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The map label for this gene is manP [H]

Identifier: 82752222

GI number: 82752222

Start: 2661673

End: 2663625

Strand: Direct

Name: manP [H]

Synonym: SAB2516

Alternate gene names: 82752222

Gene position: 2661673-2663625 (Clockwise)

Preceding gene: 82752221

Following gene: 82752223

Centisome position: 97.05

GC content: 38.2

Gene sequence:

>1953_bases
ATGAAAATTGTAGCTATTACCTCATGCCCAAATGGCATTGCACATACATATATGGCTCAAGAAAAACTTGAGCAGGTAGC
AAAAGAAATGGGTGTGGATATTAAAGTAGAGACACAGGGCGGTGTTGGTGCTGAAAATGTTTTAACTACGCAAGACATCG
AAGAAGCTGACGGTGTCATAATTGCAGCTGATAAACAAGTTGATCTGTCCCGATTTGTTGGTAAACGGTTGATTAATGAA
AATGTTCGCGAAGGGATTCATAATCCGAGAGGTCTAATTCAACGTATCATTAATCAAGATGCGCCTATTTATCAATCTGA
AACAAATTATCATTCGAAAGATCGCGGTAAGTCTAAAAGTGGTATTCAAATGGTGTATCAACATTTAATGAACGGTGTAT
CGTTTATGGTTCCTTTTATCGTAGTTGGTGGACTCCTTATCGCCATCGCGCTGACTCTAGGCGGTGAAACGACAACAAAA
GGATTAGTCATCCCAGATGATTCATTTTGGAAATCCATTGAAAACATTGGTAGTTTAGCCTTTAAATTTATGGTCCCAAT
ACTAGCTGGATATATCGCTGTTAGTATCGCTGACAAGCCCGGTCTTGTTCCTGGTATGATTGGCGGCGCTATCGCTGCTG
ACGGTAGTTTTTATGGCAGTGATGCAGGCGCAGGATTTTTAGGTGGTATTGTTGCTGGTTTCTTAGCAGGTTATATCGCA
AAGTGGATTAAAGATATTAAAGTTCCAAAAGCAATGGCACCAATTATGCCTATCATTATTATTCCCATTATTTCATCGGT
CGTTGTAGGATTGATATTTATATTTTTAATCGGTGCACCAATTTCTAATATTTTTGAGGCATTAACAACCTGGTTAAAAA
GTATGCAAGGTGCTAATATTATTATACTTGCGATGATTATAGGTGCGATGATCGCCTTCGATATGGGCGGTCCAGTAAAC
AAAGTAGCATTTTTATTTGGCTCAGCACTTATTGCTGAAGGTAATTACGCCGTTATGGGTATGGTCGCAGTTGCTGTATG
TACACCACCAATCGGTTTAGGTTTAGCAACGTTTGTTCAAAAGTATAAATTCAATCATTCCGAAAGAGAAATGGGTAAGG
CTTCCTTCACTATGGGACTATTTGGTATTACTGAAGGTGCTATTCCTTTCGCAGCGCAAGATCCATTGCGCATTATACCT
GCAAACATCATTGGTGCAATGATTGCATCAGTCATTGCAGCCATTGGTGGTGTCGGCGATAGAGTCGCACATGGAGGTCC
AATCGTGGCTGTATTAGGTGGTATTGATCATATATTATGGTTTATCTTTGCAGTGATAGTAGGTAGTCTTGTCACAATGA
TTACTGTACTATTATTAAAACGCAATACACCAGTTATAGCAGTAGACGCACCAGCGCAACACACACAACTTCATGATACA
AATATAACACAACATGATACAGAGGTTGACAATGTAGATAACACCGCGAAACATTCACATCCCAATAAACCTTCTCATGT
TTTTGATCAACAAACTATGATAATTACTGATTACGACATGTCTCGAAACGAAGCAATTGATATGTTGATTCATAAACTTA
AAATTTGCCGTTATGTAGAGCACACATCACATTTAAAAAATGCAATCCTAGAACGTGAAATGGAGTCTACGACAGCTATT
GGCATGAACGTGGCTATTCCACATGCAAAGTCTGATGTTGTAAAACAACCGATTGTAGCTGTTATGAAAAATAATCATGG
TGTTAAATGGGAAAGTCTAGATGGTAGTCTACCTCAATTGATATTCTTAATTGCCGTACCAAACAACAGTCAGGATACAC
ATTTAAAAATACTTCAGCGCTTATCTAAAGCGTTAATGAATGATGAGACACGCCAATCACTAATTAATGCAAACAGTACT
ACAGAAATTTACAACTTATTAATGAAAATATAG

Upstream 100 bases:

>100_bases
GTTATTTGAATACTTACAAGAATAATTGCCACTAGTAACGGTAATTATTCTTTTTTTAGTATCGAGAATACGCTTACAAT
ATAGAAAAGGAGATGATTTT

Downstream 100 bases:

>100_bases
AGGAGTTTTAACTATGGCATTATTTTTACAACCCGTTTTTAAAGACAGAATTTGGGGCGGTCATGCATTAAAAGCATTTA
ACTATGATATCCCTAATGAA

Product: PTS system fructose-specific II component

Products: NA

Alternate protein names: EIIBCA-Man; EII-Man; Mannose-specific phosphotransferase enzyme IIB component; PTS system mannose-specific EIIB component; Mannose permease IIC component; PTS system mannose-specific EIIC component; Mannose-specific phosphotransferase enzyme IIA component; PTS system mannose-specific EIIA component [H]

Number of amino acids: Translated: 650; Mature: 650

Protein sequence:

>650_residues
MKIVAITSCPNGIAHTYMAQEKLEQVAKEMGVDIKVETQGGVGAENVLTTQDIEEADGVIIAADKQVDLSRFVGKRLINE
NVREGIHNPRGLIQRIINQDAPIYQSETNYHSKDRGKSKSGIQMVYQHLMNGVSFMVPFIVVGGLLIAIALTLGGETTTK
GLVIPDDSFWKSIENIGSLAFKFMVPILAGYIAVSIADKPGLVPGMIGGAIAADGSFYGSDAGAGFLGGIVAGFLAGYIA
KWIKDIKVPKAMAPIMPIIIIPIISSVVVGLIFIFLIGAPISNIFEALTTWLKSMQGANIIILAMIIGAMIAFDMGGPVN
KVAFLFGSALIAEGNYAVMGMVAVAVCTPPIGLGLATFVQKYKFNHSEREMGKASFTMGLFGITEGAIPFAAQDPLRIIP
ANIIGAMIASVIAAIGGVGDRVAHGGPIVAVLGGIDHILWFIFAVIVGSLVTMITVLLLKRNTPVIAVDAPAQHTQLHDT
NITQHDTEVDNVDNTAKHSHPNKPSHVFDQQTMIITDYDMSRNEAIDMLIHKLKICRYVEHTSHLKNAILEREMESTTAI
GMNVAIPHAKSDVVKQPIVAVMKNNHGVKWESLDGSLPQLIFLIAVPNNSQDTHLKILQRLSKALMNDETRQSLINANST
TEIYNLLMKI

Sequences:

>Translated_650_residues
MKIVAITSCPNGIAHTYMAQEKLEQVAKEMGVDIKVETQGGVGAENVLTTQDIEEADGVIIAADKQVDLSRFVGKRLINE
NVREGIHNPRGLIQRIINQDAPIYQSETNYHSKDRGKSKSGIQMVYQHLMNGVSFMVPFIVVGGLLIAIALTLGGETTTK
GLVIPDDSFWKSIENIGSLAFKFMVPILAGYIAVSIADKPGLVPGMIGGAIAADGSFYGSDAGAGFLGGIVAGFLAGYIA
KWIKDIKVPKAMAPIMPIIIIPIISSVVVGLIFIFLIGAPISNIFEALTTWLKSMQGANIIILAMIIGAMIAFDMGGPVN
KVAFLFGSALIAEGNYAVMGMVAVAVCTPPIGLGLATFVQKYKFNHSEREMGKASFTMGLFGITEGAIPFAAQDPLRIIP
ANIIGAMIASVIAAIGGVGDRVAHGGPIVAVLGGIDHILWFIFAVIVGSLVTMITVLLLKRNTPVIAVDAPAQHTQLHDT
NITQHDTEVDNVDNTAKHSHPNKPSHVFDQQTMIITDYDMSRNEAIDMLIHKLKICRYVEHTSHLKNAILEREMESTTAI
GMNVAIPHAKSDVVKQPIVAVMKNNHGVKWESLDGSLPQLIFLIAVPNNSQDTHLKILQRLSKALMNDETRQSLINANST
TEIYNLLMKI
>Mature_650_residues
MKIVAITSCPNGIAHTYMAQEKLEQVAKEMGVDIKVETQGGVGAENVLTTQDIEEADGVIIAADKQVDLSRFVGKRLINE
NVREGIHNPRGLIQRIINQDAPIYQSETNYHSKDRGKSKSGIQMVYQHLMNGVSFMVPFIVVGGLLIAIALTLGGETTTK
GLVIPDDSFWKSIENIGSLAFKFMVPILAGYIAVSIADKPGLVPGMIGGAIAADGSFYGSDAGAGFLGGIVAGFLAGYIA
KWIKDIKVPKAMAPIMPIIIIPIISSVVVGLIFIFLIGAPISNIFEALTTWLKSMQGANIIILAMIIGAMIAFDMGGPVN
KVAFLFGSALIAEGNYAVMGMVAVAVCTPPIGLGLATFVQKYKFNHSEREMGKASFTMGLFGITEGAIPFAAQDPLRIIP
ANIIGAMIASVIAAIGGVGDRVAHGGPIVAVLGGIDHILWFIFAVIVGSLVTMITVLLLKRNTPVIAVDAPAQHTQLHDT
NITQHDTEVDNVDNTAKHSHPNKPSHVFDQQTMIITDYDMSRNEAIDMLIHKLKICRYVEHTSHLKNAILEREMESTTAI
GMNVAIPHAKSDVVKQPIVAVMKNNHGVKWESLDGSLPQLIFLIAVPNNSQDTHLKILQRLSKALMNDETRQSLINANST
TEIYNLLMKI

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This

COG id: COG1299

COG function: function code G; Phosphotransferase system, fructose-specific IIC component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-2 domain [H]

Homologues:

Organism=Escherichia coli, GI1788492, Length=462, Percent_Identity=42.4242424242424, Blast_Score=366, Evalue=1e-102,
Organism=Escherichia coli, GI87082348, Length=433, Percent_Identity=36.9515011547344, Blast_Score=266, Evalue=2e-72,
Organism=Escherichia coli, GI1786951, Length=469, Percent_Identity=33.6886993603412, Blast_Score=256, Evalue=2e-69,
Organism=Escherichia coli, GI1790386, Length=306, Percent_Identity=43.4640522875817, Blast_Score=251, Evalue=1e-67,
Organism=Escherichia coli, GI1788729, Length=377, Percent_Identity=27.3209549071618, Blast_Score=112, Evalue=9e-26,
Organism=Escherichia coli, GI1790387, Length=96, Percent_Identity=43.75, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1788730, Length=96, Percent_Identity=40.625, Blast_Score=73, Evalue=7e-14,
Organism=Escherichia coli, GI1788726, Length=135, Percent_Identity=31.1111111111111, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI48994992, Length=112, Percent_Identity=32.1428571428571, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016152
- InterPro:   IPR002178
- InterPro:   IPR013011
- InterPro:   IPR003501
- InterPro:   IPR003352
- InterPro:   IPR013014
- InterPro:   IPR004715
- InterPro:   IPR003353
- InterPro:   IPR006327 [H]

Pfam domain/function: PF00359 PTS_EIIA_2; PF02378 PTS_EIIC; PF02302 PTS_IIB [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 69920; Mature: 69920

Theoretical pI: Translated: 6.83; Mature: 6.83

Prosite motif: PS00372 PTS_EIIA_TYPE_2_HIS ; PS51094 PTS_EIIA_TYPE_2 ; PS51099 PTS_EIIB_TYPE_2 ; PS51104 PTS_EIIC_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIVAITSCPNGIAHTYMAQEKLEQVAKEMGVDIKVETQGGVGAENVLTTQDIEEADGVI
CEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCHHHHCCEE
IAADKQVDLSRFVGKRLINENVREGIHNPRGLIQRIINQDAPIYQSETNYHSKDRGKSKS
EEECCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCEECCCCCCCCCCCCCCH
GIQMVYQHLMNGVSFMVPFIVVGGLLIAIALTLGGETTTKGLVIPDDSFWKSIENIGSLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCHHHHHHHHHHHHHH
FKFMVPILAGYIAVSIADKPGLVPGMIGGAIAADGSFYGSDAGAGFLGGIVAGFLAGYIA
HHHHHHHHHHHHHEEECCCCCCCCHHHCCHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
KWIKDIKVPKAMAPIMPIIIIPIISSVVVGLIFIFLIGAPISNIFEALTTWLKSMQGANI
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCC
IILAMIIGAMIAFDMGGPVNKVAFLFGSALIAEGNYAVMGMVAVAVCTPPIGLGLATFVQ
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHH
KYKFNHSEREMGKASFTMGLFGITEGAIPFAAQDPLRIIPANIIGAMIASVIAAIGGVGD
HHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEECHHHHHHHHHHHHHHHCCCCC
RVAHGGPIVAVLGGIDHILWFIFAVIVGSLVTMITVLLLKRNTPVIAVDAPAQHTQLHDT
HHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCC
NITQHDTEVDNVDNTAKHSHPNKPSHVFDQQTMIITDYDMSRNEAIDMLIHKLKICRYVE
CCCCCCCCCCCCCCHHHCCCCCCCCHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHH
HTSHLKNAILEREMESTTAIGMNVAIPHAKSDVVKQPIVAVMKNNHGVKWESLDGSLPQL
HHHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHCCCCCCEEECCCCCCCEE
IFLIAVPNNSQDTHLKILQRLSKALMNDETRQSLINANSTTEIYNLLMKI
EEEEECCCCCCHHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHCC
>Mature Secondary Structure
MKIVAITSCPNGIAHTYMAQEKLEQVAKEMGVDIKVETQGGVGAENVLTTQDIEEADGVI
CEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCHHHHCCEE
IAADKQVDLSRFVGKRLINENVREGIHNPRGLIQRIINQDAPIYQSETNYHSKDRGKSKS
EEECCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCEECCCCCCCCCCCCCCH
GIQMVYQHLMNGVSFMVPFIVVGGLLIAIALTLGGETTTKGLVIPDDSFWKSIENIGSLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCHHHHHHHHHHHHHH
FKFMVPILAGYIAVSIADKPGLVPGMIGGAIAADGSFYGSDAGAGFLGGIVAGFLAGYIA
HHHHHHHHHHHHHEEECCCCCCCCHHHCCHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
KWIKDIKVPKAMAPIMPIIIIPIISSVVVGLIFIFLIGAPISNIFEALTTWLKSMQGANI
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCC
IILAMIIGAMIAFDMGGPVNKVAFLFGSALIAEGNYAVMGMVAVAVCTPPIGLGLATFVQ
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHH
KYKFNHSEREMGKASFTMGLFGITEGAIPFAAQDPLRIIPANIIGAMIASVIAAIGGVGD
HHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEECHHHHHHHHHHHHHHHCCCCC
RVAHGGPIVAVLGGIDHILWFIFAVIVGSLVTMITVLLLKRNTPVIAVDAPAQHTQLHDT
HHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCC
NITQHDTEVDNVDNTAKHSHPNKPSHVFDQQTMIITDYDMSRNEAIDMLIHKLKICRYVE
CCCCCCCCCCCCCCHHHCCCCCCCCHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHH
HTSHLKNAILEREMESTTAIGMNVAIPHAKSDVVKQPIVAVMKNNHGVKWESLDGSLPQL
HHHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHCCCCCCEEECCCCCCCEE
IFLIAVPNNSQDTHLKILQRLSKALMNDETRQSLINANSTTEIYNLLMKI
EEEEECCCCCCHHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]