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The map label for this gene is hppA

Identifier: 83589283

GI number: 83589283

Start: 419449

End: 421497

Strand: Reverse

Name: hppA

Synonym: Moth_0418

Alternate gene names: 83589283

Gene position: 421497-419449 (Counterclockwise)

Preceding gene: 83589284

Following gene: 83589282

Centisome position: 16.03

GC content: 56.81

Gene sequence:

>2049_bases
ATGGAGCTGTTTCCCATTATCCCTGCCGGTGGGATCCTGGCCCTGCTGGTGGCTCTCTACATGACCAGTAGTGTTTTAAA
AGAAGATACCGGTCCTAAGGAAATGCAGACCATTGCCGCGGCTATCAGGGAAGGGGCCATGGCCTTCTTGAACCGCCAGT
ATCGCACCATTGCGGGCCTGGCCCTTATCGTAGCCGTGCTCCTGGCCCTCCTCACACGCCAGTACCACACAGCCGTCGCC
TTTATTACCGGAGCCTTTGCCTCGGCCTTATCAGGTTATATCGGCATGTACGTGGCAGTCAACGCCAACCTGCGGGTGGC
CGCCGGGGCGCGTAATAGCCTCAATAAAGCCCTGACTGTTGCCTTCCGCGGCGGTGCCGTTACGGGCCTGGCCGTTACCG
CCCTTTCCCTCCTGGGGGTCACCTCCCTCTTCTACGCCTTTGGTGGGGCCACCAATCCCACCCGGGCTCCCCTCGATATT
GTCGGCTTTGGCTTTGGTGCCAGCTTTGTCGCCCTTTTTGCCCAGCTGAGCGGTGGTATTTACACCAAGGCTGCCGACGT
AGGGGCCGATTTAGTGGGTAAAGTAGAAGCCGGCATACCCGAAGACGATCCGCGCAATCCGGCCGTCATCGCTGACCTGG
TGGGTGACAACGTCGGTGACTGCGCCGGCCGTGGTGCCGACCTGTTTGAATCTACGGCGGCAGAAAATATAGGAGCCATG
ATCCTTGGTATAGCCCTGGTGCCGTTCTTCGGTGTCAAAGGCATCGTCTTCCCCCTGGTAGCCCGGGCGGCAGGGATTAT
TGCCTCTATAATCGGCATGTTTTTCGTCAGGGCCGAAGAAAACCAGGACCCCATGGCCGCTTTGAACCGGGGTTATATCG
TTACCAGTATCCTGGCTATAATCTTTCTCTATCCTATCAGTCGCTATATGTTGAGTGGCCCGGGGGTTAACTTCATCTAT
TTTTACGGCGCCGGGATCATCGGCATTGTTTTAAGCTTCATCTTTGTCCTCATTACCCAGTACTATACTTCCTACGACTA
CCGTCCGGTCAAGGAGATCGCCCGTGCCTCTATAACCGGCCCGGCGACGAACATCATCTCCGGTGTAGCTGTGGGCTTTG
AGAGCACGGCGCTGCCTGTCGTCTTTATTTCCCTGGCCATCCTGGGTGCTTACTGGCTGGGACTGAAAAGCGGCCTTCCC
GGTGGCGGCCTCTATGGCACCGCCGTGGCAACCATGGGTATGCTCAGCACGGCGGCCTACATCCTGGCCATGGATACCTA
TGGTCCCATTACCGATAACGCCGGCGGCATTGTCGAAATGTCCGGCGCTCCGGAAGAAGTCCGGCGGCGCACCGACCGCC
TGGATGCCTCCGGCAATACCACCAAGGCCCTGACCAAGGGTTATGCCATCGGCAGTGCCGCCCTGGCGACCTTCCTCCTC
TTCTCGGCATATATCGACGAAGTCAAAATAGCCCTGAATATCAAAGGCAATTTCCCCGTAGATATCGGCAAACCCGAAGT
CTTTGTCGGCGCCTTCATCGCCGCCATGATGGTCCTGCTGTTCAGCTCAACCGCCATCCGTGCTGTAGGCAACGCCGCCC
AGTACGTCATCCTAGAAGTCCGGCGCCAGTTTAAAGAGATTCCGGGTATTATGGAAGGCACGGCCAAGCCGGAGTATGGC
GCTTGCGTTGATATTGTTACCAGGGGAGCTTTGAAAGAAATGGTCTTACCTGGCTTGATTGTCGTCATTACCCCCATCAT
TGTCGGTCTGGTGTTGAAAGCCGAGGCTGCCGCTGCCTTTCTCATGGTAGGGACCATCACCGGCGTCATTGTGGCCCTCT
TCCTCAACAACGGCGGCGGTGCCTGGGACAACGCCAAGAAGTATATCGAGCTGGGCAACTTTGGCGGTAAAGGGTCGGAA
GCCCATAAAGCCGGTGTTGTCGGCGACACCGTAGGTGATCCTTTTAAAGATACTGCCGGGCCATCCCTGCACGTCCTGGT
AAAACTCATCAGTACCATTACCCTGGTCCTGGCAGGATTATTTATCTAA

Upstream 100 bases:

>100_bases
ATCACTAGCTGCAAAAAGCATGAATGACAAGGAAGCGAAATTTAGCACAATAAATCAAATGGGCAAGGCAAAAATCTATT
TGTAGAGGTGAAAAACGAAA

Downstream 100 bases:

>100_bases
AGGGCCTCACGTTCCCCAAGCAGAAGCCCACGATTATGGCTGGTACTGGTGGCCCCGGGTTCATGGTTTGGGCCGGAAAT
GTTATAATAGCATATGCGGC

Product: membrane-bound proton-translocating pyrophosphatase

Products: NA

Alternate protein names: Membrane-bound proton-translocating pyrophosphatase; Pyrophosphate-energized inorganic pyrophosphatase; H(+)-PPase

Number of amino acids: Translated: 682; Mature: 682

Protein sequence:

>682_residues
MELFPIIPAGGILALLVALYMTSSVLKEDTGPKEMQTIAAAIREGAMAFLNRQYRTIAGLALIVAVLLALLTRQYHTAVA
FITGAFASALSGYIGMYVAVNANLRVAAGARNSLNKALTVAFRGGAVTGLAVTALSLLGVTSLFYAFGGATNPTRAPLDI
VGFGFGASFVALFAQLSGGIYTKAADVGADLVGKVEAGIPEDDPRNPAVIADLVGDNVGDCAGRGADLFESTAAENIGAM
ILGIALVPFFGVKGIVFPLVARAAGIIASIIGMFFVRAEENQDPMAALNRGYIVTSILAIIFLYPISRYMLSGPGVNFIY
FYGAGIIGIVLSFIFVLITQYYTSYDYRPVKEIARASITGPATNIISGVAVGFESTALPVVFISLAILGAYWLGLKSGLP
GGGLYGTAVATMGMLSTAAYILAMDTYGPITDNAGGIVEMSGAPEEVRRRTDRLDASGNTTKALTKGYAIGSAALATFLL
FSAYIDEVKIALNIKGNFPVDIGKPEVFVGAFIAAMMVLLFSSTAIRAVGNAAQYVILEVRRQFKEIPGIMEGTAKPEYG
ACVDIVTRGALKEMVLPGLIVVITPIIVGLVLKAEAAAAFLMVGTITGVIVALFLNNGGGAWDNAKKYIELGNFGGKGSE
AHKAGVVGDTVGDPFKDTAGPSLHVLVKLISTITLVLAGLFI

Sequences:

>Translated_682_residues
MELFPIIPAGGILALLVALYMTSSVLKEDTGPKEMQTIAAAIREGAMAFLNRQYRTIAGLALIVAVLLALLTRQYHTAVA
FITGAFASALSGYIGMYVAVNANLRVAAGARNSLNKALTVAFRGGAVTGLAVTALSLLGVTSLFYAFGGATNPTRAPLDI
VGFGFGASFVALFAQLSGGIYTKAADVGADLVGKVEAGIPEDDPRNPAVIADLVGDNVGDCAGRGADLFESTAAENIGAM
ILGIALVPFFGVKGIVFPLVARAAGIIASIIGMFFVRAEENQDPMAALNRGYIVTSILAIIFLYPISRYMLSGPGVNFIY
FYGAGIIGIVLSFIFVLITQYYTSYDYRPVKEIARASITGPATNIISGVAVGFESTALPVVFISLAILGAYWLGLKSGLP
GGGLYGTAVATMGMLSTAAYILAMDTYGPITDNAGGIVEMSGAPEEVRRRTDRLDASGNTTKALTKGYAIGSAALATFLL
FSAYIDEVKIALNIKGNFPVDIGKPEVFVGAFIAAMMVLLFSSTAIRAVGNAAQYVILEVRRQFKEIPGIMEGTAKPEYG
ACVDIVTRGALKEMVLPGLIVVITPIIVGLVLKAEAAAAFLMVGTITGVIVALFLNNGGGAWDNAKKYIELGNFGGKGSE
AHKAGVVGDTVGDPFKDTAGPSLHVLVKLISTITLVLAGLFI
>Mature_682_residues
MELFPIIPAGGILALLVALYMTSSVLKEDTGPKEMQTIAAAIREGAMAFLNRQYRTIAGLALIVAVLLALLTRQYHTAVA
FITGAFASALSGYIGMYVAVNANLRVAAGARNSLNKALTVAFRGGAVTGLAVTALSLLGVTSLFYAFGGATNPTRAPLDI
VGFGFGASFVALFAQLSGGIYTKAADVGADLVGKVEAGIPEDDPRNPAVIADLVGDNVGDCAGRGADLFESTAAENIGAM
ILGIALVPFFGVKGIVFPLVARAAGIIASIIGMFFVRAEENQDPMAALNRGYIVTSILAIIFLYPISRYMLSGPGVNFIY
FYGAGIIGIVLSFIFVLITQYYTSYDYRPVKEIARASITGPATNIISGVAVGFESTALPVVFISLAILGAYWLGLKSGLP
GGGLYGTAVATMGMLSTAAYILAMDTYGPITDNAGGIVEMSGAPEEVRRRTDRLDASGNTTKALTKGYAIGSAALATFLL
FSAYIDEVKIALNIKGNFPVDIGKPEVFVGAFIAAMMVLLFSSTAIRAVGNAAQYVILEVRRQFKEIPGIMEGTAKPEYG
ACVDIVTRGALKEMVLPGLIVVITPIIVGLVLKAEAAAAFLMVGTITGVIVALFLNNGGGAWDNAKKYIELGNFGGKGSE
AHKAGVVGDTVGDPFKDTAGPSLHVLVKLISTITLVLAGLFI

Specific function: Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force

COG id: COG3808

COG function: function code C; Inorganic pyrophosphatase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HPPA2_MOOTA (Q2RLE0)

Other databases:

- EMBL:   CP000232
- RefSeq:   YP_429292.1
- STRING:   Q2RLE0
- GeneID:   3832101
- GenomeReviews:   CP000232_GR
- KEGG:   mta:Moth_0418
- NMPDR:   fig|264732.9.peg.398
- eggNOG:   COG3808
- HOGENOM:   HBG593668
- OMA:   AENIGAM
- ProtClustDB:   PRK00733
- BioCyc:   MTHE264732:MOTH_0418-MONOMER
- HAMAP:   MF_01129
- InterPro:   IPR004131
- PIRSF:   PIRSF001265
- TIGRFAMs:   TIGR01104

Pfam domain/function: PF03030 H_PPase

EC number: =3.6.1.1

Molecular weight: Translated: 70893; Mature: 70893

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xd0be1cc)-; HASH(0xd848efc)-; HASH(0xc11ff84)-; HASH(0xd70e148)-; HASH(0xcce4224)-; HASH(0xd125d60)-; HASH(0xc64856c)-; HASH(0xd65ca70)-; HASH(0xd62be60)-; HASH(0xd3666b4)-; HASH(0xdd69b6c)-; HASH(0xdb1f934)-; HASH(0xdd94284)-; HASH(0xd6ac100)-; HASH(0xdd91540)-; HASH(0xc676988)-; HASH(0xddad4c0)-;

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELFPIIPAGGILALLVALYMTSSVLKEDTGPKEMQTIAAAIREGAMAFLNRQYRTIAGL
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALIVAVLLALLTRQYHTAVAFITGAFASALSGYIGMYVAVNANLRVAAGARNSLNKALTV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCEEEECCCCHHHCHHEEE
AFRGGAVTGLAVTALSLLGVTSLFYAFGGATNPTRAPLDIVGFGFGASFVALFAQLSGGI
EECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHEECCHHHHHHHHHHHHCCCC
YTKAADVGADLVGKVEAGIPEDDPRNPAVIADLVGDNVGDCAGRGADLFESTAAENIGAM
EEEHHHHCHHHHHHHHCCCCCCCCCCCCEEHHHHCCCCCHHCCCCCHHHHHHHHHHHHHH
ILGIALVPFFGVKGIVFPLVARAAGIIASIIGMFFVRAEENQDPMAALNRGYIVTSILAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHCCHHHHHHHHH
IFLYPISRYMLSGPGVNFIYFYGAGIIGIVLSFIFVLITQYYTSYDYRPVKEIARASITG
HHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCC
PATNIISGVAVGFESTALPVVFISLAILGAYWLGLKSGLPGGGLYGTAVATMGMLSTAAY
CHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
ILAMDTYGPITDNAGGIVEMSGAPEEVRRRTDRLDASGNTTKALTKGYAIGSAALATFLL
HHEECCCCCCCCCCCCEEEECCCHHHHHHHHHHCCCCCCCHHHHHHCCHHHHHHHHHHHH
FSAYIDEVKIALNIKGNFPVDIGKPEVFVGAFIAAMMVLLFSSTAIRAVGNAAQYVILEV
HHHHHHHEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
RRQFKEIPGIMEGTAKPEYGACVDIVTRGALKEMVLPGLIVVITPIIVGLVLKAEAAAAF
HHHHHHCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LMVGTITGVIVALFLNNGGGAWDNAKKYIELGNFGGKGSEAHKAGVVGDTVGDPFKDTAG
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHEECCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PSLHVLVKLISTITLVLAGLFI
CHHHHHHHHHHHHHHHHHHHCH
>Mature Secondary Structure
MELFPIIPAGGILALLVALYMTSSVLKEDTGPKEMQTIAAAIREGAMAFLNRQYRTIAGL
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALIVAVLLALLTRQYHTAVAFITGAFASALSGYIGMYVAVNANLRVAAGARNSLNKALTV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCEEEECCCCHHHCHHEEE
AFRGGAVTGLAVTALSLLGVTSLFYAFGGATNPTRAPLDIVGFGFGASFVALFAQLSGGI
EECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHEECCHHHHHHHHHHHHCCCC
YTKAADVGADLVGKVEAGIPEDDPRNPAVIADLVGDNVGDCAGRGADLFESTAAENIGAM
EEEHHHHCHHHHHHHHCCCCCCCCCCCCEEHHHHCCCCCHHCCCCCHHHHHHHHHHHHHH
ILGIALVPFFGVKGIVFPLVARAAGIIASIIGMFFVRAEENQDPMAALNRGYIVTSILAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHCCHHHHHHHHH
IFLYPISRYMLSGPGVNFIYFYGAGIIGIVLSFIFVLITQYYTSYDYRPVKEIARASITG
HHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCC
PATNIISGVAVGFESTALPVVFISLAILGAYWLGLKSGLPGGGLYGTAVATMGMLSTAAY
CHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
ILAMDTYGPITDNAGGIVEMSGAPEEVRRRTDRLDASGNTTKALTKGYAIGSAALATFLL
HHEECCCCCCCCCCCCEEEECCCHHHHHHHHHHCCCCCCCHHHHHHCCHHHHHHHHHHHH
FSAYIDEVKIALNIKGNFPVDIGKPEVFVGAFIAAMMVLLFSSTAIRAVGNAAQYVILEV
HHHHHHHEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
RRQFKEIPGIMEGTAKPEYGACVDIVTRGALKEMVLPGLIVVITPIIVGLVLKAEAAAAF
HHHHHHCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LMVGTITGVIVALFLNNGGGAWDNAKKYIELGNFGGKGSEAHKAGVVGDTVGDPFKDTAG
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHEECCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PSLHVLVKLISTITLVLAGLFI
CHHHHHHHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA