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The map label for this gene is umuC [H]

Identifier: 83311165

GI number: 83311165

Start: 2245935

End: 2247212

Strand: Reverse

Name: umuC [H]

Synonym: amb2066

Alternate gene names: 83311165

Gene position: 2247212-2245935 (Counterclockwise)

Preceding gene: 83311166

Following gene: 83311160

Centisome position: 45.24

GC content: 58.53

Gene sequence:

>1278_bases
ATGGCGGTCTACGCCCTGGTGGACTGCAACAATTTTTACGTCTCTTGCGAACGGGCGTTCAATCCTGCCCTTGAAGGCAA
GCCGGTCATCGTCATGTCCAACAATGATGGCTGTGCCGTGGCCCGTTCCGCAGAGGCCAAAGCCATTGGCGTCGGCATGG
GCGAACCTGCCTTCAAATTGCGGCATCTGGTCGATAGCCATGGATTGATCATGCTGTCGAGCAACTACGCCCTGTACGGG
GACATGTCCGAAAGGGTGATGTCCGTTTTAGCGACATTCTCGCCGGGGGCCGAGATCTACAGCATCGACGAATGCTTTCT
GGATTTGGATGGCATGCCAGTGGACAACCTAACTGCATGGTCCCAGCAGGTACGTGCCACAGTGCGACGTTGGACCGGCA
TTCCCGTGTCGGTCGGGATCGGCACCACCAAGACCTTGGCGAAACTGGCCAACAGACTCGCAAAGAAATCCAAGAAGGCG
AATGGCGTGCTCGATCTGAGCCGTGATGCCCGATGGATAGAGGCCGCCCTCAAGCAGACCCCAGTCGGTGACGTGTGGGG
CATTGGCCGCCAGTATGCAGCCCTCTGTGGCGTGAATGGTATCCGAACCGCCTTTGACCTGACCTTGCAGCCAGATGGAT
GGATCAAGAAGACCATGGGGGCGGTCGGCCTTCGCACCGTGATGGAATTGCGAGGAACCCCCGTCCACACCCTGGACACG
GCACCATCAGACAAGCACACAACCTGCTGCTCGCGTTCGTTCGGTGCATCCGTTACAGAGTTTGAGCAAGTGCATGATGC
GGTGATGACCTTTGCCAGCCGGGCAGCCGAGAAAATTCGCGGTGAAGGACTGGTGTCCGGTGCTGTGCAGGTGTTCGCCT
ATACCGACAGGTTCCGCCCCGACCAGCCACAGTTTTCACTGAACTCCATGATCCGTCTGTCGCCACCGACATCATCCACG
CCGCACATCATTGGGGCGGCCCTGAAGGGGCTGAAATCAGCGTGGCGTGACGGCTACGAGTATAAGAAGGCAGGCGTGAT
CATGCTCGATTTGGTCCGCCCCGAAGACATCCCGCGTGACCTGTTTTCACCACCACCAGAATCAGGTGCACGGCCAACGG
CGTTGATGGCTGCGGTAGATGGCATCAACGGAAAGATGGGCAAAGGGGCTGTCGGATTCGGGTTGGTTCCCGACGACGCA
CCGTGGAAGATGCGATGCAGCAACCGAACCCCGAGCTTCACGACCAGTTGGGACGACATACCGGTGGTTAAGGCGTGA

Upstream 100 bases:

>100_bases
TCCGGACTACCCCAGCTTCTCCGTCGATCCTGATGATGGCGTCCAAATATGGGGCGTCGTCACCTTCTCCGTCTCGGCCT
TAGCCAAACGGTGATGGGCG

Downstream 100 bases:

>100_bases
TCAGTGGAGGATCACAGGGATCAGCCACAGCCGCATGATTTGTCGGCCTGGATCGGCGGACACGGCACCGAACCATAGGA
GCAGAACACGCAGCAATCGC

Product: DNA repair nucleotidyltransferase/DNA polymerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 425; Mature: 424

Protein sequence:

>425_residues
MAVYALVDCNNFYVSCERAFNPALEGKPVIVMSNNDGCAVARSAEAKAIGVGMGEPAFKLRHLVDSHGLIMLSSNYALYG
DMSERVMSVLATFSPGAEIYSIDECFLDLDGMPVDNLTAWSQQVRATVRRWTGIPVSVGIGTTKTLAKLANRLAKKSKKA
NGVLDLSRDARWIEAALKQTPVGDVWGIGRQYAALCGVNGIRTAFDLTLQPDGWIKKTMGAVGLRTVMELRGTPVHTLDT
APSDKHTTCCSRSFGASVTEFEQVHDAVMTFASRAAEKIRGEGLVSGAVQVFAYTDRFRPDQPQFSLNSMIRLSPPTSST
PHIIGAALKGLKSAWRDGYEYKKAGVIMLDLVRPEDIPRDLFSPPPESGARPTALMAAVDGINGKMGKGAVGFGLVPDDA
PWKMRCSNRTPSFTTSWDDIPVVKA

Sequences:

>Translated_425_residues
MAVYALVDCNNFYVSCERAFNPALEGKPVIVMSNNDGCAVARSAEAKAIGVGMGEPAFKLRHLVDSHGLIMLSSNYALYG
DMSERVMSVLATFSPGAEIYSIDECFLDLDGMPVDNLTAWSQQVRATVRRWTGIPVSVGIGTTKTLAKLANRLAKKSKKA
NGVLDLSRDARWIEAALKQTPVGDVWGIGRQYAALCGVNGIRTAFDLTLQPDGWIKKTMGAVGLRTVMELRGTPVHTLDT
APSDKHTTCCSRSFGASVTEFEQVHDAVMTFASRAAEKIRGEGLVSGAVQVFAYTDRFRPDQPQFSLNSMIRLSPPTSST
PHIIGAALKGLKSAWRDGYEYKKAGVIMLDLVRPEDIPRDLFSPPPESGARPTALMAAVDGINGKMGKGAVGFGLVPDDA
PWKMRCSNRTPSFTTSWDDIPVVKA
>Mature_424_residues
AVYALVDCNNFYVSCERAFNPALEGKPVIVMSNNDGCAVARSAEAKAIGVGMGEPAFKLRHLVDSHGLIMLSSNYALYGD
MSERVMSVLATFSPGAEIYSIDECFLDLDGMPVDNLTAWSQQVRATVRRWTGIPVSVGIGTTKTLAKLANRLAKKSKKAN
GVLDLSRDARWIEAALKQTPVGDVWGIGRQYAALCGVNGIRTAFDLTLQPDGWIKKTMGAVGLRTVMELRGTPVHTLDTA
PSDKHTTCCSRSFGASVTEFEQVHDAVMTFASRAAEKIRGEGLVSGAVQVFAYTDRFRPDQPQFSLNSMIRLSPPTSSTP
HIIGAALKGLKSAWRDGYEYKKAGVIMLDLVRPEDIPRDLFSPPPESGARPTALMAAVDGINGKMGKGAVGFGLVPDDAP
WKMRCSNRTPSFTTSWDDIPVVKA

Specific function: Involved in UV protection and mutation. Essential for induced (or SOS) mutagenesis. May modify the DNA replication machinery to allow bypass synthesis across a damaged template [H]

COG id: COG0389

COG function: function code L; Nucleotidyltransferase/DNA polymerase involved in DNA repair

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 umuC domain [H]

Homologues:

Organism=Escherichia coli, GI1787432, Length=427, Percent_Identity=41.92037470726, Blast_Score=315, Evalue=3e-87,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017961
- InterPro:   IPR001126
- InterPro:   IPR017963 [H]

Pfam domain/function: PF00817 IMS [H]

EC number: NA

Molecular weight: Translated: 45910; Mature: 45779

Theoretical pI: Translated: 8.55; Mature: 8.55

Prosite motif: PS50173 UMUC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVYALVDCNNFYVSCERAFNPALEGKPVIVMSNNDGCAVARSAEAKAIGVGMGEPAFKL
CEEEEEEECCCEEEEEEHHCCCCCCCCCEEEEECCCCCEEEECCCCCEEECCCCCHHHHH
RHLVDSHGLIMLSSNYALYGDMSERVMSVLATFSPGAEIYSIDECFLDLDGMPVDNLTAW
HHHHCCCCEEEEECCEEEECCHHHHHHHHHHHCCCCCCEEEHHHHHEECCCCCCCHHHHH
SQQVRATVRRWTGIPVSVGIGTTKTLAKLANRLAKKSKKANGVLDLSRDARWIEAALKQT
HHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCEECCCCHHHHHHHHHHC
PVGDVWGIGRQYAALCGVNGIRTAFDLTLQPDGWIKKTMGAVGLRTVMELRGTPVHTLDT
CCCHHHHCHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCEEECC
APSDKHTTCCSRSFGASVTEFEQVHDAVMTFASRAAEKIRGEGLVSGAVQVFAYTDRFRP
CCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHEEEEEECCCCCC
DQPQFSLNSMIRLSPPTSSTPHIIGAALKGLKSAWRDGYEYKKAGVIMLDLVRPEDIPRD
CCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCHH
LFSPPPESGARPTALMAAVDGINGKMGKGAVGFGLVPDDAPWKMRCSNRTPSFTTSWDDI
HCCCCCCCCCCCHHHHHHHCCCCCCCCCCCEECCCCCCCCCCEEEECCCCCCCCCCCCCC
PVVKA
CCCCC
>Mature Secondary Structure 
AVYALVDCNNFYVSCERAFNPALEGKPVIVMSNNDGCAVARSAEAKAIGVGMGEPAFKL
EEEEEEECCCEEEEEEHHCCCCCCCCCEEEEECCCCCEEEECCCCCEEECCCCCHHHHH
RHLVDSHGLIMLSSNYALYGDMSERVMSVLATFSPGAEIYSIDECFLDLDGMPVDNLTAW
HHHHCCCCEEEEECCEEEECCHHHHHHHHHHHCCCCCCEEEHHHHHEECCCCCCCHHHHH
SQQVRATVRRWTGIPVSVGIGTTKTLAKLANRLAKKSKKANGVLDLSRDARWIEAALKQT
HHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCEECCCCHHHHHHHHHHC
PVGDVWGIGRQYAALCGVNGIRTAFDLTLQPDGWIKKTMGAVGLRTVMELRGTPVHTLDT
CCCHHHHCHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCEEECC
APSDKHTTCCSRSFGASVTEFEQVHDAVMTFASRAAEKIRGEGLVSGAVQVFAYTDRFRP
CCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHEEEEEECCCCCC
DQPQFSLNSMIRLSPPTSSTPHIIGAALKGLKSAWRDGYEYKKAGVIMLDLVRPEDIPRD
CCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCHH
LFSPPPESGARPTALMAAVDGINGKMGKGAVGFGLVPDDAPWKMRCSNRTPSFTTSWDDI
HCCCCCCCCCCCHHHHHHHCCCCCCCCCCCEECCCCCCCCCCEEEECCCCCCCCCCCCCC
PVVKA
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2144275; 2203737; 11677609 [H]