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The map label for this gene is emrK [H]

Identifier: 83591496

GI number: 83591496

Start: 180433

End: 181605

Strand: Direct

Name: emrK [H]

Synonym: Rru_A0156

Alternate gene names: 83591496

Gene position: 180433-181605 (Clockwise)

Preceding gene: 83591492

Following gene: 83591497

Centisome position: 4.15

GC content: 69.74

Gene sequence:

>1173_bases
ATGTCCACCGCCCCCTCGGGACCCCGTTCAACCGTGTCTGCCGAACCGACGCTGCCCCCCGCGTCCCCCCGTTCCTGGGG
TCGCCGCCTGCTGCTTGGCGTCCTTGTCGTTGGCGCGGTGGCGGCGGCCGGGGTGTTCGGCTGGCGCTGGTGGACCGAGG
GACGGTTTCTTGAAACCACCGACAACGCCTATATCCAGGGCGACATCACCGCCATCGCCCCCAAGGTCTCGGGCTATGTG
GACGAGGTCGCCGTCGGCGACAACGAGGTGGTTAGCGCCGGTCAGCTGCTGGTGCGCTTAGATAGCGCCGATTACCGGGT
TCAGGTGGATCAGGCCCGTGCCAACGCCGAGGGCAAGGCCGCCGAACTGGCCTCGATCATCGCCAATATCGATCTTCAAC
AGACGGCGATCGCCCAGGCCCGGGGCGCGATGGACGCCGCCCAGGCGCGGTTCGATCGCGCCGCCAAGGATCTGGCCCGC
TATCAGGATCTGGTGGGCCGTGGCGCCACCAGTCGCCAGAGCCTGGACAGCGCCCGCGAACAGGCGACCTCTGGCGCGGC
CGAGCTGCGCAGCGCCGCCGCCGCCCTTGACGGCGCCCAGAAGCGTCTGGCCGTGCTCAGCGCCGATCGCGACGCGGCGG
CGGCCGAAGTGCGCTCGGCCCAGGCGCAACGCGCCCTGGCCGAGATCAATCTCGCCAATACGGAAATCCGCGCGCCGATC
GCCGGGGTGGTCGGCAATCGCGGGGTGCGGGCCGGTCAGTATGTGGCTCCCGGATCGGCGCTGATGGCGATCGTGCCGCT
TGAGGGCCTGTGGATCGCGGCGAACTTCAAGGAAACCCAATTGGGCGCCATGGCGCCGGGACAGACGGTGAAGGTGGAGA
TCGACGCCTATTCCGGTCGCCACGGCCAGGGCCGGGTGGTCAGTTTCGCCCCGGCCTCGGGGGCGCAGTTCAGCCTGCTG
CCGCCCGAGAACGCCACGGGCAATTTCACCAAGGTCGTCCAACGCGTTCCGGTGCGGATCGAGATGCTTGCCGATGATCC
GCTGTCGGCGCTGATGCGCCCGGGGCTGTCGGTCGAGGTCTCGGTCGATACCCGTGGCGGGCGCGATGTCGCGCTGGGTC
TGGTCGGCACCGCCCTGGCCGGTTCGGCCGGGTCTTCCCCCACCCACCGCTAA

Upstream 100 bases:

>100_bases
TCCTTGAAATGGGGCGGGCGCTCCGTCATTTAAACCGGGCAGTTTAGTTTGTGTCACGCGAAGTTTTGAACTCCGCGTTC
TCCGGCCTTCAGGAGCCCCC

Downstream 100 bases:

>100_bases
GTCGGGGCGCCCCGTTCCATGGCCGCCGCCCCCGCTTCCGCCGCCGTCTCCGGCGGTGCCTTGCCCTTGCGCGATCGCCT
TGGCTTCTTCGCCCTGGTGG

Product: secretion protein HlyD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 390; Mature: 389

Protein sequence:

>390_residues
MSTAPSGPRSTVSAEPTLPPASPRSWGRRLLLGVLVVGAVAAAGVFGWRWWTEGRFLETTDNAYIQGDITAIAPKVSGYV
DEVAVGDNEVVSAGQLLVRLDSADYRVQVDQARANAEGKAAELASIIANIDLQQTAIAQARGAMDAAQARFDRAAKDLAR
YQDLVGRGATSRQSLDSAREQATSGAAELRSAAAALDGAQKRLAVLSADRDAAAAEVRSAQAQRALAEINLANTEIRAPI
AGVVGNRGVRAGQYVAPGSALMAIVPLEGLWIAANFKETQLGAMAPGQTVKVEIDAYSGRHGQGRVVSFAPASGAQFSLL
PPENATGNFTKVVQRVPVRIEMLADDPLSALMRPGLSVEVSVDTRGGRDVALGLVGTALAGSAGSSPTHR

Sequences:

>Translated_390_residues
MSTAPSGPRSTVSAEPTLPPASPRSWGRRLLLGVLVVGAVAAAGVFGWRWWTEGRFLETTDNAYIQGDITAIAPKVSGYV
DEVAVGDNEVVSAGQLLVRLDSADYRVQVDQARANAEGKAAELASIIANIDLQQTAIAQARGAMDAAQARFDRAAKDLAR
YQDLVGRGATSRQSLDSAREQATSGAAELRSAAAALDGAQKRLAVLSADRDAAAAEVRSAQAQRALAEINLANTEIRAPI
AGVVGNRGVRAGQYVAPGSALMAIVPLEGLWIAANFKETQLGAMAPGQTVKVEIDAYSGRHGQGRVVSFAPASGAQFSLL
PPENATGNFTKVVQRVPVRIEMLADDPLSALMRPGLSVEVSVDTRGGRDVALGLVGTALAGSAGSSPTHR
>Mature_389_residues
STAPSGPRSTVSAEPTLPPASPRSWGRRLLLGVLVVGAVAAAGVFGWRWWTEGRFLETTDNAYIQGDITAIAPKVSGYVD
EVAVGDNEVVSAGQLLVRLDSADYRVQVDQARANAEGKAAELASIIANIDLQQTAIAQARGAMDAAQARFDRAAKDLARY
QDLVGRGATSRQSLDSAREQATSGAAELRSAAAALDGAQKRLAVLSADRDAAAAEVRSAQAQRALAEINLANTEIRAPIA
GVVGNRGVRAGQYVAPGSALMAIVPLEGLWIAANFKETQLGAMAPGQTVKVEIDAYSGRHGQGRVVSFAPASGAQFSLLP
PENATGNFTKVVQRVPVRIEMLADDPLSALMRPGLSVEVSVDTRGGRDVALGLVGTALAGSAGSSPTHR

Specific function: Unknown

COG id: COG1566

COG function: function code V; Multidrug resistance efflux pump

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1788711, Length=354, Percent_Identity=31.3559322033898, Blast_Score=170, Evalue=1e-43,
Organism=Escherichia coli, GI1789041, Length=358, Percent_Identity=34.3575418994413, Blast_Score=159, Evalue=3e-40,
Organism=Escherichia coli, GI1790519, Length=311, Percent_Identity=27.3311897106109, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI87081951, Length=301, Percent_Identity=28.2392026578073, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1790012, Length=256, Percent_Identity=30.859375, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1790024, Length=247, Percent_Identity=27.9352226720648, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1789900, Length=316, Percent_Identity=26.8987341772152, Blast_Score=70, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005694
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 40482; Mature: 40351

Theoretical pI: Translated: 7.68; Mature: 7.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTAPSGPRSTVSAEPTLPPASPRSWGRRLLLGVLVVGAVAAAGVFGWRWWTEGRFLETT
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCEEEEEC
DNAYIQGDITAIAPKVSGYVDEVAVGDNEVVSAGQLLVRLDSADYRVQVDQARANAEGKA
CCEEEEECCEEECCHHHCCHHHEECCCCHHCCCCEEEEEECCCCEEEEEEHHHCCCCCHH
AELASIIANIDLQQTAIAQARGAMDAAQARFDRAAKDLARYQDLVGRGATSRQSLDSARE
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
QATSGAAELRSAAAALDGAQKRLAVLSADRDAAAAEVRSAQAQRALAEINLANTEIRAPI
HHHCCHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCHHCCCH
AGVVGNRGVRAGQYVAPGSALMAIVPLEGLWIAANFKETQLGAMAPGQTVKVEIDAYSGR
HHHHCCCCCCCCCEECCCCEEEEEEECCCEEEEECCCCCCCCCCCCCCEEEEEEEECCCC
HGQGRVVSFAPASGAQFSLLPPENATGNFTKVVQRVPVRIEMLADDPLSALMRPGLSVEV
CCCCCEEEEECCCCCEEEEECCCCCCCHHHHHHHHCCEEEEEECCCHHHHHHCCCCEEEE
SVDTRGGRDVALGLVGTALAGSAGSSPTHR
EEECCCCCEEEHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
STAPSGPRSTVSAEPTLPPASPRSWGRRLLLGVLVVGAVAAAGVFGWRWWTEGRFLETT
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCEEEEEC
DNAYIQGDITAIAPKVSGYVDEVAVGDNEVVSAGQLLVRLDSADYRVQVDQARANAEGKA
CCEEEEECCEEECCHHHCCHHHEECCCCHHCCCCEEEEEECCCCEEEEEEHHHCCCCCHH
AELASIIANIDLQQTAIAQARGAMDAAQARFDRAAKDLARYQDLVGRGATSRQSLDSARE
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
QATSGAAELRSAAAALDGAQKRLAVLSADRDAAAAEVRSAQAQRALAEINLANTEIRAPI
HHHCCHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCHHCCCH
AGVVGNRGVRAGQYVAPGSALMAIVPLEGLWIAANFKETQLGAMAPGQTVKVEIDAYSGR
HHHHCCCCCCCCCEECCCCEEEEEEECCCEEEEECCCCCCCCCCCCCCEEEEEEEECCCC
HGQGRVVSFAPASGAQFSLLPPENATGNFTKVVQRVPVRIEMLADDPLSALMRPGLSVEV
CCCCCEEEEECCCCCEEEEECCCCCCCHHHHHHHHCCEEEEEECCCHHHHHHCCCCEEEE
SVDTRGGRDVALGLVGTALAGSAGSSPTHR
EEECCCCCEEEHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]