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The map label for this gene is qor [C]

Identifier: 83310649

GI number: 83310649

Start: 1679548

End: 1680597

Strand: Reverse

Name: qor [C]

Synonym: amb1550

Alternate gene names: 83310649

Gene position: 1680597-1679548 (Counterclockwise)

Preceding gene: 83310650

Following gene: 83310647

Centisome position: 33.83

GC content: 67.52

Gene sequence:

>1050_bases
ATGCCTCCGGACCTCTCTTTGATTTATGGGTATAAAGGGGGTCCGGGGCATCGCCCCGGATGGGTTCGGGCGATAGCCCG
ACAAGACGGAGTGCTCGCCATGAAAGCCATCCTCTGCGATCAATTCGGCGGTTCCGAGGTGATGCGCCTGGCCGAGATCG
AGACGCCCGCTCCCGGTCCGGGCGAGGTACTGATCCGAATCCATGCCGCCGGGGTCAATCCGGTGGACTGGAAGATCCGC
GAAGGCGGGCTGGCGCGCCTGTTTCCCTGCAAGTTCCCGCTGATCCCCGGCTGGGACGCCGCCGGCACCGTCGCCGCGCT
GGGCGACGGGGTGACCGGCCTGTCCCTGGGCGAGCGGGTGTGGTCCTACTGCCGCAAGCCCGAGATCCAATGGGGCACCT
ACGCCGAATACGTGGTGATGAGCGCCTACGGCGTGGCGCCCATGCCGGCCGGCTTCACCTTTGCCCAGGCCTGCACCGTA
CCGCTGGCCGCGCTGACCGCCTGGCAATCCCTGCTGGAGGTGGCGGGCCTGCGTCCGGGCCAGAGCGTGCTGATCCATGC
CGGAGCGGGCGGCGTAGGCGGCTTTGCCATTCCCATCGCCAAATGGGTGGGCGCCACGGTGATCGCCACCGCCAAAGCCG
GCAATCACGACTATGTCCGCTCTCTGGGGGCCGACCACGTCATCGACTACTCGGCCACCGACTTCGTCGCCGCCACCCGA
GCCCTGGTCCCGGACGGCGTGGACATGGCGTTCGGCACGGTGGGCGGCGAGGTGCTGACCCGCTCCTACGAGGTGGTGAA
GCCGGGCGGCATCCTGGTCTCCATCACCGACAAGACCGACAAGGATCTGGCCGAGCGCCTGGGGATTCGCTGCAAATACG
TCTTCGTCAAACCCGATGGCGGCCATCTGCGGCGCCTGGCCGGCTTGGCCGAGCAGGGAATTCTCAGAATCCCCGAGATC
GTCGAGATGCCCCTGTCCCGCGCGGCGCAAGCGCTGGACCTGTCGCGCACCGGGCATGTGCGCGGCAAGATCGTGTTGAC
TATCGGCTGA

Upstream 100 bases:

>100_bases
TCCCCCGCACCGCCACCGGCAAGGTGCAGCGGTTCAAGCTGAGAGAGGCGGGGGCCTGAGACGATACGGGGCTCCCGCCC
CGTAACCCCGGCCGGAGGCG

Downstream 100 bases:

>100_bases
AACGCCTCATGTCATCCCGAGCACAGGCGAGGGATCTCCGCCTGGAGCATTGGTGCCGGTTGGGAATAGCCGCGCCAGGA
CGAGATCCCTCACTGCGTTC

Product: NADPH

Products: NADP(+); Semiquinone. [C]

Alternate protein names: NA

Number of amino acids: Translated: 349; Mature: 348

Protein sequence:

>349_residues
MPPDLSLIYGYKGGPGHRPGWVRAIARQDGVLAMKAILCDQFGGSEVMRLAEIETPAPGPGEVLIRIHAAGVNPVDWKIR
EGGLARLFPCKFPLIPGWDAAGTVAALGDGVTGLSLGERVWSYCRKPEIQWGTYAEYVVMSAYGVAPMPAGFTFAQACTV
PLAALTAWQSLLEVAGLRPGQSVLIHAGAGGVGGFAIPIAKWVGATVIATAKAGNHDYVRSLGADHVIDYSATDFVAATR
ALVPDGVDMAFGTVGGEVLTRSYEVVKPGGILVSITDKTDKDLAERLGIRCKYVFVKPDGGHLRRLAGLAEQGILRIPEI
VEMPLSRAAQALDLSRTGHVRGKIVLTIG

Sequences:

>Translated_349_residues
MPPDLSLIYGYKGGPGHRPGWVRAIARQDGVLAMKAILCDQFGGSEVMRLAEIETPAPGPGEVLIRIHAAGVNPVDWKIR
EGGLARLFPCKFPLIPGWDAAGTVAALGDGVTGLSLGERVWSYCRKPEIQWGTYAEYVVMSAYGVAPMPAGFTFAQACTV
PLAALTAWQSLLEVAGLRPGQSVLIHAGAGGVGGFAIPIAKWVGATVIATAKAGNHDYVRSLGADHVIDYSATDFVAATR
ALVPDGVDMAFGTVGGEVLTRSYEVVKPGGILVSITDKTDKDLAERLGIRCKYVFVKPDGGHLRRLAGLAEQGILRIPEI
VEMPLSRAAQALDLSRTGHVRGKIVLTIG
>Mature_348_residues
PPDLSLIYGYKGGPGHRPGWVRAIARQDGVLAMKAILCDQFGGSEVMRLAEIETPAPGPGEVLIRIHAAGVNPVDWKIRE
GGLARLFPCKFPLIPGWDAAGTVAALGDGVTGLSLGERVWSYCRKPEIQWGTYAEYVVMSAYGVAPMPAGFTFAQACTVP
LAALTAWQSLLEVAGLRPGQSVLIHAGAGGVGGFAIPIAKWVGATVIATAKAGNHDYVRSLGADHVIDYSATDFVAATRA
LVPDGVDMAFGTVGGEVLTRSYEVVKPGGILVSITDKTDKDLAERLGIRCKYVFVKPDGGHLRRLAGLAEQGILRIPEIV
EMPLSRAAQALDLSRTGHVRGKIVLTIG

Specific function: Unknown

COG id: COG0604

COG function: function code CR; NADPH:quinone reductase and related Zn-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI24308257, Length=241, Percent_Identity=32.7800829875519, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI47519420, Length=358, Percent_Identity=30.7262569832402, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI18379349, Length=214, Percent_Identity=34.1121495327103, Blast_Score=125, Evalue=5e-29,
Organism=Homo sapiens, GI194239674, Length=256, Percent_Identity=30.078125, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI13236495, Length=256, Percent_Identity=30.078125, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI194239676, Length=205, Percent_Identity=34.1463414634146, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI22538446, Length=232, Percent_Identity=33.1896551724138, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI22538444, Length=232, Percent_Identity=33.1896551724138, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI28557745, Length=222, Percent_Identity=31.5315315315315, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI67078404, Length=326, Percent_Identity=25.7668711656442, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI67078406, Length=302, Percent_Identity=26.158940397351, Blast_Score=65, Evalue=9e-11,
Organism=Escherichia coli, GI1790485, Length=258, Percent_Identity=30.6201550387597, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1789651, Length=254, Percent_Identity=28.3464566929134, Blast_Score=72, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17507255, Length=255, Percent_Identity=30.1960784313725, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI71987554, Length=351, Percent_Identity=27.6353276353276, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17562584, Length=235, Percent_Identity=28.5106382978723, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71988145, Length=221, Percent_Identity=23.9819004524887, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17562876, Length=227, Percent_Identity=26.431718061674, Blast_Score=68, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17562582, Length=268, Percent_Identity=25.3731343283582, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6319520, Length=248, Percent_Identity=30.6451612903226, Blast_Score=103, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6323961, Length=230, Percent_Identity=27.8260869565217, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24581339, Length=351, Percent_Identity=28.4900284900285, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24581341, Length=350, Percent_Identity=28, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI45550423, Length=329, Percent_Identity=24.9240121580547, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR014182
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 36815; Mature: 36684

Theoretical pI: Translated: 8.21; Mature: 8.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPDLSLIYGYKGGPGHRPGWVRAIARQDGVLAMKAILCDQFGGSEVMRLAEIETPAPGP
CCCCCEEEEECCCCCCCCCHHHHHHHHCCCHHHHHHHHHHCCCCHHHHEEHCCCCCCCCC
GEVLIRIHAAGVNPVDWKIREGGLARLFPCKFPLIPGWDAAGTVAALGDGVTGLSLGERV
CEEEEEEEECCCCCCCEEECCCCCEEEECCCCCCCCCCCCCCCHHHHCCCCCCHHHHHHH
WSYCRKPEIQWGTYAEYVVMSAYGVAPMPAGFTFAQACTVPLAALTAWQSLLEVAGLRPG
HHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
QSVLIHAGAGGVGGFAIPIAKWVGATVIATAKAGNHDYVRSLGADHVIDYSATDFVAATR
CEEEEECCCCCCCCHHHHHHHHHCCEEEEEECCCCHHHHHHCCCCCEECCCCHHHHHHHH
ALVPDGVDMAFGTVGGEVLTRSYEVVKPGGILVSITDKTDKDLAERLGIRCKYVFVKPDG
HHCCCCCCHHHHHCCHHHHHCCEEEECCCCEEEEECCCCCHHHHHHHCCEEEEEEEECCC
GHLRRLAGLAEQGILRIPEIVEMPLSRAAQALDLSRTGHVRGKIVLTIG
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEC
>Mature Secondary Structure 
PPDLSLIYGYKGGPGHRPGWVRAIARQDGVLAMKAILCDQFGGSEVMRLAEIETPAPGP
CCCCEEEEECCCCCCCCCHHHHHHHHCCCHHHHHHHHHHCCCCHHHHEEHCCCCCCCCC
GEVLIRIHAAGVNPVDWKIREGGLARLFPCKFPLIPGWDAAGTVAALGDGVTGLSLGERV
CEEEEEEEECCCCCCCEEECCCCCEEEECCCCCCCCCCCCCCCHHHHCCCCCCHHHHHHH
WSYCRKPEIQWGTYAEYVVMSAYGVAPMPAGFTFAQACTVPLAALTAWQSLLEVAGLRPG
HHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
QSVLIHAGAGGVGGFAIPIAKWVGATVIATAKAGNHDYVRSLGADHVIDYSATDFVAATR
CEEEEECCCCCCCCHHHHHHHHHCCEEEEEECCCCHHHHHHCCCCCEECCCCHHHHHHHH
ALVPDGVDMAFGTVGGEVLTRSYEVVKPGGILVSITDKTDKDLAERLGIRCKYVFVKPDG
HHCCCCCCHHHHHCCHHHHHCCEEEECCCCEEEEECCCCCHHHHHHHCCEEEEEEEECCC
GHLRRLAGLAEQGILRIPEIVEMPLSRAAQALDLSRTGHVRGKIVLTIG
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.26 {1,4-naphthoquinone}} 0.065 {1,4-benzoquinone}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.0024 {1,2-naphthoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA