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The map label for this gene is lpxA [H]

Identifier: 83311585

GI number: 83311585

Start: 2663609

End: 2664400

Strand: Reverse

Name: lpxA [H]

Synonym: amb2486

Alternate gene names: 83311585

Gene position: 2664400-2663609 (Counterclockwise)

Preceding gene: 83311586

Following gene: 83311584

Centisome position: 53.64

GC content: 62.88

Gene sequence:

>792_bases
ATGACCAATATTCACCCTTCGGCCGTTATCGATTCCAAGGCGGAGATCGCCTCTTCGGCGATCATCGGGCCTTTCTGCGT
GGTTGGACCCGACGTCAAGTTGGGCGAATCCGTTGAACTGGTGTCCCATGTGGCGGTGGCCGGACGCACCACCATCGGCG
CCGGCACCCGTATTTTCCCGTTCGCCTCCATCGGTCACCGTCCTCAGGACCTCAAGTACAAGGGCGAGCCCTCCACCTTG
GAGATCGGGGCCAACAACCAGATCCGCGAGCATGTCACCATGAATCCCGGCACCGAGGGTGGCGGCATGGTGACCAGGGT
CGGCGACAATTGCCTGTTCATGGCCAGCGCCCACGTGGCCCATGACTGCATCCTGGGCGACAATGTCATCATGGCCAACA
ACGCCACCCTGGCGGGTCATGTGACGGTCGGCGAATACGCCTTCCTGGGCGGGCTGTCGGCGGTGCACCAGTTCGTGCGC
ATCGGTCGCCACGCCATGATCGGCGGCATGTCGGGCGTCGAGGCGGACGTCATTCCCTTCGGCATGGTGATCGGTAACCG
GGCCTATCTCAATGGGCTGAACATCGTCGGCCTGAAGCGTCGGGGCTTTTCCCGCGACGACATCCACACGCTGCGCAATG
CCTACCGTCTGATGTTCGCGCCGGAAGGCACGCTGGCCGAGCGCCTCTCCGACGTGGAGGAGCAGTTCAAGGACCATCCG
GTGGTGATGGAGATCGTGGCCTTCATCCGCTCGGATTCGTCGCGTTCGCTCAGCACGCCGAATGGCTCCTAA

Upstream 100 bases:

>100_bases
AACGCTCGCGCGGGAACGTCTGGAAGTTCCGTGGCGAAGCCAAGGTCGATGGCGTCCTTGTCGCCGAAGCCACCTACGCC
GCCATGATTCTGGACGAGAA

Downstream 100 bases:

>100_bases
GCTCGGCATCATTGCCGGCGGCGGCGACCTGCCGGGACTGGTCGCCGCCGCCTGCCGTGCCCAAGGGCGCCCCTTTCATA
TTCTCGCCCTTTCGGGCCAT

Product: UDP-N-acetylglucosamine acyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine acyltransferase [H]

Number of amino acids: Translated: 263; Mature: 262

Protein sequence:

>263_residues
MTNIHPSAVIDSKAEIASSAIIGPFCVVGPDVKLGESVELVSHVAVAGRTTIGAGTRIFPFASIGHRPQDLKYKGEPSTL
EIGANNQIREHVTMNPGTEGGGMVTRVGDNCLFMASAHVAHDCILGDNVIMANNATLAGHVTVGEYAFLGGLSAVHQFVR
IGRHAMIGGMSGVEADVIPFGMVIGNRAYLNGLNIVGLKRRGFSRDDIHTLRNAYRLMFAPEGTLAERLSDVEEQFKDHP
VVMEIVAFIRSDSSRSLSTPNGS

Sequences:

>Translated_263_residues
MTNIHPSAVIDSKAEIASSAIIGPFCVVGPDVKLGESVELVSHVAVAGRTTIGAGTRIFPFASIGHRPQDLKYKGEPSTL
EIGANNQIREHVTMNPGTEGGGMVTRVGDNCLFMASAHVAHDCILGDNVIMANNATLAGHVTVGEYAFLGGLSAVHQFVR
IGRHAMIGGMSGVEADVIPFGMVIGNRAYLNGLNIVGLKRRGFSRDDIHTLRNAYRLMFAPEGTLAERLSDVEEQFKDHP
VVMEIVAFIRSDSSRSLSTPNGS
>Mature_262_residues
TNIHPSAVIDSKAEIASSAIIGPFCVVGPDVKLGESVELVSHVAVAGRTTIGAGTRIFPFASIGHRPQDLKYKGEPSTLE
IGANNQIREHVTMNPGTEGGGMVTRVGDNCLFMASAHVAHDCILGDNVIMANNATLAGHVTVGEYAFLGGLSAVHQFVRI
GRHAMIGGMSGVEADVIPFGMVIGNRAYLNGLNIVGLKRRGFSRDDIHTLRNAYRLMFAPEGTLAERLSDVEEQFKDHPV
VMEIVAFIRSDSSRSLSTPNGS

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG1043

COG function: function code M; Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786378, Length=254, Percent_Identity=50.3937007874016, Blast_Score=249, Evalue=1e-67,
Organism=Escherichia coli, GI1786376, Length=190, Percent_Identity=26.3157894736842, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR010137
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00132 Hexapep [H]

EC number: =2.3.1.129 [H]

Molecular weight: Translated: 27992; Mature: 27861

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNIHPSAVIDSKAEIASSAIIGPFCVVGPDVKLGESVELVSHVAVAGRTTIGAGTRIFP
CCCCCCCCEECCHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHCCCEECCCCEEEE
FASIGHRPQDLKYKGEPSTLEIGANNQIREHVTMNPGTEGGGMVTRVGDNCLFMASAHVA
EHHCCCCCCCCEECCCCCEEEECCCCCEEHEEEECCCCCCCCEEEEECCCEEEEEEHHHH
HDCILGDNVIMANNATLAGHVTVGEYAFLGGLSAVHQFVRIGRHAMIGGMSGVEADVIPF
HHEEECCCEEEECCCEEEEEEEECHHHHHHHHHHHHHHHHHCCHHEECCCCCCCCCCEEE
GMVIGNRAYLNGLNIVGLKRRGFSRDDIHTLRNAYRLMFAPEGTLAERLSDVEEQFKDHP
HHHCCCCHHCCCCEEEEEECCCCCHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHCCCC
VVMEIVAFIRSDSSRSLSTPNGS
HHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
TNIHPSAVIDSKAEIASSAIIGPFCVVGPDVKLGESVELVSHVAVAGRTTIGAGTRIFP
CCCCCCCEECCHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHCCCEECCCCEEEE
FASIGHRPQDLKYKGEPSTLEIGANNQIREHVTMNPGTEGGGMVTRVGDNCLFMASAHVA
EHHCCCCCCCCEECCCCCEEEECCCCCEEHEEEECCCCCCCCEEEEECCCEEEEEEHHHH
HDCILGDNVIMANNATLAGHVTVGEYAFLGGLSAVHQFVRIGRHAMIGGMSGVEADVIPF
HHEEECCCEEEECCCEEEEEEEECHHHHHHHHHHHHHHHHHCCHHEECCCCCCCCCCEEE
GMVIGNRAYLNGLNIVGLKRRGFSRDDIHTLRNAYRLMFAPEGTLAERLSDVEEQFKDHP
HHHCCCCHHCCCCEEEEEECCCCCHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHCCCC
VVMEIVAFIRSDSSRSLSTPNGS
HHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA