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The map label for this gene is uppS [H]

Identifier: 83311593

GI number: 83311593

Start: 2672050

End: 2672781

Strand: Reverse

Name: uppS [H]

Synonym: amb2494

Alternate gene names: 83311593

Gene position: 2672781-2672050 (Counterclockwise)

Preceding gene: 83311594

Following gene: 83311592

Centisome position: 53.81

GC content: 66.53

Gene sequence:

>732_bases
ATGGAGCCCATGCTTTCCCCCGCCGACCAGCCGCCGCCGCCGGTGCACGTGGCCATCATCATGGATGGCAACGGGCGCTG
GGCCAAGGCACGCGGGCTGCCGCGCACCGCCGGCCACAAGCGTGGCGCCGAGGCGGTTCGCCGCACCGTCGAGGCCGCAC
GGGAGATGGGCGTCTCCTACCTGACCCTTTATGCCTTTTCCTCGGAAAACTGGAAGCGCCCGGCGGGCGAGGTCACTGAC
CTGATGGGGCTGCTGCGCCTGTACCTGCGCAATGAGGTCAACAACCTCCATAAGAACGGCATTCGTCTCAAGGTCATCGG
CGACCGGAGCCGCCTGGGCGCCGATATCGTCCGCCTGATCGAGGAATCCGAGGCCAAGACCGCCGGCAATACCGCCCTGA
CCTTGTTGCTGGCCCTGTCCTATGGCGGGCGGCAGGAGATCGTCGAGGCTGCCCGGGCTCTGGCCCGCGATGTGGCCGCA
GGACGTCTTTCTCCTGATGCCGTTGACGAGGACGCCATCGACGCCCGACTGTCCACGGCGGGAATTCCCGATCCCGACAT
GATTATCCGGACCAGCGGCGAACAGCGCATCAGCAACTTCCTGCTGTGGCAGGGCGCCTATGCCGAGCTGGTGTTCATGG
ATACGCTGTGGCCAGACTTCGGGCGGCCCGAGTTGGAGGCCGCCATTCGCGACTTCCAGGGTCGCGACCGCCGTTTCGGT
ACGGCCAGGTAG

Upstream 100 bases:

>100_bases
AGATCCAGGCCATCACCGACGAGACCATCAAGAAGATCGACGAGGCCTTGGGTCACAAGGAAAAGGAAATCATGCAGGTT
TGAGGAGGCGAGGACCCGGT

Downstream 100 bases:

>100_bases
CCCGTGTAGTGCTGAAAACCCGCGCCCTGTCCGCCCTGGTAATGGCTCCGCCCGCGCTGCTGGCCGCCTGGGCCGGCGGC
TACGCCTTCGGCGCCCTGAT

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 243; Mature: 243

Protein sequence:

>243_residues
MEPMLSPADQPPPPVHVAIIMDGNGRWAKARGLPRTAGHKRGAEAVRRTVEAAREMGVSYLTLYAFSSENWKRPAGEVTD
LMGLLRLYLRNEVNNLHKNGIRLKVIGDRSRLGADIVRLIEESEAKTAGNTALTLLLALSYGGRQEIVEAARALARDVAA
GRLSPDAVDEDAIDARLSTAGIPDPDMIIRTSGEQRISNFLLWQGAYAELVFMDTLWPDFGRPELEAAIRDFQGRDRRFG
TAR

Sequences:

>Translated_243_residues
MEPMLSPADQPPPPVHVAIIMDGNGRWAKARGLPRTAGHKRGAEAVRRTVEAAREMGVSYLTLYAFSSENWKRPAGEVTD
LMGLLRLYLRNEVNNLHKNGIRLKVIGDRSRLGADIVRLIEESEAKTAGNTALTLLLALSYGGRQEIVEAARALARDVAA
GRLSPDAVDEDAIDARLSTAGIPDPDMIIRTSGEQRISNFLLWQGAYAELVFMDTLWPDFGRPELEAAIRDFQGRDRRFG
TAR
>Mature_243_residues
MEPMLSPADQPPPPVHVAIIMDGNGRWAKARGLPRTAGHKRGAEAVRRTVEAAREMGVSYLTLYAFSSENWKRPAGEVTD
LMGLLRLYLRNEVNNLHKNGIRLKVIGDRSRLGADIVRLIEESEAKTAGNTALTLLLALSYGGRQEIVEAARALARDVAA
GRLSPDAVDEDAIDARLSTAGIPDPDMIIRTSGEQRISNFLLWQGAYAELVFMDTLWPDFGRPELEAAIRDFQGRDRRFG
TAR

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=235, Percent_Identity=38.7234042553192, Blast_Score=162, Evalue=2e-40,
Organism=Homo sapiens, GI45580742, Length=225, Percent_Identity=39.5555555555556, Blast_Score=162, Evalue=2e-40,
Organism=Escherichia coli, GI1786371, Length=225, Percent_Identity=54.2222222222222, Blast_Score=247, Evalue=5e-67,
Organism=Caenorhabditis elegans, GI71993029, Length=230, Percent_Identity=36.0869565217391, Blast_Score=147, Evalue=5e-36,
Organism=Saccharomyces cerevisiae, GI6319474, Length=213, Percent_Identity=38.0281690140845, Blast_Score=131, Evalue=8e-32,
Organism=Saccharomyces cerevisiae, GI6323748, Length=217, Percent_Identity=32.258064516129, Blast_Score=115, Evalue=7e-27,
Organism=Drosophila melanogaster, GI18857969, Length=227, Percent_Identity=35.6828193832599, Blast_Score=137, Evalue=6e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 26804; Mature: 26804

Theoretical pI: Translated: 7.78; Mature: 7.78

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEPMLSPADQPPPPVHVAIIMDGNGRWAKARGLPRTAGHKRGAEAVRRTVEAAREMGVSY
CCCCCCCCCCCCCCEEEEEEECCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCE
LTLYAFSSENWKRPAGEVTDLMGLLRLYLRNEVNNLHKNGIRLKVIGDRSRLGADIVRLI
EEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHH
EESEAKTAGNTALTLLLALSYGGRQEIVEAARALARDVAAGRLSPDAVDEDAIDARLSTA
HHHCCHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHC
GIPDPDMIIRTSGEQRISNFLLWQGAYAELVFMDTLWPDFGRPELEAAIRDFQGRDRRFG
CCCCCCEEEECCCHHHHHHHHHCCCCHHHEEEHHHHCCCCCCHHHHHHHHHHCCCCCCCC
TAR
CCC
>Mature Secondary Structure
MEPMLSPADQPPPPVHVAIIMDGNGRWAKARGLPRTAGHKRGAEAVRRTVEAAREMGVSY
CCCCCCCCCCCCCCEEEEEEECCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCE
LTLYAFSSENWKRPAGEVTDLMGLLRLYLRNEVNNLHKNGIRLKVIGDRSRLGADIVRLI
EEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHH
EESEAKTAGNTALTLLLALSYGGRQEIVEAARALARDVAAGRLSPDAVDEDAIDARLSTA
HHHCCHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHC
GIPDPDMIIRTSGEQRISNFLLWQGAYAELVFMDTLWPDFGRPELEAAIRDFQGRDRRFG
CCCCCCEEEECCCHHHHHHHHHCCCCHHHEEEHHHHCCCCCCHHHHHHHHHHCCCCCCCC
TAR
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194 [H]