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The map label for this gene is glcA [H]

Identifier: 83591124

GI number: 83591124

Start: 2419870

End: 2421648

Strand: Reverse

Name: glcA [H]

Synonym: Moth_2303

Alternate gene names: 83591124

Gene position: 2421648-2419870 (Counterclockwise)

Preceding gene: 83591125

Following gene: 83591123

Centisome position: 92.12

GC content: 55.26

Gene sequence:

>1779_bases
ATGCCCTGGATACAGGTTTATGACCCGGTTAATAACCTGGGGCTGTCGGCTTTATTGGCTGTTATCCCCATTCTCTTCCT
GTTTTATGCCCTGGCTATCCGAAGGATGAAGGGTCATATTGCCGGCTTCCTGACGGTAGTAGTAGCAATTATTGTCGCCA
TTTTAGGTTACCGGATGCCTGCCGGCCTGGCCGTCCTTTCCTTCCTCAATGGTGGTCTGTACGGCCTGTTCCCCATCAGC
TGGATTGTAGTAACCGCTGTCTTTTTATACCAGATTACGGTGAAGACCGGTCAGTTCGAAGTGATCAAGGATTCCATCGC
CGGCCTTACCGAAGATCGGCGCCTCCAGGCCCTCCTGATTGCCTTCTCCTTTGGCGCCTTCCTCGAGGGTTCGGCCGGTT
TCGGCACCCCCGTGGCCATTACCGCGGCCATGCTGGCCGGCCTGGGGTTCAATCCTATTTATGCCGCCAGCATCTGCTTG
CTGGCCAACACAGCGCCGGTGGCCTTCGGTGGTATCGGGGTACCGGTTATCACCCTGGCCCAGGTGTCCGGCATCGACTC
CATGCTTTTGAGCAAAATGATTAGCCGCCAGTTGATATTCCTTTCCGTCCTGGTTCCCTTTTGGCTCGTGGCCATTATGT
CGGGATGGAAGGGTGTCAAAGAAACCTGGCCGGCCTGCCTGGTTAGCGGCGGCTCCTTTGCCCTTGGCCAGTGGTTTTCG
GCCAACTATTTAGGCCCCATGTTACCGAATATTATCTCCGCCCTATTTTCTCTAGTCTGCCTGCTCCTGTTCCTGCGTGT
CTGGCAACCCAGGAATATCTGGCGTTTCCCCAACGAACCGGCAGTGAAGGGTACCCGGAACCATCACACGCCCGGTGCCG
TCCTCAAGGCCTGGATGCCCTTTATTATCCTCACCTTAATGGTGGGTGACTGGGGTATTAATTCGGTGAAGGCTGTGCTG
GATCAGGTTACTGTCAAGTTCGCCATCCCGGGACTGCATCAGGCTGTTATCAAGGCGGGTGCTTCCAAGGCCATGGACGC
CATCTTCACCTTTAACTGGCTTTCGGCAGCAGGCACCGGTATCCTCCTTGCCGCCTTTATTTCCATGTTAATCCTGGGAA
TGCGCTTTGGTGACTGGCTGCGGATCTTCGGCGAGACCTTATACGACCTGCGCTACGCCGTCCTCACTATATTTATGGTC
CTGGGTTATGCCTATATAGCCAACTTTTCCGGCATGAGCACCACCCTGGGCCAAGCCCTGACGGTCACTGGCAAGGCCTT
CCCCTTTGTGGCGCCTTTCCTGGGCTGGCTGGGGGTTTTTATTACCGGTAGTGATACGTCCGCCAACGCCCTGTTCGGAA
AACTCCAGTATATTACCGGCCAGAATATCGGCGTCGACCCGGTATTGACAGTGGCTGCTAACTCCTCCGGCGGCGTCACC
GGGAAAATGATCTCCCCCCAGACCATCGCCGTGGCTACGGCTGCTACCGGCTATGTGGGTAAAGAAGGTGATCTCTTCCG
CTTCGCCATCGTACCTAGCATTTTGATGACGGTCATTATCAGCATCATTACAGTCCTCCAGGCCTATATCTTCAAATGGA
TGATCCCGGCCCACGGCGACTTGACCCAGATGGCAACTGCTACCGCCGTCAAAGTAAACCTGGCCAACGGGGTGAGTATC
CTTGCCGGTACTATTATCGTTATTATTATCCTGGCGGTAATTGTTGCTTCGGGCAACCGCAGTCGGGGCAGCCGTGGCGT
CTATACGCCCGGAAAATGA

Upstream 100 bases:

>100_bases
AACAGCAACGCACTTTGGTAAGTGTCCGGTCTGAACACCTGGATGCCATAACAGTATATTTGAAATTTAATACATGGCAT
GGTAAGGAGGCAATGAAACA

Downstream 100 bases:

>100_bases
TGTTCGGTAAAAACCAGGCCCACCGGTAACAGCTGGTGGGCCTGGTGCCAAAAAGCCCCTTTCCGGGGCTTTTGGCTTTC
CTGGCGGAGCCGACGGGAGT

Product: L-lactate transport

Products: lactate [Cytoplasm]; Proton [Cytoplasm]; glycolate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 592; Mature: 591

Protein sequence:

>592_residues
MPWIQVYDPVNNLGLSALLAVIPILFLFYALAIRRMKGHIAGFLTVVVAIIVAILGYRMPAGLAVLSFLNGGLYGLFPIS
WIVVTAVFLYQITVKTGQFEVIKDSIAGLTEDRRLQALLIAFSFGAFLEGSAGFGTPVAITAAMLAGLGFNPIYAASICL
LANTAPVAFGGIGVPVITLAQVSGIDSMLLSKMISRQLIFLSVLVPFWLVAIMSGWKGVKETWPACLVSGGSFALGQWFS
ANYLGPMLPNIISALFSLVCLLLFLRVWQPRNIWRFPNEPAVKGTRNHHTPGAVLKAWMPFIILTLMVGDWGINSVKAVL
DQVTVKFAIPGLHQAVIKAGASKAMDAIFTFNWLSAAGTGILLAAFISMLILGMRFGDWLRIFGETLYDLRYAVLTIFMV
LGYAYIANFSGMSTTLGQALTVTGKAFPFVAPFLGWLGVFITGSDTSANALFGKLQYITGQNIGVDPVLTVAANSSGGVT
GKMISPQTIAVATAATGYVGKEGDLFRFAIVPSILMTVIISIITVLQAYIFKWMIPAHGDLTQMATATAVKVNLANGVSI
LAGTIIVIIILAVIVASGNRSRGSRGVYTPGK

Sequences:

>Translated_592_residues
MPWIQVYDPVNNLGLSALLAVIPILFLFYALAIRRMKGHIAGFLTVVVAIIVAILGYRMPAGLAVLSFLNGGLYGLFPIS
WIVVTAVFLYQITVKTGQFEVIKDSIAGLTEDRRLQALLIAFSFGAFLEGSAGFGTPVAITAAMLAGLGFNPIYAASICL
LANTAPVAFGGIGVPVITLAQVSGIDSMLLSKMISRQLIFLSVLVPFWLVAIMSGWKGVKETWPACLVSGGSFALGQWFS
ANYLGPMLPNIISALFSLVCLLLFLRVWQPRNIWRFPNEPAVKGTRNHHTPGAVLKAWMPFIILTLMVGDWGINSVKAVL
DQVTVKFAIPGLHQAVIKAGASKAMDAIFTFNWLSAAGTGILLAAFISMLILGMRFGDWLRIFGETLYDLRYAVLTIFMV
LGYAYIANFSGMSTTLGQALTVTGKAFPFVAPFLGWLGVFITGSDTSANALFGKLQYITGQNIGVDPVLTVAANSSGGVT
GKMISPQTIAVATAATGYVGKEGDLFRFAIVPSILMTVIISIITVLQAYIFKWMIPAHGDLTQMATATAVKVNLANGVSI
LAGTIIVIIILAVIVASGNRSRGSRGVYTPGK
>Mature_591_residues
PWIQVYDPVNNLGLSALLAVIPILFLFYALAIRRMKGHIAGFLTVVVAIIVAILGYRMPAGLAVLSFLNGGLYGLFPISW
IVVTAVFLYQITVKTGQFEVIKDSIAGLTEDRRLQALLIAFSFGAFLEGSAGFGTPVAITAAMLAGLGFNPIYAASICLL
ANTAPVAFGGIGVPVITLAQVSGIDSMLLSKMISRQLIFLSVLVPFWLVAIMSGWKGVKETWPACLVSGGSFALGQWFSA
NYLGPMLPNIISALFSLVCLLLFLRVWQPRNIWRFPNEPAVKGTRNHHTPGAVLKAWMPFIILTLMVGDWGINSVKAVLD
QVTVKFAIPGLHQAVIKAGASKAMDAIFTFNWLSAAGTGILLAAFISMLILGMRFGDWLRIFGETLYDLRYAVLTIFMVL
GYAYIANFSGMSTTLGQALTVTGKAFPFVAPFLGWLGVFITGSDTSANALFGKLQYITGQNIGVDPVLTVAANSSGGVTG
KMISPQTIAVATAATGYVGKEGDLFRFAIVPSILMTVIISIITVLQAYIFKWMIPAHGDLTQMATATAVKVNLANGVSIL
AGTIIVIIILAVIVASGNRSRGSRGVYTPGK

Specific function: Transports glycolate across the membrane. Can also transport L-lactate and D-lactate. Seems to be driven by a proton motive force [H]

COG id: COG1620

COG function: function code C; L-lactate permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lactate permease family [H]

Homologues:

Organism=Escherichia coli, GI1789347, Length=555, Percent_Identity=54.0540540540541, Blast_Score=568, Evalue=1e-163,
Organism=Escherichia coli, GI1790031, Length=548, Percent_Identity=52.3722627737226, Blast_Score=547, Evalue=1e-157,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003804 [H]

Pfam domain/function: PF02652 Lactate_perm [H]

EC number: NA

Molecular weight: Translated: 63123; Mature: 62992

Theoretical pI: Translated: 10.19; Mature: 10.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPWIQVYDPVNNLGLSALLAVIPILFLFYALAIRRMKGHIAGFLTVVVAIIVAILGYRMP
CCCEEEECCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
AGLAVLSFLNGGLYGLFPISWIVVTAVFLYQITVKTGQFEVIKDSIAGLTEDRRLQALLI
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHH
AFSFGAFLEGSAGFGTPVAITAAMLAGLGFNPIYAASICLLANTAPVAFGGIGVPVITLA
HHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCEECCCCHHHHHHH
QVSGIDSMLLSKMISRQLIFLSVLVPFWLVAIMSGWKGVKETWPACLVSGGSFALGQWFS
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCHHHHCCCCCCHHHCCCC
ANYLGPMLPNIISALFSLVCLLLFLRVWQPRNIWRFPNEPAVKGTRNHHTPGAVLKAWMP
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
FIILTLMVGDWGINSVKAVLDQVTVKFAIPGLHQAVIKAGASKAMDAIFTFNWLSAAGTG
HHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCHHHHHHHHHHHHHHHHCCHH
ILLAAFISMLILGMRFGDWLRIFGETLYDLRYAVLTIFMVLGYAYIANFSGMSTTLGQAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHH
TVTGKAFPFVAPFLGWLGVFITGSDTSANALFGKLQYITGQNIGVDPVLTVAANSSGGVT
EECCCCHHHHHHHHHHHHEEEECCCCCCHHHHHHHHEECCCCCCCCCEEEEEECCCCCCE
GKMISPQTIAVATAATGYVGKEGDLFRFAIVPSILMTVIISIITVLQAYIFKWMIPAHGD
EEECCCCCEEEEEHHCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
LTQMATATAVKVNLANGVSILAGTIIVIIILAVIVASGNRSRGSRGVYTPGK
HHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PWIQVYDPVNNLGLSALLAVIPILFLFYALAIRRMKGHIAGFLTVVVAIIVAILGYRMP
CCEEEECCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC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HHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: lactate [Periplasm]; Proton [Periplasm]; glycolate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + lactate [Periplasm] = Proton [Cytoplasm] + lactate [Cytoplasm] Proton [Periplasm] + glycolate [Periplasm] = Proton [Cytoplasm] + glycolate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9278503; 11283302; 11785976 [H]