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The map label for this gene is nuoF2 [H]

Identifier: 83590554

GI number: 83590554

Start: 1760846

End: 1762705

Strand: Reverse

Name: nuoF2 [H]

Synonym: Moth_1718

Alternate gene names: 83590554

Gene position: 1762705-1760846 (Counterclockwise)

Preceding gene: 83590555

Following gene: 83590553

Centisome position: 67.05

GC content: 57.9

Gene sequence:

>1860_bases
GTGATTAAGTCGATGGAAGAACTGCAGAAGTTCAAGGAAAGCCAGTTGGAAGCCATGCAATCCCAAGAAGCGGGCGCGAA
GGCGAAGATCGTCGTGGGGATGGGAACCTGCGGCATCGCTGCCGGGGCCCGGGAGGTTATGAACGCCATCCTCGATGAAG
TAGCTAAACGCCAGTTAACGGGGGTGACGGTTAGCCAGACAAGTTGCATCGGCCTTTGCGCCCAGGAGCCCCTCGTTGAC
GTGATCTTACCCGGCCAGCCGAAGGTGACTTACGGGAAGGTAGACGCCGCCAAAGCCAGGGAAATCGTGGGTCGCCATGT
CGTTGACGGCCACATTGTAACCGAGTGGGTCGTGAACCGCCAGGGGGACGCCGTCAGGCCCTACACGGAGTTGCCCTTTT
TTAAACACCAGGTCCGCATAGCCCTGCGCAACTGCGGTCTCATAGATCCGGAATCCATTGGCGAATATATCGCCCACGAC
GGCTACCAAGCCCTGAGTAAAGTTCTGACTACCATGAAACCGTATGAGGTTATCGAGACCATTAAAAAATCTGGTTTACG
CGGCCGGGGCGGCGGTGGTTTTCCCACCGGTCTTAAGTGGGAGTTTGCCTATCGTTCCCCCGGTCCGGTCAAGTATTTTG
TCTGCAATGCCGACGAGGGCGACCCGGGGGCTTTTATGGATCGCAGTATCCTGGAGGGTGACCCCCACGCCGTCCTGGAA
GGCATGGCTATCGGGGCCTACGCCATCGGCGCCAGCCAGGGCTATATCTATGTCCGGGCCGAATACCCTGTTGCCGTCCA
GCGGTTAAAGCTGGCCATTAGCCAGGCGCGTGAGCAGGGACTTCTGGGGAAAAACCTGTTTAACTCCGGGTTTGATTTCG
ACATTGATATTCGCCTGGGGGCCGGGGCCTTTGTTTGTGGCGAGGAGACGGCCCTGCTGGCCTCCATTGAAGGCCGCCGG
GGTGAACCGCGGCCGCGGCCGCCCTTCCCGGCCGTTTCCGGGCTCTGGGGCAAGCCGACGGTTATTAACAACGTGGAGAC
CCTGGCCAATATTCCCACAATTATCCGCCAGGGATGGGAATGGTTTGCCGGTATCGGCACGGAAAAGAGCAAGGGCACCA
AGGTCTTTGCCCTGGCCGGCAAGATTAACAACAACGGCCTGGTTGAAATCCCCATGGGGACTTCCCTCCGCCAGGTTATT
TATGAAATTGGCGGCGGTATCCCGGGCGGCAAGAAGTTTAAAGCGGCGCAGACCGGAGGTCCGTCGGGCGGTTGCATCCC
TGCCGAGCACCTGGATGCGCCCATTGATTATGAAAACCTGACGGCCCTGGGCACCATTATGGGCTCCGGCGGCCTCATCA
TTATGGATGAAGACACCTGTATGGTAGATGTAGCCAAATTCTTCATGGACTTTGTCAAAGACGAATCCTGCGGCAAGTGC
ACCCCCTGCCGGATCGGCACTACGCGGATGCTAGAAATCTTGAATCGCATCACCAGGGGACAGGGGGAAGAAAAAGACCT
GGATCTCTTGGTAGAACTGGCGCGCCAGATCAAGGATACAGCCCTCTGCGGCCTGGGCCAGACGGCCCCGAACCCGGTTT
TGAGCACCATCACCTATTTCCGGGACGAGTACCTTGCCCATATTCGCGACCACCGTTGCCCGGCTCATGTCTGCCAGGAG
CTGCTTTCATATGTTATTGATGCCGGAAAATGCACCGGTTGCGGGGCCTGCAGTCGCGTCTGCCCGGTGGGGGCCATAAG
CGGCGGCAAAAAGGAAGCCCATCAGATTGATCCTGCAGCCTGCATTAAATGCGGCAGCTGTTATGAGAAATGCAGGTTCG
GCGCCATAACGAGGGAATAA

Upstream 100 bases:

>100_bases
ACCAGAAGGCCCATGGCCGCTTAACCCCGGATACCGCCCTGGAGATATTAAAGGAATACCAGTAATAAGGTCTCGCCAAA
ATGCACGGGGGTGATGAGTT

Downstream 100 bases:

>100_bases
CGGAGGAAAACGGGAGGCGAACAAGTTGAGCACCGTAAAACTGACCATTGACAATATACCGGTGGAAGTTGAGGCCGGAA
CGACGATCTTAAAGGCCGCC

Product: NADH dehydrogenase (quinone)

Products: NA

Alternate protein names: NADH dehydrogenase I subunit F 2; NDH-1 subunit F 2 [H]

Number of amino acids: Translated: 619; Mature: 619

Protein sequence:

>619_residues
MIKSMEELQKFKESQLEAMQSQEAGAKAKIVVGMGTCGIAAGAREVMNAILDEVAKRQLTGVTVSQTSCIGLCAQEPLVD
VILPGQPKVTYGKVDAAKAREIVGRHVVDGHIVTEWVVNRQGDAVRPYTELPFFKHQVRIALRNCGLIDPESIGEYIAHD
GYQALSKVLTTMKPYEVIETIKKSGLRGRGGGGFPTGLKWEFAYRSPGPVKYFVCNADEGDPGAFMDRSILEGDPHAVLE
GMAIGAYAIGASQGYIYVRAEYPVAVQRLKLAISQAREQGLLGKNLFNSGFDFDIDIRLGAGAFVCGEETALLASIEGRR
GEPRPRPPFPAVSGLWGKPTVINNVETLANIPTIIRQGWEWFAGIGTEKSKGTKVFALAGKINNNGLVEIPMGTSLRQVI
YEIGGGIPGGKKFKAAQTGGPSGGCIPAEHLDAPIDYENLTALGTIMGSGGLIIMDEDTCMVDVAKFFMDFVKDESCGKC
TPCRIGTTRMLEILNRITRGQGEEKDLDLLVELARQIKDTALCGLGQTAPNPVLSTITYFRDEYLAHIRDHRCPAHVCQE
LLSYVIDAGKCTGCGACSRVCPVGAISGGKKEAHQIDPAACIKCGSCYEKCRFGAITRE

Sequences:

>Translated_619_residues
MIKSMEELQKFKESQLEAMQSQEAGAKAKIVVGMGTCGIAAGAREVMNAILDEVAKRQLTGVTVSQTSCIGLCAQEPLVD
VILPGQPKVTYGKVDAAKAREIVGRHVVDGHIVTEWVVNRQGDAVRPYTELPFFKHQVRIALRNCGLIDPESIGEYIAHD
GYQALSKVLTTMKPYEVIETIKKSGLRGRGGGGFPTGLKWEFAYRSPGPVKYFVCNADEGDPGAFMDRSILEGDPHAVLE
GMAIGAYAIGASQGYIYVRAEYPVAVQRLKLAISQAREQGLLGKNLFNSGFDFDIDIRLGAGAFVCGEETALLASIEGRR
GEPRPRPPFPAVSGLWGKPTVINNVETLANIPTIIRQGWEWFAGIGTEKSKGTKVFALAGKINNNGLVEIPMGTSLRQVI
YEIGGGIPGGKKFKAAQTGGPSGGCIPAEHLDAPIDYENLTALGTIMGSGGLIIMDEDTCMVDVAKFFMDFVKDESCGKC
TPCRIGTTRMLEILNRITRGQGEEKDLDLLVELARQIKDTALCGLGQTAPNPVLSTITYFRDEYLAHIRDHRCPAHVCQE
LLSYVIDAGKCTGCGACSRVCPVGAISGGKKEAHQIDPAACIKCGSCYEKCRFGAITRE
>Mature_619_residues
MIKSMEELQKFKESQLEAMQSQEAGAKAKIVVGMGTCGIAAGAREVMNAILDEVAKRQLTGVTVSQTSCIGLCAQEPLVD
VILPGQPKVTYGKVDAAKAREIVGRHVVDGHIVTEWVVNRQGDAVRPYTELPFFKHQVRIALRNCGLIDPESIGEYIAHD
GYQALSKVLTTMKPYEVIETIKKSGLRGRGGGGFPTGLKWEFAYRSPGPVKYFVCNADEGDPGAFMDRSILEGDPHAVLE
GMAIGAYAIGASQGYIYVRAEYPVAVQRLKLAISQAREQGLLGKNLFNSGFDFDIDIRLGAGAFVCGEETALLASIEGRR
GEPRPRPPFPAVSGLWGKPTVINNVETLANIPTIIRQGWEWFAGIGTEKSKGTKVFALAGKINNNGLVEIPMGTSLRQVI
YEIGGGIPGGKKFKAAQTGGPSGGCIPAEHLDAPIDYENLTALGTIMGSGGLIIMDEDTCMVDVAKFFMDFVKDESCGKC
TPCRIGTTRMLEILNRITRGQGEEKDLDLLVELARQIKDTALCGLGQTAPNPVLSTITYFRDEYLAHIRDHRCPAHVCQE
LLSYVIDAGKCTGCGACSRVCPVGAISGGKKEAHQIDPAACIKCGSCYEKCRFGAITRE

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1894

COG function: function code C; NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 51 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI20149568, Length=430, Percent_Identity=42.7906976744186, Blast_Score=326, Evalue=5e-89,
Organism=Homo sapiens, GI260656005, Length=418, Percent_Identity=43.0622009569378, Blast_Score=324, Evalue=1e-88,
Organism=Escherichia coli, GI1788620, Length=410, Percent_Identity=42.1951219512195, Blast_Score=360, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17531727, Length=370, Percent_Identity=42.4324324324324, Blast_Score=304, Evalue=9e-83,
Organism=Drosophila melanogaster, GI45550452, Length=368, Percent_Identity=44.5652173913043, Blast_Score=316, Evalue=2e-86,
Organism=Drosophila melanogaster, GI19920794, Length=378, Percent_Identity=42.5925925925926, Blast_Score=314, Evalue=1e-85,
Organism=Drosophila melanogaster, GI24653819, Length=372, Percent_Identity=33.0645161290323, Blast_Score=227, Evalue=2e-59,
Organism=Drosophila melanogaster, GI24653817, Length=347, Percent_Identity=31.1239193083574, Blast_Score=197, Evalue=1e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001949
- InterPro:   IPR019575
- InterPro:   IPR011537
- InterPro:   IPR011538
- InterPro:   IPR019554 [H]

Pfam domain/function: PF01512 Complex1_51K; PF10589 NADH_4Fe-4S; PF10531 SLBB [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 66659; Mature: 66659

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: PS00645 COMPLEX1_51K_2 ; PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
3.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKSMEELQKFKESQLEAMQSQEAGAKAKIVVGMGTCGIAAGAREVMNAILDEVAKRQLT
CCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHC
GVTVSQTSCIGLCAQEPLVDVILPGQPKVTYGKVDAAKAREIVGRHVVDGHIVTEWVVNR
CCEEECCHHHHHHCCCCCEEEEECCCCCEEECCCCHHHHHHHHHHHHCCCEEHHHHHHCC
QGDAVRPYTELPFFKHQVRIALRNCGLIDPESIGEYIAHDGYQALSKVLTTMKPYEVIET
CCCCCCCHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHH
IKKSGLRGRGGGGFPTGLKWEFAYRSPGPVKYFVCNADEGDPGAFMDRSILEGDPHAVLE
HHHCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCCHHHCCHHHCCCCHHHHH
GMAIGAYAIGASQGYIYVRAEYPVAVQRLKLAISQAREQGLLGKNLFNSGFDFDIDIRLG
HHHHCEEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCHHHHCCCCCEEEEEEEC
AGAFVCGEETALLASIEGRRGEPRPRPPFPAVSGLWGKPTVINNVETLANIPTIIRQGWE
CCEEEECCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHCCHHHHHHHHHHHHCCHH
WFAGIGTEKSKGTKVFALAGKINNNGLVEIPMGTSLRQVIYEIGGGIPGGKKFKAAQTGG
HHHCCCCCCCCCCEEEEEEEEECCCCEEEECCCCHHHHHHHHHCCCCCCCCCEEECCCCC
PSGGCIPAEHLDAPIDYENLTALGTIMGSGGLIIMDEDTCMVDVAKFFMDFVKDESCGKC
CCCCCCCHHHCCCCCCHHHHHHHHHEECCCCEEEEECCCHHHHHHHHHHHHHCCCCCCCC
TPCRIGTTRMLEILNRITRGQGEEKDLDLLVELARQIKDTALCGLGQTAPNPVLSTITYF
CCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
RDEYLAHIRDHRCPAHVCQELLSYVIDAGKCTGCGACSRVCPVGAISGGKKEAHQIDPAA
HHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCCCHHHHHCCHHH
CIKCGSCYEKCRFGAITRE
HHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MIKSMEELQKFKESQLEAMQSQEAGAKAKIVVGMGTCGIAAGAREVMNAILDEVAKRQLT
CCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHC
GVTVSQTSCIGLCAQEPLVDVILPGQPKVTYGKVDAAKAREIVGRHVVDGHIVTEWVVNR
CCEEECCHHHHHHCCCCCEEEEECCCCCEEECCCCHHHHHHHHHHHHCCCEEHHHHHHCC
QGDAVRPYTELPFFKHQVRIALRNCGLIDPESIGEYIAHDGYQALSKVLTTMKPYEVIET
CCCCCCCHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHH
IKKSGLRGRGGGGFPTGLKWEFAYRSPGPVKYFVCNADEGDPGAFMDRSILEGDPHAVLE
HHHCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCCHHHCCHHHCCCCHHHHH
GMAIGAYAIGASQGYIYVRAEYPVAVQRLKLAISQAREQGLLGKNLFNSGFDFDIDIRLG
HHHHCEEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCHHHHCCCCCEEEEEEEC
AGAFVCGEETALLASIEGRRGEPRPRPPFPAVSGLWGKPTVINNVETLANIPTIIRQGWE
CCEEEECCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHCCHHHHHHHHHHHHCCHH
WFAGIGTEKSKGTKVFALAGKINNNGLVEIPMGTSLRQVIYEIGGGIPGGKKFKAAQTGG
HHHCCCCCCCCCCEEEEEEEEECCCCEEEECCCCHHHHHHHHHCCCCCCCCCEEECCCCC
PSGGCIPAEHLDAPIDYENLTALGTIMGSGGLIIMDEDTCMVDVAKFFMDFVKDESCGKC
CCCCCCCHHHCCCCCCHHHHHHHHHEECCCCEEEEECCCHHHHHHHHHHHHHCCCCCCCC
TPCRIGTTRMLEILNRITRGQGEEKDLDLLVELARQIKDTALCGLGQTAPNPVLSTITYF
CCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
RDEYLAHIRDHRCPAHVCQELLSYVIDAGKCTGCGACSRVCPVGAISGGKKEAHQIDPAA
HHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCCCHHHHHCCHHH
CIKCGSCYEKCRFGAITRE
HHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11481432 [H]