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The map label for this gene is truD [H]

Identifier: 83590580

GI number: 83590580

Start: 1796991

End: 1798151

Strand: Reverse

Name: truD [H]

Synonym: Moth_1745

Alternate gene names: 83590580

Gene position: 1798151-1796991 (Counterclockwise)

Preceding gene: 83590581

Following gene: 83590579

Centisome position: 68.4

GC content: 53.83

Gene sequence:

>1161_bases
ATGAAATTAAAGGTGATCCCCGAGGATTTCGTGGTCCGGGAACTGGCCCGCCTTCCTATTCGGGAAAAGGGGCCTTACCG
GCTGTATCTTTTTGAAAAGAAGGGATGGAATACCATCGATCTTTTGATACGGCTGGCAAAGGCCCATCGCCTTCCCTACC
GACTTTTTGCTTACGGGGGGTTAAAGGACCGGCACGCCCATACCTTTCAGTACGTCACAGTGAAGCATCCCGCCGATTTA
ACCACTGAGGCAGAAAACTTTTCCTTGCAGAGTATTGGCTATATGGACAGGCCCATGGGTCCCGATCTCCTGGAGGGGAA
CGAGTTTGCTATCACCATCCGCGCCCTGGGAGCGGCGGAGGTATGCCGCATCAGCCGCCGGGTTGACGAGGTGCGGGGTT
TCGGCTACCCCAACTACTATGACAACCAGCGTTTTGGCAGCATGGACCGCCAGATGGGCCTCATGGCCGAGAGACTGCTG
AAGAAGCATTATAACGGCAGCCTGCAGATCTACCTTACCGGCATTTACCCGGAAGAAAAAAAAGAGGCCAGGGAACGCAA
GCTCTTTTTCCGCGAACACTGGGGTGATTGGTCGACCTGCCTGGCACGTGCTAAAACCACTATGGAGAGCAGAATATTTT
CCTTGCTTGTCGAAAAACCCAAAGCTTACATCGAGGCTTTGCAGATGATACCCCGCGAAGAGCTCTCCCTGCTTTTTTCA
GCCTACCAGAGTTTTCTTTTTAACGAGCTTTTAAGGAGGATTTTGCAGGAATTCGGCCTCGATCTTACGGCCGTACCCGG
CACCGCCGGGCCCTATCTTTTTTACCGGCGTCTAGAAAGGAAAGAGCTGGGCTATTTAAGAGCGCTTAGCTTACCGCTGG
CTGCCAGCCGCATGGAATTTCCCGATGCCATGAGCGAGCGGCTCTTTGCGGCCATCCTGGAAGAAAGGGGCATCAAGCGC
AGCAGTTTCAACCTGCGTAAGGTCCGGCAGGCCTTTTTTAAGTCGACGCCCAGGGAAGCCATAGTTTTTCCCGGTAATTT
TCGAATACAGCCGGCGGAGCCCGATGACCTTTACCCCGGCAGGCAAAAAATCCGCCTCTTCTTCAAGCTGCCGCGGGGGA
GCTACGGGACAATGCTCATCAAAAGGCTGACCATGCCTTGA

Upstream 100 bases:

>100_bases
TAGGGTTCCGGCTTTTGTTTTCGCTCCGGTCCATTTGCAAAGCGGTAGGGATTGTGGTACATATTTAGGAAGGTGATAAC
CAGGCATAAGGAGTAAAGCA

Downstream 100 bases:

>100_bases
ACCGGGATGGCATCCGGCGGGATAGGGAAGGGTGATGAGGTAAAAAATGGCGGCAAAGGAGCGGCAGCGCCTGGATAGAG
TGCTGGCCCACATGGGGTTT

Product: pseudouridylate synthase

Products: NA

Alternate protein names: tRNA pseudouridylate synthase D; tRNA-uridine isomerase D [H]

Number of amino acids: Translated: 386; Mature: 386

Protein sequence:

>386_residues
MKLKVIPEDFVVRELARLPIREKGPYRLYLFEKKGWNTIDLLIRLAKAHRLPYRLFAYGGLKDRHAHTFQYVTVKHPADL
TTEAENFSLQSIGYMDRPMGPDLLEGNEFAITIRALGAAEVCRISRRVDEVRGFGYPNYYDNQRFGSMDRQMGLMAERLL
KKHYNGSLQIYLTGIYPEEKKEARERKLFFREHWGDWSTCLARAKTTMESRIFSLLVEKPKAYIEALQMIPREELSLLFS
AYQSFLFNELLRRILQEFGLDLTAVPGTAGPYLFYRRLERKELGYLRALSLPLAASRMEFPDAMSERLFAAILEERGIKR
SSFNLRKVRQAFFKSTPREAIVFPGNFRIQPAEPDDLYPGRQKIRLFFKLPRGSYGTMLIKRLTMP

Sequences:

