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The map label for this gene is lysC [H]

Identifier: 83590151

GI number: 83590151

Start: 1346992

End: 1348209

Strand: Reverse

Name: lysC [H]

Synonym: Moth_1304

Alternate gene names: 83590151

Gene position: 1348209-1346992 (Counterclockwise)

Preceding gene: 83590152

Following gene: 83590150

Centisome position: 51.29

GC content: 58.21

Gene sequence:

>1218_bases
ATGGCCCTCATCGTCCAAAAGTACGGCGGCACTTCCGTTAACGGCCCGGAACGGGTCAAAAACGTAGCCCGCCGGGTAGT
AAATACCCGACGCGCCGGGAACGACGTGGTCGTTATTGTGTCAGCTCCGGGCGATATGACCGACGATCTCATCGCCATGG
CCCACGAGATCAGCCCCAACCCGCCGGCCAGAGAAATGGACATGCTTCTGGCTACCGGGGAGCAGACATCGATAGCCCTC
CTGGCCATGGCCATCCACGAGCTTGGCGAACCGGTTATCTCCCTGACCGGCCCCCAGGTGGGCATCCTGACCGACAACGT
CCATTCCAAGGCGCGCATTATGGAAGTGAGCTGCGAGCGCCTGCGCCGGGAATTAGAACAGGGCAAGATCGTTATTGTAG
CCGGCTTCCAGGGCAAGACCTGTGAAGGCGAGATAACGACCCTGGGCCGGGGAGGCTCCGATACAACGGCCGTGGCCGTG
GCCGCCGCCCTGAAGGCCGACGTTTGCCAGATCTATACCGATGTGGACGGCGTTTATACGGCCGATCCCCGGGTGGTGCC
GGAGGCCAGAAAATTACCGGTTATTTCCTACGATGAAATGCTAGAATTGGCGAGTCTAGGTGCCCAGGTGCTGCAACCCC
GGTCGGTAGAGTTTGGCAAACTCAACCATGTCGTCCTCGAGGTACGATCAAGCTTTAATGATCATGAAGGAACCCTGGTC
AAAGAGGTGACGGAAATGGAGAGGAAAATGGTCGTCAGCGGCGTAGCCGGTGACCGCAACGTAGCCAGGATAGCCCTGCA
CGACGTCCCCGACCGGCCGGGCATCGCCAGGACCCTCTTTGTAGCCCTGGCCCGAGAGAGCATCAATGTTGATATGATCG
TCCAGAGCGCCATGCGGGACGGGATTAATGATATCGCCTTCACCGTAGGGCGTGACGATCTCCAGAAGGCGGTTGAGGTA
ACGGAAAGGGTACGTCAGGAAATTGGTGCCAGCAAGGTGACTTCTAACGACCGGGTGGCCAAGGTATCCATCGTCGGCGC
CGGTATGATCACCAATCCCGGCGTGGCTGCCGACATGTTCGCCTGCCTGGCTGAGGAAGGCATTAATATTCACATGATCA
GTACTTCAGAGATCAAGGTATCCTGCATCATTGACGAAGAACACCTGACCCGGGCCATGCAAGCCCTGCACCGTCACTTT
AAACTGGACCGGGAGTAA

Upstream 100 bases:

>100_bases
GCCGCGGCCTTCGCCCGTAAGGGGGTAAAATGTACCGTCAAAGAACTGGCCCCTTGTAACCACGGGGCAGTAGTCATTTG
AGATTCCGGAGGAGGTTACT

Downstream 100 bases:

>100_bases
GGGAGGTACCTTTAGCTGAACCCGCGCATAAGATGCAGGGAGCGAAACCTGCAAGGGGTGATTATGCGTGGGCCAGAAGC
AGGTACCATGTCCATCCGGC

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase 2; Aspartokinase II [H]

Number of amino acids: Translated: 405; Mature: 404

Protein sequence:

>405_residues
MALIVQKYGGTSVNGPERVKNVARRVVNTRRAGNDVVVIVSAPGDMTDDLIAMAHEISPNPPAREMDMLLATGEQTSIAL
LAMAIHELGEPVISLTGPQVGILTDNVHSKARIMEVSCERLRRELEQGKIVIVAGFQGKTCEGEITTLGRGGSDTTAVAV
AAALKADVCQIYTDVDGVYTADPRVVPEARKLPVISYDEMLELASLGAQVLQPRSVEFGKLNHVVLEVRSSFNDHEGTLV
KEVTEMERKMVVSGVAGDRNVARIALHDVPDRPGIARTLFVALARESINVDMIVQSAMRDGINDIAFTVGRDDLQKAVEV
TERVRQEIGASKVTSNDRVAKVSIVGAGMITNPGVAADMFACLAEEGINIHMISTSEIKVSCIIDEEHLTRAMQALHRHF
KLDRE

Sequences:

>Translated_405_residues
MALIVQKYGGTSVNGPERVKNVARRVVNTRRAGNDVVVIVSAPGDMTDDLIAMAHEISPNPPAREMDMLLATGEQTSIAL
LAMAIHELGEPVISLTGPQVGILTDNVHSKARIMEVSCERLRRELEQGKIVIVAGFQGKTCEGEITTLGRGGSDTTAVAV
AAALKADVCQIYTDVDGVYTADPRVVPEARKLPVISYDEMLELASLGAQVLQPRSVEFGKLNHVVLEVRSSFNDHEGTLV
KEVTEMERKMVVSGVAGDRNVARIALHDVPDRPGIARTLFVALARESINVDMIVQSAMRDGINDIAFTVGRDDLQKAVEV
TERVRQEIGASKVTSNDRVAKVSIVGAGMITNPGVAADMFACLAEEGINIHMISTSEIKVSCIIDEEHLTRAMQALHRHF
KLDRE
>Mature_404_residues
ALIVQKYGGTSVNGPERVKNVARRVVNTRRAGNDVVVIVSAPGDMTDDLIAMAHEISPNPPAREMDMLLATGEQTSIALL
AMAIHELGEPVISLTGPQVGILTDNVHSKARIMEVSCERLRRELEQGKIVIVAGFQGKTCEGEITTLGRGGSDTTAVAVA
AALKADVCQIYTDVDGVYTADPRVVPEARKLPVISYDEMLELASLGAQVLQPRSVEFGKLNHVVLEVRSSFNDHEGTLVK
EVTEMERKMVVSGVAGDRNVARIALHDVPDRPGIARTLFVALARESINVDMIVQSAMRDGINDIAFTVGRDDLQKAVEVT
ERVRQEIGASKVTSNDRVAKVSIVGAGMITNPGVAADMFACLAEEGINIHMISTSEIKVSCIIDEEHLTRAMQALHRHFK
LDRE

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=345, Percent_Identity=32.463768115942, Blast_Score=149, Evalue=4e-37,
Organism=Escherichia coli, GI1790455, Length=279, Percent_Identity=32.258064516129, Blast_Score=98, Evalue=8e-22,
Organism=Escherichia coli, GI1790376, Length=179, Percent_Identity=32.9608938547486, Blast_Score=80, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6320893, Length=291, Percent_Identity=28.5223367697594, Blast_Score=113, Evalue=6e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 43802; Mature: 43671

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALIVQKYGGTSVNGPERVKNVARRVVNTRRAGNDVVVIVSAPGDMTDDLIAMAHEISPN
CEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHCCCC
PPAREMDMLLATGEQTSIALLAMAIHELGEPVISLTGPQVGILTDNVHSKARIMEVSCER
CCHHHHHHHEECCCCHHHHHHHHHHHHHCCCEEEECCCEEEEEECCCCCHHHHHHHHHHH
LRRELEQGKIVIVAGFQGKTCEGEITTLGRGGSDTTAVAVAAALKADVCQIYTDVDGVYT
HHHHHHCCCEEEEECCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEE
ADPRVVPEARKLPVISYDEMLELASLGAQVLQPRSVEFGKLNHVVLEVRSSFNDHEGTLV
CCCCCCCCHHCCCEECHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCHHH
KEVTEMERKMVVSGVAGDRNVARIALHDVPDRPGIARTLFVALARESINVDMIVQSAMRD
HHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHC
GINDIAFTVGRDDLQKAVEVTERVRQEIGASKVTSNDRVAKVSIVGAGMITNPGVAADMF
CCCHHEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCCCCCHHHHHH
ACLAEEGINIHMISTSEIKVSCIIDEEHLTRAMQALHRHFKLDRE
HHHHHCCCEEEEEECCCEEEEEEECHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
ALIVQKYGGTSVNGPERVKNVARRVVNTRRAGNDVVVIVSAPGDMTDDLIAMAHEISPN
EEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHCCCC
PPAREMDMLLATGEQTSIALLAMAIHELGEPVISLTGPQVGILTDNVHSKARIMEVSCER
CCHHHHHHHEECCCCHHHHHHHHHHHHHCCCEEEECCCEEEEEECCCCCHHHHHHHHHHH
LRRELEQGKIVIVAGFQGKTCEGEITTLGRGGSDTTAVAVAAALKADVCQIYTDVDGVYT
HHHHHHCCCEEEEECCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEE
ADPRVVPEARKLPVISYDEMLELASLGAQVLQPRSVEFGKLNHVVLEVRSSFNDHEGTLV
CCCCCCCCHHCCCEECHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCHHH
KEVTEMERKMVVSGVAGDRNVARIALHDVPDRPGIARTLFVALARESINVDMIVQSAMRD
HHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHC
GINDIAFTVGRDDLQKAVEVTERVRQEIGASKVTSNDRVAKVSIVGAGMITNPGVAADMF
CCCHHEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCCCCCHHHHHH
ACLAEEGINIHMISTSEIKVSCIIDEEHLTRAMQALHRHFKLDRE
HHHHHCCCEEEEEECCCEEEEEEECHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1444390 [H]