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The map label for this gene is dcuS [H]

Identifier: 83590458

GI number: 83590458

Start: 1658998

End: 1659825

Strand: Reverse

Name: dcuS [H]

Synonym: Moth_1622

Alternate gene names: 83590458

Gene position: 1659825-1658998 (Counterclockwise)

Preceding gene: 83590459

Following gene: 83590457

Centisome position: 63.14

GC content: 50.0

Gene sequence:

>828_bases
ATGGGCAGACAAAATACCAATTATTGGATTTTAATTATCCTGCTTGGCCAGACTTTTCTATTAAATATAGCGGTGCAAAA
CCTCCAGCTTTCCCCGTATGCCGGTATTCAGCCCATCACCCTGGGCGCCAACCTGGTTAGCCTCTCCTTCTACTTTATGA
CCCTGCTGTTAATCAAAAAATTGTTGGATATAAAGGAGCAACAAAAGCTTTTAGGGCAAAAAGAAAAGGAAATGGACAGC
CTGCAAAACCTTCTTCGCACCGTGCGTGCCCAGAGACACGATATTATCAACCACCTGGATACCGTGTATGCCCTGCTCTC
CCTTGGAAGAGAGGTGCCGGCTAGAGAATATACCGGCCAGTTGGTCCAGGTGGCGGCCAATACAAGCCATTTGCTGCGGT
TGGAGCAACCGGTCGTCGCCGCTTTTTTACAGAATAAAGCCAGCCAGGCTATGGCCAGGGGAATAACCTTCTATATCGAT
GTGCGTGCAGACTTAAAAGGGCTAAAGGTTAAGCCCTATGCCCTTGTCACCGTCCTGGGCAATATCCTGGAGAACGCCAT
GGAAGCTGTGGAACCGCTACCTGGGGAACAACGTCTTATCCAACTAGATATATCCAGATCTGAGACGGGATATATCTTTA
GTATCAGCAATTCGGGGCCTCCCCTGGACTCGGCCATGAAAGAGGCTATCTTCCGGCCCGGCGTATCCACCAAAGGGCTG
GACCGGGGGTTAGGCCTGGCAACAGTGTGGGAGATGGTAATAAGTCATGGTGGCACTATCGAAGTAGAGACTGATCCGGT
AACTTTCCGGGTGAAGTTCCCGGTATGA

Upstream 100 bases:

>100_bases
TATTTTTATGGCCGTACCGGAGCTGGCCATTTTGGCTCTGATTACCTATAGGATTTATAGAAACAATATCTGTGGTCGTG
GACATCGAGGTGATTAGATA

Downstream 100 bases:

>100_bases
AGTTGCTTATCTAAGGGGTGGCATTATGCTAACGGGCATTATTGCTGATGACAATGAAATTGAAAGGTTGTATTTCTGCA
AGCTACTGGAAGAAACTAAT

Product: signal transduction histidine kinase regulating citrate/malate metabolism

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 275; Mature: 274

Protein sequence:

>275_residues
MGRQNTNYWILIILLGQTFLLNIAVQNLQLSPYAGIQPITLGANLVSLSFYFMTLLLIKKLLDIKEQQKLLGQKEKEMDS
LQNLLRTVRAQRHDIINHLDTVYALLSLGREVPAREYTGQLVQVAANTSHLLRLEQPVVAAFLQNKASQAMARGITFYID
VRADLKGLKVKPYALVTVLGNILENAMEAVEPLPGEQRLIQLDISRSETGYIFSISNSGPPLDSAMKEAIFRPGVSTKGL
DRGLGLATVWEMVISHGGTIEVETDPVTFRVKFPV

Sequences:

>Translated_275_residues
MGRQNTNYWILIILLGQTFLLNIAVQNLQLSPYAGIQPITLGANLVSLSFYFMTLLLIKKLLDIKEQQKLLGQKEKEMDS
LQNLLRTVRAQRHDIINHLDTVYALLSLGREVPAREYTGQLVQVAANTSHLLRLEQPVVAAFLQNKASQAMARGITFYID
VRADLKGLKVKPYALVTVLGNILENAMEAVEPLPGEQRLIQLDISRSETGYIFSISNSGPPLDSAMKEAIFRPGVSTKGL
DRGLGLATVWEMVISHGGTIEVETDPVTFRVKFPV
>Mature_274_residues
GRQNTNYWILIILLGQTFLLNIAVQNLQLSPYAGIQPITLGANLVSLSFYFMTLLLIKKLLDIKEQQKLLGQKEKEMDSL
QNLLRTVRAQRHDIINHLDTVYALLSLGREVPAREYTGQLVQVAANTSHLLRLEQPVVAAFLQNKASQAMARGITFYIDV
RADLKGLKVKPYALVTVLGNILENAMEAVEPLPGEQRLIQLDISRSETGYIFSISNSGPPLDSAMKEAIFRPGVSTKGLD
RGLGLATVWEMVISHGGTIEVETDPVTFRVKFPV

Specific function: Member of the two-component regulatory system dcuR/dcuS. Involved in the C4-dicarboxylate-stimulated regulation of the genes encoding the anaerobic fumarate respiratory system (frdABCD; nuoAN; dcuB; dcuC; sdhCDAB; etc.). Weakly regulates the aerobic C4-di

COG id: COG3290

COG function: function code T; Signal transduction histidine kinase regulating citrate/malate metabolism

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1790567, Length=220, Percent_Identity=31.8181818181818, Blast_Score=94, Evalue=9e-21,
Organism=Escherichia coli, GI1790436, Length=250, Percent_Identity=30, Blast_Score=68, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR016120
- InterPro:   IPR005467
- InterPro:   IPR016121 [H]

Pfam domain/function: PF02518 HATPase_c; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 30555; Mature: 30424

Theoretical pI: Translated: 9.20; Mature: 9.20

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRQNTNYWILIILLGQTFLLNIAVQNLQLSPYAGIQPITLGANLVSLSFYFMTLLLIKK
CCCCCCCEEEEEEEHHHHHHHHHHHHCEEECCCCCCCEEEECCHHHHHHHHHHHHHHHHH
LLDIKEQQKLLGQKEKEMDSLQNLLRTVRAQRHDIINHLDTVYALLSLGREVPAREYTGQ
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCH
LVQVAANTSHLLRLEQPVVAAFLQNKASQAMARGITFYIDVRADLKGLKVKPYALVTVLG
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEECCCCCEECHHHHHHHHH
NILENAMEAVEPLPGEQRLIQLDISRSETGYIFSISNSGPPLDSAMKEAIFRPGVSTKGL
HHHHHHHHHHCCCCCCCEEEEEEECCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCCC
DRGLGLATVWEMVISHGGTIEVETDPVTFRVKFPV
CCCCCHHHHHHHHHHCCCEEEEECCCEEEEEECCC
>Mature Secondary Structure 
GRQNTNYWILIILLGQTFLLNIAVQNLQLSPYAGIQPITLGANLVSLSFYFMTLLLIKK
CCCCCCEEEEEEEHHHHHHHHHHHHCEEECCCCCCCEEEECCHHHHHHHHHHHHHHHHH
LLDIKEQQKLLGQKEKEMDSLQNLLRTVRAQRHDIINHLDTVYALLSLGREVPAREYTGQ
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCH
LVQVAANTSHLLRLEQPVVAAFLQNKASQAMARGITFYIDVRADLKGLKVKPYALVTVLG
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEECCCCCEECHHHHHHHHH
NILENAMEAVEPLPGEQRLIQLDISRSETGYIFSISNSGPPLDSAMKEAIFRPGVSTKGL
HHHHHHHHHHCCCCCCCEEEEEEECCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCCC
DRGLGLATVWEMVISHGGTIEVETDPVTFRVKFPV
CCCCCHHHHHHHHHHCCCEEEEECCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]