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The map label for this gene is glmS [H]

Identifier: 83310378

GI number: 83310378

Start: 1394949

End: 1396772

Strand: Reverse

Name: glmS [H]

Synonym: amb1279

Alternate gene names: 83310378

Gene position: 1396772-1394949 (Counterclockwise)

Preceding gene: 83310379

Following gene: 83310375

Centisome position: 28.12

GC content: 67.65

Gene sequence:

>1824_bases
ATGTGCGGCATCGTCGGAATCATCGGCAAAGTGGAAGCGGCCCCCCTCCTGGTGGAGGGATTGCGGCGCCTGGAATATCG
CGGCTATGACTCGGCGGGCATCGCCACCCTGGTGGACGGCCAGATCGAGCGCCGCCGCGCCGAAGGCAAGCTGGCCAATC
TCGAAGCCCTGCTGAAGACCCGGCCGGTGGGCGGGCTGATCGGCATCGGCCACACCCGCTGGGCCACCCACGGCGTGCCC
AACGAGCGCAACGCCCACCCCCATGCCACCAAGCGGGTGGCGGTGGTGCACAACGGCATCATCGAGAACTTCCACGAGTT
GAAGGCCGAACTGTCGGCCAAGGGCCAGGTGTTCGAGAGCGACACCGACACCGAGGCAGTGGCCCAGCTCATCGACTATC
ATCTCGCCCAGGGCATGGGGGCCGAGGACGCCACCGCCAAGGCCCTGGAGCGTCTGCAGGGCGCCTTCGCCCTGGGCATC
GTCTTCGCCGGGCGGCCCGACATGATGATCGCGGCGCGGCAGGGCTCGCCGCTGGCCATCGGCTATGGCGCGGGCGAGAT
GTATCTGGGCTCGGACGCCCTGGCGCTGGCGCCGCTGACCCAGAAGATCGCCTATCTCAACGATGGCGACTGGGCGGTGC
TGACCGCCGAGACCGTGGTCATCCGCGACCGCACCGGCGCCACCGTCACCCGCGAGGTGCGCCAGACCCAGTTCTCGGGC
GCCATGATCGGCAAGGGCGAGCACCGCCACTTCATGCTCAAGGAAATCTTCGAGCAGCCCGAAGTGGTGAGCAACGCGCT
CAACACCATGCTGAACCCGGCCGACCGCACCATCACCCTGCCCCGGCTGCCCTTCGATCTGGCGGCGGTGAAGCGGGTGC
GGATCATCGCCTGCGGCACCTCGTTCTACGCCGGTTCGGTGGCCAAGTACTGGATCGAGAAGCTGGCCCGCCTGCCGGTG
GAAGTGGATATCGCCTCCGAGTTCCGCTACCGCTGCCCGCCCATGGAGGCCGATGGCCTGGCCATCTTCATCTCCCAGTC
GGGCGAGACCGCCGACACCCTGGCTGCTCTGCGCTATTGCCGCGAGCATGGCCAGCACACCCTGTCCCTGGTCAACGTGC
CGGAAAGCACCATCGCCCGCGAATCCGAGGCCGCCCTGCTGACCATGGCCGGCCCCGAGATCGGCGTGGCGTCGACCAAG
GCCTTTACCACCCAGCTGACTGTGCTGGCCTGCCTGGCCATCGGCATGGGCCGCGCCACCGGCGCCCTGTCGGCGGAGGC
CGAGGCCGATATCTGTCGCTCGCTGTCGGAAATCCCCGCCCGCATCGCCGAAGTGCTGCGGCGCGACGACGACATCCGCG
TCATCGCCCAGGGCATCGCCGAGGCCCGCGACGTGCTCTATCTCGGGCGTGGCACCGGCTATCCCATCGCCCTGGAAGGC
GCGCTGAAGCTCAAGGAAATCAGCTATATCCACGCCGAGGCCTATGCCGCCGGCGAGCTCAAGCACGGCCCCATCGCGCT
GATCGACGATTCGGTCCCGGTCATCGTCATCTGCCCGACCGACGAGCTTTACGAGAAGACGGCCAGCAACGTCCAGGAAG
TGGTGGCCCGCGGCGGCCGCGTGGTGTTCTTCTCCGATCGGGAAGGCATCGACCGCCTGTCGGCCAAGGTCTTCTCCTCC
ATGGCCCTGCCCTCCGTCGACCCGGTGGTCGCACCCATCCTCTACGCTATTCCGGTGCAGTTGCTGGCCTATCACGTGGC
CGTCGCCAAGGGCACCGACGTGGATCAGCCCCGCAATCTGGCGAAAAGCGTCACGGTGGAATAA

Upstream 100 bases:

>100_bases
CGCTGGCGGTGGCGCGCGGCTCGCAGATGGAGCTGAAGGGCTGGGCCGAGCGCTTCCGCGCCCAGCAAGCCGCCAAGAAA
GCGAAGAAGGACTAGACGCC

Downstream 100 bases:

>100_bases
AAACGGGACCCTCGCCCCGGATGGGCCGGGCCATAAGACCCGATACGGTCGTCGGCGGCCCTCTACCGCCCCAGAAGGCT
CCGGATCCAGAGGACCGATT

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 607; Mature: 607

Protein sequence:

>607_residues
MCGIVGIIGKVEAAPLLVEGLRRLEYRGYDSAGIATLVDGQIERRRAEGKLANLEALLKTRPVGGLIGIGHTRWATHGVP
NERNAHPHATKRVAVVHNGIIENFHELKAELSAKGQVFESDTDTEAVAQLIDYHLAQGMGAEDATAKALERLQGAFALGI
VFAGRPDMMIAARQGSPLAIGYGAGEMYLGSDALALAPLTQKIAYLNDGDWAVLTAETVVIRDRTGATVTREVRQTQFSG
AMIGKGEHRHFMLKEIFEQPEVVSNALNTMLNPADRTITLPRLPFDLAAVKRVRIIACGTSFYAGSVAKYWIEKLARLPV
EVDIASEFRYRCPPMEADGLAIFISQSGETADTLAALRYCREHGQHTLSLVNVPESTIARESEAALLTMAGPEIGVASTK
AFTTQLTVLACLAIGMGRATGALSAEAEADICRSLSEIPARIAEVLRRDDDIRVIAQGIAEARDVLYLGRGTGYPIALEG
ALKLKEISYIHAEAYAAGELKHGPIALIDDSVPVIVICPTDELYEKTASNVQEVVARGGRVVFFSDREGIDRLSAKVFSS
MALPSVDPVVAPILYAIPVQLLAYHVAVAKGTDVDQPRNLAKSVTVE

Sequences:

>Translated_607_residues
MCGIVGIIGKVEAAPLLVEGLRRLEYRGYDSAGIATLVDGQIERRRAEGKLANLEALLKTRPVGGLIGIGHTRWATHGVP
NERNAHPHATKRVAVVHNGIIENFHELKAELSAKGQVFESDTDTEAVAQLIDYHLAQGMGAEDATAKALERLQGAFALGI
VFAGRPDMMIAARQGSPLAIGYGAGEMYLGSDALALAPLTQKIAYLNDGDWAVLTAETVVIRDRTGATVTREVRQTQFSG
AMIGKGEHRHFMLKEIFEQPEVVSNALNTMLNPADRTITLPRLPFDLAAVKRVRIIACGTSFYAGSVAKYWIEKLARLPV
EVDIASEFRYRCPPMEADGLAIFISQSGETADTLAALRYCREHGQHTLSLVNVPESTIARESEAALLTMAGPEIGVASTK
AFTTQLTVLACLAIGMGRATGALSAEAEADICRSLSEIPARIAEVLRRDDDIRVIAQGIAEARDVLYLGRGTGYPIALEG
ALKLKEISYIHAEAYAAGELKHGPIALIDDSVPVIVICPTDELYEKTASNVQEVVARGGRVVFFSDREGIDRLSAKVFSS
MALPSVDPVVAPILYAIPVQLLAYHVAVAKGTDVDQPRNLAKSVTVE
>Mature_607_residues
MCGIVGIIGKVEAAPLLVEGLRRLEYRGYDSAGIATLVDGQIERRRAEGKLANLEALLKTRPVGGLIGIGHTRWATHGVP
NERNAHPHATKRVAVVHNGIIENFHELKAELSAKGQVFESDTDTEAVAQLIDYHLAQGMGAEDATAKALERLQGAFALGI
VFAGRPDMMIAARQGSPLAIGYGAGEMYLGSDALALAPLTQKIAYLNDGDWAVLTAETVVIRDRTGATVTREVRQTQFSG
AMIGKGEHRHFMLKEIFEQPEVVSNALNTMLNPADRTITLPRLPFDLAAVKRVRIIACGTSFYAGSVAKYWIEKLARLPV
EVDIASEFRYRCPPMEADGLAIFISQSGETADTLAALRYCREHGQHTLSLVNVPESTIARESEAALLTMAGPEIGVASTK
AFTTQLTVLACLAIGMGRATGALSAEAEADICRSLSEIPARIAEVLRRDDDIRVIAQGIAEARDVLYLGRGTGYPIALEG
ALKLKEISYIHAEAYAAGELKHGPIALIDDSVPVIVICPTDELYEKTASNVQEVVARGGRVVFFSDREGIDRLSAKVFSS
MALPSVDPVVAPILYAIPVQLLAYHVAVAKGTDVDQPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI205277386, Length=685, Percent_Identity=38.5401459854015, Blast_Score=421, Evalue=1e-117,
Organism=Homo sapiens, GI4826742, Length=688, Percent_Identity=37.9360465116279, Blast_Score=416, Evalue=1e-116,
Organism=Escherichia coli, GI1790167, Length=611, Percent_Identity=51.063829787234, Blast_Score=599, Evalue=1e-172,
Organism=Escherichia coli, GI87082251, Length=313, Percent_Identity=22.0447284345048, Blast_Score=73, Evalue=6e-14,
Organism=Escherichia coli, GI1788651, Length=136, Percent_Identity=30.8823529411765, Blast_Score=66, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17532899, Length=715, Percent_Identity=33.4265734265734, Blast_Score=363, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17539970, Length=429, Percent_Identity=39.3939393939394, Blast_Score=297, Evalue=1e-80,
Organism=Caenorhabditis elegans, GI17532897, Length=429, Percent_Identity=38.4615384615385, Blast_Score=292, Evalue=4e-79,
Organism=Saccharomyces cerevisiae, GI6322745, Length=729, Percent_Identity=34.8422496570645, Blast_Score=338, Evalue=2e-93,
Organism=Saccharomyces cerevisiae, GI6323731, Length=429, Percent_Identity=31.9347319347319, Blast_Score=207, Evalue=5e-54,
Organism=Saccharomyces cerevisiae, GI6323730, Length=232, Percent_Identity=37.9310344827586, Blast_Score=125, Evalue=2e-29,
Organism=Drosophila melanogaster, GI21357745, Length=686, Percent_Identity=37.3177842565598, Blast_Score=419, Evalue=1e-117,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 65247; Mature: 65247

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGIIGKVEAAPLLVEGLRRLEYRGYDSAGIATLVDGQIERRRAEGKLANLEALLKT
CCCCEEEHHCCCHHHHHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHCCCHHHHHHHHHH
RPVGGLIGIGHTRWATHGVPNERNAHPHATKRVAVVHNGIIENFHELKAELSAKGQVFES
CCCCCEEECCCCCHHCCCCCCCCCCCCCHHHEEHHHHHHHHHHHHHHHHHHHCCCCEECC
DTDTEAVAQLIDYHLAQGMGAEDATAKALERLQGAFALGIVFAGRPDMMIAARQGSPLAI
CCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCEEEEEEEECCCCEEEEECCCCCEEE
GYGAGEMYLGSDALALAPLTQKIAYLNDGDWAVLTAETVVIRDRTGATVTREVRQTQFSG
EECCCCEEECCCCHHHHHHHHHHEEECCCCEEEEEEEEEEEECCCCCHHHHHHHHHHHCC
AMIGKGEHRHFMLKEIFEQPEVVSNALNTMLNPADRTITLPRLPFDLAAVKRVRIIACGT
CEECCCCCCCHHHHHHHCCHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHCEEEEEEECC
SFYAGSVAKYWIEKLARLPVEVDIASEFRYRCPPMEADGLAIFISQSGETADTLAALRYC
CHHHHHHHHHHHHHHHHCCEEEEEHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHHHHH
REHGQHTLSLVNVPESTIARESEAALLTMAGPEIGVASTKAFTTQLTVLACLAIGMGRAT
HHCCCCEEEEEECCHHHHCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCC
GALSAEAEADICRSLSEIPARIAEVLRRDDDIRVIAQGIAEARDVLYLGRGTGYPIALEG
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHEEEEECCCCCCEEEEC
ALKLKEISYIHAEAYAAGELKHGPIALIDDSVPVIVICPTDELYEKTASNVQEVVARGGR
CEEEHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHCCCE
VVFFSDREGIDRLSAKVFSSMALPSVDPVVAPILYAIPVQLLAYHVAVAKGTDVDQPRNL
EEEEECCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
AKSVTVE
HHHCCCC
>Mature Secondary Structure
MCGIVGIIGKVEAAPLLVEGLRRLEYRGYDSAGIATLVDGQIERRRAEGKLANLEALLKT
CCCCEEEHHCCCHHHHHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHCCCHHHHHHHHHH
RPVGGLIGIGHTRWATHGVPNERNAHPHATKRVAVVHNGIIENFHELKAELSAKGQVFES
CCCCCEEECCCCCHHCCCCCCCCCCCCCHHHEEHHHHHHHHHHHHHHHHHHHCCCCEECC
DTDTEAVAQLIDYHLAQGMGAEDATAKALERLQGAFALGIVFAGRPDMMIAARQGSPLAI
CCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCEEEEEEEECCCCEEEEECCCCCEEE
GYGAGEMYLGSDALALAPLTQKIAYLNDGDWAVLTAETVVIRDRTGATVTREVRQTQFSG
EECCCCEEECCCCHHHHHHHHHHEEECCCCEEEEEEEEEEEECCCCCHHHHHHHHHHHCC
AMIGKGEHRHFMLKEIFEQPEVVSNALNTMLNPADRTITLPRLPFDLAAVKRVRIIACGT
CEECCCCCCCHHHHHHHCCHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHCEEEEEEECC
SFYAGSVAKYWIEKLARLPVEVDIASEFRYRCPPMEADGLAIFISQSGETADTLAALRYC
CHHHHHHHHHHHHHHHHCCEEEEEHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHHHHH
REHGQHTLSLVNVPESTIARESEAALLTMAGPEIGVASTKAFTTQLTVLACLAIGMGRAT
HHCCCCEEEEEECCHHHHCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCC
GALSAEAEADICRSLSEIPARIAEVLRRDDDIRVIAQGIAEARDVLYLGRGTGYPIALEG
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHEEEEECCCCCCEEEEC
ALKLKEISYIHAEAYAAGELKHGPIALIDDSVPVIVICPTDELYEKTASNVQEVVARGGR
CEEEHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHCCCE
VVFFSDREGIDRLSAKVFSSMALPSVDPVVAPILYAIPVQLLAYHVAVAKGTDVDQPRNL
EEEEECCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
AKSVTVE
HHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]