Click here to switch to the map view.

The map label for this gene is echA12 [H]

Identifier: 83311688

GI number: 83311688

Start: 2775329

End: 2776147

Strand: Reverse

Name: echA12 [H]

Synonym: amb2589

Alternate gene names: 83311688

Gene position: 2776147-2775329 (Counterclockwise)

Preceding gene: 83311689

Following gene: 83311687

Centisome position: 55.89

GC content: 65.08

Gene sequence:

>819_bases
ATGCGCAAGTTCAAGGCTGCCGAGTACAAGGCCGTTCATTTCGACTGGAAGGTGGACGGCAAGGTGGCGACGCTCACCCT
CAACCGCCCTGACAGAAAAAACCCTCTGACGTTTGATTCTTATGGAGAACTTCGCGACCTGTTCGAGAACATGGTCTATG
CGGACGACGTCAAGGCGGTGATCGTCACCGGCTCGGGCGGCAATTTCTGCTCGGGCGGCGACGTGCATGAGATCATCGGG
CCGCTGACCAAGATGGACATGCCCGAGCTGCTGGAATTCACCCGCATGACCGGCGACGCCGTGCGTGCCATGCGCAACGC
GCCCCAGCCGATCATCGCCGCCATCGACGGCATCTGCGCCGGCGCCGGTACCATGTTGGGCTGCGCCTCCGACATCCGTC
TGGGCACGGCGCGGTCCAAGGTGGCCTTCCTGTTCGTGCGCGTCGGCCTGGCCGGCGCCGATATGGGCGCCTGCACCCTG
CTGCCCCGCCTGATCGGCCTGTCGCGTGCCGCCGAGCTGCTCTACACCGGCCGCGCCATGGGCGGCGAGGAGGCCGAGCG
CGTCGGCTACTACAACTCGCTGCATGCGCCGGAAGAACTGCTGGACGCCGCCAACAAGCTGGCCCAGTCCCTGGCCAACG
GCCCCACCTTCGGTCACGCCATGACCAAGAAGATGCTGTGGCAGGAATGGAACCACGGCCTGGGCGAGTGCATCGAGGCC
GAGGCTCAGGCTCAGGCCATCTGCATGCAGACCAAGGACTTCGAGCGCGCCTATGTCGCCTTCGCCAACAAGCAGGCGCC
GGTGTTCGAAGGCAACTGA

Upstream 100 bases:

>100_bases
GGGCCGACTACATCACCGGCCAGGTTCTGTCGGTCAACGGCGGCATCACCATGGTGGGCTAAGAGCCCCCTTCGCAACAT
CAAGACAAGAGGACAATCCC

Downstream 100 bases:

>100_bases
TCTCGGCTTTGCCCCCCTCTCCCGCAAGCGGGAGAGGGGCTAAAAAGGAAAAGTATCATGAGTGACGCCACGTTTCTCGA
CTGGCCCTTTCTCGACGAGT

Product: enoyl-CoA hydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 272; Mature: 272

Protein sequence:

>272_residues
MRKFKAAEYKAVHFDWKVDGKVATLTLNRPDRKNPLTFDSYGELRDLFENMVYADDVKAVIVTGSGGNFCSGGDVHEIIG
PLTKMDMPELLEFTRMTGDAVRAMRNAPQPIIAAIDGICAGAGTMLGCASDIRLGTARSKVAFLFVRVGLAGADMGACTL
LPRLIGLSRAAELLYTGRAMGGEEAERVGYYNSLHAPEELLDAANKLAQSLANGPTFGHAMTKKMLWQEWNHGLGECIEA
EAQAQAICMQTKDFERAYVAFANKQAPVFEGN

Sequences:

