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The map label for this gene is glyA

Identifier: 83591206

GI number: 83591206

Start: 2511980

End: 2513230

Strand: Reverse

Name: glyA

Synonym: Moth_2390

Alternate gene names: 83591206

Gene position: 2513230-2511980 (Counterclockwise)

Preceding gene: 83591207

Following gene: 83591205

Centisome position: 95.6

GC content: 61.47

Gene sequence:

>1251_bases
ATGAACCTGGAAACAGTAGCCAAGGTTGATCCCGAAATAGTAGCCGCCGTCAGGGGCGAGCTTCAACGCCAGCGGACCCA
CCTGGAACTAATCGCCTCAGAGAACTTCGTCAGCCAGGCCGTCATGGAGGCCTATAGCTGCGTCCTGACCAATAAATACG
CCGAAGGGTATCCCGGCAAACGCTATTATGGCGGTTGTGAATGGGCCGACGTAGTCGAAAACTTGGCCCGGGAAAGGGCC
AAAGCCCTCTTCGGGGCCGAGCACGCCAATGTCCAGCCCCATTCCGGCAGCCAGGCCAACACCGCCGTCTACCTGGCCGT
TCTGAACCCGGGCGATAAGGCCCTGGGCATGAACCTGGCCCACGGCGGCCATTTGACCCACGGTAGCCCGGTAAGCCTTT
CCGGCAAATACTATAACTTCTGTTTCTACGGCGTCGATGCCAAAACCGGCCGTATTGACTATGACGCCGTAGCCCGCATC
GCCCGTGAGGAGCGGCCCAGACTGATCGTCGCCGGGGCCAGCGCCTACCCGCGGGTAATCGACTTTGCCCGTTTCCGCGA
GATTGCCGACGAGGTCGGCGCCCTGCTGATGGTGGATATGGCCCATATCGCCGGACTGGTGGCCGCCGGTATCCATCCCA
ACCCGGTACCCTACGCCCACTTCGTGACCACCACCACCCATAAGACCATGCGCGGTCCGCGGGGTGGGATTATCCTGACC
ACCAGGGAATACGCCCGGGATATCGATAAGGCCGTCTTCCCCGGTGTCCAGGGCGGTCCCCTGATGCACGTCATCGCCGC
CAAGGCTGTGGCCTTAAAGGAGGCCATGCTGCCGGAGTTCAAACGTTACCAGGAGCAAATAGTTACCAATGCCCGTACCC
TGGCCGACGCCCTCATGGGCTACGGATTTAACCTGGTTTCCGGCGGTACCGACAACCACCTAATGCTCGTCGACCTACGC
AATAAGAATATAACCGGCCGGGAGGCCGAAGATATCCTGGCCTCGGTCCAGATTACCGTCAACAAGAACGCCATCCCCTT
CGACCCGCAGAAGCCCAGCGTAACCAGCGGCATCCGCCTGGGAACGGCCGCTCTGACCTCCCGGGGCATGGACGCCGACG
CCATGGTCCAGGTGGCCCGGGCCATCGACCTGGCCCTCTCCTACGGTCCGGATGAGAAGAAACTGGAGGAAGCCAGGGGT
ATCGTCGCCGAACTCTGCCGGGCCTTCCCCCTCTACCAGGAGCTCGACTAA

Upstream 100 bases:

>100_bases
CCATCGGCGCAGCGCCGGTAACTGCAGCCCGGACGCGGCCCCCCTTAATCGGCGGCCAGCGGGCAGTATATAAGTAATTT
TCGAAGGAGGCCTTTACCAA

Downstream 100 bases:

