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The map label for this gene is hyuA [H]

Identifier: 83590827

GI number: 83590827

Start: 2080835

End: 2082199

Strand: Reverse

Name: hyuA [H]

Synonym: Moth_1997

Alternate gene names: 83590827

Gene position: 2082199-2080835 (Counterclockwise)

Preceding gene: 83590828

Following gene: 83590826

Centisome position: 79.21

GC content: 61.83

Gene sequence:

>1365_bases
ATGGATCTCTTGCTGAAGGGCGGCTGGGTTGTTACCCAGGAGCGGGTGGAGCAGGCCGATATAGCCGTCGAAGGGGAGAA
AATTGCCGCCATAGGCCCGGACCTGGAGGCCCGGGCGGCTGCCGTCAGGGATGTCACCGGGAAATACATCCTGCCCGGCG
CCATCGACGCCCACGTCCACTACCAGATGCCCATCGGCGAGCTCCTGACCGCCGACGACTGGTTCACCGGTACCAGACTG
GCAGCCTGCGGCGGGGTTACCACCGTCATTGATTATGCCGAGCCCGCCGGCCCGGCCGAACCCTTGACGGAAGCCCTGGC
CAAACGCCTGGAGGAAGCCCGGGAGCAGGCGTGCGTTGACTATGGTCTGCACCAGGTGGTGCTGCCCGGCCAGGAAGAAG
ACACCGGTGAGCTGGCAAAGGTAATAGAGCAGGGAGTCACCAGCTTTAAAGTCTTTACCACCTACAAGCAGTGCCTGGGT
TACGCGGCCATCGGCCGCCTGCTTAAGCAGGCCCGGCGGTTGGGAGCCCTGGTGACGGTTCACTGTGAGGATCATGATCT
GGTAACGGCCAGGCGGAGGGAACTGGAGGCTACCGGCCAGACAGACCCGGCCTACCACGCCAACAGCCGGCCCGCAGCGG
CCGAAGTAAAGGCCATAGAAAAGGTTATCCGCCAGGCAGCCGCGGCCGGGGCGCCAGTTTATATCGTCCATGTCTCCACC
GGCGGGGGGGCGGAATTAATTGCCGCCGCCCGGGCCCGAGGACAGCAGGTCTTTGGTGAAACCTGCCCCCACTACCTCTT
ACTAACAGAGGAGAGGTATGCCGGTCCGGACAGCCGCCTCTTCCTGATGTGCCCACCCCTGAGGACGGTAAAAGATAACC
GGATTCTCTGGCAGCACCTGGCCAGTGGTGATCTCCAGGTGGTAGCGACTGACCATTGCAGCTACAGCCCGGAACAGAAG
GCTGCCGGAACGGCTTTTTATAACACCCCCTCGGGCGTACCGGGGACGGAGACCCTTTTACCCCTACTTTATTCTTATGG
TGTACGCCAGGGGCGGCTGACCCTGCCGCAAATGGTCCGGGTGCTGGCCACCAACCCGGCCCGCCTTTTCGGTCTTTACC
CGCGTAAAGGTTGCCTGGCGCCGGGCAGCGATGCCGACCTGGTGGTCTTCGACCCCAGCCAGGAGGTTATACTCAAGGCT
TCTGACCTGCATTCTGCCGCAGCTTATACCATCTTTGAGGGCTTTGCTCTCCAGGGGTACGTGGAAGCAACCTATCTACG
GGGTCGGCTTATTTATGACCTGGGCCGTTTCCTGGGCCGGGCCGGTCAGGGAGAGTTTATCCCTGGAAAAATTACCGTCC
TGTAA

Upstream 100 bases:

>100_bases
TTAAAGGAAGCCCTGGCTCGGTACGGGAAATGAACCGCGGCCGGGAAGAGACAGGTAGGGCGGATATATAATGTAGATTA
CAAAGGAGGCGCCGGAGAAA

Downstream 100 bases:

>100_bases
TTATTCCGGCCGGGCCCCGCCCAATCTCGGCCTTCTCCATTCCGGTGGCCCGGGCCACGTCCATGTCTCCATCCTCCCAT
ATTCGGCCGCAGAGCAGGCC

Product: dihydropyrimidinase

Products: NA

Alternate protein names: Hydantoin-utilizing enzyme hyuA [H]

Number of amino acids: Translated: 454; Mature: 454

Protein sequence:

>454_residues
MDLLLKGGWVVTQERVEQADIAVEGEKIAAIGPDLEARAAAVRDVTGKYILPGAIDAHVHYQMPIGELLTADDWFTGTRL
AACGGVTTVIDYAEPAGPAEPLTEALAKRLEEAREQACVDYGLHQVVLPGQEEDTGELAKVIEQGVTSFKVFTTYKQCLG
YAAIGRLLKQARRLGALVTVHCEDHDLVTARRRELEATGQTDPAYHANSRPAAAEVKAIEKVIRQAAAAGAPVYIVHVST
GGGAELIAAARARGQQVFGETCPHYLLLTEERYAGPDSRLFLMCPPLRTVKDNRILWQHLASGDLQVVATDHCSYSPEQK
AAGTAFYNTPSGVPGTETLLPLLYSYGVRQGRLTLPQMVRVLATNPARLFGLYPRKGCLAPGSDADLVVFDPSQEVILKA
SDLHSAAAYTIFEGFALQGYVEATYLRGRLIYDLGRFLGRAGQGEFIPGKITVL

Sequences:

>Translated_454_residues
MDLLLKGGWVVTQERVEQADIAVEGEKIAAIGPDLEARAAAVRDVTGKYILPGAIDAHVHYQMPIGELLTADDWFTGTRL
AACGGVTTVIDYAEPAGPAEPLTEALAKRLEEAREQACVDYGLHQVVLPGQEEDTGELAKVIEQGVTSFKVFTTYKQCLG
YAAIGRLLKQARRLGALVTVHCEDHDLVTARRRELEATGQTDPAYHANSRPAAAEVKAIEKVIRQAAAAGAPVYIVHVST
GGGAELIAAARARGQQVFGETCPHYLLLTEERYAGPDSRLFLMCPPLRTVKDNRILWQHLASGDLQVVATDHCSYSPEQK
AAGTAFYNTPSGVPGTETLLPLLYSYGVRQGRLTLPQMVRVLATNPARLFGLYPRKGCLAPGSDADLVVFDPSQEVILKA
SDLHSAAAYTIFEGFALQGYVEATYLRGRLIYDLGRFLGRAGQGEFIPGKITVL
>Mature_454_residues
MDLLLKGGWVVTQERVEQADIAVEGEKIAAIGPDLEARAAAVRDVTGKYILPGAIDAHVHYQMPIGELLTADDWFTGTRL
AACGGVTTVIDYAEPAGPAEPLTEALAKRLEEAREQACVDYGLHQVVLPGQEEDTGELAKVIEQGVTSFKVFTTYKQCLG
YAAIGRLLKQARRLGALVTVHCEDHDLVTARRRELEATGQTDPAYHANSRPAAAEVKAIEKVIRQAAAAGAPVYIVHVST
GGGAELIAAARARGQQVFGETCPHYLLLTEERYAGPDSRLFLMCPPLRTVKDNRILWQHLASGDLQVVATDHCSYSPEQK
AAGTAFYNTPSGVPGTETLLPLLYSYGVRQGRLTLPQMVRVLATNPARLFGLYPRKGCLAPGSDADLVVFDPSQEVILKA
SDLHSAAAYTIFEGFALQGYVEATYLRGRLIYDLGRFLGRAGQGEFIPGKITVL

Specific function: Catalyzes the stereospecific hydrolysis of the cyclic amide bond of D-hydantoin derivatives with an aromatic side chains at the 5'-position. Has no activity on dihydropyrimidines. The physiological function is unknown [H]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503375, Length=461, Percent_Identity=35.7917570498915, Blast_Score=262, Evalue=5e-70,
Organism=Homo sapiens, GI4503379, Length=457, Percent_Identity=35.0109409190372, Blast_Score=260, Evalue=2e-69,
Organism=Homo sapiens, GI4503051, Length=461, Percent_Identity=34.9240780911063, Blast_Score=246, Evalue=4e-65,
Organism=Homo sapiens, GI62422571, Length=461, Percent_Identity=34.9240780911063, Blast_Score=244, Evalue=9e-65,
Organism=Homo sapiens, GI4503377, Length=461, Percent_Identity=34.056399132321, Blast_Score=241, Evalue=8e-64,
Organism=Homo sapiens, GI190194363, Length=460, Percent_Identity=34.5652173913044, Blast_Score=235, Evalue=6e-62,
Organism=Homo sapiens, GI19923821, Length=455, Percent_Identity=32.7472527472527, Blast_Score=232, Evalue=7e-61,
Organism=Homo sapiens, GI18105007, Length=396, Percent_Identity=28.7878787878788, Blast_Score=103, Evalue=5e-22,
Organism=Escherichia coli, GI87082175, Length=454, Percent_Identity=39.4273127753304, Blast_Score=327, Evalue=8e-91,
Organism=Escherichia coli, GI1786722, Length=456, Percent_Identity=31.359649122807, Blast_Score=210, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI71989490, Length=457, Percent_Identity=34.1356673960613, Blast_Score=258, Evalue=3e-69,
Organism=Caenorhabditis elegans, GI17539558, Length=464, Percent_Identity=32.5431034482759, Blast_Score=231, Evalue=7e-61,
Organism=Caenorhabditis elegans, GI86575075, Length=446, Percent_Identity=28.9237668161435, Blast_Score=154, Evalue=9e-38,
Organism=Caenorhabditis elegans, GI193204318, Length=409, Percent_Identity=27.8728606356968, Blast_Score=118, Evalue=8e-27,
Organism=Saccharomyces cerevisiae, GI6322218, Length=400, Percent_Identity=30.5, Blast_Score=159, Evalue=9e-40,
Organism=Drosophila melanogaster, GI17137462, Length=456, Percent_Identity=33.5526315789474, Blast_Score=247, Evalue=1e-65,
Organism=Drosophila melanogaster, GI221377917, Length=461, Percent_Identity=34.9240780911063, Blast_Score=244, Evalue=6e-65,
Organism=Drosophila melanogaster, GI24644287, Length=269, Percent_Identity=34.9442379182156, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24644289, Length=227, Percent_Identity=33.4801762114537, Blast_Score=118, Evalue=9e-27,
Organism=Drosophila melanogaster, GI18859883, Length=432, Percent_Identity=28.7037037037037, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24642586, Length=406, Percent_Identity=29.5566502463054, Blast_Score=108, Evalue=7e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011778
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: 3.-.-.- [C]

Molecular weight: Translated: 49027; Mature: 49027

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLLLKGGWVVTQERVEQADIAVEGEKIAAIGPDLEARAAAVRDVTGKYILPGAIDAHVH
CCEEEECCEEEEHHHHHHHCEEECCCEEEEECCCHHHHHHHHHHCCCCEEECCCEECEEE
YQMPIGELLTADDWFTGTRLAACGGVTTVIDYAEPAGPAEPLTEALAKRLEEAREQACVD
EECCHHHHHCCCCCCCCCHHHHCCCHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHH
YGLHQVVLPGQEEDTGELAKVIEQGVTSFKVFTTYKQCLGYAAIGRLLKQARRLGALVTV
CCCCEEEECCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
HCEDHDLVTARRRELEATGQTDPAYHANSRPAAAEVKAIEKVIRQAAAAGAPVYIVHVST
EECCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEC
GGGAELIAAARARGQQVFGETCPHYLLLTEERYAGPDSRLFLMCPPLRTVKDNRILWQHL
CCCHHHHHHHHHCCHHHHHHCCCCEEEEECHHCCCCCCEEEEECCCCCCCCCCHHHHHHH
ASGDLQVVATDHCSYSPEQKAAGTAFYNTPSGVPGTETLLPLLYSYGVRQGRLTLPQMVR
CCCCEEEEEECCCCCCCCHHCCCCEEECCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHH
VLATNPARLFGLYPRKGCLAPGSDADLVVFDPSQEVILKASDLHSAAAYTIFEGFALQGY
HHHCCCHHEEECCCCCCCCCCCCCCCEEEECCCCCEEEEECHHHHHHHHHHHHCCCCEEE
VEATYLRGRLIYDLGRFLGRAGQGEFIPGKITVL
HEEHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEC
>Mature Secondary Structure
MDLLLKGGWVVTQERVEQADIAVEGEKIAAIGPDLEARAAAVRDVTGKYILPGAIDAHVH
CCEEEECCEEEEHHHHHHHCEEECCCEEEEECCCHHHHHHHHHHCCCCEEECCCEECEEE
YQMPIGELLTADDWFTGTRLAACGGVTTVIDYAEPAGPAEPLTEALAKRLEEAREQACVD
EECCHHHHHCCCCCCCCCHHHHCCCHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHH
YGLHQVVLPGQEEDTGELAKVIEQGVTSFKVFTTYKQCLGYAAIGRLLKQARRLGALVTV
CCCCEEEECCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
HCEDHDLVTARRRELEATGQTDPAYHANSRPAAAEVKAIEKVIRQAAAAGAPVYIVHVST
EECCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEC
GGGAELIAAARARGQQVFGETCPHYLLLTEERYAGPDSRLFLMCPPLRTVKDNRILWQHL
CCCHHHHHHHHHCCHHHHHHCCCCEEEEECHHCCCCCCEEEEECCCCCCCCCCHHHHHHH
ASGDLQVVATDHCSYSPEQKAAGTAFYNTPSGVPGTETLLPLLYSYGVRQGRLTLPQMVR
CCCCEEEEEECCCCCCCCHHCCCCEEECCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHH
VLATNPARLFGLYPRKGCLAPGSDADLVVFDPSQEVILKASDLHSAAAYTIFEGFALQGY
HHHCCCHHEEECCCCCCCCCCCCCCCEEEECCCCCEEEEECHHHHHHHHHHHHCCCCEEE
VEATYLRGRLIYDLGRFLGRAGQGEFIPGKITVL
HEEHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA