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The map label for this gene is wecG [H]

Identifier: 83310538

GI number: 83310538

Start: 1567706

End: 1568473

Strand: Reverse

Name: wecG [H]

Synonym: amb1439

Alternate gene names: 83310538

Gene position: 1568473-1567706 (Counterclockwise)

Preceding gene: 83310539

Following gene: 83310535

Centisome position: 31.58

GC content: 68.88

Gene sequence:

>768_bases
ATGACCCACATCCCCAGCATCCTGATCGCGGGAGTCCGCGTCGATTCGCCCAGCTTCGCCGGGACCCTGGACTGGACCCT
GAACCGGATCACGGAGAGAAGCGGCGGCTATATCTGCCACCTGGGTGCCCATGGCGTGGTCGACGCCCAGCAAGACGCCG
TCCTGGCCCGGGCTCTGGCCGGCGCCGCCCTGGCCCTGCCCGACGGCATGCCCCTGGTCTGGCTGGGGCGATGGTTGGGC
CTGAAATCCGAGAGAGTCTATGGCCCGGACTTCATGCGGAGCCTGCTGGCGGCCACAGGGGATGGGCGTTGCCGCCACTT
CCTGTTCGGCTCCACCCCACAGGTGCTACGGGACCTGGAACGGCGCATCAGGGCGGACTATCCGGGGGCCACCATCGCGG
GCTGCCTGTCGCCGCCCTTCGGCCCTTCCAGTCCGGAGGAGACCGAGGCCCATCTCCATGCCATTCGCAACGCCGGGGCG
GATGTGGTCTGGGTAGGACTGGGGGCGCCCCGCCAGGAGAAATGGATGGCGGACGTCACCGCCCGCCTGCCCGGCATCCT
GCTGTTCGGCGTGGGAGCGGCCTTCGATTTCCTGTCGGGGACCAAGCCCCAGGCACCGGCCTTTGTCCGCCGAAGCGGCC
TGGAATGGGCCTTTCGCTGGCTGTCCGAGCCGCGACGCCTGACCAGCCGCTACGGGCGGGTTATTCCCGTCTTCCTGTGG
CTCGCCGCCAGGGAGCTGTGGTCAAGACGCCAGAACCGACCGGTATAG

Upstream 100 bases:

>100_bases
TGGGCCAAAACGCCCGCCAGGTCTATGCCTGCCGTTACAGCCCCCAGGTGGTCACCGACCTTCTGCTCGGCCATTACGCC
CGCCTGCGGGCCTCGCCGCC

Downstream 100 bases:

>100_bases
GGCCAGATACTCCTCGACCACCCGGTCCATGGTGAAGCGGGTGCGGACCGCGTCCCACCCGGCCCGACCCGTCCGCTCCC
AGGTTTTCGGGTCGGACAGC

Product: teichoic acid biosynthesis protein

Products: C55-PP-GlcNAc-ManNAcA; UDP [C]

Alternate protein names: UDP-ManNAcA transferase [H]

Number of amino acids: Translated: 255; Mature: 254

Protein sequence:

>255_residues
MTHIPSILIAGVRVDSPSFAGTLDWTLNRITERSGGYICHLGAHGVVDAQQDAVLARALAGAALALPDGMPLVWLGRWLG
LKSERVYGPDFMRSLLAATGDGRCRHFLFGSTPQVLRDLERRIRADYPGATIAGCLSPPFGPSSPEETEAHLHAIRNAGA
DVVWVGLGAPRQEKWMADVTARLPGILLFGVGAAFDFLSGTKPQAPAFVRRSGLEWAFRWLSEPRRLTSRYGRVIPVFLW
LAARELWSRRQNRPV

Sequences:

>Translated_255_residues
MTHIPSILIAGVRVDSPSFAGTLDWTLNRITERSGGYICHLGAHGVVDAQQDAVLARALAGAALALPDGMPLVWLGRWLG
LKSERVYGPDFMRSLLAATGDGRCRHFLFGSTPQVLRDLERRIRADYPGATIAGCLSPPFGPSSPEETEAHLHAIRNAGA
DVVWVGLGAPRQEKWMADVTARLPGILLFGVGAAFDFLSGTKPQAPAFVRRSGLEWAFRWLSEPRRLTSRYGRVIPVFLW
LAARELWSRRQNRPV
>Mature_254_residues
THIPSILIAGVRVDSPSFAGTLDWTLNRITERSGGYICHLGAHGVVDAQQDAVLARALAGAALALPDGMPLVWLGRWLGL
KSERVYGPDFMRSLLAATGDGRCRHFLFGSTPQVLRDLERRIRADYPGATIAGCLSPPFGPSSPEETEAHLHAIRNAGAD
VVWVGLGAPRQEKWMADVTARLPGILLFGVGAAFDFLSGTKPQAPAFVRRSGLEWAFRWLSEPRRLTSRYGRVIPVFLWL
AARELWSRRQNRPV

Specific function: Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA (Lipid II), the second lipid-linked intermediate involved in ECA synthesis [H]

COG id: COG1922

COG function: function code M; Teichoic acid biosynthesis proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 26 family [H]

Homologues:

Organism=Escherichia coli, GI2367289, Length=194, Percent_Identity=29.8969072164948, Blast_Score=87, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023085
- InterPro:   IPR004629 [H]

Pfam domain/function: PF03808 Glyco_tran_WecB [H]

EC number: 2.4.1.- [C]

Molecular weight: Translated: 28002; Mature: 27870

Theoretical pI: Translated: 10.48; Mature: 10.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHIPSILIAGVRVDSPSFAGTLDWTLNRITERSGGYICHLGAHGVVDAQQDAVLARALA
CCCCCCHHEEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHH
GAALALPDGMPLVWLGRWLGLKSERVYGPDFMRSLLAATGDGRCRHFLFGSTPQVLRDLE
HHHHCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHH
RRIRADYPGATIAGCLSPPFGPSSPEETEAHLHAIRNAGADVVWVGLGAPRQEKWMADVT
HHHHCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHH
ARLPGILLFGVGAAFDFLSGTKPQAPAFVRRSGLEWAFRWLSEPRRLTSRYGRVIPVFLW
HHCCHHEEHHHHHHHHHHCCCCCCCCHHHHHCCHHHHHHHHCCHHHHHHHHCCHHHHHHH
LAARELWSRRQNRPV
HHHHHHHHHHCCCCC
>Mature Secondary Structure 
THIPSILIAGVRVDSPSFAGTLDWTLNRITERSGGYICHLGAHGVVDAQQDAVLARALA
CCCCCHHEEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHH
GAALALPDGMPLVWLGRWLGLKSERVYGPDFMRSLLAATGDGRCRHFLFGSTPQVLRDLE
HHHHCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHH
RRIRADYPGATIAGCLSPPFGPSSPEETEAHLHAIRNAGADVVWVGLGAPRQEKWMADVT
HHHHCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHH
ARLPGILLFGVGAAFDFLSGTKPQAPAFVRRSGLEWAFRWLSEPRRLTSRYGRVIPVFLW
HHCCHHEEHHHHHHHHHHCCCCCCCCHHHHHCCHHHHHHHHCCHHHHHHHHCCHHHHHHH
LAARELWSRRQNRPV
HHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosaminuronic-acid; undecaprenyl-N-acetyl-alpha-D-glucosaminyl-pyrophosphate [C]

Specific reaction: UDP-N-acetyl-D-mannosaminuronic-acid + undecaprenyl-N-acetyl-alpha-D-glucosaminyl-pyrophosphate = C55-PP-GlcNAc-ManNAcA + UDP [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14528314 [H]