>100_bases
ACAAAAAGCCCTCCCGGAAGGACAATTGCGGGAGGGCTTTTCAATAAAAAACACTGGCCGGAAACGATAATTTATGCTAA
ATTAAATCAGGAAACGCGCA

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT; Serine methylase

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MNLETVAKVDPEIVAAVRGELQRQRTHLELIASENFVSQAVMEAYSCVLTNKYAEGYPGKRYYGGCEWADVVENLARERA
KALFGAEHANVQPHSGSQANTAVYLAVLNPGDKALGMNLAHGGHLTHGSPVSLSGKYYNFCFYGVDAKTGRIDYDAVARI
AREERPRLIVAGASAYPRVIDFARFREIADEVGALLMVDMAHIAGLVAAGIHPNPVPYAHFVTTTTHKTMRGPRGGIILT
TREYARDIDKAVFPGVQGGPLMHVIAAKAVALKEAMLPEFKRYQEQIVTNARTLADALMGYGFNLVSGGTDNHLMLVDLR
NKNITGREAEDILASVQITVNKNAIPFDPQKPSVTSGIRLGTAALTSRGMDADAMVQVARAIDLALSYGPDEKKLEEARG
IVAELCRAFPLYQELD

Sequences:

>Translated_416_residues
MNLETVAKVDPEIVAAVRGELQRQRTHLELIASENFVSQAVMEAYSCVLTNKYAEGYPGKRYYGGCEWADVVENLARERA
KALFGAEHANVQPHSGSQANTAVYLAVLNPGDKALGMNLAHGGHLTHGSPVSLSGKYYNFCFYGVDAKTGRIDYDAVARI
AREERPRLIVAGASAYPRVIDFARFREIADEVGALLMVDMAHIAGLVAAGIHPNPVPYAHFVTTTTHKTMRGPRGGIILT
TREYARDIDKAVFPGVQGGPLMHVIAAKAVALKEAMLPEFKRYQEQIVTNARTLADALMGYGFNLVSGGTDNHLMLVDLR
NKNITGREAEDILASVQITVNKNAIPFDPQKPSVTSGIRLGTAALTSRGMDADAMVQVARAIDLALSYGPDEKKLEEARG
IVAELCRAFPLYQELD
>Mature_416_residues
MNLETVAKVDPEIVAAVRGELQRQRTHLELIASENFVSQAVMEAYSCVLTNKYAEGYPGKRYYGGCEWADVVENLARERA
KALFGAEHANVQPHSGSQANTAVYLAVLNPGDKALGMNLAHGGHLTHGSPVSLSGKYYNFCFYGVDAKTGRIDYDAVARI
AREERPRLIVAGASAYPRVIDFARFREIADEVGALLMVDMAHIAGLVAAGIHPNPVPYAHFVTTTTHKTMRGPRGGIILT
TREYARDIDKAVFPGVQGGPLMHVIAAKAVALKEAMLPEFKRYQEQIVTNARTLADALMGYGFNLVSGGTDNHLMLVDLR
NKNITGREAEDILASVQITVNKNAIPFDPQKPSVTSGIRLGTAALTSRGMDADAMVQVARAIDLALSYGPDEKKLEEARG
IVAELCRAFPLYQELD

Specific function: Interconversion of serine and glycine

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family

Homologues:

Organism=Homo sapiens, GI19923315, Length=454, Percent_Identity=46.6960352422907, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI261862352, Length=454, Percent_Identity=46.6960352422907, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI261862350, Length=454, Percent_Identity=46.6960352422907, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI261862348, Length=454, Percent_Identity=46.6960352422907, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI261862346, Length=454, Percent_Identity=45.374449339207, Blast_Score=345, Evalue=4e-95,
Organism=Homo sapiens, GI22547186, Length=410, Percent_Identity=47.8048780487805, Blast_Score=330, Evalue=1e-90,
Organism=Homo sapiens, GI22547189, Length=395, Percent_Identity=46.3291139240506, Blast_Score=301, Evalue=6e-82,
Organism=Escherichia coli, GI1788902, Length=411, Percent_Identity=58.6374695863747, Blast_Score=472, Evalue=1e-134,
Organism=Caenorhabditis elegans, GI25144732, Length=405, Percent_Identity=47.4074074074074, Blast_Score=349, Evalue=2e-96,
Organism=Caenorhabditis elegans, GI25144729, Length=405, Percent_Identity=47.4074074074074, Blast_Score=349, Evalue=2e-96,
Organism=Saccharomyces cerevisiae, GI6319739, Length=415, Percent_Identity=46.7469879518072, Blast_Score=368, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6323087, Length=404, Percent_Identity=44.8019801980198, Blast_Score=338, Evalue=8e-94,
Organism=Drosophila melanogaster, GI24640005, Length=452, Percent_Identity=45.575221238938, Blast_Score=381, Evalue=1e-106,
Organism=Drosophila melanogaster, GI221329721, Length=452, Percent_Identity=45.575221238938, Blast_Score=380, Evalue=1e-106,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): GLYA_MOOTA (Q2RFW7)

Other databases:

- EMBL:   CP000232
- RefSeq:   YP_431215.1
- ProteinModelPortal:   Q2RFW7
- SMR:   Q2RFW7
- STRING:   Q2RFW7
- GeneID:   3832029
- GenomeReviews:   CP000232_GR
- KEGG:   mta:Moth_2390
- NMPDR:   fig|264732.9.peg.2422
- eggNOG:   COG0112
- HOGENOM:   HBG301263
- OMA:   PEEMNID
- PhylomeDB:   Q2RFW7
- BioCyc:   MTHE264732:MOTH_2390-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00051_B
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11680
- PIRSF:   PIRSF000412

Pfam domain/function: PF00464 SHMT; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.1.2.1

Molecular weight: Translated: 45196; Mature: 45196

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLETVAKVDPEIVAAVRGELQRQRTHLELIASENFVSQAVMEAYSCVLTNKYAEGYPGK
CCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCC
RYYGGCEWADVVENLARERAKALFGAEHANVQPHSGSQANTAVYLAVLNPGDKALGMNLA
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCHHHCCEEC
HGGHLTHGSPVSLSGKYYNFCFYGVDAKTGRIDYDAVARIAREERPRLIVAGASAYPRVI
CCCCCCCCCCCEECCCEEEEEEEECCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCHHHH
DFARFREIADEVGALLMVDMAHIAGLVAAGIHPNPVPYAHFVTTTTHKTMRGPRGGIILT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCHHHHCCCCCCEEEE
TREYARDIDKAVFPGVQGGPLMHVIAAKAVALKEAMLPEFKRYQEQIVTNARTLADALMG
EHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YGFNLVSGGTDNHLMLVDLRNKNITGREAEDILASVQITVNKNAIPFDPQKPSVTSGIRL
CCCEEECCCCCCEEEEEEECCCCCCCCCHHHHHEEEEEEECCCCCCCCCCCCCCCCCCCH
GTAALTSRGMDADAMVQVARAIDLALSYGPDEKKLEEARGIVAELCRAFPLYQELD
HHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCHHHHCC
>Mature Secondary Structure
MNLETVAKVDPEIVAAVRGELQRQRTHLELIASENFVSQAVMEAYSCVLTNKYAEGYPGK
CCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCC
RYYGGCEWADVVENLARERAKALFGAEHANVQPHSGSQANTAVYLAVLNPGDKALGMNLA
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCHHHCCEEC
HGGHLTHGSPVSLSGKYYNFCFYGVDAKTGRIDYDAVARIAREERPRLIVAGASAYPRVI
CCCCCCCCCCCEECCCEEEEEEEECCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCHHHH
DFARFREIADEVGALLMVDMAHIAGLVAAGIHPNPVPYAHFVTTTTHKTMRGPRGGIILT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCHHHHCCCCCCEEEE
TREYARDIDKAVFPGVQGGPLMHVIAAKAVALKEAMLPEFKRYQEQIVTNARTLADALMG
EHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YGFNLVSGGTDNHLMLVDLRNKNITGREAEDILASVQITVNKNAIPFDPQKPSVTSGIRL
CCCEEECCCCCCEEEEEEECCCCCCCCCHHHHHEEEEEEECCCCCCCCCCCCCCCCCCCH
GTAALTSRGMDADAMVQVARAIDLALSYGPDEKKLEEARGIVAELCRAFPLYQELD
HHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA