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The map label for this gene is guaA

Identifier: 83590931

GI number: 83590931

Start: 2198413

End: 2199963

Strand: Reverse

Name: guaA

Synonym: Moth_2105

Alternate gene names: 83590931

Gene position: 2199963-2198413 (Counterclockwise)

Preceding gene: 83590932

Following gene: 83590929

Centisome position: 83.69

GC content: 60.09

Gene sequence:

>1551_bases
ATGATTGGAGAAAACAAACAGCTTGCAGAAATAGTACTGGTGCTGGATTTCGGCGGCCAGTACAACCAGTTGATCGCCCG
GCGGGTCCGCGAAGCCGGGGTTTACTCGGAGATGATACCCTATAACACGCCCCTGGAAAAGATCCTGGCCCGGCGACCCC
GGGGGATTATTTTTTCCGGCGGGCCGGCCAGCGTCTATAGCCTCGGGGCACCCCGTATCGACCGGGCCCTCTATGAAAGC
GGCATTCCCATTTTGGGCATCTGTTATGGTATGCAGCTCATGGCCCATGACCTGGGCGGTAGGGTAGAGGGGGCCTCGGG
ACGGGAGTATGGTAAAACCCAGCTGGAAATAACAGCAGCAGATCCCCTTTTCGCCGGTTTACCTGAAAGTATACAGTGCT
GGATGAGCCACGGCGACTATATCAGCGCCCCGCCGCCTGGCTTCCAGGTGACGGCCCGCTCGGCCTATACCCCGGTGGCG
GCTATGAGCGACCCGGCCAGGAAGCTTTATGGCGTTCAGTTTCACCCGGAAGTAAAGCATACTCCCATGGGGCAGGAGAT
ACTGCGTCGTTTTCTCTTCCAGGTATGCGGCTGCCGGGGTGACTGGTCGGTGAGTTCCTTCATTGAAGACCAGGTGGCGG
CCATTCGCCGGCAGGTAGGTAACGGCCGGGTCCTCTGCGCCCTGAGCGGCGGGGTCGATTCCTCGGTGGCTGCGGCCCTG
GTCCACCGGGCCGTCGGCGACCGCTTGACCTGCGTGTTTGTTAACCACGGTCTCCTGCGCCAGGGGGAGGCCGAACAGGT
GCAGCGGGCCTTTGGCCAGGCCATGGGCATGAACATCGTCTATGTCGATGCCAGCCGGCGTTTCCTGGAGAAACTCACCG
GCGTTACAGACCCGGAAGAAAAGCGCAAAATTATCGGCCATGAATTTATCCGGGTCTTTGAGGAGGAAGCCAGGAAACTG
GGACGGGTGGATTTCCTGGTCCAGGGCACCCTTTACCCCGATGTCATTGAGAGCGGTACCGAAACGGCCGCCGTCATCAA
GAGCCACCATAACGTCGGTGGCCTGCCGGAAGATATGGAACTGGAATTAATTGAACCCCTGCGCCTTTTATTTAAGGACG
AAGTGCGCCGGGTAGGGGAGGAACTGGGCCTGCCGGAGGAGATTGTCTGGCGGCAACCCTTCCCGGGGCCGGGCCTGGCT
ATCCGCATCCTGGGGGAAGTCACCCCGGAGAAACTGGAAATCTTACGTCAGGCTGACGCCATTGTCACCGAGGAGATCCG
GCGAGCCGGCCTCTACCGGGAAATCTGGCAGTCCTTTGCGGTATTGCCCTCCATGAAGAGTGTGGGTGTTATGGGCGACG
AGCGGACCTATGCCTACCCCATCGTCCTGCGGGCCGTGACCAGCGATGACGCCATGACTGCCGACTGGGCCAGGCTCCCC
TACGACCTCCTGGAGCGTATCTCCTCCCGGATCGTCAACGAGGTGCGTCATATCAACCGGGTCGTTTACGACATCACTTC
CAAACCCCCGGCGACCATAGAGTGGGAGTAG

Upstream 100 bases:

>100_bases
GGTTACGGCCTGGATTACGCCCAGAAATACCGTCACTTGCCGGATATCTGCGTTTTAAAACCAGAGGTTTACAGACGGAA
GAAATAGTGAGGTTGGATAG

Downstream 100 bases:

>100_bases
GATAAAAAAATTGACCCCTTATCCTGCAACAACAGGTTAAGGGGTCTCCTTATTTTTCTGTGGCGTAAGTCGACATGAGA
GTTCTAGGCGCGCCGAACAG

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase

Number of amino acids: Translated: 516; Mature: 516

Protein sequence:

>516_residues
MIGENKQLAEIVLVLDFGGQYNQLIARRVREAGVYSEMIPYNTPLEKILARRPRGIIFSGGPASVYSLGAPRIDRALYES
GIPILGICYGMQLMAHDLGGRVEGASGREYGKTQLEITAADPLFAGLPESIQCWMSHGDYISAPPPGFQVTARSAYTPVA
AMSDPARKLYGVQFHPEVKHTPMGQEILRRFLFQVCGCRGDWSVSSFIEDQVAAIRRQVGNGRVLCALSGGVDSSVAAAL
VHRAVGDRLTCVFVNHGLLRQGEAEQVQRAFGQAMGMNIVYVDASRRFLEKLTGVTDPEEKRKIIGHEFIRVFEEEARKL
GRVDFLVQGTLYPDVIESGTETAAVIKSHHNVGGLPEDMELELIEPLRLLFKDEVRRVGEELGLPEEIVWRQPFPGPGLA
IRILGEVTPEKLEILRQADAIVTEEIRRAGLYREIWQSFAVLPSMKSVGVMGDERTYAYPIVLRAVTSDDAMTADWARLP
YDLLERISSRIVNEVRHINRVVYDITSKPPATIEWE

Sequences:

>Translated_516_residues
MIGENKQLAEIVLVLDFGGQYNQLIARRVREAGVYSEMIPYNTPLEKILARRPRGIIFSGGPASVYSLGAPRIDRALYES
GIPILGICYGMQLMAHDLGGRVEGASGREYGKTQLEITAADPLFAGLPESIQCWMSHGDYISAPPPGFQVTARSAYTPVA
AMSDPARKLYGVQFHPEVKHTPMGQEILRRFLFQVCGCRGDWSVSSFIEDQVAAIRRQVGNGRVLCALSGGVDSSVAAAL
VHRAVGDRLTCVFVNHGLLRQGEAEQVQRAFGQAMGMNIVYVDASRRFLEKLTGVTDPEEKRKIIGHEFIRVFEEEARKL
GRVDFLVQGTLYPDVIESGTETAAVIKSHHNVGGLPEDMELELIEPLRLLFKDEVRRVGEELGLPEEIVWRQPFPGPGLA
IRILGEVTPEKLEILRQADAIVTEEIRRAGLYREIWQSFAVLPSMKSVGVMGDERTYAYPIVLRAVTSDDAMTADWARLP
YDLLERISSRIVNEVRHINRVVYDITSKPPATIEWE
>Mature_516_residues
MIGENKQLAEIVLVLDFGGQYNQLIARRVREAGVYSEMIPYNTPLEKILARRPRGIIFSGGPASVYSLGAPRIDRALYES
GIPILGICYGMQLMAHDLGGRVEGASGREYGKTQLEITAADPLFAGLPESIQCWMSHGDYISAPPPGFQVTARSAYTPVA
AMSDPARKLYGVQFHPEVKHTPMGQEILRRFLFQVCGCRGDWSVSSFIEDQVAAIRRQVGNGRVLCALSGGVDSSVAAAL
VHRAVGDRLTCVFVNHGLLRQGEAEQVQRAFGQAMGMNIVYVDASRRFLEKLTGVTDPEEKRKIIGHEFIRVFEEEARKL
GRVDFLVQGTLYPDVIESGTETAAVIKSHHNVGGLPEDMELELIEPLRLLFKDEVRRVGEELGLPEEIVWRQPFPGPGLA
IRILGEVTPEKLEILRQADAIVTEEIRRAGLYREIWQSFAVLPSMKSVGVMGDERTYAYPIVLRAVTSDDAMTADWARLP
YDLLERISSRIVNEVRHINRVVYDITSKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain

Homologues:

Organism=Homo sapiens, GI4504035, Length=550, Percent_Identity=37.4545454545455, Blast_Score=317, Evalue=2e-86,
Organism=Escherichia coli, GI1788854, Length=516, Percent_Identity=53.2945736434108, Blast_Score=561, Evalue=1e-161,
Organism=Escherichia coli, GI1789760, Length=150, Percent_Identity=32, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71992717, Length=569, Percent_Identity=36.7311072056239, Blast_Score=314, Evalue=6e-86,
Organism=Caenorhabditis elegans, GI71992710, Length=569, Percent_Identity=36.7311072056239, Blast_Score=314, Evalue=8e-86,
Organism=Caenorhabditis elegans, GI133901714, Length=569, Percent_Identity=36.7311072056239, Blast_Score=314, Evalue=9e-86,
Organism=Saccharomyces cerevisiae, GI6323873, Length=519, Percent_Identity=50.4816955684008, Blast_Score=534, Evalue=1e-152,
Organism=Drosophila melanogaster, GI281365319, Length=553, Percent_Identity=35.8047016274864, Blast_Score=303, Evalue=2e-82,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GUAA_MOOTA (Q2RGP2)

Other databases:

- EMBL:   CP000232
- RefSeq:   YP_430940.1
- ProteinModelPortal:   Q2RGP2
- SMR:   Q2RGP2
- STRING:   Q2RGP2
- GeneID:   3832472
- GenomeReviews:   CP000232_GR
- KEGG:   mta:Moth_2105
- NMPDR:   fig|264732.9.peg.2128
- eggNOG:   COG0519
- HOGENOM:   HBG391775
- OMA:   MKLVEPL
- PhylomeDB:   Q2RGP2
- ProtClustDB:   PRK00074
- BioCyc:   MTHE264732:MOTH_2105-MONOMER
- HAMAP:   MF_00344
- InterPro:   IPR006220
- InterPro:   IPR001962
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PRINTS:   PR00097
- PRINTS:   PR00099
- PRINTS:   PR00096
- TIGRFAMs:   TIGR00884
- TIGRFAMs:   TIGR00888

Pfam domain/function: PF00733 Asn_synthase; PF00117 GATase; PF00958 GMP_synt_C

EC number: =6.3.5.2

Molecular weight: Translated: 57372; Mature: 57372

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 88-88 ACT_SITE 175-175 ACT_SITE 177-177

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGENKQLAEIVLVLDFGGQYNQLIARRVREAGVYSEMIPYNTPLEKILARRPRGIIFSG
CCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHCCHHHHCCCCCCHHHHHHCCCCCEEEEC
GPASVYSLGAPRIDRALYESGIPILGICYGMQLMAHDLGGRVEGASGREYGKTQLEITAA
CCCHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEC
DPLFAGLPESIQCWMSHGDYISAPPPGFQVTARSAYTPVAAMSDPARKLYGVQFHPEVKH
CCHHHCCCHHHHHHHHCCCCCCCCCCCCEEEECCCCCCHHHCCCHHHHHCCCEECCCCCC
TPMGQEILRRFLFQVCGCRGDWSVSSFIEDQVAAIRRQVGNGRVLCALSGGVDSSVAAAL
CCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHH
VHRAVGDRLTCVFVNHGLLRQGEAEQVQRAFGQAMGMNIVYVDASRRFLEKLTGVTDPEE
HHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCEEEEECCHHHHHHHHCCCCCCHH
KRKIIGHEFIRVFEEEARKLGRVDFLVQGTLYPDVIESGTETAAVIKSHHNVGGLPEDME
HHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHCCCHHHHHHHHCCCCCCCCCCCH
LELIEPLRLLFKDEVRRVGEELGLPEEIVWRQPFPGPGLAIRILGEVTPEKLEILRQADA
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCEEEEEECCCCHHHHHHHHHHHH
IVTEEIRRAGLYREIWQSFAVLPSMKSVGVMGDERTYAYPIVLRAVTSDDAMTADWARLP
HHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCEEEEEEEEEECCCCCCCCHHHHCC
YDLLERISSRIVNEVRHINRVVYDITSKPPATIEWE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MIGENKQLAEIVLVLDFGGQYNQLIARRVREAGVYSEMIPYNTPLEKILARRPRGIIFSG
CCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHCCHHHHCCCCCCHHHHHHCCCCCEEEEC
GPASVYSLGAPRIDRALYESGIPILGICYGMQLMAHDLGGRVEGASGREYGKTQLEITAA
CCCHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEC
DPLFAGLPESIQCWMSHGDYISAPPPGFQVTARSAYTPVAAMSDPARKLYGVQFHPEVKH
CCHHHCCCHHHHHHHHCCCCCCCCCCCCEEEECCCCCCHHHCCCHHHHHCCCEECCCCCC
TPMGQEILRRFLFQVCGCRGDWSVSSFIEDQVAAIRRQVGNGRVLCALSGGVDSSVAAAL
CCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHH
VHRAVGDRLTCVFVNHGLLRQGEAEQVQRAFGQAMGMNIVYVDASRRFLEKLTGVTDPEE
HHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCEEEEECCHHHHHHHHCCCCCCHH
KRKIIGHEFIRVFEEEARKLGRVDFLVQGTLYPDVIESGTETAAVIKSHHNVGGLPEDME
HHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHCCCHHHHHHHHCCCCCCCCCCCH
LELIEPLRLLFKDEVRRVGEELGLPEEIVWRQPFPGPGLAIRILGEVTPEKLEILRQADA
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCEEEEEECCCCHHHHHHHHHHHH
IVTEEIRRAGLYREIWQSFAVLPSMKSVGVMGDERTYAYPIVLRAVTSDDAMTADWARLP
HHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCEEEEEEEEEECCCCCCCCHHHHCC
YDLLERISSRIVNEVRHINRVVYDITSKPPATIEWE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA