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The map label for this gene is fdhF [H]

Identifier: 83591664

GI number: 83591664

Start: 392708

End: 394849

Strand: Direct

Name: fdhF [H]

Synonym: Rru_A0324

Alternate gene names: 83591664

Gene position: 392708-394849 (Clockwise)

Preceding gene: 83591663

Following gene: 83591665

Centisome position: 9.02

GC content: 61.76

Gene sequence:

>2142_bases
ATGGAAAAGGTTTTGACCGTCTGCCCGTATTGCGGCTCGGGGTGCAAGATCAACCTGCTCGTCGAGAACGATCAGGTGAT
TGGCGCTGAACCGGCCCAGGGCGTGACCAACCAGGGCGAATTGTGCCTTAAAGGCTATTACGGCTGGGACTTCCTGAATG
ATCCCAAGCTGCTGACCCCGCGCCTGCGCAAGCCGCTGATCCGCCGGACCCGTGACTCGGCCTTCGAGGAGGTGTCGTGG
TACGAGGCGATCAACTTCGCCGCCACCCGCTTGCAAGAGATCAAGCATAAGTACGGCCCGGATTCGATCATGCTGACCGG
TTCGGCCCGGGGGCCGGGCAACGAAGCCAACTACGTGATGCAGAAGTTCGCCCGCGCCGTGGTCGGAACCAACAACATCG
ACCATTGCGCCCGCGTCTGCCACGGCCCCAGCGTCGCCGGTCTGCAGGTGACCCTGGGCAATGGCGCCATGAGCAATTCG
GTCGAGGAGATCGAAAACACCAAATGCGTTTTCGTCTTCGGCTATAACGCCGCCGTTTCCCATCCGATCGTCGCCCGCCG
CATCCTCAAGGCCAAGGAGAAGGGCGCCAAGATCATCGTCTGTGACCCGCGCTTCATCGAGACCGCGCGCATCGCCGATC
TGTGGTTGCCGCTGAAGAACGGCACCAACATGGCCCTGGTCAACGCCTTCGCCCATGTGCTGCTTGAAGAAAACCTTTAC
GACAAGGATTTCGTGGCGAAGTACACCGAAGGCCTGGATGACTACAAGGCGACGGTGGCCAAATACACCCCGGAATACGC
CGAAAAGATCACCGGCGTTCCCGCCCAGCAGATCCGCGAAGCCATGCGGATGTACGCCGGGGCCGAGACGGCGACCGTCA
TGTGGGGCATGGGCGTCACCCAGTGGTCCCAGGCCGTCGATGTGGTCAAGGGGCTGTCGGGTCTGGCCTTGCTGACGGGC
AATCTGGGCAAGCCGTCGTGTGGCGTCGCCCCGGTGCGCGGACAAAACAACGTCCAGGGCGCCTGCGATCATGGCGCGCT
GCCCAACATGCTGCCGGGCTATCAGCCGGTGACCGATGCGGCGGCGCGGGCCAAGTTCGAGAAGGCCTGGGGGGTGAGCA
ATCTTCCCGACAAGCCCGGCGTCTGCCTGACCGAAGTGCCCAAGATGGTTAAGGCCGGCAAGCTCAAGGCCTATTACATC
TTCGGCGAAGACCCCGCCCAGACCGATCCCGATCTGCATGAAGTTCGTGAATCCATGCGCGATCTGGAATTCGTCATCTG
CCAGGAAATCTTCATGACCAAGACGGCGATGATGGCCGACGTGGTCTTCCCGGCCACCTCGTGGGGCGAGCACGAGGGCG
TCTATTCCAGCTGCGACCGTGGCTTCCAGCGCTTCTACAAGGCGATCGAACCGCAGGGCGACGTCAAGCCCGACTGGGAG
ATCATCTCGCTGATGGCGACGGCCATGGGCTATCCCATGAAGTACAGCAATACCCAGGAGATCTGGGACGAGCTGCGCGA
GCTTTGCCCGATCTATTACGGAGCGACCTACGAGAAGATGGCCGGCCTGGGCTATATCCAGTGGCCTTGCCCCGATCTCG
ACCATCCCGGCACGCCTTATCTCTATGCGGACAAGAAGTTCCAGACGCCTTCGGGCAAGGGATTGCTGTTCGCCTGCGAG
TGGCGCCCGCCGATGGAAAAGGTCGATGCCGCCTATCCGCTGATTCTCAGCACGGTGCGCGAGGTCGGTCACTATTCCTG
CCGGACGATGACGGGCAACTGTCACGCCCTGCAGACCCTGGCCGACGAGCCGGGCTATATCAGCATGCACAGCAAGGACG
CCAAGGCGCTGGGCATCAGTGACCAGCATCTGGTGTCGATCTCATCGCGTCGCGGCAAGATCATCGCCCGTGCCGATATC
GACGACCGCATCAACGAAGGCGCCGTTTACATGACCTACCAGTGGTGGGTTGGCGCCTGCAACGAACTGACCGCCGAGCA
CCTCGATCCGATCTCCAAGACCCCGGAATACAAGTATTCCGCCGTCAAGGTCGAGGCCATCGCCGATCAGGCCTGGGCCG
AAAACCACGTCCAGGAGGTCTATAGCCAGCTCAAGGCCGATCTGGCGAACGCCGTCGCCTAA

Upstream 100 bases:

>100_bases
GGAGGTGCTGCGCAAGCGCCAGCTCCAGGCCGCCCTCGACGCCTCGGGCATGTCCCTCTGAGCGCGACAAGCACATCCAT
CGCCTAAAGGAGTAGAGAAG

Downstream 100 bases:

>100_bases
GGCGTCTTCTCCCGCCGGCCTTAGGCGTTAACCGGGGAGCCCGGGTCCTGGCCGCCTTCCAGGATCCGGGCCCTTCCGGC
GGGCGCCGAGGGTCGTTTCT

Product: formate dehydrogenase subunit alpha

Products: NA

Alternate protein names: Formate dehydrogenase-H subunit alpha; FDH-H; Formate-hydrogen-lyase-linked, selenocysteine-containing polypeptide [H]

Number of amino acids: Translated: 713; Mature: 713

Protein sequence:

>713_residues
MEKVLTVCPYCGSGCKINLLVENDQVIGAEPAQGVTNQGELCLKGYYGWDFLNDPKLLTPRLRKPLIRRTRDSAFEEVSW
YEAINFAATRLQEIKHKYGPDSIMLTGSARGPGNEANYVMQKFARAVVGTNNIDHCARVCHGPSVAGLQVTLGNGAMSNS
VEEIENTKCVFVFGYNAAVSHPIVARRILKAKEKGAKIIVCDPRFIETARIADLWLPLKNGTNMALVNAFAHVLLEENLY
DKDFVAKYTEGLDDYKATVAKYTPEYAEKITGVPAQQIREAMRMYAGAETATVMWGMGVTQWSQAVDVVKGLSGLALLTG
NLGKPSCGVAPVRGQNNVQGACDHGALPNMLPGYQPVTDAAARAKFEKAWGVSNLPDKPGVCLTEVPKMVKAGKLKAYYI
FGEDPAQTDPDLHEVRESMRDLEFVICQEIFMTKTAMMADVVFPATSWGEHEGVYSSCDRGFQRFYKAIEPQGDVKPDWE
IISLMATAMGYPMKYSNTQEIWDELRELCPIYYGATYEKMAGLGYIQWPCPDLDHPGTPYLYADKKFQTPSGKGLLFACE
WRPPMEKVDAAYPLILSTVREVGHYSCRTMTGNCHALQTLADEPGYISMHSKDAKALGISDQHLVSISSRRGKIIARADI
DDRINEGAVYMTYQWWVGACNELTAEHLDPISKTPEYKYSAVKVEAIADQAWAENHVQEVYSQLKADLANAVA

Sequences:

>Translated_713_residues
MEKVLTVCPYCGSGCKINLLVENDQVIGAEPAQGVTNQGELCLKGYYGWDFLNDPKLLTPRLRKPLIRRTRDSAFEEVSW
YEAINFAATRLQEIKHKYGPDSIMLTGSARGPGNEANYVMQKFARAVVGTNNIDHCARVCHGPSVAGLQVTLGNGAMSNS
VEEIENTKCVFVFGYNAAVSHPIVARRILKAKEKGAKIIVCDPRFIETARIADLWLPLKNGTNMALVNAFAHVLLEENLY
DKDFVAKYTEGLDDYKATVAKYTPEYAEKITGVPAQQIREAMRMYAGAETATVMWGMGVTQWSQAVDVVKGLSGLALLTG
NLGKPSCGVAPVRGQNNVQGACDHGALPNMLPGYQPVTDAAARAKFEKAWGVSNLPDKPGVCLTEVPKMVKAGKLKAYYI
FGEDPAQTDPDLHEVRESMRDLEFVICQEIFMTKTAMMADVVFPATSWGEHEGVYSSCDRGFQRFYKAIEPQGDVKPDWE
IISLMATAMGYPMKYSNTQEIWDELRELCPIYYGATYEKMAGLGYIQWPCPDLDHPGTPYLYADKKFQTPSGKGLLFACE
WRPPMEKVDAAYPLILSTVREVGHYSCRTMTGNCHALQTLADEPGYISMHSKDAKALGISDQHLVSISSRRGKIIARADI
DDRINEGAVYMTYQWWVGACNELTAEHLDPISKTPEYKYSAVKVEAIADQAWAENHVQEVYSQLKADLANAVA
>Mature_713_residues
MEKVLTVCPYCGSGCKINLLVENDQVIGAEPAQGVTNQGELCLKGYYGWDFLNDPKLLTPRLRKPLIRRTRDSAFEEVSW
YEAINFAATRLQEIKHKYGPDSIMLTGSARGPGNEANYVMQKFARAVVGTNNIDHCARVCHGPSVAGLQVTLGNGAMSNS
VEEIENTKCVFVFGYNAAVSHPIVARRILKAKEKGAKIIVCDPRFIETARIADLWLPLKNGTNMALVNAFAHVLLEENLY
DKDFVAKYTEGLDDYKATVAKYTPEYAEKITGVPAQQIREAMRMYAGAETATVMWGMGVTQWSQAVDVVKGLSGLALLTG
NLGKPSCGVAPVRGQNNVQGACDHGALPNMLPGYQPVTDAAARAKFEKAWGVSNLPDKPGVCLTEVPKMVKAGKLKAYYI
FGEDPAQTDPDLHEVRESMRDLEFVICQEIFMTKTAMMADVVFPATSWGEHEGVYSSCDRGFQRFYKAIEPQGDVKPDWE
IISLMATAMGYPMKYSNTQEIWDELRELCPIYYGATYEKMAGLGYIQWPCPDLDHPGTPYLYADKKFQTPSGKGLLFACE
WRPPMEKVDAAYPLILSTVREVGHYSCRTMTGNCHALQTLADEPGYISMHSKDAKALGISDQHLVSISSRRGKIIARADI
DDRINEGAVYMTYQWWVGACNELTAEHLDPISKTPEYKYSAVKVEAIADQAWAENHVQEVYSQLKADLANAVA

Specific function: Decomposes formic acid to hydrogen and carbon dioxide under anaerobic conditions in the absence of exogenous electron acceptors [H]

COG id: COG0243

COG function: function code C; Anaerobic dehydrogenases, typically selenocysteine-containing

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI3868721, Length=713, Percent_Identity=63.6746143057504, Blast_Score=971, Evalue=0.0,
Organism=Escherichia coli, GI1788534, Length=791, Percent_Identity=25.5372945638432, Blast_Score=234, Evalue=1e-62,
Organism=Escherichia coli, GI3868720, Length=616, Percent_Identity=26.461038961039, Blast_Score=184, Evalue=1e-47,
Organism=Escherichia coli, GI3868719, Length=619, Percent_Identity=25.5250403877221, Blast_Score=182, Evalue=5e-47,
Organism=Escherichia coli, GI87081797, Length=784, Percent_Identity=25.5102040816327, Blast_Score=151, Evalue=1e-37,
Organism=Escherichia coli, GI1787870, Length=787, Percent_Identity=24.9047013977128, Blast_Score=145, Evalue=1e-35,
Organism=Escherichia coli, GI171474008, Length=793, Percent_Identity=25.094577553594, Blast_Score=144, Evalue=3e-35,
Organism=Escherichia coli, GI1787778, Length=682, Percent_Identity=22.8739002932551, Blast_Score=143, Evalue=3e-35,
Organism=Escherichia coli, GI1787231, Length=695, Percent_Identity=24.1726618705036, Blast_Score=100, Evalue=4e-22,
Organism=Escherichia coli, GI87081994, Length=713, Percent_Identity=23.0014025245442, Blast_Score=98, Evalue=2e-21,
Organism=Escherichia coli, GI145693196, Length=677, Percent_Identity=21.2703101920236, Blast_Score=84, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17565758, Length=121, Percent_Identity=30.5785123966942, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009010
- InterPro:   IPR006478
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006963
- InterPro:   IPR006655 [H]

Pfam domain/function: PF04879 Molybdop_Fe4S4; PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: =1.2.1.2 [H]

Molecular weight: Translated: 78903; Mature: 78903

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: PS00551 MOLYBDOPTERIN_PROK_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKVLTVCPYCGSGCKINLLVENDQVIGAEPAQGVTNQGELCLKGYYGWDFLNDPKLLTP
CCCCEEECCCCCCCCEEEEEEECCCEECCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCH
RLRKPLIRRTRDSAFEEVSWYEAINFAATRLQEIKHKYGPDSIMLTGSARGPGNEANYVM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHH
QKFARAVVGTNNIDHCARVCHGPSVAGLQVTLGNGAMSNSVEEIENTKCVFVFGYNAAVS
HHHHHHHHCCCCHHHHHHHHCCCCCCEEEEEECCCCHHCCHHHHCCCCEEEEEECCHHHC
HPIVARRILKAKEKGAKIIVCDPRFIETARIADLWLPLKNGTNMALVNAFAHVLLEENLY
CHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHCCCC
DKDFVAKYTEGLDDYKATVAKYTPEYAEKITGVPAQQIREAMRMYAGAETATVMWGMGVT
CHHHHHHHHCCHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHCCCCHHEEEECCCHH
QWSQAVDVVKGLSGLALLTGNLGKPSCGVAPVRGQNNVQGACDHGALPNMLPGYQPVTDA
HHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHH
AARAKFEKAWGVSNLPDKPGVCLTEVPKMVKAGKLKAYYIFGEDPAQTDPDLHEVRESMR
HHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHHHHHHHH
DLEFVICQEIFMTKTAMMADVVFPATSWGEHEGVYSSCDRGFQRFYKAIEPQGDVKPDWE
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHH
IISLMATAMGYPMKYSNTQEIWDELRELCPIYYGATYEKMAGLGYIQWPCPDLDHPGTPY
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHCCCCEEECCCCCCCCCCCCE
LYADKKFQTPSGKGLLFACEWRPPMEKVDAAYPLILSTVREVGHYSCRTMTGNCHALQTL
EEECCEECCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHH
ADEPGYISMHSKDAKALGISDQHLVSISSRRGKIIARADIDDRINEGAVYMTYQWWVGAC
CCCCCEEEEECCCCCEECCCCHHEEEECCCCCCEEEECCCCCCCCCCEEEEEEEHHHHCH
NELTAEHLDPISKTPEYKYSAVKVEAIADQAWAENHVQEVYSQLKADLANAVA
HHHHHHHCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEKVLTVCPYCGSGCKINLLVENDQVIGAEPAQGVTNQGELCLKGYYGWDFLNDPKLLTP
CCCCEEECCCCCCCCEEEEEEECCCEECCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCH
RLRKPLIRRTRDSAFEEVSWYEAINFAATRLQEIKHKYGPDSIMLTGSARGPGNEANYVM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHH
QKFARAVVGTNNIDHCARVCHGPSVAGLQVTLGNGAMSNSVEEIENTKCVFVFGYNAAVS
HHHHHHHHCCCCHHHHHHHHCCCCCCEEEEEECCCCHHCCHHHHCCCCEEEEEECCHHHC
HPIVARRILKAKEKGAKIIVCDPRFIETARIADLWLPLKNGTNMALVNAFAHVLLEENLY
CHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHCCCC
DKDFVAKYTEGLDDYKATVAKYTPEYAEKITGVPAQQIREAMRMYAGAETATVMWGMGVT
CHHHHHHHHCCHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHCCCCHHEEEECCCHH
QWSQAVDVVKGLSGLALLTGNLGKPSCGVAPVRGQNNVQGACDHGALPNMLPGYQPVTDA
HHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHH
AARAKFEKAWGVSNLPDKPGVCLTEVPKMVKAGKLKAYYIFGEDPAQTDPDLHEVRESMR
HHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHHHHHHHH
DLEFVICQEIFMTKTAMMADVVFPATSWGEHEGVYSSCDRGFQRFYKAIEPQGDVKPDWE
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHH
IISLMATAMGYPMKYSNTQEIWDELRELCPIYYGATYEKMAGLGYIQWPCPDLDHPGTPY
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHCCCCEEECCCCCCCCCCCCE
LYADKKFQTPSGKGLLFACEWRPPMEKVDAAYPLILSTVREVGHYSCRTMTGNCHALQTL
EEECCEECCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHH
ADEPGYISMHSKDAKALGISDQHLVSISSRRGKIIARADIDDRINEGAVYMTYQWWVGAC
CCCCCEEEEECCCCCEECCCCHHEEEECCCCCCEEEECCCCCCCCCCEEEEEEEHHHHCH
NELTAEHLDPISKTPEYKYSAVKVEAIADQAWAENHVQEVYSQLKADLANAVA
HHHHHHHCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2941757; 8265357; 9278503; 2211698; 9036855 [H]