGTCCCTCGGCCACCATCG
GGCCCGGCGATCTGACGCCCTATGAATCGGACCAGACCACGCATTTTTCCATCATCGACAAGAACGGGAGCGCGGTTGCC
AACACCTATACCCTCAACCTGAGCTATGGCTCGGGTCTGGTGGCCGAGGGGACGGGTGTTTTGATGAACAACGAAATGGA
TGATTTCTCGGCCAAACCCGGTGTGCCCAACGCCTTCGGGCTGGTCGGCGGCGACGCCAACGCGGTTCAGGCGGGCAAGC
GGCCGCTGTCGTCGATGACGCCGACGATCGTGCTCAAGGATGGCAAGGTCTGGCTTGTCACCGGCTCGCCCGGCGGGGCG
CGGATCATCACCACCGTGCTGCAGGTGATCATGAACATGATCGATCACAAGATGAACGTGGCGGAGGCCTCGACCGCCCC
CCGGGCCCATCATCAGTGGCTGCCCGATGAACTGCGCATCGAGGAGGGGATCAGCCTGGATACGATCCGCATCCTGCAGG
CCAAGGGCCATACGATCGCCCTAAAACCGGCGATGGGGTCGACGCAATCGATCATGCGCGATGGCGCGAGCGGCGCCGTC
TATGGCGCCTCGGACCCGCGCGACCCGGATGCGGCGACGGTGGGCTATTGA

Upstream 100 bases:

>100_bases
TTCTTACTCGCGGGAAACTTGTGATCTTTTCGCAGAGTGCAGGCGCGCTTAAGGGCGTCGCGGTCTTGGCGTTTGGGTCG
AAGACGGGCAGGGGGTTGGA

Downstream 100 bases:

>100_bases
GCGTTCGATCGGCCCCCCGGCCCTTTGAGAGGGGCCGGCGGGCGCTTTTCCGCGAAGTCAGAGGGGCGGGGGCGGGCCGA
ACAGGTCGGTGAAGCGCTTC

Product: gamma-glutamyltransferase 1

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 576; Mature: 575

Protein sequence:

>576_residues
MGVLKVVVTTGLAFAALTLPSMAQEKAIFDPMDRIHPVWAEHGMVAAQERLAAEIGRDILAKGGNAVDAGVAVAFALAVT
LPQAGNIGGGGFMIVHDGPTGKTVAIDYREKAPAGASRDMFLDAQGNADSGKSLYSGAASGVPGTVAGMKAALDAFGSMD
WAEVIAPAIRLAEGGIVVTPKLADSLKDARKQLEAFPSSARIFLKEGGADYRPGDRLVQADLAATLKTIAAEGPDGFYKG
AVAEKISAAVQAAGGLITPQDMADYTVVMREPVRGGYRGYEIVSMPPPSSGGVHLVQILNALEGYPIGALGQNTGQTLHL
MAETMKLAYADRAHYLGDPDFTAVPVAALTSKDYAAAMRETISADFARPSATIGPGDLTPYESDQTTHFSIIDKNGSAVA
NTYTLNLSYGSGLVAEGTGVLMNNEMDDFSAKPGVPNAFGLVGGDANAVQAGKRPLSSMTPTIVLKDGKVWLVTGSPGGA
RIITTVLQVIMNMIDHKMNVAEASTAPRAHHQWLPDELRIEEGISLDTIRILQAKGHTIALKPAMGSTQSIMRDGASGAV
YGASDPRDPDAATVGY

Sequences:

>Translated_576_residues
MGVLKVVVTTGLAFAALTLPSMAQEKAIFDPMDRIHPVWAEHGMVAAQERLAAEIGRDILAKGGNAVDAGVAVAFALAVT
LPQAGNIGGGGFMIVHDGPTGKTVAIDYREKAPAGASRDMFLDAQGNADSGKSLYSGAASGVPGTVAGMKAALDAFGSMD
WAEVIAPAIRLAEGGIVVTPKLADSLKDARKQLEAFPSSARIFLKEGGADYRPGDRLVQADLAATLKTIAAEGPDGFYKG
AVAEKISAAVQAAGGLITPQDMADYTVVMREPVRGGYRGYEIVSMPPPSSGGVHLVQILNALEGYPIGALGQNTGQTLHL
MAETMKLAYADRAHYLGDPDFTAVPVAALTSKDYAAAMRETISADFARPSATIGPGDLTPYESDQTTHFSIIDKNGSAVA
NTYTLNLSYGSGLVAEGTGVLMNNEMDDFSAKPGVPNAFGLVGGDANAVQAGKRPLSSMTPTIVLKDGKVWLVTGSPGGA
RIITTVLQVIMNMIDHKMNVAEASTAPRAHHQWLPDELRIEEGISLDTIRILQAKGHTIALKPAMGSTQSIMRDGASGAV
YGASDPRDPDAATVGY
>Mature_575_residues
GVLKVVVTTGLAFAALTLPSMAQEKAIFDPMDRIHPVWAEHGMVAAQERLAAEIGRDILAKGGNAVDAGVAVAFALAVTL
PQAGNIGGGGFMIVHDGPTGKTVAIDYREKAPAGASRDMFLDAQGNADSGKSLYSGAASGVPGTVAGMKAALDAFGSMDW
AEVIAPAIRLAEGGIVVTPKLADSLKDARKQLEAFPSSARIFLKEGGADYRPGDRLVQADLAATLKTIAAEGPDGFYKGA
VAEKISAAVQAAGGLITPQDMADYTVVMREPVRGGYRGYEIVSMPPPSSGGVHLVQILNALEGYPIGALGQNTGQTLHLM
AETMKLAYADRAHYLGDPDFTAVPVAALTSKDYAAAMRETISADFARPSATIGPGDLTPYESDQTTHFSIIDKNGSAVAN
TYTLNLSYGSGLVAEGTGVLMNNEMDDFSAKPGVPNAFGLVGGDANAVQAGKRPLSSMTPTIVLKDGKVWLVTGSPGGAR
IITTVLQVIMNMIDHKMNVAEASTAPRAHHQWLPDELRIEEGISLDTIRILQAKGHTIALKPAMGSTQSIMRDGASGAVY
GASDPRDPDAATVGY

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=561, Percent_Identity=34.5811051693405, Blast_Score=279, Evalue=5e-75,
Organism=Homo sapiens, GI73915090, Length=561, Percent_Identity=34.5811051693405, Blast_Score=279, Evalue=5e-75,
Organism=Homo sapiens, GI73915096, Length=561, Percent_Identity=34.5811051693405, Blast_Score=279, Evalue=5e-75,
Organism=Homo sapiens, GI73915094, Length=561, Percent_Identity=34.5811051693405, Blast_Score=279, Evalue=5e-75,
Organism=Homo sapiens, GI113429324, Length=561, Percent_Identity=33.3333333333333, Blast_Score=252, Evalue=7e-67,
Organism=Homo sapiens, GI113429326, Length=566, Percent_Identity=32.6855123674912, Blast_Score=245, Evalue=1e-64,
Organism=Homo sapiens, GI109148539, Length=585, Percent_Identity=31.7948717948718, Blast_Score=214, Evalue=2e-55,
Organism=Homo sapiens, GI153266885, Length=546, Percent_Identity=30.5860805860806, Blast_Score=181, Evalue=2e-45,
Organism=Homo sapiens, GI153266901, Length=547, Percent_Identity=30.5301645338208, Blast_Score=180, Evalue=3e-45,
Organism=Homo sapiens, GI153266907, Length=545, Percent_Identity=28.4403669724771, Blast_Score=159, Evalue=5e-39,
Organism=Homo sapiens, GI30581157, Length=222, Percent_Identity=36.4864864864865, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI30581155, Length=222, Percent_Identity=36.4864864864865, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI218505805, Length=221, Percent_Identity=34.3891402714932, Blast_Score=110, Evalue=5e-24,
Organism=Homo sapiens, GI310124095, Length=221, Percent_Identity=32.1266968325792, Blast_Score=92, Evalue=1e-18,
Organism=Escherichia coli, GI1789856, Length=545, Percent_Identity=59.4495412844037, Blast_Score=647, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17506189, Length=594, Percent_Identity=32.6599326599327, Blast_Score=267, Evalue=1e-71,
Organism=Caenorhabditis elegans, GI212646519, Length=502, Percent_Identity=35.6573705179283, Blast_Score=265, Evalue=5e-71,
Organism=Caenorhabditis elegans, GI72000294, Length=502, Percent_Identity=35.6573705179283, Blast_Score=265, Evalue=6e-71,
Organism=Caenorhabditis elegans, GI193208247, Length=547, Percent_Identity=31.2614259597806, Blast_Score=228, Evalue=5e-60,
Organism=Caenorhabditis elegans, GI193208245, Length=547, Percent_Identity=31.2614259597806, Blast_Score=228, Evalue=5e-60,
Organism=Caenorhabditis elegans, GI17542894, Length=531, Percent_Identity=31.8267419962335, Blast_Score=216, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI17564448, Length=452, Percent_Identity=26.3274336283186, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI72001497, Length=222, Percent_Identity=28.8288288288288, Blast_Score=90, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI72001495, Length=222, Percent_Identity=28.8288288288288, Blast_Score=89, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6323330, Length=516, Percent_Identity=29.4573643410853, Blast_Score=162, Evalue=1e-40,
Organism=Drosophila melanogaster, GI161077496, Length=508, Percent_Identity=32.8740157480315, Blast_Score=236, Evalue=4e-62,
Organism=Drosophila melanogaster, GI161077880, Length=543, Percent_Identity=32.0441988950276, Blast_Score=234, Evalue=1e-61,
Organism=Drosophila melanogaster, GI24642670, Length=540, Percent_Identity=31.8518518518519, Blast_Score=234, Evalue=1e-61,
Organism=Drosophila melanogaster, GI24642666, Length=540, Percent_Identity=31.8518518518519, Blast_Score=234, Evalue=1e-61,
Organism=Drosophila melanogaster, GI45551474, Length=543, Percent_Identity=32.0441988950276, Blast_Score=234, Evalue=2e-61,
Organism=Drosophila melanogaster, GI161077878, Length=543, Percent_Identity=32.0441988950276, Blast_Score=233, Evalue=2e-61,
Organism=Drosophila melanogaster, GI18859893, Length=520, Percent_Identity=32.8846153846154, Blast_Score=233, Evalue=4e-61,
Organism=Drosophila melanogaster, GI18859741, Length=535, Percent_Identity=28.785046728972, Blast_Score=194, Evalue=2e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 59803; Mature: 59671

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: PS00462 G_GLU_TRANSPEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVLKVVVTTGLAFAALTLPSMAQEKAIFDPMDRIHPVWAEHGMVAAQERLAAEIGRDIL
CCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCHHHHHCCHHHHHHHHHHHHHHHHH
AKGGNAVDAGVAVAFALAVTLPQAGNIGGGGFMIVHDGPTGKTVAIDYREKAPAGASRDM
HCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCEEEEECCCCCCCCCCCCE
FLDAQGNADSGKSLYSGAASGVPGTVAGMKAALDAFGSMDWAEVIAPAIRLAEGGIVVTP
EEECCCCCCCCCHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEECH
KLADSLKDARKQLEAFPSSARIFLKEGGADYRPGDRLVQADLAATLKTIAAEGPDGFYKG
HHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHH
AVAEKISAAVQAAGGLITPQDMADYTVVMREPVRGGYRGYEIVSMPPPSSGGVHLVQILN
HHHHHHHHHHHHHCCCCCCHHHCCEEEEEECCCCCCCCCEEEEECCCCCCCCHHHHHHHH
ALEGYPIGALGQNTGQTLHLMAETMKLAYADRAHYLGDPDFTAVPVAALTSKDYAAAMRE
HHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEECHHHHCCHHHHHHHHH
TISADFARPSATIGPGDLTPYESDQTTHFSIIDKNGSAVANTYTLNLSYGSGLVAEGTGV
HHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEEEEEEEECCCCEEECCCEE
LMNNEMDDFSAKPGVPNAFGLVGGDANAVQAGKRPLSSMTPTIVLKDGKVWLVTGSPGGA
EECCCCCCCCCCCCCCCCCEEECCCCHHHHHCCCCCCCCCCEEEEECCEEEEEECCCCCH
RIITTVLQVIMNMIDHKMNVAEASTAPRAHHQWLPDELRIEEGISLDTIRILQAKGHTIA
HHHHHHHHHHHHHHHHHCCHHHCCCCCCHHHCCCCHHHHHHCCCCCCEEEEEEECCCEEE
LKPAMGSTQSIMRDGASGAVYGASDPRDPDAATVGY
EECCCCCHHHHHHCCCCCEEECCCCCCCCCCCCCCC
>Mature Secondary Structure 
GVLKVVVTTGLAFAALTLPSMAQEKAIFDPMDRIHPVWAEHGMVAAQERLAAEIGRDIL
CCEEEHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCHHHHHCCHHHHHHHHHHHHHHHHH
AKGGNAVDAGVAVAFALAVTLPQAGNIGGGGFMIVHDGPTGKTVAIDYREKAPAGASRDM
HCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCEEEEECCCCCCCCCCCCE
FLDAQGNADSGKSLYSGAASGVPGTVAGMKAALDAFGSMDWAEVIAPAIRLAEGGIVVTP
EEECCCCCCCCCHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEECH
KLADSLKDARKQLEAFPSSARIFLKEGGADYRPGDRLVQADLAATLKTIAAEGPDGFYKG
HHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHH
AVAEKISAAVQAAGGLITPQDMADYTVVMREPVRGGYRGYEIVSMPPPSSGGVHLVQILN
HHHHHHHHHHHHHCCCCCCHHHCCEEEEEECCCCCCCCCEEEEECCCCCCCCHHHHHHHH
ALEGYPIGALGQNTGQTLHLMAETMKLAYADRAHYLGDPDFTAVPVAALTSKDYAAAMRE
HHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEECHHHHCCHHHHHHHHH
TISADFARPSATIGPGDLTPYESDQTTHFSIIDKNGSAVANTYTLNLSYGSGLVAEGTGV
HHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEEEEEEEECCCCEEECCCEE
LMNNEMDDFSAKPGVPNAFGLVGGDANAVQAGKRPLSSMTPTIVLKDGKVWLVTGSPGGA
EECCCCCCCCCCCCCCCCCEEECCCCHHHHHCCCCCCCCCCEEEEECCEEEEEECCCCCH
RIITTVLQVIMNMIDHKMNVAEASTAPRAHHQWLPDELRIEEGISLDTIRILQAKGHTIA
HHHHHHHHHHHHHHHHHCCHHHCCCCCCHHHCCCCHHHHHHCCCCCCEEEEEEECCCEEE
LKPAMGSTQSIMRDGASGAVYGASDPRDPDAATVGY
EECCCCCHHHHHHCCCCCEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2570061; 9278503; 8041620; 1360205 [H]