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The map label for this gene is hpt [H]

Identifier: 83590932

GI number: 83590932

Start: 2199977

End: 2200522

Strand: Reverse

Name: hpt [H]

Synonym: Moth_2106

Alternate gene names: 83590932

Gene position: 2200522-2199977 (Counterclockwise)

Preceding gene: 83590936

Following gene: 83590931

Centisome position: 83.71

GC content: 53.3

Gene sequence:

>546_bases
GTGCACGAAGATATTGCCGAGGTTCTGGTCAGCGCCGCCGATATTCAAAAAAGGGTGAAGGAAATGGGTGCGGCTATTAG
CCGCGATTACGCCGGGAAGGACCTGCTGGTGGTCGGTATTCTTAAAGGGGCGATTATTTTCCTGGCCGACCTGGTGCGGG
AGATCACCATTCCCCTGCAGCTTGATTTTATGGCCGTTTCCAGCTACGGGTCCGGCACCAGCACATCGGGGGCGGTCCGG
ATCTTGAAGGACCTGGAGGTACCGGTGGAGGACAAGCATCTTCTGATAGTTGAGGATATTATCGACACCGGCTTGACCCT
GAAATACCTGCTGGAGAACCTCAAGGCCCGCCAGCCCTTGAGCGTCAAAGCCTGCACCATCCTGGACAAACCGGAACGGC
GTCTGGTAGATGTTCATGTTGATTACAGCGGTTTTTGCATTCCGGATTACTTTGTCGTTGGTTACGGCCTGGATTACGCC
CAGAAATACCGTCACTTGCCGGATATCTGCGTTTTAAAACCAGAGGTTTACAGACGGAAGAAATAG

Upstream 100 bases:

>100_bases
AGGCAGGATTTTAACGCTATATAGCGAAGATAACAAGGTTATGGTAAACTGTCAAGCGGTATATTAAATACAGCAGGTTA
CTCCGGGGGAGGAAAAAAGA

Downstream 100 bases:

>100_bases
TGAGGTTGGATAGATGATTGGAGAAAACAAACAGCTTGCAGAAATAGTACTGGTGCTGGATTTCGGCGGCCAGTACAACC
AGTTGATCGCCCGGCGGGTC

Product: hypoxanthine phosphoribosyltransferase

Products: NA

Alternate protein names: HGPRT; HGPRTase [H]

Number of amino acids: Translated: 181; Mature: 181

Protein sequence:

>181_residues
MHEDIAEVLVSAADIQKRVKEMGAAISRDYAGKDLLVVGILKGAIIFLADLVREITIPLQLDFMAVSSYGSGTSTSGAVR
ILKDLEVPVEDKHLLIVEDIIDTGLTLKYLLENLKARQPLSVKACTILDKPERRLVDVHVDYSGFCIPDYFVVGYGLDYA
QKYRHLPDICVLKPEVYRRKK

Sequences:

>Translated_181_residues
MHEDIAEVLVSAADIQKRVKEMGAAISRDYAGKDLLVVGILKGAIIFLADLVREITIPLQLDFMAVSSYGSGTSTSGAVR
ILKDLEVPVEDKHLLIVEDIIDTGLTLKYLLENLKARQPLSVKACTILDKPERRLVDVHVDYSGFCIPDYFVVGYGLDYA
QKYRHLPDICVLKPEVYRRKK
>Mature_181_residues
MHEDIAEVLVSAADIQKRVKEMGAAISRDYAGKDLLVVGILKGAIIFLADLVREITIPLQLDFMAVSSYGSGTSTSGAVR
ILKDLEVPVEDKHLLIVEDIIDTGLTLKYLLENLKARQPLSVKACTILDKPERRLVDVHVDYSGFCIPDYFVVGYGLDYA
QKYRHLPDICVLKPEVYRRKK

Specific function: This Enzyme Acts Exclusively On Hypoxanthine; It Does Not Act On Guanine (By Similarity). [C]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4504483, Length=179, Percent_Identity=35.195530726257, Blast_Score=102, Evalue=2e-22,
Organism=Homo sapiens, GI9910262, Length=189, Percent_Identity=33.8624338624339, Blast_Score=100, Evalue=7e-22,
Organism=Escherichia coli, GI87081689, Length=163, Percent_Identity=52.760736196319, Blast_Score=178, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17510817, Length=180, Percent_Identity=36.6666666666667, Blast_Score=102, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 20248; Mature: 20248

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHEDIAEVLVSAADIQKRVKEMGAAISRDYAGKDLLVVGILKGAIIFLADLVREITIPLQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHHCCCEE
LDFMAVSSYGSGTSTSGAVRILKDLEVPVEDKHLLIVEDIIDTGLTLKYLLENLKARQPL
EEEEEEECCCCCCCCHHHHHHHHHCCCCCCCCEEEEEHHHHCCCCHHHHHHHHHCCCCCC
SVKACTILDKPERRLVDVHVDYSGFCIPDYFVVGYGLDYAQKYRHLPDICVLKPEVYRRK
CEEEEEECCCCCCEEEEEEECCCCEECCCHHEEECCCHHHHHHHCCCCEEEECHHHHCCC
K
C
>Mature Secondary Structure
MHEDIAEVLVSAADIQKRVKEMGAAISRDYAGKDLLVVGILKGAIIFLADLVREITIPLQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHHCCCEE
LDFMAVSSYGSGTSTSGAVRILKDLEVPVEDKHLLIVEDIIDTGLTLKYLLENLKARQPL
EEEEEEECCCCCCCCHHHHHHHHHCCCCCCCCEEEEEHHHHCCCCHHHHHHHHHCCCCCC
SVKACTILDKPERRLVDVHVDYSGFCIPDYFVVGYGLDYAQKYRHLPDICVLKPEVYRRK
CEEEEEECCCCCCEEEEEEECCCCEECCCHHEEECCCHHHHHHHCCCCEEEECHHHHCCC
K
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12663927 [H]