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The map label for this gene is lysA [H]

Identifier: 83590211

GI number: 83590211

Start: 1407172

End: 1408476

Strand: Reverse

Name: lysA [H]

Synonym: Moth_1364

Alternate gene names: 83590211

Gene position: 1408476-1407172 (Counterclockwise)

Preceding gene: 83590212

Following gene: 83590210

Centisome position: 53.58

GC content: 60.0

Gene sequence:

>1305_bases
ATGGCGATAAATGAACACGGACGGCTGGTCATCGGCGGCTGTGAGGTTGTCCAGCTGGCCCGTGACTTTGGCACCCCCCT
TTATATTTTTGATGAAGACTGTATCCGGGACAACTGCCGCCAGTTTTATCGGGCCTTTAACGCCGGCAGCGGCCAGGCCG
AGGTTATCTATGCCGGCAAGGCTTTTCTTACTACGGCCATGTGCCGGATCATCGCCAGTGAAGGGCTGGGACTGGATGTT
GTCTCCGGCGGCGAACTTTACACCGCCCTGGCGGCCGGTTTTCCCGTGGAACGGATTTATTTTCATGGTAACAACAAGAG
CTATGCCGAGCTCTGCCAGGGCCTGGAGGCCGGAATAGGCAGGTTCATGGTCGATAACTTTACAGAGCTGGAACTGTTAA
GCCGCCTTGCAGTGGAGCGTGGCCAGGTGGCCAAGGTAATCCTGAGGGTCACCCCGGGAATTGAGGCCCACACCCATGAC
TATATCCGCACCGGCCAGGTTGATTCCAAGTTCGGTTTTACCCTGCCGGGGGGCCAAGCACTAGCGGCTGCCAGGAGGGC
CGGCGAGTTACCGGGGATCGAGTTCATGGGTTTGCACTGCCATATTGGCTCCCAGATTTTCGAACTGGAGCCCTACAATG
AAGCCGTAGCCGTGATGATGGAGCTGGCTGCTGCGGTCAAGGAGGCGACAGGGCTGGTAACCGCCGAGTTGGATCTCGGG
GGCGGCTTTGGCATATACTATACTACCGGTGACGAACCCCGGCCGATAAGGGCTTATGCGGAAACCATCCTGGCCCGGGT
CCGGGAGGAAGCCCGGCGCTTGAACCTGCCCCAACCGCGAGTCCTGGTCGAACCGGGTCGGTCCATTGTCGGGCCGGCGG
GCAGCACTGCCTACACCGTCGGGAGCATCAAAGAGATCCCCGGCGTCCGCAAGTATGTGGCTGTTGACGGCGGGATGGCC
GATAACATTCGCCCGGCCCTTTACGGTGCGAAGTATGAGGCCATCCTGGCCAATAAGGCCGGTATGCCGGCTACAGAGAA
GGTAACCGTCACCGGGAAGTGCTGCGAATCAGGGGATATGCTGATCTGGGAAGCGGAATTGCCCCCGGTAGAGAGGGGCG
ACATCCTCCTGATGCCCTGTACCGGGGCCTATGGTTATACCATGGCCAGCAATTATAACCGCCTGGGCCGGCCGGCAGCC
GTCCTGGTGCGGGATGGCGTCGCCGACTTGATTATAAAGCGGGAGGATTACAGCGACCTGATCCGTAACGACGTGATCCC
GGCCCGCCTGGCCTGCCCTCGCTAG

Upstream 100 bases:

>100_bases
GTTCCCTTAAATTTTCTAGACAGGAGCTGCCGCCTCGGGTAAAATGGAGATATATTTGGTGAAAGGAGCAACCGGTAATT
AAATGCACTTGCAGGGAACG

Downstream 100 bases:

>100_bases
GCCGGTACTGTCATGATTCCCTACCGGAAGCTTTTTAACCAGCACCAGCTAGCCATCCTGGCCCGGGCCAGGAAAATAGC
CCACCTCAAGGGCCAGCGAG

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 434; Mature: 433

Protein sequence:

>434_residues
MAINEHGRLVIGGCEVVQLARDFGTPLYIFDEDCIRDNCRQFYRAFNAGSGQAEVIYAGKAFLTTAMCRIIASEGLGLDV
VSGGELYTALAAGFPVERIYFHGNNKSYAELCQGLEAGIGRFMVDNFTELELLSRLAVERGQVAKVILRVTPGIEAHTHD
YIRTGQVDSKFGFTLPGGQALAAARRAGELPGIEFMGLHCHIGSQIFELEPYNEAVAVMMELAAAVKEATGLVTAELDLG
GGFGIYYTTGDEPRPIRAYAETILARVREEARRLNLPQPRVLVEPGRSIVGPAGSTAYTVGSIKEIPGVRKYVAVDGGMA
DNIRPALYGAKYEAILANKAGMPATEKVTVTGKCCESGDMLIWEAELPPVERGDILLMPCTGAYGYTMASNYNRLGRPAA
VLVRDGVADLIIKREDYSDLIRNDVIPARLACPR

Sequences:

>Translated_434_residues
MAINEHGRLVIGGCEVVQLARDFGTPLYIFDEDCIRDNCRQFYRAFNAGSGQAEVIYAGKAFLTTAMCRIIASEGLGLDV
VSGGELYTALAAGFPVERIYFHGNNKSYAELCQGLEAGIGRFMVDNFTELELLSRLAVERGQVAKVILRVTPGIEAHTHD
YIRTGQVDSKFGFTLPGGQALAAARRAGELPGIEFMGLHCHIGSQIFELEPYNEAVAVMMELAAAVKEATGLVTAELDLG
GGFGIYYTTGDEPRPIRAYAETILARVREEARRLNLPQPRVLVEPGRSIVGPAGSTAYTVGSIKEIPGVRKYVAVDGGMA
DNIRPALYGAKYEAILANKAGMPATEKVTVTGKCCESGDMLIWEAELPPVERGDILLMPCTGAYGYTMASNYNRLGRPAA
VLVRDGVADLIIKREDYSDLIRNDVIPARLACPR
>Mature_433_residues
AINEHGRLVIGGCEVVQLARDFGTPLYIFDEDCIRDNCRQFYRAFNAGSGQAEVIYAGKAFLTTAMCRIIASEGLGLDVV
SGGELYTALAAGFPVERIYFHGNNKSYAELCQGLEAGIGRFMVDNFTELELLSRLAVERGQVAKVILRVTPGIEAHTHDY
IRTGQVDSKFGFTLPGGQALAAARRAGELPGIEFMGLHCHIGSQIFELEPYNEAVAVMMELAAAVKEATGLVTAELDLGG
GFGIYYTTGDEPRPIRAYAETILARVREEARRLNLPQPRVLVEPGRSIVGPAGSTAYTVGSIKEIPGVRKYVAVDGGMAD
NIRPALYGAKYEAILANKAGMPATEKVTVTGKCCESGDMLIWEAELPPVERGDILLMPCTGAYGYTMASNYNRLGRPAAV
LVRDGVADLIIKREDYSDLIRNDVIPARLACPR

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=380, Percent_Identity=25, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI1789203, Length=422, Percent_Identity=30.0947867298578, Blast_Score=134, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 46938; Mature: 46806

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAINEHGRLVIGGCEVVQLARDFGTPLYIFDEDCIRDNCRQFYRAFNAGSGQAEVIYAGK
CCCCCCCCEEECCHHHHHHHHHHCCEEEEECHHHHHHHHHHHHHHHCCCCCCEEEEEECH
AFLTTAMCRIIASEGLGLDVVSGGELYTALAAGFPVERIYFHGNNKSYAELCQGLEAGIG
HHHHHHHHHHHHHCCCCEEEECCCHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHH
RFMVDNFTELELLSRLAVERGQVAKVILRVTPGIEAHTHDYIRTGQVDSKFGFTLPGGQA
HHHHCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCEECCCCCCCCCEECCCCHH
LAAARRAGELPGIEFMGLHCHIGSQIFELEPYNEAVAVMMELAAAVKEATGLVTAELDLG
HHHHHHHCCCCCEEEEEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHCCEEEEEEECC
GGFGIYYTTGDEPRPIRAYAETILARVREEARRLNLPQPRVLVEPGRSIVGPAGSTAYTV
CCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCEECCCCCCEEEE
GSIKEIPGVRKYVAVDGGMADNIRPALYGAKYEAILANKAGMPATEKVTVTGKCCESGDM
CCHHHCCCCEEEEEECCCCCCCCCHHHCCCCEEEEEECCCCCCCCCEEEEEECCCCCCCE
LIWEAELPPVERGDILLMPCTGAYGYTMASNYNRLGRPAAVLVRDGVADLIIKREDYSDL
EEEECCCCCCCCCCEEEEECCCCCCCEECCCCCCCCCCEEEEEECCCHHEEEECCCHHHH
IRNDVIPARLACPR
HHHCCCCCCCCCCC
>Mature Secondary Structure 
AINEHGRLVIGGCEVVQLARDFGTPLYIFDEDCIRDNCRQFYRAFNAGSGQAEVIYAGK
CCCCCCCEEECCHHHHHHHHHHCCEEEEECHHHHHHHHHHHHHHHCCCCCCEEEEEECH
AFLTTAMCRIIASEGLGLDVVSGGELYTALAAGFPVERIYFHGNNKSYAELCQGLEAGIG
HHHHHHHHHHHHHCCCCEEEECCCHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHH
RFMVDNFTELELLSRLAVERGQVAKVILRVTPGIEAHTHDYIRTGQVDSKFGFTLPGGQA
HHHHCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCEECCCCCCCCCEECCCCHH
LAAARRAGELPGIEFMGLHCHIGSQIFELEPYNEAVAVMMELAAAVKEATGLVTAELDLG
HHHHHHHCCCCCEEEEEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHCCEEEEEEECC
GGFGIYYTTGDEPRPIRAYAETILARVREEARRLNLPQPRVLVEPGRSIVGPAGSTAYTV
CCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCEECCCCCCEEEE
GSIKEIPGVRKYVAVDGGMADNIRPALYGAKYEAILANKAGMPATEKVTVTGKCCESGDM
CCHHHCCCCEEEEEECCCCCCCCCHHHCCCCEEEEEECCCCCCCCCEEEEEECCCCCCCE
LIWEAELPPVERGDILLMPCTGAYGYTMASNYNRLGRPAAVLVRDGVADLIIKREDYSDL
EEEECCCCCCCCCCEEEEECCCCCCCEECCCCCCCCCCEEEEEECCCHHEEEECCCHHHH
IRNDVIPARLACPR
HHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2513554; 7934829; 1368705; 8969508; 9384377 [H]