>Translated_272_residues
MRKFKAAEYKAVHFDWKVDGKVATLTLNRPDRKNPLTFDSYGELRDLFENMVYADDVKAVIVTGSGGNFCSGGDVHEIIG
PLTKMDMPELLEFTRMTGDAVRAMRNAPQPIIAAIDGICAGAGTMLGCASDIRLGTARSKVAFLFVRVGLAGADMGACTL
LPRLIGLSRAAELLYTGRAMGGEEAERVGYYNSLHAPEELLDAANKLAQSLANGPTFGHAMTKKMLWQEWNHGLGECIEA
EAQAQAICMQTKDFERAYVAFANKQAPVFEGN
>Mature_272_residues
MRKFKAAEYKAVHFDWKVDGKVATLTLNRPDRKNPLTFDSYGELRDLFENMVYADDVKAVIVTGSGGNFCSGGDVHEIIG
PLTKMDMPELLEFTRMTGDAVRAMRNAPQPIIAAIDGICAGAGTMLGCASDIRLGTARSKVAFLFVRVGLAGADMGACTL
LPRLIGLSRAAELLYTGRAMGGEEAERVGYYNSLHAPEELLDAANKLAQSLANGPTFGHAMTKKMLWQEWNHGLGECIEA
EAQAQAICMQTKDFERAYVAFANKQAPVFEGN

Specific function: Could possibly oxidize fatty acids using specific components [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI70995211, Length=248, Percent_Identity=27.8225806451613, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI31542718, Length=253, Percent_Identity=24.1106719367589, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI20127408, Length=244, Percent_Identity=24.1803278688525, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI4502327, Length=272, Percent_Identity=28.3088235294118, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI68989263, Length=212, Percent_Identity=27.3584905660377, Blast_Score=71, Evalue=8e-13,
Organism=Escherichia coli, GI1787660, Length=259, Percent_Identity=30.5019305019305, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI221142681, Length=258, Percent_Identity=26.3565891472868, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1790281, Length=206, Percent_Identity=24.7572815533981, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1787659, Length=252, Percent_Identity=25.3968253968254, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1788682, Length=228, Percent_Identity=27.1929824561404, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1788597, Length=187, Percent_Identity=24.0641711229947, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17560910, Length=223, Percent_Identity=27.8026905829596, Blast_Score=97, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI17540714, Length=202, Percent_Identity=30.6930693069307, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17536985, Length=261, Percent_Identity=24.904214559387, Blast_Score=88, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17534483, Length=261, Percent_Identity=26.0536398467433, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI25145438, Length=246, Percent_Identity=25.609756097561, Blast_Score=77, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17554946, Length=254, Percent_Identity=26.7716535433071, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17535521, Length=252, Percent_Identity=25.7936507936508, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI25141363, Length=222, Percent_Identity=26.1261261261261, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24653139, Length=259, Percent_Identity=31.2741312741313, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI21357171, Length=197, Percent_Identity=30.9644670050761, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI19920382, Length=256, Percent_Identity=26.953125, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI20129971, Length=253, Percent_Identity=26.8774703557312, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24653477, Length=253, Percent_Identity=26.8774703557312, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24650670, Length=198, Percent_Identity=28.7878787878788, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.17 [H]

Molecular weight: Translated: 29518; Mature: 29518

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKFKAAEYKAVHFDWKVDGKVATLTLNRPDRKNPLTFDSYGELRDLFENMVYADDVKAV
CCCCCCCCEEEEEEEEEECCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEE
IVTGSGGNFCSGGDVHEIIGPLTKMDMPELLEFTRMTGDAVRAMRNAPQPIIAAIDGICA
EEECCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
GAGTMLGCASDIRLGTARSKVAFLFVRVGLAGADMGACTLLPRLIGLSRAAELLYTGRAM
CCCHHHHCHHHCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
GGEEAERVGYYNSLHAPEELLDAANKLAQSLANGPTFGHAMTKKMLWQEWNHGLGECIEA
CCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHH
EAQAQAICMQTKDFERAYVAFANKQAPVFEGN
HHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MRKFKAAEYKAVHFDWKVDGKVATLTLNRPDRKNPLTFDSYGELRDLFENMVYADDVKAV
CCCCCCCCEEEEEEEEEECCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEE
IVTGSGGNFCSGGDVHEIIGPLTKMDMPELLEFTRMTGDAVRAMRNAPQPIIAAIDGICA
EEECCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
GAGTMLGCASDIRLGTARSKVAFLFVRVGLAGADMGACTLLPRLIGLSRAAELLYTGRAM
CCCHHHHCHHHCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
GGEEAERVGYYNSLHAPEELLDAANKLAQSLANGPTFGHAMTKKMLWQEWNHGLGECIEA
CCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHH
EAQAQAICMQTKDFERAYVAFANKQAPVFEGN
HHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]