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The map label for this gene is xdhA [H]

Identifier: 83590792

GI number: 83590792

Start: 2038062

End: 2040353

Strand: Reverse

Name: xdhA [H]

Synonym: Moth_1960

Alternate gene names: 83590792

Gene position: 2040353-2038062 (Counterclockwise)

Preceding gene: 83590793

Following gene: 83590791

Centisome position: 77.62

GC content: 55.06

Gene sequence:

>2292_bases
ATGGCTTCTACAGCAGTGGGGAAGAGTGTCACCAGGGTTGATGCTGTGGCCAAAGTTACCGGGCAAGCAAAGTATACCGG
GGATTTTATGTTCAGGGACATGCTGGTCGGTAAGGTCTTAAGAAGTCCCTATGCCCATGCCATCGTTAAAAACATTGATG
TCAGCCAGGCCAGGGCTTTACCCGGCGTGGAAGGGGTCCTGACTTATAAGGATGTACCGCGGAATAAATTCCCCACTGCC
GGGCATCCCTATTCCCTGGATCCGGCCCACGGCGATAAGGCCGACCGTACCATCCTGACCGATAAAGCCCGCTTCGTCGG
TGACGCCATCGCGGCGGTAATAGCCAGGGATGAGCTGACGGCCGCCGAGGCCCTGAAGCTTATTAAGGTAGAGTACGAGG
TGTTAGAACCCCTCCTCACCCCGGAGGCAGCCATGCGGGAGGGCGCGCCCCTGATTCATGAGGATTGCCCTGGCAACATC
CTCAGTGCCAGTGGCTATGCCATCGGCGACGTCGACGAGGCTTTTAAAGAAGCCGACTATATCTTTGAGGATGAACTGGA
AACTAGCATTGTTCAGCATTGCCAGCTGGAAAATCATATATCCTGCGCTTATGTCGACAGCGACGGCCGCATAGTGATTA
TAACCTCCACCCAGATCCCCCATATTGTCAGGAGAATCGTCGGCCAGGCCTTGGGTATCCCTTGGGGCAGGATCCGGGTA
ATCAAGCCCTACGTCGGGGGCGGCTTTGGTAGCAAACAGGATGTCTGCACCGAACCCCTGGCCGCAGCCATGACCCTGGC
CGTGGGGGGAAGGCCGGTAAAACTGGAACTTTCCCGGGAAGAATGCATGATTGCCACCCGCACCCGCCATGCCTTCAAGT
TTAAGATCAAAACCGGGGTTTCCCGGGACGGCAGGTTAATCGGGATGCATATCAAGGCCATTTCCAATACCGGGGCCTAT
GCCTCCCACGGTCATTCCATCGCCATGGCCGGTGGTTCCAAATTCAGGATTCTTTATCCCATGAAGGCTTTGAAATATGA
ACCATTTACAGTTTACACCAACCTGCCGGTGGCGGGAGCCATGAGGGGTTATGGATCGCCCCAGATAACCTTTGCCGTGG
AAAGCCATCTGGATAACATCGCCAGCAAACTCAATATCGATCCTATTGAGTTCCGTCTGAAAAACCTGGTTAAAGAGGGT
TATGTCGATCCTTTAAATGGCAACGCGGTGCGGAGTTGCGGCATTCGCGAGTGCATTGCCCGGGGCAAAGAGTTGATCAA
GTGGGACGAGAAAAAAGCGCGGTATAAAAACCAAACCGGCAGCAGACGCCGGGGCCTGGGCATGGCCTGCTTCAGCTACG
GTTCCGGCACTTACCCGGTGGGGCTGGAAATAGGAGGGGCGCGGATCGTCCTGAACCAGGACGGTTCCGTCCAGCTACAG
GTTGGAGCTACAGAAATAGGTCAGGGCAGCGATACCGTCTTTGCCCAGATGGTAGCCGAGGTCCTGGGTATTCCGGTGGA
TATGGTCCATGTCCTTTCCACCCAGGATACAGATATTTCCCCCTTTGATACCGGTGCCTATGCTTCCCGGCAGACCTATA
TCACCGGTATGGCGGTGGCCAGGGCGGCCGCGGAGGTCAAGGAGAAGATCCTGGATTTTGCCTGGGGGATGACCGATATC
CCAGCCCATGCCCTGGATATTAAAGATGCCAATATCGTCTATAAACACTCGGGCGAAGTGGTCATGCCCCTGGCCGAGGT
GGCCCTGCACACCTATTACGACACCGTTTTCGCCAAACCGATAACGAGCGATACCTCCAATAATGCCCGGGTCAACGCCT
TTGTTTTTGGCGTTACCTTTGCCGAGGTGGAAGTAGACCTGAAAACCGGCCGGATCGAGGTCCTGGAGATATATAACGTC
CACGATTCCGGCAGGATTATCAACCGCCAGCTGGCGGCAGCCCAGGTCCACGGCGGCGTGGGCATGGGCATAGGTTATGC
CCTCTCCGAGCAATTGCTCTTTGACGAGAAGACCGGCCAACCACTGAATAACAATCTGCTGGATTACAAACTGCCTACGA
TTATGGATATTCCCGCAATCGGCGTAGATTTTGTGGAAACCTTTGAACCTACCAGCCCCTTTGGCTGCAAGGCTTTAGGC
GAGCCGCCGATTATTCCTGTGGCCCCGGCCATTCGTAATGCCGTTTTCGACGCCACGGGCGTGGCTTTTGACAGGTTGCC
CATGAATCCCCAACGGGTTTTCGAAAAGTTCAAGGAAGCCGGGTTAATATAG

Upstream 100 bases:

>100_bases
ACCGGCTATGCTAAAATTATCGCGGCCGTGGAAAAAGCAGCAGCCGTTATGGCAGCGGCGGGTAGAAAAAATTAGAACCT
GATTTTATGGAGGGGGTAAA

Downstream 100 bases:

>100_bases
TAAGGTGGTGAGGGCTGATGTTCAACATCCAGGAATATTTTGAGGCTGCAACAGTAGAGGAAGCCACGGCGTTGCTGGCG
GCCCATCCCGGCCTGACAGT

Product: xanthine dehydrogenase subunit XdhA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 763; Mature: 762

Protein sequence:

>763_residues
MASTAVGKSVTRVDAVAKVTGQAKYTGDFMFRDMLVGKVLRSPYAHAIVKNIDVSQARALPGVEGVLTYKDVPRNKFPTA
GHPYSLDPAHGDKADRTILTDKARFVGDAIAAVIARDELTAAEALKLIKVEYEVLEPLLTPEAAMREGAPLIHEDCPGNI
LSASGYAIGDVDEAFKEADYIFEDELETSIVQHCQLENHISCAYVDSDGRIVIITSTQIPHIVRRIVGQALGIPWGRIRV
IKPYVGGGFGSKQDVCTEPLAAAMTLAVGGRPVKLELSREECMIATRTRHAFKFKIKTGVSRDGRLIGMHIKAISNTGAY
ASHGHSIAMAGGSKFRILYPMKALKYEPFTVYTNLPVAGAMRGYGSPQITFAVESHLDNIASKLNIDPIEFRLKNLVKEG
YVDPLNGNAVRSCGIRECIARGKELIKWDEKKARYKNQTGSRRRGLGMACFSYGSGTYPVGLEIGGARIVLNQDGSVQLQ
VGATEIGQGSDTVFAQMVAEVLGIPVDMVHVLSTQDTDISPFDTGAYASRQTYITGMAVARAAAEVKEKILDFAWGMTDI
PAHALDIKDANIVYKHSGEVVMPLAEVALHTYYDTVFAKPITSDTSNNARVNAFVFGVTFAEVEVDLKTGRIEVLEIYNV
HDSGRIINRQLAAAQVHGGVGMGIGYALSEQLLFDEKTGQPLNNNLLDYKLPTIMDIPAIGVDFVETFEPTSPFGCKALG
EPPIIPVAPAIRNAVFDATGVAFDRLPMNPQRVFEKFKEAGLI

Sequences:

