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The map label for this gene is ttuC [H]

Identifier: 83312275

GI number: 83312275

Start: 3438153

End: 3439229

Strand: Reverse

Name: ttuC [H]

Synonym: amb3176

Alternate gene names: 83312275

Gene position: 3439229-3438153 (Counterclockwise)

Preceding gene: 83312276

Following gene: 83312274

Centisome position: 69.24

GC content: 62.12

Gene sequence:

>1077_bases
ATGCGTGAATTCAAGATTGCGGCCATTCCGGCCGATGGAATCGGCAAGGAAGTCGTGGCGGCCGGACTTGAGGTTCTCGA
CGTGCTTGCCAAGCGTGACGGCGGCTTCCGTCTGAACATCGAGACCTTCGACTGGGGATCCGACTACTACAAGAAGCATG
GCACCATGATGCCGGAGAACGGTCGCGAGACGTTGAAACAGTTCGACGCCATCTATTTCGGTGCGGTTGGCGCCCCCGAC
GTCCCCGACCACGTTACCTTGTGGGGATTGCGTCTCAACATCTGCCAGCCATTCGACCAGTATGCCAATGTCCGGCCGAC
CCGCATCCTGCCGGGTATCAAAAGCCCTCTGGCCGGTGTCGGGCCACGCCTACTCAATTGGGTGATCGTCCGCGAGAATT
CCGAAGGCGAATATGCCGGACAAGGAGGCCGTTCCCATCGCGGCTTCCCAGAGGAGGTGGCGACCGAGGTGGCCATCTTT
ACCCGGGCCGGGGTGACACGGATCATGCGTTTCGCCTTCAAGCTGGCCCAGTCGCGTCCCCGCAAGCTGCTGACCGTGGT
GACCAAGTCCAACGCCCAGCGCCACGGCATGGTGATGTGGGACGAGATCGCCGCCGAGGTGGCAGGAGAGTTCCCAGACG
TGACCTGGGACAAGATGCTGGTCGATGCCATGACCATGCGCATGACCTTGAAGCCGGAGACCCTGGACACCATCGTGGCG
ACCAATCTCCACGCCGACATCCTGTCCGATCTGGCGGCGGCTCTGGCCGGGTCGCTCGGCATCGCTCCCACCGCCAACCT
CAACCCGGAACGCAAGTTCCCGTCCATGTTCGAGCCGATCCACGGATCCGCCTTCGACATCACCGGCAAAGGTATCGCCA
ATCCAATCGGCACCTTCTGGACCGCCTGTATGATGCTTGACCATCTGGGCGAGACAGCGGCCTCAGCCCGACTGATGCGG
GCCATCGAAAGGGTGACCGCCAACCCGTTGCTGCATACTCCCGATCTCGGGGGCAAGGCGACCACGCGGATCGTCACCGA
TGCGGTCATCGCGGCAATCGAGGCCGACAACGAGTAA

Upstream 100 bases:

>100_bases
CTGCTTGCCCGTTCGCAAAGGAAGTCAGCGGCGGCCTCAGCCGCTGCGGCCCAAGCCGCTTCCAACTAACGCCGGCCATC
CGAGCCAATGGAGATCGATC

Downstream 100 bases:

>100_bases
TCCGAAGAATGCGGGGCAAAGGGCAAAGCCTTTGCCCCGCAGGCATCTCACCCCAACACGGATGGATCGACCATGACCCA
ATCCCATAGGGATTTGCTTC

Product: tartrate dehydrogenase

Products: NA

Alternate protein names: TDH; D-malate dehydrogenase [decarboxylating] [H]

Number of amino acids: Translated: 358; Mature: 358

Protein sequence:

>358_residues
MREFKIAAIPADGIGKEVVAAGLEVLDVLAKRDGGFRLNIETFDWGSDYYKKHGTMMPENGRETLKQFDAIYFGAVGAPD
VPDHVTLWGLRLNICQPFDQYANVRPTRILPGIKSPLAGVGPRLLNWVIVRENSEGEYAGQGGRSHRGFPEEVATEVAIF
TRAGVTRIMRFAFKLAQSRPRKLLTVVTKSNAQRHGMVMWDEIAAEVAGEFPDVTWDKMLVDAMTMRMTLKPETLDTIVA
TNLHADILSDLAAALAGSLGIAPTANLNPERKFPSMFEPIHGSAFDITGKGIANPIGTFWTACMMLDHLGETAASARLMR
AIERVTANPLLHTPDLGGKATTRIVTDAVIAAIEADNE

Sequences:

>Translated_358_residues
MREFKIAAIPADGIGKEVVAAGLEVLDVLAKRDGGFRLNIETFDWGSDYYKKHGTMMPENGRETLKQFDAIYFGAVGAPD
VPDHVTLWGLRLNICQPFDQYANVRPTRILPGIKSPLAGVGPRLLNWVIVRENSEGEYAGQGGRSHRGFPEEVATEVAIF
TRAGVTRIMRFAFKLAQSRPRKLLTVVTKSNAQRHGMVMWDEIAAEVAGEFPDVTWDKMLVDAMTMRMTLKPETLDTIVA
TNLHADILSDLAAALAGSLGIAPTANLNPERKFPSMFEPIHGSAFDITGKGIANPIGTFWTACMMLDHLGETAASARLMR
AIERVTANPLLHTPDLGGKATTRIVTDAVIAAIEADNE
>Mature_358_residues
MREFKIAAIPADGIGKEVVAAGLEVLDVLAKRDGGFRLNIETFDWGSDYYKKHGTMMPENGRETLKQFDAIYFGAVGAPD
VPDHVTLWGLRLNICQPFDQYANVRPTRILPGIKSPLAGVGPRLLNWVIVRENSEGEYAGQGGRSHRGFPEEVATEVAIF
TRAGVTRIMRFAFKLAQSRPRKLLTVVTKSNAQRHGMVMWDEIAAEVAGEFPDVTWDKMLVDAMTMRMTLKPETLDTIVA
TNLHADILSDLAAALAGSLGIAPTANLNPERKFPSMFEPIHGSAFDITGKGIANPIGTFWTACMMLDHLGETAASARLMR
AIERVTANPLLHTPDLGGKATTRIVTDAVIAAIEADNE

Specific function: Unknown

COG id: COG0473

COG function: function code CE; Isocitrate/isopropylmalate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=349, Percent_Identity=30.6590257879656, Blast_Score=161, Evalue=9e-40,
Organism=Homo sapiens, GI4758582, Length=261, Percent_Identity=34.4827586206897, Blast_Score=149, Evalue=6e-36,
Organism=Homo sapiens, GI28178816, Length=356, Percent_Identity=28.9325842696629, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI28178838, Length=226, Percent_Identity=34.070796460177, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI28178821, Length=357, Percent_Identity=27.7310924369748, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI28178819, Length=199, Percent_Identity=30.6532663316583, Blast_Score=96, Evalue=4e-20,
Organism=Escherichia coli, GI1788101, Length=360, Percent_Identity=51.9444444444444, Blast_Score=366, Evalue=1e-102,
Organism=Escherichia coli, GI87081683, Length=332, Percent_Identity=35.5421686746988, Blast_Score=178, Evalue=4e-46,
Organism=Escherichia coli, GI1787381, Length=365, Percent_Identity=27.6712328767123, Blast_Score=106, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI71986051, Length=364, Percent_Identity=30.2197802197802, Blast_Score=154, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI17550882, Length=352, Percent_Identity=30.6818181818182, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI25144293, Length=356, Percent_Identity=25.2808988764045, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17505779, Length=257, Percent_Identity=28.4046692607004, Blast_Score=122, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6322097, Length=367, Percent_Identity=35.6948228882834, Blast_Score=186, Evalue=4e-48,
Organism=Saccharomyces cerevisiae, GI6324709, Length=352, Percent_Identity=31.25, Blast_Score=154, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6324291, Length=352, Percent_Identity=28.9772727272727, Blast_Score=139, Evalue=7e-34,
Organism=Saccharomyces cerevisiae, GI6319830, Length=361, Percent_Identity=28.5318559556787, Blast_Score=124, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24643268, Length=264, Percent_Identity=32.5757575757576, Blast_Score=149, Evalue=3e-36,
Organism=Drosophila melanogaster, GI24643270, Length=353, Percent_Identity=30.028328611898, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI24661184, Length=355, Percent_Identity=28.7323943661972, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI281362242, Length=346, Percent_Identity=28.9017341040462, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24648872, Length=346, Percent_Identity=28.9017341040462, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI161078639, Length=263, Percent_Identity=26.615969581749, Blast_Score=114, Evalue=7e-26,
Organism=Drosophila melanogaster, GI161078637, Length=263, Percent_Identity=26.615969581749, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI161078633, Length=263, Percent_Identity=26.615969581749, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24650122, Length=263, Percent_Identity=26.615969581749, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI161078635, Length=263, Percent_Identity=26.615969581749, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI20130355, Length=351, Percent_Identity=26.7806267806268, Blast_Score=108, Evalue=8e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR011829 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.93; =4.1.1.73; =1.1.1.83 [H]

Molecular weight: Translated: 39054; Mature: 39054

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREFKIAAIPADGIGKEVVAAGLEVLDVLAKRDGGFRLNIETFDWGSDYYKKHGTMMPEN
CCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHCCCCCCCC
GRETLKQFDAIYFGAVGAPDVPDHVTLWGLRLNICQPFDQYANVRPTRILPGIKSPLAGV
CHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEECCCCHHHHCCCCCHHCCCCCCCCHHHC
GPRLLNWVIVRENSEGEYAGQGGRSHRGFPEEVATEVAIFTRAGVTRIMRFAFKLAQSRP
CHHHEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
RKLLTVVTKSNAQRHGMVMWDEIAAEVAGEFPDVTWDKMLVDAMTMRMTLKPETLDTIVA
CEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHEEECCHHHHHHHH
TNLHADILSDLAAALAGSLGIAPTANLNPERKFPSMFEPIHGSAFDITGKGIANPIGTFW
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHCCCCCCEEEECCCCCCCHHHHHH
TACMMLDHLGETAASARLMRAIERVTANPLLHTPDLGGKATTRIVTDAVIAAIEADNE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MREFKIAAIPADGIGKEVVAAGLEVLDVLAKRDGGFRLNIETFDWGSDYYKKHGTMMPEN
CCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHCCCCCCCC
GRETLKQFDAIYFGAVGAPDVPDHVTLWGLRLNICQPFDQYANVRPTRILPGIKSPLAGV
CHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEECCCCHHHHCCCCCHHCCCCCCCCHHHC
GPRLLNWVIVRENSEGEYAGQGGRSHRGFPEEVATEVAIFTRAGVTRIMRFAFKLAQSRP
CHHHEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
RKLLTVVTKSNAQRHGMVMWDEIAAEVAGEFPDVTWDKMLVDAMTMRMTLKPETLDTIVA
CEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHEEECCHHHHHHHH
TNLHADILSDLAAALAGSLGIAPTANLNPERKFPSMFEPIHGSAFDITGKGIANPIGTFW
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHCCCCCCEEEECCCCCCCHHHHHH
TACMMLDHLGETAASARLMRAIERVTANPLLHTPDLGGKATTRIVTDAVIAAIEADNE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7592429 [H]