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The map label for this gene is bcc [H]

Identifier: 83590003

GI number: 83590003

Start: 1187336

End: 1187722

Strand: Reverse

Name: bcc [H]

Synonym: Moth_1155

Alternate gene names: 83590003

Gene position: 1187722-1187336 (Counterclockwise)

Preceding gene: 83590004

Following gene: 83590002

Centisome position: 45.18

GC content: 60.72

Gene sequence:

>387_bases
TTGAAAAGGCATTTTCAAGTAACGGTCAATGGTGAAACCTTTCAGGTAGAAGTAGAGGAAAGGCCGGAATCGGCCTGGCC
GCCTGTTTCTCCTGCTATGATGGCTCCACCGGCAGCGGCGGTTATCCCGCGATCCGGCCGTCTGGCAGCAGCTCCCACCC
CGCCGCTGCGGGATAACCGGACCGTTACCGCTCCCCTGCCGGGTACGGTAGTGGAGGTAAGAGTTAAACCCGGCCAGAGG
GTGACTGCCGGCCAGGTACTGGTGATAATTGAAGCTATGAAGATGGAAAACGAGATCCCGGCTCCGGCCGGGGGGGTTGT
CCGGGAGGTGCTGGTCGAGGCCGGAGCCACCGTCAGCAGCGGCCAGCCTCTGGTTACTTTGGCTTGA

Upstream 100 bases:

>100_bases
CTATCCGGCCCCAGGACCGGCCCTTGCGCCGCTGGAGCCTGGCCGGTCGCCAGGAATTAATCAATAATTCCATGGCCTTC
GAAAGGAGGAGACCGGCGGT

Downstream 100 bases:

>100_bases
ACGGTTTCCGAAGAGGAAGTGTATTTAAATGCTCCCCCAGACTTATGTCGTCCTGGATGTGGAAACCACCGGCCTGGATC
CAGCCCGGGACAGAATAATT

Product: biotin/lipoyl attachment

Products: propanoyl-CoA; CO2

Alternate protein names: BCCP [H]

Number of amino acids: Translated: 128; Mature: 128

Protein sequence:

>128_residues
MKRHFQVTVNGETFQVEVEERPESAWPPVSPAMMAPPAAAVIPRSGRLAAAPTPPLRDNRTVTAPLPGTVVEVRVKPGQR
VTAGQVLVIIEAMKMENEIPAPAGGVVREVLVEAGATVSSGQPLVTLA

Sequences:

>Translated_128_residues
MKRHFQVTVNGETFQVEVEERPESAWPPVSPAMMAPPAAAVIPRSGRLAAAPTPPLRDNRTVTAPLPGTVVEVRVKPGQR
VTAGQVLVIIEAMKMENEIPAPAGGVVREVLVEAGATVSSGQPLVTLA
>Mature_128_residues
MKRHFQVTVNGETFQVEVEERPESAWPPVSPAMMAPPAAAVIPRSGRLAAAPTPPLRDNRTVTAPLPGTVVEVRVKPGQR
VTAGQVLVIIEAMKMENEIPAPAGGVVREVLVEAGATVSSGQPLVTLA

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG0511

COG function: function code I; Biotin carboxyl carrier protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotinyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI65506442, Length=64, Percent_Identity=50, Blast_Score=63, Evalue=7e-11,
Organism=Homo sapiens, GI189095269, Length=64, Percent_Identity=50, Blast_Score=63, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI17567343, Length=66, Percent_Identity=50, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001882
- InterPro:   IPR000089
- InterPro:   IPR011053 [H]

Pfam domain/function: PF00364 Biotin_lipoyl [H]

EC number: 4.1.1.41

Molecular weight: Translated: 13449; Mature: 13449

Theoretical pI: Translated: 7.55; Mature: 7.55

Prosite motif: PS50968 BIOTINYL_LIPOYL ; PS00188 BIOTIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRHFQVTVNGETFQVEVEERPESAWPPVSPAMMAPPAAAVIPRSGRLAAAPTPPLRDNR
CCCEEEEEECCCEEEEEECCCCCCCCCCCCCCCCCCCCEEEECCCCCEEECCCCCCCCCC
TVTAPLPGTVVEVRVKPGQRVTAGQVLVIIEAMKMENEIPAPAGGVVREVLVEAGATVSS
EEEECCCCEEEEEEECCCCEECCCEEEEEEEEECCCCCCCCCCCHHHHHHHHHCCCCCCC
GQPLVTLA
CCEEEEEC
>Mature Secondary Structure
MKRHFQVTVNGETFQVEVEERPESAWPPVSPAMMAPPAAAVIPRSGRLAAAPTPPLRDNR
CCCEEEEEECCCEEEEEECCCCCCCCCCCCCCCCCCCCEEEECCCCCEEECCCCCCCCCC
TVTAPLPGTVVEVRVKPGQRVTAGQVLVIIEAMKMENEIPAPAGGVVREVLVEAGATVSS
EEEECCCCEEEEEEECCCCEECCCEEEEEEEEECCCCCCCCCCCHHHHHHHHHCCCCCCC
GQPLVTLA
CCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-methylmalonyl-CoA

Specific reaction: (S)-methylmalonyl-CoA = propanoyl-CoA + CO2

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8431283; 12397186 [H]