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The map label for this gene is relA [H]

Identifier: 83590516

GI number: 83590516

Start: 1716705

End: 1718858

Strand: Reverse

Name: relA [H]

Synonym: Moth_1680

Alternate gene names: 83590516

Gene position: 1718858-1716705 (Counterclockwise)

Preceding gene: 83590517

Following gene: 83590515

Centisome position: 65.39

GC content: 58.12

Gene sequence:

>2154_bases
GTGGACCTGCAAGAACTGGAACAACAGATTAGAAATTACCAGCCGGATGCCGATTTGAAGCTGGTCCGGGACGCCTATAC
CCTCGCGGCTACGGCCCATCGAGGCCAGAAACGGCGCTCCGGGGAGGATTACATTACCCATCCCCTGCAGGTGGCTGCTA
TCCTGGCGGAACTCCAGCTCGACGTAGTCACCATCGCCGCCGCCCTCCTTCATGATGTGGTGGAAGATACTCCTGTCAGC
CTGGACACCATCAAAGAACTCTTTGGCGAGGAAGTGGCCCTGCTGGTGGACGGGGTCACCAAGTTGAGCCGCCTGGAGTA
CAAGACCAAGGAAGAGCAGCAGGCGGAAACCCTGCGTAAGATGTTCCTGACCATGGCCCAAGACATCCGGGTCATCCTTA
TCAAGCTGGCCGACCGCCTGCACAACATGCGGACTTTAAAATACCATCCACCGGAAAAGCAGCAGGAGATTGCCCGGGAA
ACCCTGGAGATCTTTGCTCCCCTGGCCCATCGACTGGGTATCTTCCGCCTGAAGTGGGAACTGGAAGACCAGTCCCTGCG
CTACCTGGAACCGGAGCGCTACTACGAACTGGTCAACAGTATCAACATGAAGCGGCGGGAACGGGAAGAGTATATCCGGC
AGGTAGTCGACATCCTGCGGCAGAAGCTGGATGAAGCCGGCATCAAAGCCGATATCCAGGGAAGGCCCAAACACTTTTAT
AGCATCTACAACAAGATGGTAAAGCAGGGCAAGGAACTGAGCGAGATCTACGACCTCATCGCCGTGCGGGTGATTGTCGA
TACTGTCAAGGAATGTTACGCCGTCCTGGGGGTAGTCCACGCCATCTGGAAGCCCATCCCCGGGCGTTTCAAGGACTACG
TGGCCATGCCCAAGCCCAATATGTACCAGTCCCTGCATACCACCGTCATTGGGCCCAACGGGGATCCCTTTGAGATCCAG
ATCCGCACCTGGGAGATGCACCGTACGGCCGAATACGGTATCGCCGCCCACTGGCGCTATAAAGAAGGGGGCGGTACTTC
CGACCGGGAGTTCGAGCAGAAATTGACATGGTTGCGCCAGCTCCTGGACTGGCAGCGGGAGATGCGGGACCCCCGGGAGT
TCATGGAATCCCTGCGTATCGACCTCTTTTCCGACCGGGTCTATGTCTTTACCCCTAAAGGGGATGTCGTCGAATTGCCG
GCGGGTTCGGTACCCATTGATTTTGCCTACCGGGTGCATACGGACGTCGGGCATCGCTGTACCGGCGCCCGGGTGAACGG
CCGCATCGTTCCCCTGGACTACCAGTTAAAGACCGGCGATATAGTAGAGGTACTGACGACCAAGGGTAGCCGGCCCAGCC
GGGACTGGCTGCATATCGTCAAGACTTCCCAGGCCAAAAACCGCATTCGCCAGTGGTTTAAGAAAGAGGAACGGGAGAAG
AACCTGGCCCGGGGACGGGAACTTCTGGAAAAGGAATGCCAGAAACAGGGGTTCGACCCGGAAGAGGTCCTCAAGCCGTC
CTTCCTCCAGGAAGCAGCCCGGAAATTCAACCTGGCCACCGTAGAGGACCTCTACGCAACGGTTGGAGACGGCGTTATCA
CCCCCTTCCAGGTCCTTGGCCGCCTCAAAGGGGAAGAAGAACCGCCGCCTGAGGAAGTGGTCAAGAACACCCTCAAGCCC
TGGAGCGGTTATGGCAAGCCTTCCCACGGCGTACGGGTCAAAGGAGTCGACAACCTGGAGATCCGCCTGGCCCACTGCTG
TAATCCCCTGCCCGGCGATGCCATTATCGGCTATATCACCAGGGGCCGGGGAGTAACTGTCCACCGGGCCGATTGTCCCA
ATATTCTCCATCACCAGGAGACGGAGAAGGAGCGGATTATCGAAGTAGCCTGGGACGACGGAGCCGAAGCAACCTACCAG
GTGCAGATTGAAGCCCTGGCCCTGGACAGGCCCAACCTGGCCCTGGACATCATGACCGCGGTGGCGGATACCAAGACTAT
TATCAACTCCATCCATGCCCGGGCCACCCGCAATGACCAGGCCCTGGTGGATCTGAAAATTGAGATCAGAAGCCTGGAGC
ACCTGGAGTACATCATGGACAAGGTGCGCCGCATCCGGGATGTGACCGAGGTCAAAAGGGTAGTTCCCGGGTAA

Upstream 100 bases:

>100_bases
GACCTGATGGCTTCCAGACGCTACCGGCAGCTCCGGGCCGAAAGGGAACTGGCCCGGCAATTCAGGCGACAACTGCCGGG
AGGGGAGGTGCGGTAACCTG

Downstream 100 bases:

>100_bases
AGGAGTTACTATTATCGTGAGATGCTAATAACTATAGAAGTCGGGGTGTATTTGTGTTAAACTGCAGGAGAGGTGGCCAC
CCATGAGGGCGGTAGTCCAG

Product: (p)ppGpp synthetase I (GTP pyrophosphokinase), SpoT/RelA

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]

Number of amino acids: Translated: 717; Mature: 717

Protein sequence:

>717_residues
MDLQELEQQIRNYQPDADLKLVRDAYTLAATAHRGQKRRSGEDYITHPLQVAAILAELQLDVVTIAAALLHDVVEDTPVS
LDTIKELFGEEVALLVDGVTKLSRLEYKTKEEQQAETLRKMFLTMAQDIRVILIKLADRLHNMRTLKYHPPEKQQEIARE
TLEIFAPLAHRLGIFRLKWELEDQSLRYLEPERYYELVNSINMKRREREEYIRQVVDILRQKLDEAGIKADIQGRPKHFY
SIYNKMVKQGKELSEIYDLIAVRVIVDTVKECYAVLGVVHAIWKPIPGRFKDYVAMPKPNMYQSLHTTVIGPNGDPFEIQ
IRTWEMHRTAEYGIAAHWRYKEGGGTSDREFEQKLTWLRQLLDWQREMRDPREFMESLRIDLFSDRVYVFTPKGDVVELP
AGSVPIDFAYRVHTDVGHRCTGARVNGRIVPLDYQLKTGDIVEVLTTKGSRPSRDWLHIVKTSQAKNRIRQWFKKEEREK
NLARGRELLEKECQKQGFDPEEVLKPSFLQEAARKFNLATVEDLYATVGDGVITPFQVLGRLKGEEEPPPEEVVKNTLKP
WSGYGKPSHGVRVKGVDNLEIRLAHCCNPLPGDAIIGYITRGRGVTVHRADCPNILHHQETEKERIIEVAWDDGAEATYQ
VQIEALALDRPNLALDIMTAVADTKTIINSIHARATRNDQALVDLKIEIRSLEHLEYIMDKVRRIRDVTEVKRVVPG

Sequences:

>Translated_717_residues
MDLQELEQQIRNYQPDADLKLVRDAYTLAATAHRGQKRRSGEDYITHPLQVAAILAELQLDVVTIAAALLHDVVEDTPVS
LDTIKELFGEEVALLVDGVTKLSRLEYKTKEEQQAETLRKMFLTMAQDIRVILIKLADRLHNMRTLKYHPPEKQQEIARE
TLEIFAPLAHRLGIFRLKWELEDQSLRYLEPERYYELVNSINMKRREREEYIRQVVDILRQKLDEAGIKADIQGRPKHFY
SIYNKMVKQGKELSEIYDLIAVRVIVDTVKECYAVLGVVHAIWKPIPGRFKDYVAMPKPNMYQSLHTTVIGPNGDPFEIQ
IRTWEMHRTAEYGIAAHWRYKEGGGTSDREFEQKLTWLRQLLDWQREMRDPREFMESLRIDLFSDRVYVFTPKGDVVELP
AGSVPIDFAYRVHTDVGHRCTGARVNGRIVPLDYQLKTGDIVEVLTTKGSRPSRDWLHIVKTSQAKNRIRQWFKKEEREK
NLARGRELLEKECQKQGFDPEEVLKPSFLQEAARKFNLATVEDLYATVGDGVITPFQVLGRLKGEEEPPPEEVVKNTLKP
WSGYGKPSHGVRVKGVDNLEIRLAHCCNPLPGDAIIGYITRGRGVTVHRADCPNILHHQETEKERIIEVAWDDGAEATYQ
VQIEALALDRPNLALDIMTAVADTKTIINSIHARATRNDQALVDLKIEIRSLEHLEYIMDKVRRIRDVTEVKRVVPG
>Mature_717_residues
MDLQELEQQIRNYQPDADLKLVRDAYTLAATAHRGQKRRSGEDYITHPLQVAAILAELQLDVVTIAAALLHDVVEDTPVS
LDTIKELFGEEVALLVDGVTKLSRLEYKTKEEQQAETLRKMFLTMAQDIRVILIKLADRLHNMRTLKYHPPEKQQEIARE
TLEIFAPLAHRLGIFRLKWELEDQSLRYLEPERYYELVNSINMKRREREEYIRQVVDILRQKLDEAGIKADIQGRPKHFY
SIYNKMVKQGKELSEIYDLIAVRVIVDTVKECYAVLGVVHAIWKPIPGRFKDYVAMPKPNMYQSLHTTVIGPNGDPFEIQ
IRTWEMHRTAEYGIAAHWRYKEGGGTSDREFEQKLTWLRQLLDWQREMRDPREFMESLRIDLFSDRVYVFTPKGDVVELP
AGSVPIDFAYRVHTDVGHRCTGARVNGRIVPLDYQLKTGDIVEVLTTKGSRPSRDWLHIVKTSQAKNRIRQWFKKEEREK
NLARGRELLEKECQKQGFDPEEVLKPSFLQEAARKFNLATVEDLYATVGDGVITPFQVLGRLKGEEEPPPEEVVKNTLKP
WSGYGKPSHGVRVKGVDNLEIRLAHCCNPLPGDAIIGYITRGRGVTVHRADCPNILHHQETEKERIIEVAWDDGAEATYQ
VQIEALALDRPNLALDIMTAVADTKTIINSIHARATRNDQALVDLKIEIRSLEHLEYIMDKVRRIRDVTEVKRVVPG

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HD domain [H]

Homologues:

Organism=Homo sapiens, GI38348360, Length=136, Percent_Identity=39.7058823529412, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI1790082, Length=716, Percent_Identity=43.1564245810056, Blast_Score=584, Evalue=1e-168,
Organism=Escherichia coli, GI1789147, Length=687, Percent_Identity=40.4657933042213, Blast_Score=543, Evalue=1e-155,
Organism=Caenorhabditis elegans, GI25143118, Length=138, Percent_Identity=38.4057971014493, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24650996, Length=127, Percent_Identity=38.5826771653543, Blast_Score=74, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR003607
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 82688; Mature: 82688

Theoretical pI: Translated: 6.99; Mature: 6.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLQELEQQIRNYQPDADLKLVRDAYTLAATAHRGQKRRSGEDYITHPLQVAAILAELQL
CCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHCCCCCHHHHHHHHHHHHHHHHH
DVVTIAAALLHDVVEDTPVSLDTIKELFGEEVALLVDGVTKLSRLEYKTKEEQQAETLRK
HHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MFLTMAQDIRVILIKLADRLHNMRTLKYHPPEKQQEIARETLEIFAPLAHRLGIFRLKWE
HHHHHHHHHHHHHHHHHHHHHCCCEECCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEEE
LEDQSLRYLEPERYYELVNSINMKRREREEYIRQVVDILRQKLDEAGIKADIQGRPKHFY
ECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCHHHHH
SIYNKMVKQGKELSEIYDLIAVRVIVDTVKECYAVLGVVHAIWKPIPGRFKDYVAMPKPN
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCH
MYQSLHTTVIGPNGDPFEIQIRTWEMHRTAEYGIAAHWRYKEGGGTSDREFEQKLTWLRQ
HHHHHHHEEECCCCCCEEEEEEEEEEHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHH
LLDWQREMRDPREFMESLRIDLFSDRVYVFTPKGDVVELPAGSVPIDFAYRVHTDVGHRC
HHHHHHHHCCHHHHHHHHHHEEECCEEEEECCCCCEEECCCCCCCEEEEEEEECCCCCCC
TGARVNGRIVPLDYQLKTGDIVEVLTTKGSRPSRDWLHIVKTSQAKNRIRQWFKKEEREK
CCCEECCEEEEEEEEECCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
NLARGRELLEKECQKQGFDPEEVLKPSFLQEAARKFNLATVEDLYATVGDGVITPFQVLG
HHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHH
RLKGEEEPPPEEVVKNTLKPWSGYGKPSHGVRVKGVDNLEIRLAHCCNPLPGDAIIGYIT
HHCCCCCCCHHHHHHHHCCCCCCCCCCCCCEEEECCCCHHEEHHHHCCCCCCCCEEEEEE
RGRGVTVHRADCPNILHHQETEKERIIEVAWDDGAEATYQVQIEALALDRPNLALDIMTA
CCCCEEEECCCCCCHHCCCCCCHHHEEEEEECCCCCCEEEEEEEEEEECCCCHHHHHHHH
VADTKTIINSIHARATRNDQALVDLKIEIRSLEHLEYIMDKVRRIRDVTEVKRVVPG
HHHHHHHHHHHHHHCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDLQELEQQIRNYQPDADLKLVRDAYTLAATAHRGQKRRSGEDYITHPLQVAAILAELQL
CCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHCCCCCHHHHHHHHHHHHHHHHH
DVVTIAAALLHDVVEDTPVSLDTIKELFGEEVALLVDGVTKLSRLEYKTKEEQQAETLRK
HHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MFLTMAQDIRVILIKLADRLHNMRTLKYHPPEKQQEIARETLEIFAPLAHRLGIFRLKWE
HHHHHHHHHHHHHHHHHHHHHCCCEECCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEEE
LEDQSLRYLEPERYYELVNSINMKRREREEYIRQVVDILRQKLDEAGIKADIQGRPKHFY
ECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCHHHHH
SIYNKMVKQGKELSEIYDLIAVRVIVDTVKECYAVLGVVHAIWKPIPGRFKDYVAMPKPN
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCH
MYQSLHTTVIGPNGDPFEIQIRTWEMHRTAEYGIAAHWRYKEGGGTSDREFEQKLTWLRQ
HHHHHHHEEECCCCCCEEEEEEEEEEHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHH
LLDWQREMRDPREFMESLRIDLFSDRVYVFTPKGDVVELPAGSVPIDFAYRVHTDVGHRC
HHHHHHHHCCHHHHHHHHHHEEECCEEEEECCCCCEEECCCCCCCEEEEEEEECCCCCCC
TGARVNGRIVPLDYQLKTGDIVEVLTTKGSRPSRDWLHIVKTSQAKNRIRQWFKKEEREK
CCCEECCEEEEEEEEECCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
NLARGRELLEKECQKQGFDPEEVLKPSFLQEAARKFNLATVEDLYATVGDGVITPFQVLG
HHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHH
RLKGEEEPPPEEVVKNTLKPWSGYGKPSHGVRVKGVDNLEIRLAHCCNPLPGDAIIGYIT
HHCCCCCCCHHHHHHHHCCCCCCCCCCCCCEEEECCCCHHEEHHHHCCCCCCCCEEEEEE
RGRGVTVHRADCPNILHHQETEKERIIEVAWDDGAEATYQVQIEALALDRPNLALDIMTA
CCCCEEEECCCCCCHHCCCCCCHHHEEEEEECCCCCCEEEEEEEEEEECCCCHHHHHHHH
VADTKTIINSIHARATRNDQALVDLKIEIRSLEHLEYIMDKVRRIRDVTEVKRVVPG
HHHHHHHHHHHHHHCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9383190; 9384377 [H]