>Translated_386_residues
MKLKVIPEDFVVRELARLPIREKGPYRLYLFEKKGWNTIDLLIRLAKAHRLPYRLFAYGGLKDRHAHTFQYVTVKHPADL
TTEAENFSLQSIGYMDRPMGPDLLEGNEFAITIRALGAAEVCRISRRVDEVRGFGYPNYYDNQRFGSMDRQMGLMAERLL
KKHYNGSLQIYLTGIYPEEKKEARERKLFFREHWGDWSTCLARAKTTMESRIFSLLVEKPKAYIEALQMIPREELSLLFS
AYQSFLFNELLRRILQEFGLDLTAVPGTAGPYLFYRRLERKELGYLRALSLPLAASRMEFPDAMSERLFAAILEERGIKR
SSFNLRKVRQAFFKSTPREAIVFPGNFRIQPAEPDDLYPGRQKIRLFFKLPRGSYGTMLIKRLTMP
>Mature_386_residues
MKLKVIPEDFVVRELARLPIREKGPYRLYLFEKKGWNTIDLLIRLAKAHRLPYRLFAYGGLKDRHAHTFQYVTVKHPADL
TTEAENFSLQSIGYMDRPMGPDLLEGNEFAITIRALGAAEVCRISRRVDEVRGFGYPNYYDNQRFGSMDRQMGLMAERLL
KKHYNGSLQIYLTGIYPEEKKEARERKLFFREHWGDWSTCLARAKTTMESRIFSLLVEKPKAYIEALQMIPREELSLLFS
AYQSFLFNELLRRILQEFGLDLTAVPGTAGPYLFYRRLERKELGYLRALSLPLAASRMEFPDAMSERLFAAILEERGIKR
SSFNLRKVRQAFFKSTPREAIVFPGNFRIQPAEPDDLYPGRQKIRLFFKLPRGSYGTMLIKRLTMP

Specific function: Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs [H]

COG id: COG0585

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 TRUD domain [H]

Homologues:

Organism=Homo sapiens, GI50727002, Length=402, Percent_Identity=21.3930348258706, Blast_Score=84, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17557232, Length=290, Percent_Identity=23.448275862069, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6324817, Length=269, Percent_Identity=24.1635687732342, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21355799, Length=261, Percent_Identity=27.9693486590038, Blast_Score=72, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020103
- InterPro:   IPR001656
- InterPro:   IPR020119
- InterPro:   IPR011760 [H]

Pfam domain/function: PF01142 TruD [H]

EC number: NA

Molecular weight: Translated: 45124; Mature: 45124

Theoretical pI: Translated: 10.23; Mature: 10.23

Prosite motif: PS50984 TRUD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLKVIPEDFVVRELARLPIREKGPYRLYLFEKKGWNTIDLLIRLAKAHRLPYRLFAYGG
CEEEECCHHHHHHHHHHCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCEEEEEECC
LKDRHAHTFQYVTVKHPADLTTEAENFSLQSIGYMDRPMGPDLLEGNEFAITIRALGAAE
CCCCCCCEEEEEEEECCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCEEEEEEEECCHHH
VCRISRRVDEVRGFGYPNYYDNQRFGSMDRQMGLMAERLLKKHYNGSLQIYLTGIYPEEK
HHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEECCCHHH
KEARERKLFFREHWGDWSTCLARAKTTMESRIFSLLVEKPKAYIEALQMIPREELSLLFS
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
AYQSFLFNELLRRILQEFGLDLTAVPGTAGPYLFYRRLERKELGYLRALSLPLAASRMEF
HHHHHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHCCC
PDAMSERLFAAILEERGIKRSSFNLRKVRQAFFKSTPREAIVFPGNFRIQPAEPDDLYPG
CHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCEEEECCCCEECCCCCCCCCCC
RQKIRLFFKLPRGSYGTMLIKRLTMP
HHEEEEEEECCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MKLKVIPEDFVVRELARLPIREKGPYRLYLFEKKGWNTIDLLIRLAKAHRLPYRLFAYGG
CEEEECCHHHHHHHHHHCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCEEEEEECC
LKDRHAHTFQYVTVKHPADLTTEAENFSLQSIGYMDRPMGPDLLEGNEFAITIRALGAAE
CCCCCCCEEEEEEEECCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCEEEEEEEECCHHH
VCRISRRVDEVRGFGYPNYYDNQRFGSMDRQMGLMAERLLKKHYNGSLQIYLTGIYPEEK
HHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEECCCHHH
KEARERKLFFREHWGDWSTCLARAKTTMESRIFSLLVEKPKAYIEALQMIPREELSLLFS
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
AYQSFLFNELLRRILQEFGLDLTAVPGTAGPYLFYRRLERKELGYLRALSLPLAASRMEF
HHHHHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHCCC
PDAMSERLFAAILEERGIKRSSFNLRKVRQAFFKSTPREAIVFPGNFRIQPAEPDDLYPG
CHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCEEEECCCCEECCCCCCCCCCC
RQKIRLFFKLPRGSYGTMLIKRLTMP
HHEEEEEEECCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA