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The map label for this gene is hmrR [H]

Identifier: 83591722

GI number: 83591722

Start: 460121

End: 460585

Strand: Direct

Name: hmrR [H]

Synonym: Rru_A0382

Alternate gene names: 83591722

Gene position: 460121-460585 (Clockwise)

Preceding gene: 83591720

Following gene: 83591723

Centisome position: 10.57

GC content: 61.72

Gene sequence:

>465_bases
ATGAAAGTCCTCGATATCGGCGAGGTCTCCGCGCAAACGGGGTTCCCCGCCTCGGCCCTTCGCTATTACGAGGAGGTCGG
CCTGATTTCCTCGATCGCCCGCCATGGCCTGCGCCGGCAGTTCGCCCCCGAGGTGCTGGTGCAGTTGAAGCTGATCGCGC
TGGGAAAAACCGCCGGATTCTCGCTCGACGAGATTTCCGCGATGTTTGGCAAAACCGGCGCGCCAGACCTGCCGCGCGCC
ATGCTCCATGAAAAGGCCGACGCGCTGGATCGACAAATCCGCGACCTGACGGCTTTGCGCGATACCCTGCGCCACGTCGC
CGAGTGCCGCGCCCCCTCGCACATGGAATGTCCTACCTTCAGGCGCTTGGTGGAGCTTGCCGGCAAGCACGGCAAGCTCC
GCGCCAGGAAAGGGGTTGGAAAAAAGAGCGTATTAAAAGAGAAAAAATCAGGAGTGGACGCCTAA

Upstream 100 bases:

>100_bases
CGACCGGCACCGATGATCCTGGTGGTTTCATATCCTCGCCCTCTTGCTGGAAACGTCTTGATGGGGCAGGCTACGAAATC
AAGTCAACTTGAGGTCAAGC

Downstream 100 bases:

>100_bases
GTAAAAATAAGCGCACGGATTTTTCCTAGGGAAAACGCCAAAGTTTGATGGTATCACTTCTTTCTAATGGGACTTCTTTG
CCGGTGTTTTCTGCCTTGAT

Product: MerR family transcriptional regulator

Products: NA

Alternate protein names: Copper efflux regulator; Copper export regulator [H]

Number of amino acids: Translated: 154; Mature: 154

Protein sequence:

>154_residues
MKVLDIGEVSAQTGFPASALRYYEEVGLISSIARHGLRRQFAPEVLVQLKLIALGKTAGFSLDEISAMFGKTGAPDLPRA
MLHEKADALDRQIRDLTALRDTLRHVAECRAPSHMECPTFRRLVELAGKHGKLRARKGVGKKSVLKEKKSGVDA

Sequences:

>Translated_154_residues
MKVLDIGEVSAQTGFPASALRYYEEVGLISSIARHGLRRQFAPEVLVQLKLIALGKTAGFSLDEISAMFGKTGAPDLPRA
MLHEKADALDRQIRDLTALRDTLRHVAECRAPSHMECPTFRRLVELAGKHGKLRARKGVGKKSVLKEKKSGVDA
>Mature_154_residues
MKVLDIGEVSAQTGFPASALRYYEEVGLISSIARHGLRRQFAPEVLVQLKLIALGKTAGFSLDEISAMFGKTGAPDLPRA
MLHEKADALDRQIRDLTALRDTLRHVAECRAPSHMECPTFRRLVELAGKHGKLRARKGVGKKSVLKEKKSGVDA

Specific function: Regulates the transcription of actP. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations. In the absence of copper, it negatively regulates the transcription of actP [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790498, Length=121, Percent_Identity=33.0578512396694, Blast_Score=63, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011789
- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 16889; Mature: 16889

Theoretical pI: Translated: 10.52; Mature: 10.52

Prosite motif: PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVLDIGEVSAQTGFPASALRYYEEVGLISSIARHGLRRQFAPEVLVQLKLIALGKTAGF
CCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
SLDEISAMFGKTGAPDLPRAMLHEKADALDRQIRDLTALRDTLRHVAECRAPSHMECPTF
CHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
RRLVELAGKHGKLRARKGVGKKSVLKEKKSGVDA
HHHHHHHCCCCCHHHHHCCCHHHHHHHHHCCCCC
>Mature Secondary Structure
MKVLDIGEVSAQTGFPASALRYYEEVGLISSIARHGLRRQFAPEVLVQLKLIALGKTAGF
CCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
SLDEISAMFGKTGAPDLPRAMLHEKADALDRQIRDLTALRDTLRHVAECRAPSHMECPTF
CHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
RRLVELAGKHGKLRARKGVGKKSVLKEKKSGVDA
HHHHHHHCCCCCHHHHHCCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11936079 [H]