>Translated_763_residues
MASTAVGKSVTRVDAVAKVTGQAKYTGDFMFRDMLVGKVLRSPYAHAIVKNIDVSQARALPGVEGVLTYKDVPRNKFPTA
GHPYSLDPAHGDKADRTILTDKARFVGDAIAAVIARDELTAAEALKLIKVEYEVLEPLLTPEAAMREGAPLIHEDCPGNI
LSASGYAIGDVDEAFKEADYIFEDELETSIVQHCQLENHISCAYVDSDGRIVIITSTQIPHIVRRIVGQALGIPWGRIRV
IKPYVGGGFGSKQDVCTEPLAAAMTLAVGGRPVKLELSREECMIATRTRHAFKFKIKTGVSRDGRLIGMHIKAISNTGAY
ASHGHSIAMAGGSKFRILYPMKALKYEPFTVYTNLPVAGAMRGYGSPQITFAVESHLDNIASKLNIDPIEFRLKNLVKEG
YVDPLNGNAVRSCGIRECIARGKELIKWDEKKARYKNQTGSRRRGLGMACFSYGSGTYPVGLEIGGARIVLNQDGSVQLQ
VGATEIGQGSDTVFAQMVAEVLGIPVDMVHVLSTQDTDISPFDTGAYASRQTYITGMAVARAAAEVKEKILDFAWGMTDI
PAHALDIKDANIVYKHSGEVVMPLAEVALHTYYDTVFAKPITSDTSNNARVNAFVFGVTFAEVEVDLKTGRIEVLEIYNV
HDSGRIINRQLAAAQVHGGVGMGIGYALSEQLLFDEKTGQPLNNNLLDYKLPTIMDIPAIGVDFVETFEPTSPFGCKALG
EPPIIPVAPAIRNAVFDATGVAFDRLPMNPQRVFEKFKEAGLI
>Mature_762_residues
ASTAVGKSVTRVDAVAKVTGQAKYTGDFMFRDMLVGKVLRSPYAHAIVKNIDVSQARALPGVEGVLTYKDVPRNKFPTAG
HPYSLDPAHGDKADRTILTDKARFVGDAIAAVIARDELTAAEALKLIKVEYEVLEPLLTPEAAMREGAPLIHEDCPGNIL
SASGYAIGDVDEAFKEADYIFEDELETSIVQHCQLENHISCAYVDSDGRIVIITSTQIPHIVRRIVGQALGIPWGRIRVI
KPYVGGGFGSKQDVCTEPLAAAMTLAVGGRPVKLELSREECMIATRTRHAFKFKIKTGVSRDGRLIGMHIKAISNTGAYA
SHGHSIAMAGGSKFRILYPMKALKYEPFTVYTNLPVAGAMRGYGSPQITFAVESHLDNIASKLNIDPIEFRLKNLVKEGY
VDPLNGNAVRSCGIRECIARGKELIKWDEKKARYKNQTGSRRRGLGMACFSYGSGTYPVGLEIGGARIVLNQDGSVQLQV
GATEIGQGSDTVFAQMVAEVLGIPVDMVHVLSTQDTDISPFDTGAYASRQTYITGMAVARAAAEVKEKILDFAWGMTDIP
AHALDIKDANIVYKHSGEVVMPLAEVALHTYYDTVFAKPITSDTSNNARVNAFVFGVTFAEVEVDLKTGRIEVLEIYNVH
DSGRIINRQLAAAQVHGGVGMGIGYALSEQLLFDEKTGQPLNNNLLDYKLPTIMDIPAIGVDFVETFEPTSPFGCKALGE
PPIIPVAPAIRNAVFDATGVAFDRLPMNPQRVFEKFKEAGLI

Specific function: Presumed to be a dehydrogenase, but possibly an oxidase. Participates in limited purine salvage (requires aspartate) but does not support aerobic growth on purines as the sole carbon source (purine catabolism) [H]

COG id: COG1529

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=764, Percent_Identity=27.4869109947644, Blast_Score=206, Evalue=8e-53,
Organism=Homo sapiens, GI71773480, Length=707, Percent_Identity=27.2984441301273, Blast_Score=203, Evalue=5e-52,
Organism=Escherichia coli, GI1789230, Length=753, Percent_Identity=51.792828685259, Blast_Score=793, Evalue=0.0,
Organism=Escherichia coli, GI1789246, Length=804, Percent_Identity=33.955223880597, Blast_Score=406, Evalue=1e-114,
Organism=Escherichia coli, GI1786478, Length=769, Percent_Identity=27.5682704811443, Blast_Score=194, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17540638, Length=751, Percent_Identity=26.4980026631158, Blast_Score=204, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI17539860, Length=759, Percent_Identity=25.9552042160738, Blast_Score=179, Evalue=7e-45,
Organism=Caenorhabditis elegans, GI32566215, Length=588, Percent_Identity=25.3401360544218, Blast_Score=168, Evalue=1e-41,
Organism=Drosophila melanogaster, GI17737937, Length=750, Percent_Identity=28, Blast_Score=229, Evalue=5e-60,
Organism=Drosophila melanogaster, GI24647193, Length=759, Percent_Identity=24.5059288537549, Blast_Score=152, Evalue=6e-37,
Organism=Drosophila melanogaster, GI24647199, Length=763, Percent_Identity=24.3774574049803, Blast_Score=150, Evalue=3e-36,
Organism=Drosophila melanogaster, GI24647201, Length=764, Percent_Identity=23.8219895287958, Blast_Score=143, Evalue=4e-34,
Organism=Drosophila melanogaster, GI24647195, Length=760, Percent_Identity=23.8157894736842, Blast_Score=130, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24647197, Length=748, Percent_Identity=23.9304812834225, Blast_Score=127, Evalue=4e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000674
- InterPro:   IPR008274 [H]

Pfam domain/function: PF01315 Ald_Xan_dh_C; PF02738 Ald_Xan_dh_C2 [H]

EC number: =1.17.1.4 [H]

