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The map label for this gene is sirC [H]

Identifier: 82752199

GI number: 82752199

Start: 2633637

End: 2634242

Strand: Reverse

Name: sirC [H]

Synonym: SAB2493c

Alternate gene names: 82752199

Gene position: 2634242-2633637 (Counterclockwise)

Preceding gene: 82752200

Following gene: 82752198

Centisome position: 96.05

GC content: 36.63

Gene sequence:

>606_bases
ATGAATATGCCATTAATGCTAGATTTAACAAATAAAAATGTCGTCATAGTTGGTGGAGGCGTCGTTGCAAGTCGTCGGGC
ACAAACATTAAGTCAATATATTGAACATATAATGGTTATCAGTCCTGAAATCACTGAAAAACTTCAAAATATGGTAGATA
AAGGTGTCGTCATATGGAAAGAAAAAGAGTTTGAACCAAGTGATATTGTAGACGCCTATCTAGTCATTGCAGCAACCAAT
GAGCCACGTGTCAATGAAGCGGTAAAACAAGCCTTACCTGAGCATGCCCTTTTTAATAATGTTGGAGATGCATCAAATGG
CAATGTTGTATTTCCAAGTGCACTACACCGCGACAAGCTAACTATCAGTGTATCAACTGATGGTGCGAGTCCTAAGTTGA
CAAAATCAATTATGGCAGAGCTTGAGGCGTTATATCCACCATCATACAGTTCGTATATCGACTTTTTATATACTTGCCGA
CAGAAAATAAAAGTACTTGATATGAATCACAGCGAAAAGCAGCAATTGTTATCACAAATAGTGACGAAAGAATTTTTAAA
CGATACTAAACAAGCTCAATTTTTGGCATGGTTAGATAAACAATAA

Upstream 100 bases:

>100_bases
TGAAACAACAACAACGCTATCAACGTGATGTTTATTAACGATTGGTGTTAAATATTTTAAGGTGTAATGATGTAAAATTA
TATAAAGGATGTTGCTCAAC

Downstream 100 bases:

>100_bases
TAACTGTGTGCCGTCTAAAGGCAGTCTTGAAGTAATAACATGTCTGTTTATAAATGAAGATGGGATGCACACTAATAATT
TCTAAGCGAAGATGATAAAC

Product: precorrin-2 dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 201; Mature: 201

Protein sequence:

>201_residues
MNMPLMLDLTNKNVVIVGGGVVASRRAQTLSQYIEHIMVISPEITEKLQNMVDKGVVIWKEKEFEPSDIVDAYLVIAATN
EPRVNEAVKQALPEHALFNNVGDASNGNVVFPSALHRDKLTISVSTDGASPKLTKSIMAELEALYPPSYSSYIDFLYTCR
QKIKVLDMNHSEKQQLLSQIVTKEFLNDTKQAQFLAWLDKQ

Sequences:

>Translated_201_residues
MNMPLMLDLTNKNVVIVGGGVVASRRAQTLSQYIEHIMVISPEITEKLQNMVDKGVVIWKEKEFEPSDIVDAYLVIAATN
EPRVNEAVKQALPEHALFNNVGDASNGNVVFPSALHRDKLTISVSTDGASPKLTKSIMAELEALYPPSYSSYIDFLYTCR
QKIKVLDMNHSEKQQLLSQIVTKEFLNDTKQAQFLAWLDKQ
>Mature_201_residues
MNMPLMLDLTNKNVVIVGGGVVASRRAQTLSQYIEHIMVISPEITEKLQNMVDKGVVIWKEKEFEPSDIVDAYLVIAATN
EPRVNEAVKQALPEHALFNNVGDASNGNVVFPSALHRDKLTISVSTDGASPKLTKSIMAELEALYPPSYSSYIDFLYTCR
QKIKVLDMNHSEKQQLLSQIVTKEFLNDTKQAQFLAWLDKQ

Specific function: Catalyzes the dehydrogenation of precorrin-2 to form sirohydrochlorin used as precursor in both siroheme biosynthesis and in the anaerobic branch of adenosylcobalamin biosynthesis [H]

COG id: COG1648

COG function: function code H; Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1789768, Length=196, Percent_Identity=28.0612244897959, Blast_Score=83, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR006367 [H]

Pfam domain/function: NA

EC number: =1.3.1.76 [H]

Molecular weight: Translated: 22524; Mature: 22524

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNMPLMLDLTNKNVVIVGGGVVASRRAQTLSQYIEHIMVISPEITEKLQNMVDKGVVIWK
CCCCEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCEEEEE
EKEFEPSDIVDAYLVIAATNEPRVNEAVKQALPEHALFNNVGDASNGNVVFPSALHRDKL
CCCCCCHHHHEEEEEEEECCCCHHHHHHHHHCCHHHHHHCCCCCCCCCEEECCCCCCCEE
TISVSTDGASPKLTKSIMAELEALYPPSYSSYIDFLYTCRQKIKVLDMNHSEKQQLLSQI
EEEEECCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHH
VTKEFLNDTKQAQFLAWLDKQ
HHHHHHCHHHHHHHHHHHCCC
>Mature Secondary Structure
MNMPLMLDLTNKNVVIVGGGVVASRRAQTLSQYIEHIMVISPEITEKLQNMVDKGVVIWK
CCCCEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCEEEEE
EKEFEPSDIVDAYLVIAATNEPRVNEAVKQALPEHALFNNVGDASNGNVVFPSALHRDKL
CCCCCCHHHHEEEEEEEECCCCHHHHHHHHHCCHHHHHHCCCCCCCCCEEECCCCCCCEE
TISVSTDGASPKLTKSIMAELEALYPPSYSSYIDFLYTCRQKIKVLDMNHSEKQQLLSQI
EEEEECCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHH
VTKEFLNDTKQAQFLAWLDKQ
HHHHHHCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA