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The map label for this gene is hoxA [H]

Identifier: 83311383

GI number: 83311383

Start: 2485288

End: 2486727

Strand: Reverse

Name: hoxA [H]

Synonym: amb2284

Alternate gene names: 83311383

Gene position: 2486727-2485288 (Counterclockwise)

Preceding gene: 83311386

Following gene: 83311381

Centisome position: 50.06

GC content: 66.94

Gene sequence:

>1440_bases
ATGACCAGCCTGCCGATCATTCTGGTGGTCGACGACGAAAAGCAGTCGCAGGAGGCGCTGCGCCGGGTGCTGGCCGACGA
GTTCCAGGTGCTGACCGCCTCGACGGCGGAGGAAGCCGAAGGATTGCTGGAGCAGGAAATGGTCCATGCCATCCTGTGCG
ACCAGCGCATGCCCGGCATCCAGGGGGTGGACTTCCTCAAGGCGGTCCGCGACCGCTGGCCCGACCCGGTACGCATGATC
ATCTCGGGCTATTCCGAGGCCGAGGACATCATCGCCGGCGTCAACGAGGCCGGCATCTACCAGTACATCACCAAGCCGTG
GGAGCCGGACGAGTTGGTCCAGACCCTGCACGGCGCGCTGAAGCTGTATTCCCTCCAACGGGAAAACGCCCAGGCCAGCC
TGGACCTCAAGGTTCCTCCGGCGGCGCTGGAGCGCTCCATCGCCCGCAAAACCGGCACGCTGAAGCGCCAGCATCACTTC
GACGGCATCATCCATGCCCCGGATTCGCCCCTGACCGAGGTGATCGAGATGGCGCGCAAGGTGTCGTCCTTCGACATCTC
GGTGCTGATCACCGGCGAATCGGGCACCGGCAAGGAATTGCTGGCCCGCGCCATCCATTACAATTCCCCTCGCGGCAACA
AGCCCTTCGTGGTGGAGAATTGCGGCGCCCTGCCCGACCAATTGCTGGAATCCGAGCTGTTCGGCTGCAAGAAGGGCGCC
TTCACCGGCGCCTACGAGGACCGCATCGGCTTGTTCGAGCAGGCCTCGGGCGGCACCATCTTCCTCGACGAGATCGGCGA
GACCTCGCCCGCCTTCCAGGTCAAGCTCCTGCGCGTGCTGCAGGAAGGCGAAATCCGCCCCCTGGGCGCGCGCCTCACCC
GCAAGGTGGATGTGCGCGTCATCGCCGCCACCAACCGCAACCTGGAAGAAGAGGTGCGGGAAAAGCACTTCCGCCGCGAC
CTGTTCTACCGCCTGGCCGCCTTCCCCATCCATCTCCCGCCGCTGCGTGAACGCCCCATGGACGTGCCGCTGCTGGCTGA
ACGGCTGCTGGGCGAGACGGGCAAGGGATTCGGGCGGCCCAATCTGCGCTTCGGCCCCGAGGCCATGGCCCAGATGCGGG
GCTATGACTGGCCGGGCAATGTGCGCGAGCTGCAAAACGAGATCCAGCGCATGGTCGCCCTGGCGGAACACGCGGTGCTG
AGCCCCGACCTGCTGAGCCCCCGCCTCAGGGCGCGCATCTGCCCGGCCGGACGGGCCCTGGCCGACCAGGGCGAGCCGGC
CACCCTGAAGGAACAGGTGGAGATGCTCGAAGCCCGCCTGCTGGCCGAATCCTTGGGCCGGCACCGCTGGAACATCACCC
GGGTGGCCGAGGAGACCGGTCTGTCCCGGGTCGGCCTGCGGGCCAAGCTGCGGCGTTATGGCCTGGAACGGGAGGATTGA

Upstream 100 bases:

>100_bases
GTCATGATCCATCCATGCTGGTAATGAGTTGACCACCGTGGGCCGAGAGCCCAAGAATAGCGCACCTCACGCCCCCCTGA
CCACTGGAGCCAGTCCGGAC

Downstream 100 bases:

>100_bases
ACCAAGGGCTACGCCGCCCGCCGATCCAGTCGCCTCCGCAGGTCGTCCCAGTCGTTGGGCGCCATGCGCATGCTTTCAGC
CCAACCGGGCTTGGTGGGCT

Product: response regulator containing CheY-like receiver

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 479; Mature: 478

Protein sequence:

>479_residues
MTSLPIILVVDDEKQSQEALRRVLADEFQVLTASTAEEAEGLLEQEMVHAILCDQRMPGIQGVDFLKAVRDRWPDPVRMI
ISGYSEAEDIIAGVNEAGIYQYITKPWEPDELVQTLHGALKLYSLQRENAQASLDLKVPPAALERSIARKTGTLKRQHHF
DGIIHAPDSPLTEVIEMARKVSSFDISVLITGESGTGKELLARAIHYNSPRGNKPFVVENCGALPDQLLESELFGCKKGA
FTGAYEDRIGLFEQASGGTIFLDEIGETSPAFQVKLLRVLQEGEIRPLGARLTRKVDVRVIAATNRNLEEEVREKHFRRD
LFYRLAAFPIHLPPLRERPMDVPLLAERLLGETGKGFGRPNLRFGPEAMAQMRGYDWPGNVRELQNEIQRMVALAEHAVL
SPDLLSPRLRARICPAGRALADQGEPATLKEQVEMLEARLLAESLGRHRWNITRVAEETGLSRVGLRAKLRRYGLERED

Sequences:

>Translated_479_residues
MTSLPIILVVDDEKQSQEALRRVLADEFQVLTASTAEEAEGLLEQEMVHAILCDQRMPGIQGVDFLKAVRDRWPDPVRMI
ISGYSEAEDIIAGVNEAGIYQYITKPWEPDELVQTLHGALKLYSLQRENAQASLDLKVPPAALERSIARKTGTLKRQHHF
DGIIHAPDSPLTEVIEMARKVSSFDISVLITGESGTGKELLARAIHYNSPRGNKPFVVENCGALPDQLLESELFGCKKGA
FTGAYEDRIGLFEQASGGTIFLDEIGETSPAFQVKLLRVLQEGEIRPLGARLTRKVDVRVIAATNRNLEEEVREKHFRRD
LFYRLAAFPIHLPPLRERPMDVPLLAERLLGETGKGFGRPNLRFGPEAMAQMRGYDWPGNVRELQNEIQRMVALAEHAVL
SPDLLSPRLRARICPAGRALADQGEPATLKEQVEMLEARLLAESLGRHRWNITRVAEETGLSRVGLRAKLRRYGLERED
>Mature_478_residues
TSLPIILVVDDEKQSQEALRRVLADEFQVLTASTAEEAEGLLEQEMVHAILCDQRMPGIQGVDFLKAVRDRWPDPVRMII
SGYSEAEDIIAGVNEAGIYQYITKPWEPDELVQTLHGALKLYSLQRENAQASLDLKVPPAALERSIARKTGTLKRQHHFD
GIIHAPDSPLTEVIEMARKVSSFDISVLITGESGTGKELLARAIHYNSPRGNKPFVVENCGALPDQLLESELFGCKKGAF
TGAYEDRIGLFEQASGGTIFLDEIGETSPAFQVKLLRVLQEGEIRPLGARLTRKVDVRVIAATNRNLEEEVREKHFRRDL
FYRLAAFPIHLPPLRERPMDVPLLAERLLGETGKGFGRPNLRFGPEAMAQMRGYDWPGNVRELQNEIQRMVALAEHAVLS
PDLLSPRLRARICPAGRALADQGEPATLKEQVEMLEARLLAESLGRHRWNITRVAEETGLSRVGLRAKLRRYGLERED

Specific function: Probable member of the two-component regulatory system involved in the regulation of the hydrogenase activity. HoxA is probably phosphorylated by a sensory component (which could be hoxX) and then acts in conjunction with sigma-54 as a transcriptional act

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=480, Percent_Identity=38.5416666666667, Blast_Score=307, Evalue=1e-84,
Organism=Escherichia coli, GI1788905, Length=479, Percent_Identity=36.5344467640919, Blast_Score=270, Evalue=1e-73,
Organism=Escherichia coli, GI1790437, Length=467, Percent_Identity=37.0449678800857, Blast_Score=254, Evalue=1e-68,
Organism=Escherichia coli, GI1790299, Length=492, Percent_Identity=36.7886178861789, Blast_Score=254, Evalue=1e-68,
Organism=Escherichia coli, GI87082117, Length=307, Percent_Identity=45.6026058631922, Blast_Score=237, Evalue=1e-63,
Organism=Escherichia coli, GI1789087, Length=310, Percent_Identity=43.5483870967742, Blast_Score=231, Evalue=8e-62,
Organism=Escherichia coli, GI1789233, Length=345, Percent_Identity=39.1304347826087, Blast_Score=223, Evalue=2e-59,
Organism=Escherichia coli, GI87082152, Length=227, Percent_Identity=52.863436123348, Blast_Score=217, Evalue=2e-57,
Organism=Escherichia coli, GI1787583, Length=316, Percent_Identity=38.6075949367089, Blast_Score=204, Evalue=1e-53,
Organism=Escherichia coli, GI1786524, Length=299, Percent_Identity=43.1438127090301, Blast_Score=194, Evalue=1e-50,
Organism=Escherichia coli, GI87081872, Length=321, Percent_Identity=38.3177570093458, Blast_Score=185, Evalue=6e-48,
Organism=Escherichia coli, GI87081858, Length=239, Percent_Identity=36.4016736401674, Blast_Score=130, Evalue=3e-31,
Organism=Escherichia coli, GI1789828, Length=356, Percent_Identity=31.4606741573034, Blast_Score=124, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 53651; Mature: 53520

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSLPIILVVDDEKQSQEALRRVLADEFQVLTASTAEEAEGLLEQEMVHAILCDQRMPGI
CCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCC
QGVDFLKAVRDRWPDPVRMIISGYSEAEDIIAGVNEAGIYQYITKPWEPDELVQTLHGAL
CCHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHCCCCHHHHHHHCCCCCHHHHHHHHHHHH
KLYSLQRENAQASLDLKVPPAALERSIARKTGTLKRQHHFDGIIHAPDSPLTEVIEMARK
HHHHHHHCCCCCEEEECCCHHHHHHHHHHHHCCHHHHHCCCCEEECCCCCHHHHHHHHHH
VSSFDISVLITGESGTGKELLARAIHYNSPRGNKPFVVENCGALPDQLLESELFGCKKGA
HCCCEEEEEEECCCCCCHHHHHHHHHCCCCCCCCCEEEECCCCCHHHHHHHHHHCCCCCC
FTGAYEDRIGLFEQASGGTIFLDEIGETSPAFQVKLLRVLQEGEIRPLGARLTRKVDVRV
CCCCHHHHHCHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCHHHHHCEEEEEEE
IAATNRNLEEEVREKHFRRDLFYRLAAFPIHLPPLRERPMDVPLLAERLLGETGKGFGRP
EEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCC
NLRFGPEAMAQMRGYDWPGNVRELQNEIQRMVALAEHAVLSPDLLSPRLRARICPAGRAL
CCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHCCHHHHHHCCCCCCHH
ADQGEPATLKEQVEMLEARLLAESLGRHRWNITRVAEETGLSRVGLRAKLRRYGLERED
HCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TSLPIILVVDDEKQSQEALRRVLADEFQVLTASTAEEAEGLLEQEMVHAILCDQRMPGI
CCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCC
QGVDFLKAVRDRWPDPVRMIISGYSEAEDIIAGVNEAGIYQYITKPWEPDELVQTLHGAL
CCHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHCCCCHHHHHHHCCCCCHHHHHHHHHHHH
KLYSLQRENAQASLDLKVPPAALERSIARKTGTLKRQHHFDGIIHAPDSPLTEVIEMARK
HHHHHHHCCCCCEEEECCCHHHHHHHHHHHHCCHHHHHCCCCEEECCCCCHHHHHHHHHH
VSSFDISVLITGESGTGKELLARAIHYNSPRGNKPFVVENCGALPDQLLESELFGCKKGA
HCCCEEEEEEECCCCCCHHHHHHHHHCCCCCCCCCEEEECCCCCHHHHHHHHHHCCCCCC
FTGAYEDRIGLFEQASGGTIFLDEIGETSPAFQVKLLRVLQEGEIRPLGARLTRKVDVRV
CCCCHHHHHCHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCHHHHHCEEEEEEE
IAATNRNLEEEVREKHFRRDLFYRLAAFPIHLPPLRERPMDVPLLAERLLGETGKGFGRP
EEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCC
NLRFGPEAMAQMRGYDWPGNVRELQNEIQRMVALAEHAVLSPDLLSPRLRARICPAGRAL
CCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHCCHHHHHHCCCCCCHH
ADQGEPATLKEQVEMLEARLLAESLGRHRWNITRVAEETGLSRVGLRAKLRRYGLERED
HCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8510650; 12597275 [H]