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The map label for this gene is hisI [H]

Identifier: 83590860

GI number: 83590860

Start: 2120511

End: 2121359

Strand: Reverse

Name: hisI [H]

Synonym: Moth_2030

Alternate gene names: 83590860

Gene position: 2121359-2120511 (Counterclockwise)

Preceding gene: 83590861

Following gene: 83590859

Centisome position: 80.7

GC content: 61.6

Gene sequence:

>849_bases
ATGAGTGTCACCATCCCTGAGGATATTCACTTTAACGCCGAGGGCCTGATCCCGGCCATCATCCAGGACGCGGCCAGCGG
CCAGGTCTTGATGCTGGCCTACATGAACCGGGAGTCCCTGGCCCGGTCCCTGGCTACCGGCGAGACATGGTTTTACAGCC
GCAGCCGCCGCGAACTCTGGCATAAGGGCGCCACTTCCGGTCACCGCCAGTATATTGAGTCTGCCAGTTACGACTGTGAC
GCCGACGCCCTGCTCTTTAAGGTGCGCCAGGTGGGTGTGGCCTGCCATGAAGGGGAGTTCTCCTGCTTCCACAACCCCCT
CCCCCTGCAAGTCAGCCGGCCCAGGGAAACCGGGGCGGGAGGCGACGCTCAAGCAGCCGGCGCGCCCCGCGGGGCGGCTT
TCCCCTTACCGGAAGGGGTGGGGAAAGCTGCAAATAAAGGAGAGGCCGGCCGGGTCGTAACCACAACCGCCGGGGAGCAG
CAGGAGGCCGGCTCTTACTGCGACCACACCAGCGGGCAAGAGAAGCAGGGCCGTAGGGAGGGAAACACCAGCAGCCAGGT
TAATGCCGACCTGGGAACCATCCTGTCCCAGGTCTTCCAGGTCATCAAGGAGCGCCAGGCGACTCGACCTGAAGGGTCCT
ATACAGCCTACCTTTTTAATAACGGCCAGGATAAGATCCTCAAGAAGATAGGCGAAGAGGCCGGCGAGACCATTATTGCC
TCTAAAAACGACAGCCGGCACGAGATACTATACGAAATGGCCGACCTTTACTACCATACTCTGGTCCTCCTGGCTTACCA
CGGTCTGGAACCTGAGCAACTGGCGGCTGAGCTGGCCGCCCGCCGCTGA

Upstream 100 bases:

>100_bases
GGCGGCTTCTATTTTCCATTTTGGCACCTATACCATCAAAGAGGCCAAGGACTACCTGGCGGCCCGCGGCGTCCCGGTGC
GGTTATAGGAGGTAAACCTC

Downstream 100 bases:

>100_bases
CGGCGCCAGTGACCTGCCGGCGGCCCGGTGATCCCTCCAGGTCCGGTGCTGCTGCCCCTGCCGCCGGCAGGTTACCGGCA
GGGAACGCCAGTTACGGAAC

Product: phosphoribosyl-ATP pyrophosphatase / phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: Phosphoribosyl-AMP cyclohydrolase; PRA-CH; Phosphoribosyl-ATP pyrophosphatase; PRA-PH [H]

Number of amino acids: Translated: 282; Mature: 281

Protein sequence:

>282_residues
MSVTIPEDIHFNAEGLIPAIIQDAASGQVLMLAYMNRESLARSLATGETWFYSRSRRELWHKGATSGHRQYIESASYDCD
ADALLFKVRQVGVACHEGEFSCFHNPLPLQVSRPRETGAGGDAQAAGAPRGAAFPLPEGVGKAANKGEAGRVVTTTAGEQ
QEAGSYCDHTSGQEKQGRREGNTSSQVNADLGTILSQVFQVIKERQATRPEGSYTAYLFNNGQDKILKKIGEEAGETIIA
SKNDSRHEILYEMADLYYHTLVLLAYHGLEPEQLAAELAARR

Sequences:

>Translated_282_residues
MSVTIPEDIHFNAEGLIPAIIQDAASGQVLMLAYMNRESLARSLATGETWFYSRSRRELWHKGATSGHRQYIESASYDCD
ADALLFKVRQVGVACHEGEFSCFHNPLPLQVSRPRETGAGGDAQAAGAPRGAAFPLPEGVGKAANKGEAGRVVTTTAGEQ
QEAGSYCDHTSGQEKQGRREGNTSSQVNADLGTILSQVFQVIKERQATRPEGSYTAYLFNNGQDKILKKIGEEAGETIIA
SKNDSRHEILYEMADLYYHTLVLLAYHGLEPEQLAAELAARR
>Mature_281_residues
SVTIPEDIHFNAEGLIPAIIQDAASGQVLMLAYMNRESLARSLATGETWFYSRSRRELWHKGATSGHRQYIESASYDCDA
DALLFKVRQVGVACHEGEFSCFHNPLPLQVSRPRETGAGGDAQAAGAPRGAAFPLPEGVGKAANKGEAGRVVTTTAGEQQ
EAGSYCDHTSGQEKQGRREGNTSSQVNADLGTILSQVFQVIKERQATRPEGSYTAYLFNNGQDKILKKIGEEAGETIIAS
KNDSRHEILYEMADLYYHTLVLLAYHGLEPEQLAAELAARR

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PRA-PH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=91, Percent_Identity=47.2527472527472, Blast_Score=99, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6319819, Length=91, Percent_Identity=41.7582417582418, Blast_Score=72, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023019
- InterPro:   IPR008179
- InterPro:   IPR021130
- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH; PF01503 PRA-PH [H]

EC number: =3.5.4.19; =3.6.1.31 [H]

Molecular weight: Translated: 30732; Mature: 30600

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVTIPEDIHFNAEGLIPAIIQDAASGQVLMLAYMNRESLARSLATGETWFYSRSRRELW
CCCCCCCCCCCCCCCCHHHHHHHCCCCCEEEEEECCHHHHHHHHHCCCHHHHHHHHHHHH
HKGATSGHRQYIESASYDCDADALLFKVRQVGVACHEGEFSCFHNPLPLQVSRPRETGAG
HCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCEEECCCCHHCCCCCCCEEECCCCCCCC
GDAQAAGAPRGAAFPLPEGVGKAANKGEAGRVVTTTAGEQQEAGSYCDHTSGQEKQGRRE
CCCCCCCCCCCCCCCCCHHHCCCCCCCCCCEEEEECCCCHHHCCCCCCCCCCCHHHHHCC
GNTSSQVNADLGTILSQVFQVIKERQATRPEGSYTAYLFNNGQDKILKKIGEEAGETIIA
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCHHHHHHHHHHHHCCEEEE
SKNDSRHEILYEMADLYYHTLVLLAYHGLEPEQLAAELAARR
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
SVTIPEDIHFNAEGLIPAIIQDAASGQVLMLAYMNRESLARSLATGETWFYSRSRRELW
CCCCCCCCCCCCCCCHHHHHHHCCCCCEEEEEECCHHHHHHHHHCCCHHHHHHHHHHHH
HKGATSGHRQYIESASYDCDADALLFKVRQVGVACHEGEFSCFHNPLPLQVSRPRETGAG
HCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCEEECCCCHHCCCCCCCEEECCCCCCCC
GDAQAAGAPRGAAFPLPEGVGKAANKGEAGRVVTTTAGEQQEAGSYCDHTSGQEKQGRRE
CCCCCCCCCCCCCCCCCHHHCCCCCCCCCCEEEEECCCCHHHCCCCCCCCCCCHHHHHCC
GNTSSQVNADLGTILSQVFQVIKERQATRPEGSYTAYLFNNGQDKILKKIGEEAGETIIA
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCHHHHHHHHHHHHCCEEEE
SKNDSRHEILYEMADLYYHTLVLLAYHGLEPEQLAAELAARR
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12917641 [H]