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The map label for this gene is comEC [H]

Identifier: 83311901

GI number: 83311901

Start: 2993023

End: 2995167

Strand: Reverse

Name: comEC [H]

Synonym: amb2802

Alternate gene names: 83311901

Gene position: 2995167-2993023 (Counterclockwise)

Preceding gene: 83311906

Following gene: 83311897

Centisome position: 60.3

GC content: 70.58

Gene sequence:

>2145_bases
ATGGGGGAGTGCCTGCTGGCGGAGCGCGGGCGCTGGCCCCTTTGGCTGCCCGTTTTCCTGGGATTGGGCATCGGCCTGTA
CTTCGCCCTGCCGTCCGAGCCGCCGGCGTGGTGGGGAGGCGTGGCTGTTCTGCTGGCGGCCGCCGGCCTGCTTTTGGTCC
GGGGGCGGAGTCTGGCGCCGCTGCTGGCGGCCTCGTGCCTGCTGGCGATCGCCTTGGGTTTCGCCGCGACCCAGTGGCGC
AGCCTTCGTCTGGCCGCCCCGGTGATCGAGCGGCATAGCGGCGCCCTGATGCTTGAAGGCGTGGTGGTGGAGGTGGAGGC
CTTGCCCGACGGCGGCAGCCGTCTGACCCTGGGGCAACTGGTCCACGACCGCGACGATGTCTTGGTGCCGGCCCGGGCAC
GGATCAAGGCCAAGGCGGGCCTGTCCCTGGCCACCGTCGGCGATCGTATCCGGGTGCGGGCCATGCTGATGCCGCCGCCC
CAGCCTGCCATGCCGGGGGCCTTCGACTTCGCCCGCTTCGCCTGGTTTCGCCAGTTGGGCGCCATCGGCACGGCCCTGGG
GCCGGTGGAGGTGATCGCGGCCGGGGCGGCGACCGGCTGGCGGGCCGACCTCGCCACCAACGTCAACGAGATCCGCCACG
CCATCACCGCCCGCATCCTGGCGGTGCTGCCCGGCGACCGGGGCGCGGTGACGGCGGCGCTGACCACCGGCGACCAGATG
CCCATCTCGGCGCCCATGATGCAGGCCTACCGGGATTCCGGCCTGGCCCACATCCTGTCCATCTCGGGCCTGCACATCAC
CATGGCCGCCGGGCTGGTCTTCGTCGGCCTGCGCACCTTGCTGGCCCTGTTTCCGCCGGTGGCCCTGCGCTATCCCATCA
AGAAGTGGGCGGCGGCGCTGGCCATCGTCTTCGCGGGCTTTTACACCCTGCTGGCCGGGTCGCCGGTTCCAGCCCAGCGA
TCGTTCTTCATGACCGGGCTGGTGCTGTTGGCGGTGCTGCTGGACCGCCGGGCCTTGTCCATGCGGCTGGTGGCCTGGGC
GGCGGTGGCCATTCTGTTGTGGCAGCCCGACGAGTTGATCGGCCCCAGCTTTCAGATGTCCTTCGCCGCAGTGGCGGCCA
TGATCGCCGTCTACGAAAGCCTGACCCCCAGGCAGACCGCCTGGCGGGCCGCCCATCCCGGCTGGTTGCCCGCCATCGGT
CTTTACGTCTTCGGCACGGTGGTGACCACCCTGATCGCCGGCTTCGCCACGGCAGTCTACGGCATCCACCATTTCAACCG
CTTCGCCGTATGGTCGGTGGCGGCCAACATGATCGCCGTGCCCCTGACCGGCTTTTGGGTGATGCCCTGGGCGCTGGTGA
TGTTCGTGCTGCTGCCCTTCGGCCTGGAATCCCTGGCCCTGGTCCCTCTCGGCTGGGGGGTGGAGGGCGTCAATTGGGTG
GCGACCTGGGTGGCGTCGTGGCCCAGTTCGGCGGTGACCCTGCCCATCCTGCCGCTGTGGGCCATGGTTGTGTTCACCCT
GGGCGGGTGCTGGCTGTGCCTTTGGCGGGGGCGATGGCGGTGGTGGGGATTGCTGCCCATGGCGGTGGCGGTGGCCTCCA
TGGCCTTTGCCCGGCCGCCGGACCTGTTGGTGGACGGACGCGGCGACGGCTTGGCGTTGCGCACCGGCGAGGGGAGGCTG
CTGCTCAACGGCAAGGGCGGGCGAATCCTCAAGGACACCTGGAGCCGCCGGGCCGGGCCCGAGGCGCCCGAGCGTTGGCC
GAAGAAAAGCTCCTCCCGGGACGGCCGGCTGCGCTGCGACGAGACCGGTTGCCTGTGGCGGGTGGACGGCAAGGTGGTGG
CCCTGGTCAAGGATGAGGACAATCCCGAGAAGGCCTGCGCCGGTGCCGACATCGTGGTGAGCAGCGTGCCGCTGCGCGGC
ACCTGCCGCGAGGCCAGGGTGATTGTCGACCGCTTCGACCTGTGGCGGCGGGGACCTCATTCCCTGTGGCTGGGACCGAA
CGGAGCTTCGGTGGAGACGGTGGCGGGCTGGCAGGGCGACCGGCCCTGGGCCTGGCATCCCCACCCCAGGAAGAAGGCCA
AGGCACCGCCCCCGGTTGCGCCTCGCGAACCGGACGAGAAGAAGGACGAGGAGGCGGAGGATTAA

Upstream 100 bases:

>100_bases
CCGGTGTTGGGGGTGGATGGCAAAAAACCCGCCCGATTGGATAGGGGTTTTCCCGACCGCACGCTCCGGATCGGACGCGG
TGGCGGGAGTACTGCGCGTA

Downstream 100 bases:

>100_bases
TCCCCGCTGGCGTCGCTGGCGGTGAAGAAGAAGGTGGAACCTTCCCCTGGCCTTGACTCGACCCAGATGCGGCCGCCCAG
GCGGGTCACGATGCGTTGGC

Product: membrane metal-binding protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 714; Mature: 713

Protein sequence:

>714_residues
MGECLLAERGRWPLWLPVFLGLGIGLYFALPSEPPAWWGGVAVLLAAAGLLLVRGRSLAPLLAASCLLAIALGFAATQWR
SLRLAAPVIERHSGALMLEGVVVEVEALPDGGSRLTLGQLVHDRDDVLVPARARIKAKAGLSLATVGDRIRVRAMLMPPP
QPAMPGAFDFARFAWFRQLGAIGTALGPVEVIAAGAATGWRADLATNVNEIRHAITARILAVLPGDRGAVTAALTTGDQM
PISAPMMQAYRDSGLAHILSISGLHITMAAGLVFVGLRTLLALFPPVALRYPIKKWAAALAIVFAGFYTLLAGSPVPAQR
SFFMTGLVLLAVLLDRRALSMRLVAWAAVAILLWQPDELIGPSFQMSFAAVAAMIAVYESLTPRQTAWRAAHPGWLPAIG
LYVFGTVVTTLIAGFATAVYGIHHFNRFAVWSVAANMIAVPLTGFWVMPWALVMFVLLPFGLESLALVPLGWGVEGVNWV
ATWVASWPSSAVTLPILPLWAMVVFTLGGCWLCLWRGRWRWWGLLPMAVAVASMAFARPPDLLVDGRGDGLALRTGEGRL
LLNGKGGRILKDTWSRRAGPEAPERWPKKSSSRDGRLRCDETGCLWRVDGKVVALVKDEDNPEKACAGADIVVSSVPLRG
TCREARVIVDRFDLWRRGPHSLWLGPNGASVETVAGWQGDRPWAWHPHPRKKAKAPPPVAPREPDEKKDEEAED

Sequences:

>Translated_714_residues
MGECLLAERGRWPLWLPVFLGLGIGLYFALPSEPPAWWGGVAVLLAAAGLLLVRGRSLAPLLAASCLLAIALGFAATQWR
SLRLAAPVIERHSGALMLEGVVVEVEALPDGGSRLTLGQLVHDRDDVLVPARARIKAKAGLSLATVGDRIRVRAMLMPPP
QPAMPGAFDFARFAWFRQLGAIGTALGPVEVIAAGAATGWRADLATNVNEIRHAITARILAVLPGDRGAVTAALTTGDQM
PISAPMMQAYRDSGLAHILSISGLHITMAAGLVFVGLRTLLALFPPVALRYPIKKWAAALAIVFAGFYTLLAGSPVPAQR
SFFMTGLVLLAVLLDRRALSMRLVAWAAVAILLWQPDELIGPSFQMSFAAVAAMIAVYESLTPRQTAWRAAHPGWLPAIG
LYVFGTVVTTLIAGFATAVYGIHHFNRFAVWSVAANMIAVPLTGFWVMPWALVMFVLLPFGLESLALVPLGWGVEGVNWV
ATWVASWPSSAVTLPILPLWAMVVFTLGGCWLCLWRGRWRWWGLLPMAVAVASMAFARPPDLLVDGRGDGLALRTGEGRL
LLNGKGGRILKDTWSRRAGPEAPERWPKKSSSRDGRLRCDETGCLWRVDGKVVALVKDEDNPEKACAGADIVVSSVPLRG
TCREARVIVDRFDLWRRGPHSLWLGPNGASVETVAGWQGDRPWAWHPHPRKKAKAPPPVAPREPDEKKDEEAED
>Mature_713_residues
GECLLAERGRWPLWLPVFLGLGIGLYFALPSEPPAWWGGVAVLLAAAGLLLVRGRSLAPLLAASCLLAIALGFAATQWRS
LRLAAPVIERHSGALMLEGVVVEVEALPDGGSRLTLGQLVHDRDDVLVPARARIKAKAGLSLATVGDRIRVRAMLMPPPQ
PAMPGAFDFARFAWFRQLGAIGTALGPVEVIAAGAATGWRADLATNVNEIRHAITARILAVLPGDRGAVTAALTTGDQMP
ISAPMMQAYRDSGLAHILSISGLHITMAAGLVFVGLRTLLALFPPVALRYPIKKWAAALAIVFAGFYTLLAGSPVPAQRS
FFMTGLVLLAVLLDRRALSMRLVAWAAVAILLWQPDELIGPSFQMSFAAVAAMIAVYESLTPRQTAWRAAHPGWLPAIGL
YVFGTVVTTLIAGFATAVYGIHHFNRFAVWSVAANMIAVPLTGFWVMPWALVMFVLLPFGLESLALVPLGWGVEGVNWVA
TWVASWPSSAVTLPILPLWAMVVFTLGGCWLCLWRGRWRWWGLLPMAVAVASMAFARPPDLLVDGRGDGLALRTGEGRLL
LNGKGGRILKDTWSRRAGPEAPERWPKKSSSRDGRLRCDETGCLWRVDGKVVALVKDEDNPEKACAGADIVVSSVPLRGT
CREARVIVDRFDLWRRGPHSLWLGPNGASVETVAGWQGDRPWAWHPHPRKKAKAPPPVAPREPDEKKDEEAED

Specific function: The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding [H]

COG id: COG0658

COG function: function code R; Predicted membrane metal-binding protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 77129; Mature: 76998

Theoretical pI: Translated: 10.18; Mature: 10.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGECLLAERGRWPLWLPVFLGLGIGLYFALPSEPPAWWGGVAVLLAAAGLLLVRGRSLAP
CCCCEECCCCCCCCHHHHHHHCCHHEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCHHH
LLAASCLLAIALGFAATQWRSLRLAAPVIERHSGALMLEGVVVEVEALPDGGSRLTLGQL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEEECCCCCCEEEHHHH
VHDRDDVLVPARARIKAKAGLSLATVGDRIRVRAMLMPPPQPAMPGAFDFARFAWFRQLG
HCCCCCEEECCHHHHHHHCCCEEEECCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHH
AIGTALGPVEVIAAGAATGWRADLATNVNEIRHAITARILAVLPGDRGAVTAALTTGDQM
HHHHCCCHHHHHCCCCCCCCHHHHHCCHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCC
PISAPMMQAYRDSGLAHILSISGLHITMAAGLVFVGLRTLLALFPPVALRYPIKKWAAAL
CCCHHHHHHHHHCCCEEEHEECCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHH
AIVFAGFYTLLAGSPVPAQRSFFMTGLVLLAVLLDRRALSMRLVAWAAVAILLWQPDELI
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCHHHC
GPSFQMSFAAVAAMIAVYESLTPRQTAWRAAHPGWLPAIGLYVFGTVVTTLIAGFATAVY
CCCHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
GIHHFNRFAVWSVAANMIAVPLTGFWVMPWALVMFVLLPFGLESLALVPLGWGVEGVNWV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHH
ATWVASWPSSAVTLPILPLWAMVVFTLGGCWLCLWRGRWRWWGLLPMAVAVASMAFARPP
HHHHHHCCCCCEEEHHHHHHHHHHHHHCHHHEEHCCCCCCEEHHHHHHHHHHHHHHCCCC
DLLVDGRGDGLALRTGEGRLLLNGKGGRILKDTWSRRAGPEAPERWPKKSSSRDGRLRCD
CEEEECCCCCEEEEECCCEEEEECCCCCCHHHHHHCCCCCCCCHHCCCCCCCCCCCEEEC
ETGCLWRVDGKVVALVKDEDNPEKACAGADIVVSSVPLRGTCREARVIVDRFDLWRRGPH
CCCCEEEECCEEEEEEECCCCHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHCCCC
SLWLGPNGASVETVAGWQGDRPWAWHPHPRKKAKAPPPVAPREPDEKKDEEAED
EEEECCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
GECLLAERGRWPLWLPVFLGLGIGLYFALPSEPPAWWGGVAVLLAAAGLLLVRGRSLAP
CCCEECCCCCCCCHHHHHHHCCHHEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCHHH
LLAASCLLAIALGFAATQWRSLRLAAPVIERHSGALMLEGVVVEVEALPDGGSRLTLGQL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEEECCCCCCEEEHHHH
VHDRDDVLVPARARIKAKAGLSLATVGDRIRVRAMLMPPPQPAMPGAFDFARFAWFRQLG
HCCCCCEEECCHHHHHHHCCCEEEECCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHH
AIGTALGPVEVIAAGAATGWRADLATNVNEIRHAITARILAVLPGDRGAVTAALTTGDQM
HHHHCCCHHHHHCCCCCCCCHHHHHCCHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCC
PISAPMMQAYRDSGLAHILSISGLHITMAAGLVFVGLRTLLALFPPVALRYPIKKWAAAL
CCCHHHHHHHHHCCCEEEHEECCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHH
AIVFAGFYTLLAGSPVPAQRSFFMTGLVLLAVLLDRRALSMRLVAWAAVAILLWQPDELI
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCHHHC
GPSFQMSFAAVAAMIAVYESLTPRQTAWRAAHPGWLPAIGLYVFGTVVTTLIAGFATAVY
CCCHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
GIHHFNRFAVWSVAANMIAVPLTGFWVMPWALVMFVLLPFGLESLALVPLGWGVEGVNWV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHH
ATWVASWPSSAVTLPILPLWAMVVFTLGGCWLCLWRGRWRWWGLLPMAVAVASMAFARPP
HHHHHHCCCCCEEEHHHHHHHHHHHHHCHHHEEHCCCCCCEEHHHHHHHHHHHHHHCCCC
DLLVDGRGDGLALRTGEGRLLLNGKGGRILKDTWSRRAGPEAPERWPKKSSSRDGRLRCD
CEEEECCCCCEEEEECCCEEEEECCCCCCHHHHHHCCCCCCCCHHCCCCCCCCCCCEEEC
ETGCLWRVDGKVVALVKDEDNPEKACAGADIVVSSVPLRGTCREARVIVDRFDLWRRGPH
CCCCEEEECCEEEEEEECCCCHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHCCCC
SLWLGPNGASVETVAGWQGDRPWAWHPHPRKKAKAPPPVAPREPDEKKDEEAED
EEEECCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]