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The map label for this gene is adk

Identifier: 83312209

GI number: 83312209

Start: 3365582

End: 3366235

Strand: Reverse

Name: adk

Synonym: amb3110

Alternate gene names: 83312209

Gene position: 3366235-3365582 (Counterclockwise)

Preceding gene: 83312210

Following gene: 83312208

Centisome position: 67.77

GC content: 63.76

Gene sequence:

>654_bases
ATGAATCTCGTTCTGTTGGGTCCGCCCGGTGGCGGCAAGGGAACCCAGGCCAAGCGTCTTCAGGACAAGTACGGTCTGGT
GCAACTGTCGACCGGCGACATGCTGCGCGCCGCCGTGGCGTCCGGCTCCGAAGTGGGCAAGAAGGCCAAGGCCGTGATGG
ATGCCGGCCAGCTGGTGTCCGACGAGATCGTCATCGCCATCATCGATGAGCGCCTGGACCAGGCCGACGTGGCCAAGGGC
GCCATCTTCGACGGCTTCCCGCGCACTGTGGCCCAGGCCGAAGCCCTCGACGCCATGATGGCCAAGAAGGGCAAGAAGCT
GGACTTCGCCATCGAGATCCGCGTCCCCGACGCCTATATCGTCGAGCGCATCACCGGGCGCTATACCTGCGCTAAATGCG
GCGCCGGCTACCACGACAAGTTTCAGCTGCCCCAGGTCGCCGGCAAGTGCGATTCCTGCGGCGGCACCGAGTTCGCTCGC
CGTCCGGACGACAATGTCGACACCGTGACCAAGCGTCTCGACGCGTATCATGCCCAGACCGCTCCGCTGCTGCCCTATTA
CGACAAGAAGGGCTCCTTGAAGCTGGTTGACGGCACCATGGACATTGCCGACGTGACCAAGGCCCTGGAAGGGATTCTGG
ACGCGTCGAAGTAA

Upstream 100 bases:

>100_bases
TCAGGTTCAGTCGCATCTGCTTGCGCACCAGTACGAGGGGCTCATCAAGAAGTCCCGGCTGCGCGGGCGGCGTTAACTGC
CAAGAAAAAGGGGACATCCG

Downstream 100 bases:

>100_bases
TGTGATTCGGTAGGGCGAGACGGTTGACTCTTGATCGAATCGCCCTATAATCCCGCACCTTCGGTTTCCCCCGTCATGGG
CGAGGCCAGGGGCGCGTTTT

Product: adenylate kinase-like kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 217; Mature: 217

Protein sequence:

>217_residues
MNLVLLGPPGGGKGTQAKRLQDKYGLVQLSTGDMLRAAVASGSEVGKKAKAVMDAGQLVSDEIVIAIIDERLDQADVAKG
AIFDGFPRTVAQAEALDAMMAKKGKKLDFAIEIRVPDAYIVERITGRYTCAKCGAGYHDKFQLPQVAGKCDSCGGTEFAR
RPDDNVDTVTKRLDAYHAQTAPLLPYYDKKGSLKLVDGTMDIADVTKALEGILDASK

Sequences:

>Translated_217_residues
MNLVLLGPPGGGKGTQAKRLQDKYGLVQLSTGDMLRAAVASGSEVGKKAKAVMDAGQLVSDEIVIAIIDERLDQADVAKG
AIFDGFPRTVAQAEALDAMMAKKGKKLDFAIEIRVPDAYIVERITGRYTCAKCGAGYHDKFQLPQVAGKCDSCGGTEFAR
RPDDNVDTVTKRLDAYHAQTAPLLPYYDKKGSLKLVDGTMDIADVTKALEGILDASK
>Mature_217_residues
MNLVLLGPPGGGKGTQAKRLQDKYGLVQLSTGDMLRAAVASGSEVGKKAKAVMDAGQLVSDEIVIAIIDERLDQADVAKG
AIFDGFPRTVAQAEALDAMMAKKGKKLDFAIEIRVPDAYIVERITGRYTCAKCGAGYHDKFQLPQVAGKCDSCGGTEFAR
RPDDNVDTVTKRLDAYHAQTAPLLPYYDKKGSLKLVDGTMDIADVTKALEGILDASK

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI7524346, Length=196, Percent_Identity=51.530612244898, Blast_Score=204, Evalue=5e-53,
Organism=Homo sapiens, GI4502013, Length=196, Percent_Identity=51.530612244898, Blast_Score=204, Evalue=7e-53,
Organism=Homo sapiens, GI19923437, Length=196, Percent_Identity=38.7755102040816, Blast_Score=139, Evalue=2e-33,
Organism=Homo sapiens, GI310110345, Length=196, Percent_Identity=32.6530612244898, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI53832003, Length=196, Percent_Identity=32.6530612244898, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI8051579, Length=196, Percent_Identity=32.6530612244898, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI53832001, Length=196, Percent_Identity=32.6530612244898, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI4502011, Length=216, Percent_Identity=30.0925925925926, Blast_Score=104, Evalue=6e-23,
Organism=Homo sapiens, GI28144897, Length=218, Percent_Identity=30.7339449541284, Blast_Score=88, Evalue=5e-18,
Organism=Homo sapiens, GI28144899, Length=218, Percent_Identity=30.7339449541284, Blast_Score=88, Evalue=6e-18,
Organism=Homo sapiens, GI22749187, Length=215, Percent_Identity=28.8372093023256, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI7706497, Length=217, Percent_Identity=27.1889400921659, Blast_Score=79, Evalue=2e-15,
Organism=Escherichia coli, GI1786680, Length=218, Percent_Identity=52.2935779816514, Blast_Score=208, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI17552384, Length=210, Percent_Identity=45.2380952380952, Blast_Score=184, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17567503, Length=214, Percent_Identity=32.2429906542056, Blast_Score=104, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17533833, Length=217, Percent_Identity=28.5714285714286, Blast_Score=94, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17550688, Length=216, Percent_Identity=26.3888888888889, Blast_Score=88, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17537943, Length=193, Percent_Identity=27.979274611399, Blast_Score=84, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6320432, Length=206, Percent_Identity=45.6310679611651, Blast_Score=180, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6321018, Length=201, Percent_Identity=36.81592039801, Blast_Score=129, Evalue=5e-31,
Organism=Saccharomyces cerevisiae, GI6322828, Length=211, Percent_Identity=27.4881516587678, Blast_Score=83, Evalue=3e-17,
Organism=Drosophila melanogaster, GI22026816, Length=213, Percent_Identity=46.0093896713615, Blast_Score=194, Evalue=3e-50,
Organism=Drosophila melanogaster, GI17737899, Length=195, Percent_Identity=37.4358974358974, Blast_Score=130, Evalue=5e-31,
Organism=Drosophila melanogaster, GI24645822, Length=195, Percent_Identity=37.4358974358974, Blast_Score=130, Evalue=5e-31,
Organism=Drosophila melanogaster, GI24663208, Length=189, Percent_Identity=31.2169312169312, Blast_Score=94, Evalue=6e-20,
Organism=Drosophila melanogaster, GI17647141, Length=189, Percent_Identity=31.2169312169312, Blast_Score=94, Evalue=6e-20,
Organism=Drosophila melanogaster, GI221459597, Length=215, Percent_Identity=27.4418604651163, Blast_Score=87, Evalue=7e-18,
Organism=Drosophila melanogaster, GI21356893, Length=215, Percent_Identity=27.4418604651163, Blast_Score=87, Evalue=7e-18,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_MAGSA (Q2W2L1)

Other databases:

- EMBL:   AP007255
- RefSeq:   YP_422473.1
- HSSP:   P69441
- ProteinModelPortal:   Q2W2L1
- SMR:   Q2W2L1
- STRING:   Q2W2L1
- GeneID:   3804457
- GenomeReviews:   AP007255_GR
- KEGG:   mag:amb3110
- NMPDR:   fig|342108.5.peg.2793
- eggNOG:   COG0563
- HOGENOM:   HBG630208
- OMA:   CGEGYHD
- PhylomeDB:   Q2W2L1
- BioCyc:   MMAG342108:AMB3110-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid; SSF57774 Adenylate_kinase_Znf_lid

EC number: =2.7.4.3

Molecular weight: Translated: 23167; Mature: 23167

Theoretical pI: Translated: 7.29; Mature: 7.29

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLVLLGPPGGGKGTQAKRLQDKYGLVQLSTGDMLRAAVASGSEVGKKAKAVMDAGQLVS
CCEEEECCCCCCCCCHHHHHHHHHCEEEECCCHHHHHHHHCCHHHHHHHHHHHHHHHHHC
DEIVIAIIDERLDQADVAKGAIFDGFPRTVAQAEALDAMMAKKGKKLDFAIEIRVPDAYI
CCEEEEEEHHHCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHH
VERITGRYTCAKCGAGYHDKFQLPQVAGKCDSCGGTEFARRPDDNVDTVTKRLDAYHAQT
HHHHHCCEEHHHCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC
APLLPYYDKKGSLKLVDGTMDIADVTKALEGILDASK
CCCCCEECCCCCEEEEECCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNLVLLGPPGGGKGTQAKRLQDKYGLVQLSTGDMLRAAVASGSEVGKKAKAVMDAGQLVS
CCEEEECCCCCCCCCHHHHHHHHHCEEEECCCHHHHHHHHCCHHHHHHHHHHHHHHHHHC
DEIVIAIIDERLDQADVAKGAIFDGFPRTVAQAEALDAMMAKKGKKLDFAIEIRVPDAYI
CCEEEEEEHHHCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHH
VERITGRYTCAKCGAGYHDKFQLPQVAGKCDSCGGTEFARRPDDNVDTVTKRLDAYHAQT
HHHHHCCEEHHHCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC
APLLPYYDKKGSLKLVDGTMDIADVTKALEGILDASK
CCCCCEECCCCCEEEEECCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA