Click here to switch to the map view.

The map label for this gene is ndhS [H]

Identifier: 83590793

GI number: 83590793

Start: 2040379

End: 2040864

Strand: Reverse

Name: ndhS [H]

Synonym: Moth_1961

Alternate gene names: 83590793

Gene position: 2040864-2040379 (Counterclockwise)

Preceding gene: 83590794

Following gene: 83590792

Centisome position: 77.64

GC content: 62.55

Gene sequence:

>486_bases
ATGCCCGGGTTTAAGCTTAAAGTCAATGGCCGGGAGTACCAGGTCGAGGCCCCGGCGGATATTACCCTGCTGGAGCTGCT
GCGGGAGTATCTGGGCCTCACCGGTACCAAGGAGGGGTGTGGCAAGGGAGAGTGCGGCGCCTGCACCGTGCTCCTGGACG
GCCAGGCGGTTAATTCCTGCCTGATTCCCGCCGCCAAGGCGGAGGGAGCCGAGGTCCTGACCATCGAGGGCCTGGCCTCG
CCGGACGGTAAACTCCATCCCCTCCAGGAGGCCTTCATTACTGAGGGGGCTGTCCAGTGCGGCTTCTGCACCCCGGGGAT
GATCTTGAGCGCCAAGGCCCTCCTGGACAGCAACCCCCGCCCTGGCCGCGAGGAGATTAAGATGGCCCTTTCAGGCAATC
TGTGCCGCTGCACCGGCTATGCTAAAATTATCGCGGCCGTGGAAAAAGCAGCAGCCGTTATGGCAGCGGCGGGTAGAAAA
AATTAG

Upstream 100 bases:

>100_bases
CTACCAGGTGACCGGAATCACCTCGGCTACGAGGGTGAGCGGCAGCTGGTTTCTTTATATCCATTTTTTGGAGTTCGAGA
TTACCAGGGGGGTAACGAAG

Downstream 100 bases:

>100_bases
AACCTGATTTTATGGAGGGGGTAAAATGGCTTCTACAGCAGTGGGGAAGAGTGTCACCAGGGTTGATGCTGTGGCCAAAG
TTACCGGGCAAGCAAAGTAT

Product: (2Fe-2S)-binding

Products: NA

Alternate protein names: NDH; Nicotinic acid hydroxylase small FeS subunit; NAH [H]

Number of amino acids: Translated: 161; Mature: 160

Protein sequence:

>161_residues
MPGFKLKVNGREYQVEAPADITLLELLREYLGLTGTKEGCGKGECGACTVLLDGQAVNSCLIPAAKAEGAEVLTIEGLAS
PDGKLHPLQEAFITEGAVQCGFCTPGMILSAKALLDSNPRPGREEIKMALSGNLCRCTGYAKIIAAVEKAAAVMAAAGRK
N

Sequences:

>Translated_161_residues
MPGFKLKVNGREYQVEAPADITLLELLREYLGLTGTKEGCGKGECGACTVLLDGQAVNSCLIPAAKAEGAEVLTIEGLAS
PDGKLHPLQEAFITEGAVQCGFCTPGMILSAKALLDSNPRPGREEIKMALSGNLCRCTGYAKIIAAVEKAAAVMAAAGRK
N
>Mature_160_residues
PGFKLKVNGREYQVEAPADITLLELLREYLGLTGTKEGCGKGECGACTVLLDGQAVNSCLIPAAKAEGAEVLTIEGLASP
DGKLHPLQEAFITEGAVQCGFCTPGMILSAKALLDSNPRPGREEIKMALSGNLCRCTGYAKIIAAVEKAAAVMAAAGRKN

Specific function: Catalyzes the hydroxylation of nicotinate to 6- hydroxynicotinate. Also active against 2-pyrazinecarboxylic acid, but inactive against other nicotinate analogs [H]

COG id: COG2080

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 2Fe-2S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=156, Percent_Identity=46.1538461538462, Blast_Score=107, Evalue=3e-24,
Organism=Homo sapiens, GI71773480, Length=89, Percent_Identity=49.438202247191, Blast_Score=96, Evalue=1e-20,
Organism=Escherichia coli, GI1786480, Length=166, Percent_Identity=48.7951807228916, Blast_Score=150, Evalue=3e-38,
Organism=Escherichia coli, GI1789232, Length=143, Percent_Identity=52.4475524475524, Blast_Score=132, Evalue=1e-32,
Organism=Escherichia coli, GI1789246, Length=112, Percent_Identity=35.7142857142857, Blast_Score=61, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17539860, Length=160, Percent_Identity=44.375, Blast_Score=131, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17540638, Length=149, Percent_Identity=44.2953020134228, Blast_Score=127, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI32566215, Length=158, Percent_Identity=43.0379746835443, Blast_Score=126, Evalue=5e-30,
Organism=Drosophila melanogaster, GI17737937, Length=148, Percent_Identity=45.2702702702703, Blast_Score=123, Evalue=4e-29,
Organism=Drosophila melanogaster, GI24647197, Length=161, Percent_Identity=36.6459627329193, Blast_Score=108, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24647195, Length=161, Percent_Identity=36.6459627329193, Blast_Score=107, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24647193, Length=161, Percent_Identity=37.888198757764, Blast_Score=105, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24647201, Length=152, Percent_Identity=38.1578947368421, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24647199, Length=155, Percent_Identity=38.0645161290323, Blast_Score=102, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002888
- InterPro:   IPR006058
- InterPro:   IPR012675
- InterPro:   IPR001041 [H]

Pfam domain/function: PF00111 Fer2; PF01799 Fer2_2 [H]

EC number: =1.17.1.5 [H]

Molecular weight: Translated: 16723; Mature: 16591

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
7.5 %Cys+Met (Translated Protein)
5.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGFKLKVNGREYQVEAPADITLLELLREYLGLTGTKEGCGKGECGACTVLLDGQAVNSC
CCCCEEEECCCEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCHH
LIPAAKAEGAEVLTIEGLASPDGKLHPLQEAFITEGAVQCGFCTPGMILSAKALLDSNPR
CCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHCCCCEEECCCCCCHHHHHHHHHCCCCC
PGREEIKMALSGNLCRCTGYAKIIAAVEKAAAVMAAAGRKN
CCHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
PGFKLKVNGREYQVEAPADITLLELLREYLGLTGTKEGCGKGECGACTVLLDGQAVNSC
CCCEEEECCCEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCHH
LIPAAKAEGAEVLTIEGLASPDGKLHPLQEAFITEGAVQCGFCTPGMILSAKALLDSNPR
CCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHCCCCEEECCCCCCHHHHHHHHHCCCCC
PGREEIKMALSGNLCRCTGYAKIIAAVEKAAAVMAAAGRKN
CCHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA