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The map label for this gene is trxA [H]

Identifier: 83590509

GI number: 83590509

Start: 1710518

End: 1710847

Strand: Reverse

Name: trxA [H]

Synonym: Moth_1673

Alternate gene names: 83590509

Gene position: 1710847-1710518 (Counterclockwise)

Preceding gene: 83590510

Following gene: 83590508

Centisome position: 65.08

GC content: 53.33

Gene sequence:

>330_bases
ATGGCAGCGTCAAATATTATAACCCTGACGGACGCCAATTTTGAAGAAGAAGTGCTCTCGGCAACAACCCCGGTCCTGGT
TGATTTCTGGGCCGCTTGGTGCGGTCCCTGCCGGATGATTGCTCCCATTGTGGACGAGCTGGCGCAGGAGTACGCCGGCA
AAGTCAAGGTGGCCAAGCTGAACGTAGACGAGTACCCCAAGATCCCCGCCGACTACGGGATCATGAGCATCCCTACCCTG
ATCCTGTTTAAAAACGGTGAGGTTATCGCCCGGACAGTCGGTTATCAGAGCAAGGAAAAACTGGCCCAGGTTTTGGAGAA
TAATTTATAG

Upstream 100 bases:

>100_bases
CGGACGGCGATCGTCAACCAGGCAGATAAAGAGATCATCAGCGAACTCATTGATGTCCTAAACCGCTTCATAAGTTAAAA
AATCCTGGGGAGGCAGCGCT

Downstream 100 bases:

>100_bases
CTTATAGATATATCGCCCCCGGGGACAACGCAGGTAGTACCCCGGGGTTTTTGTTTGGATGGCCTGCCCCCAGGATGCGG
TCATTGCATGAGGGGCCTAG

Product: thioredoxin

Products: NA

Alternate protein names: Trx-1; Thioredoxin-M [H]

Number of amino acids: Translated: 109; Mature: 108

Protein sequence:

>109_residues
MAASNIITLTDANFEEEVLSATTPVLVDFWAAWCGPCRMIAPIVDELAQEYAGKVKVAKLNVDEYPKIPADYGIMSIPTL
ILFKNGEVIARTVGYQSKEKLAQVLENNL

Sequences:

>Translated_109_residues
MAASNIITLTDANFEEEVLSATTPVLVDFWAAWCGPCRMIAPIVDELAQEYAGKVKVAKLNVDEYPKIPADYGIMSIPTL
ILFKNGEVIARTVGYQSKEKLAQVLENNL
>Mature_108_residues
AASNIITLTDANFEEEVLSATTPVLVDFWAAWCGPCRMIAPIVDELAQEYAGKVKVAKLNVDEYPKIPADYGIMSIPTLI
LFKNGEVIARTVGYQSKEKLAQVLENNL

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=95, Percent_Identity=33.6842105263158, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI87082331, Length=107, Percent_Identity=57.9439252336449, Blast_Score=132, Evalue=4e-33,
Organism=Escherichia coli, GI1788936, Length=94, Percent_Identity=41.4893617021277, Blast_Score=90, Evalue=4e-20,
Organism=Escherichia coli, GI87081747, Length=108, Percent_Identity=36.1111111111111, Blast_Score=74, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI212646193, Length=97, Percent_Identity=41.2371134020619, Blast_Score=90, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI115532380, Length=103, Percent_Identity=34.9514563106796, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17544108, Length=103, Percent_Identity=34.9514563106796, Blast_Score=76, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI115532378, Length=112, Percent_Identity=33.0357142857143, Blast_Score=75, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI71998175, Length=83, Percent_Identity=42.1686746987952, Blast_Score=73, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17509965, Length=65, Percent_Identity=44.6153846153846, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71980562, Length=105, Percent_Identity=33.3333333333333, Blast_Score=69, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI71980565, Length=104, Percent_Identity=35.5769230769231, Blast_Score=69, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17556044, Length=81, Percent_Identity=35.8024691358025, Blast_Score=69, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17510299, Length=89, Percent_Identity=35.9550561797753, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17507705, Length=106, Percent_Identity=33.9622641509434, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17554386, Length=95, Percent_Identity=33.6842105263158, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17549970, Length=102, Percent_Identity=29.4117647058824, Blast_Score=63, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=70, Percent_Identity=44.2857142857143, Blast_Score=75, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6321648, Length=83, Percent_Identity=38.5542168674699, Blast_Score=75, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6319925, Length=91, Percent_Identity=32.967032967033, Blast_Score=70, Evalue=9e-14,
Organism=Drosophila melanogaster, GI28573567, Length=97, Percent_Identity=38.1443298969072, Blast_Score=95, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24639826, Length=91, Percent_Identity=45.0549450549451, Blast_Score=91, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21358065, Length=89, Percent_Identity=35.9550561797753, Blast_Score=80, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17648013, Length=85, Percent_Identity=41.1764705882353, Blast_Score=75, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24583090, Length=85, Percent_Identity=41.1764705882353, Blast_Score=75, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24664269, Length=96, Percent_Identity=37.5, Blast_Score=72, Evalue=6e-14,
Organism=Drosophila melanogaster, GI19921434, Length=82, Percent_Identity=36.5853658536585, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11989; Mature: 11858

Theoretical pI: Translated: 4.31; Mature: 4.31

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAASNIITLTDANFEEEVLSATTPVLVDFWAAWCGPCRMIAPIVDELAQEYAGKVKVAKL
CCCCCEEEEECCCHHHHHHHHCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCEEEEEE
NVDEYPKIPADYGIMSIPTLILFKNGEVIARTVGYQSKEKLAQVLENNL
CCCCCCCCCCCCCHHHCCEEEEEECCCEEEECCCCCCHHHHHHHHHCCC
>Mature Secondary Structure 
AASNIITLTDANFEEEVLSATTPVLVDFWAAWCGPCRMIAPIVDELAQEYAGKVKVAKL
CCCCEEEEECCCHHHHHHHHCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCEEEEEE
NVDEYPKIPADYGIMSIPTLILFKNGEVIARTVGYQSKEKLAQVLENNL
CCCCCCCCCCCCCHHHCCEEEEEECCCEEEECCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3096973; 3926769 [H]