Molecular weight: Translated: 82752; Mature: 82621

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASTAVGKSVTRVDAVAKVTGQAKYTGDFMFRDMLVGKVLRSPYAHAIVKNIDVSQARAL
CCCCHHCCHHHHHHHHHHHCCCCEECHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHCC
PGVEGVLTYKDVPRNKFPTAGHPYSLDPAHGDKADRTILTDKARFVGDAIAAVIARDELT
CCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHH
AAEALKLIKVEYEVLEPLLTPEAAMREGAPLIHEDCPGNILSASGYAIGDVDEAFKEADY
HHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCEECCCCCCEEECCCCEECCHHHHHHHHCC
IFEDELETSIVQHCQLENHISCAYVDSDGRIVIITSTQIPHIVRRIVGQALGIPWGRIRV
HHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEEECCCHHHHHHHHHHHHHCCCCCEEEE
IKPYVGGGFGSKQDVCTEPLAAAMTLAVGGRPVKLELSREECMIATRTRHAFKFKIKTGV
EECCCCCCCCCCCCHHHHHHHHHHHHEECCEEEEEEECCCCEEEEEECCEEEEEEEECCC
SRDGRLIGMHIKAISNTGAYASHGHSIAMAGGSKFRILYPMKALKYEPFTVYTNLPVAGA
CCCCEEEEEEEEEECCCCCCCCCCCEEEEECCCEEEEEECHHHHCCCCEEEEECCCHHHH
MRGYGSPQITFAVESHLDNIASKLNIDPIEFRLKNLVKEGYVDPLNGNAVRSCGIRECIA
HCCCCCCEEEEEEHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCHHHHCCHHHHHH
RGKELIKWDEKKARYKNQTGSRRRGLGMACFSYGSGTYPVGLEIGGARIVLNQDGSVQLQ
CCHHHHHCCHHHHHHCCCCCCHHCCCCEEEEECCCCCCEEEEEECCEEEEEECCCCEEEE
VGATEIGQGSDTVFAQMVAEVLGIPVDMVHVLSTQDTDISPFDTGAYASRQTYITGMAVA
ECCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHH
RAAAEVKEKILDFAWGMTDIPAHALDIKDANIVYKHSGEVVMPLAEVALHTYYDTVFAKP
HHHHHHHHHHHHHHCCCCCCCCCEEECCCCEEEEECCCCEEEHHHHHHHHHHHHHHHCCC
ITSDTSNNARVNAFVFGVTFAEVEVDLKTGRIEVLEIYNVHDSGRIINRQLAAAQVHGGV
CCCCCCCCCEEEEEEEEEEEEEEEEEEECCCEEEEEEEEECCCCCCHHHHHHHHHHCCCC
GMGIGYALSEQLLFDEKTGQPLNNNLLDYKLPTIMDIPAIGVDFVETFEPTSPFGCKALG
CCCHHHHHHHHHHEECCCCCCCCCCCCCEECCCEECCCCCCCHHHHHCCCCCCCCCCCCC
EPPIIPVAPAIRNAVFDATGVAFDRLPMNPQRVFEKFKEAGLI
CCCCEECCHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure 
ASTAVGKSVTRVDAVAKVTGQAKYTGDFMFRDMLVGKVLRSPYAHAIVKNIDVSQARAL
CCCHHCCHHHHHHHHHHHCCCCEECHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHCC
PGVEGVLTYKDVPRNKFPTAGHPYSLDPAHGDKADRTILTDKARFVGDAIAAVIARDELT
CCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHH
AAEALKLIKVEYEVLEPLLTPEAAMREGAPLIHEDCPGNILSASGYAIGDVDEAFKEADY
HHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCEECCCCCCEEECCCCEECCHHHHHHHHCC
IFEDELETSIVQHCQLENHISCAYVDSDGRIVIITSTQIPHIVRRIVGQALGIPWGRIRV
HHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEEECCCHHHHHHHHHHHHHCCCCCEEEE
IKPYVGGGFGSKQDVCTEPLAAAMTLAVGGRPVKLELSREECMIATRTRHAFKFKIKTGV
EECCCCCCCCCCCCHHHHHHHHHHHHEECCEEEEEEECCCCEEEEEECCEEEEEEEECCC
SRDGRLIGMHIKAISNTGAYASHGHSIAMAGGSKFRILYPMKALKYEPFTVYTNLPVAGA
CCCCEEEEEEEEEECCCCCCCCCCCEEEEECCCEEEEEECHHHHCCCCEEEEECCCHHHH
MRGYGSPQITFAVESHLDNIASKLNIDPIEFRLKNLVKEGYVDPLNGNAVRSCGIRECIA
HCCCCCCEEEEEEHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCHHHHCCHHHHHH
RGKELIKWDEKKARYKNQTGSRRRGLGMACFSYGSGTYPVGLEIGGARIVLNQDGSVQLQ
CCHHHHHCCHHHHHHCCCCCCHHCCCCEEEEECCCCCCEEEEEECCEEEEEECCCCEEEE
VGATEIGQGSDTVFAQMVAEVLGIPVDMVHVLSTQDTDISPFDTGAYASRQTYITGMAVA
ECCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHH
RAAAEVKEKILDFAWGMTDIPAHALDIKDANIVYKHSGEVVMPLAEVALHTYYDTVFAKP
HHHHHHHHHHHHHHCCCCCCCCCEEECCCCEEEEECCCCEEEHHHHHHHHHHHHHHHCCC
ITSDTSNNARVNAFVFGVTFAEVEVDLKTGRIEVLEIYNVHDSGRIINRQLAAAQVHGGV
CCCCCCCCCEEEEEEEEEEEEEEEEEEECCCEEEEEEEEECCCCCCHHHHHHHHHHCCCC
GMGIGYALSEQLLFDEKTGQPLNNNLLDYKLPTIMDIPAIGVDFVETFEPTSPFGCKALG
CCCHHHHHHHHHHEECCCCCCCCCCCCCEECCCEECCCCCCCHHHHHCCCCCCCCCCCCC
EPPIIPVAPAIRNAVFDATGVAFDRLPMNPQRVFEKFKEAGLI
CCCCEECCHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]