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The map label for this gene is nhaK [H]

Identifier: 82752035

GI number: 82752035

Start: 2452208

End: 2454286

Strand: Direct

Name: nhaK [H]

Synonym: SAB2321

Alternate gene names: 82752035

Gene position: 2452208-2454286 (Clockwise)

Preceding gene: 82752034

Following gene: 82752037

Centisome position: 89.41

GC content: 32.28

Gene sequence:

>2079_bases
ATGGCACTATTAGAAGCATTTTTAATTTTTATTTTTGCTGTGATTATTAGTTCGGTTATCAATAATCGATTCCCACAAAT
TCCTACTGCCTTTATTCAAATTGCATTAGGTGTCGTTATTTTCATTATTCCAATACAAGTTGATTTCCAATTCAATTCTG
AAGTATTTATGTTTGCCGTTATCGCGCCACTACTTTTTGTGGAAGGTACCCACGTCTCTCGAACAAAATTATTAGAATAT
CGTAAACCTATACTATTAATGTCAATGGCACTAGTTTTTGCAACTGTAGTCGGTGTTGGCTATTTTATACATTGGATTTG
GCCTGCCTTACCAATGCCAGCCGCTTTTGCAATAGCAGCAATTTTATGTCCTACTGATGCAGTAGCAGTATCTGCTATTA
CACGTGGAAAATTATTACCTAAAGGTTCTATGACGATTTTAGAAGGTGAATCTTTACTCAATGATGCAGCAGGTATCATT
TCATTTAAAATTGCTGTTACTGCATTAGTAACTGGTACCTTTTCATTATTCCAAGCTGTTGAACAATTTATCATTTCAAC
AATACTAGGTGTACTTATTGGTGCAATTATTGGATTCGTTGTCGTTAGAATACGTATAGACTTATCAGCTAATAAAGGTT
TAAAAGATAACAATACCTTAACTTTTATTCAATTATTAACTCCTTTTGTCGTATACTTTTTAGCAGAAGAAGTTCATGCT
TCAGGTATCATTGCAGTTGTAATCGCAGGTCTAATCCATGGTTTAGAACGCGACCGTTTAATTAGAGCACAAACGGAACT
ACAAATGAATTACCATCAAATTTGGAACACATTTAGTTATGCCTTAAATGGTTTTGTATTTGTTGTATTAGGTTTTATGA
TTCCTACTGTAGTCATAGATATTTTCCAAACAGAGCCTGACAACTTTTCATTTTTAATAGTGATCACTATATTAATCGCT
ATTGCAATTTATGCATGTCGATTTGTTTGGGTTTATTTCTGGTACAAAGATTTTTATTTCCCGAAAAATATACAATCTTA
TCTAGACGAGGAACATGATTCACATGAAACACCACCTTCTCGTGTGCGTTACGCATTTATTATGACGATGTGTGGTATTC
ACGGTACAATTTCACTTTCAATGGCACTTACATTACCATTTATCATTACAAAAGGACAAGCATTCGAATACCGTAATGAT
TTATTGTTTATTGCATCTTTCATGGTATTAATTAGTTTAATCTTAGCGCAAATTGTTTTACCTTTAATTACACCATCTGC
CGAAGATACTACTTTTAAAGGTATGACTTATCAATCTGCCAAAATTTTCATTGTTCAAAAAGTGATCCAGCATTTTAAAA
ACGAAAGTAAAAAAGACAAAAACGATACAAATTATCGCCCAGTATTAAACCAATACTATGGAGAATTGTTATTTTTATTA
AATTCAGAACCTGATAATCAAAATACAAAAGAACTCAAACGTTTAGAAGATATTGCAAAAGTAATCGAAACATCTACACT
TGAGCGTTTAATTGATAAAGGTAAGGCAACATATCAGGATATAAATAATTACCGCAATATTGTCGAATTAACAGAGACAC
ACCGTACTGCTTCATTTGTTGAAAAATTTGCAAACTTCTTCAAGATGTTATGGCTTAGACTTAAAGCGATGAAGCACTAC
AAAGCCTTAAACAAAGAATCTAAGAAGCAAGAATTTGAAAATTCATTCAAAGATGTTCAAAAAATTATGCGTATTGTGAA
TCACAATATTATTTTACGCTTAAAAGAAGAACAAAATAGTACAAATGTACTTGAGGTTAGCTTAGTCATTAATCATTACT
ATGATATGAGTCGCTCATTAAAGTGGCGTGCACAACGTCGAAAAGAACGTCAAGAAAACAGCAATCAAATCATACCGCAA
GCTATGTTCCATAACCACAAATTGGAAGCATTGTACTTACAACGTCATCTTTTAGATGAATTAATTCGCAAAAATAAAAT
CAACAATATCGTTGCAGCTCAAATTCGAGAAAATATCAATTACAACGAAATTGTCTTGTCTTTACAGTCCAAACATTAA

Upstream 100 bases:

>100_bases
CTAGAGTTTTTTGAAAATAACTTCATTTTATCAATATATCTATGTCATTATGCCTTAAAAGTGATAAAATATTAACTATT
AAAATTTTGAGGAGTATTGT

Downstream 100 bases:

>100_bases
GCAAGACATAACAACACCCCCCGTACATATGAGACAAAGTCATTATCATCTCATATATACGGGCTTTTTATATTCAACAT
CAAAAAATCGGATTGATGAA

Product: sodium hydrogen exchanger family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 692; Mature: 691

Protein sequence:

>692_residues
MALLEAFLIFIFAVIISSVINNRFPQIPTAFIQIALGVVIFIIPIQVDFQFNSEVFMFAVIAPLLFVEGTHVSRTKLLEY
RKPILLMSMALVFATVVGVGYFIHWIWPALPMPAAFAIAAILCPTDAVAVSAITRGKLLPKGSMTILEGESLLNDAAGII
SFKIAVTALVTGTFSLFQAVEQFIISTILGVLIGAIIGFVVVRIRIDLSANKGLKDNNTLTFIQLLTPFVVYFLAEEVHA
SGIIAVVIAGLIHGLERDRLIRAQTELQMNYHQIWNTFSYALNGFVFVVLGFMIPTVVIDIFQTEPDNFSFLIVITILIA
IAIYACRFVWVYFWYKDFYFPKNIQSYLDEEHDSHETPPSRVRYAFIMTMCGIHGTISLSMALTLPFIITKGQAFEYRND
LLFIASFMVLISLILAQIVLPLITPSAEDTTFKGMTYQSAKIFIVQKVIQHFKNESKKDKNDTNYRPVLNQYYGELLFLL
NSEPDNQNTKELKRLEDIAKVIETSTLERLIDKGKATYQDINNYRNIVELTETHRTASFVEKFANFFKMLWLRLKAMKHY
KALNKESKKQEFENSFKDVQKIMRIVNHNIILRLKEEQNSTNVLEVSLVINHYYDMSRSLKWRAQRRKERQENSNQIIPQ
AMFHNHKLEALYLQRHLLDELIRKNKINNIVAAQIRENINYNEIVLSLQSKH

Sequences:

>Translated_692_residues
MALLEAFLIFIFAVIISSVINNRFPQIPTAFIQIALGVVIFIIPIQVDFQFNSEVFMFAVIAPLLFVEGTHVSRTKLLEY
RKPILLMSMALVFATVVGVGYFIHWIWPALPMPAAFAIAAILCPTDAVAVSAITRGKLLPKGSMTILEGESLLNDAAGII
SFKIAVTALVTGTFSLFQAVEQFIISTILGVLIGAIIGFVVVRIRIDLSANKGLKDNNTLTFIQLLTPFVVYFLAEEVHA
SGIIAVVIAGLIHGLERDRLIRAQTELQMNYHQIWNTFSYALNGFVFVVLGFMIPTVVIDIFQTEPDNFSFLIVITILIA
IAIYACRFVWVYFWYKDFYFPKNIQSYLDEEHDSHETPPSRVRYAFIMTMCGIHGTISLSMALTLPFIITKGQAFEYRND
LLFIASFMVLISLILAQIVLPLITPSAEDTTFKGMTYQSAKIFIVQKVIQHFKNESKKDKNDTNYRPVLNQYYGELLFLL
NSEPDNQNTKELKRLEDIAKVIETSTLERLIDKGKATYQDINNYRNIVELTETHRTASFVEKFANFFKMLWLRLKAMKHY
KALNKESKKQEFENSFKDVQKIMRIVNHNIILRLKEEQNSTNVLEVSLVINHYYDMSRSLKWRAQRRKERQENSNQIIPQ
AMFHNHKLEALYLQRHLLDELIRKNKINNIVAAQIRENINYNEIVLSLQSKH
>Mature_691_residues
ALLEAFLIFIFAVIISSVINNRFPQIPTAFIQIALGVVIFIIPIQVDFQFNSEVFMFAVIAPLLFVEGTHVSRTKLLEYR
KPILLMSMALVFATVVGVGYFIHWIWPALPMPAAFAIAAILCPTDAVAVSAITRGKLLPKGSMTILEGESLLNDAAGIIS
FKIAVTALVTGTFSLFQAVEQFIISTILGVLIGAIIGFVVVRIRIDLSANKGLKDNNTLTFIQLLTPFVVYFLAEEVHAS
GIIAVVIAGLIHGLERDRLIRAQTELQMNYHQIWNTFSYALNGFVFVVLGFMIPTVVIDIFQTEPDNFSFLIVITILIAI
AIYACRFVWVYFWYKDFYFPKNIQSYLDEEHDSHETPPSRVRYAFIMTMCGIHGTISLSMALTLPFIITKGQAFEYRNDL
LFIASFMVLISLILAQIVLPLITPSAEDTTFKGMTYQSAKIFIVQKVIQHFKNESKKDKNDTNYRPVLNQYYGELLFLLN
SEPDNQNTKELKRLEDIAKVIETSTLERLIDKGKATYQDINNYRNIVELTETHRTASFVEKFANFFKMLWLRLKAMKHYK
ALNKESKKQEFENSFKDVQKIMRIVNHNIILRLKEEQNSTNVLEVSLVINHYYDMSRSLKWRAQRRKERQENSNQIIPQA
MFHNHKLEALYLQRHLLDELIRKNKINNIVAAQIRENINYNEIVLSLQSKH

Specific function: Transporter involved in the efflux of sodium, potassium, lithium and rubidium [H]

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. Nhak (TC 2.A.36.3.2) subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790501, Length=521, Percent_Identity=29.5585412667946, Blast_Score=201, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6320663, Length=377, Percent_Identity=24.1379310344828, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR018417
- InterPro:   IPR004705
- InterPro:   IPR002014 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 79327; Mature: 79196

Theoretical pI: Translated: 9.22; Mature: 9.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALLEAFLIFIFAVIISSVINNRFPQIPTAFIQIALGVVIFIIPIQVDFQFNSEVFMFAV
CHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHEEEEEEEEECCHHHHHHH
IAPLLFVEGTHVSRTKLLEYRKPILLMSMALVFATVVGVGYFIHWIWPALPMPAAFAIAA
HHHHHHHCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
ILCPTDAVAVSAITRGKLLPKGSMTILEGESLLNDAAGIISFKIAVTALVTGTFSLFQAV
HHCCCHHHHHHHHHCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EQFIISTILGVLIGAIIGFVVVRIRIDLSANKGLKDNNTLTFIQLLTPFVVYFLAEEVHA
HHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
SGIIAVVIAGLIHGLERDRLIRAQTELQMNYHQIWNTFSYALNGFVFVVLGFMIPTVVID
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IFQTEPDNFSFLIVITILIAIAIYACRFVWVYFWYKDFYFPKNIQSYLDEEHDSHETPPS
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCHH
RVRYAFIMTMCGIHGTISLSMALTLPFIITKGQAFEYRNDLLFIASFMVLISLILAQIVL
HHHHHHHHHHHCCCHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
PLITPSAEDTTFKGMTYQSAKIFIVQKVIQHFKNESKKDKNDTNYRPVLNQYYGELLFLL
HHHCCCCCCCEECCCEECCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHEEEE
NSEPDNQNTKELKRLEDIAKVIETSTLERLIDKGKATYQDINNYRNIVELTETHRTASFV
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
EKFANFFKMLWLRLKAMKHYKALNKESKKQEFENSFKDVQKIMRIVNHNIILRLKEEQNS
HHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCC
TNVLEVSLVINHYYDMSRSLKWRAQRRKERQENSNQIIPQAMFHNHKLEALYLQRHLLDE
CCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCHHHHHHHHHHHHH
LIRKNKINNIVAAQIRENINYNEIVLSLQSKH
HHHHHCCCHHHHHHHHHCCCHHHEEEEEECCC
>Mature Secondary Structure 
ALLEAFLIFIFAVIISSVINNRFPQIPTAFIQIALGVVIFIIPIQVDFQFNSEVFMFAV
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHEEEEEEEEECCHHHHHHH
IAPLLFVEGTHVSRTKLLEYRKPILLMSMALVFATVVGVGYFIHWIWPALPMPAAFAIAA
HHHHHHHCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
ILCPTDAVAVSAITRGKLLPKGSMTILEGESLLNDAAGIISFKIAVTALVTGTFSLFQAV
HHCCCHHHHHHHHHCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EQFIISTILGVLIGAIIGFVVVRIRIDLSANKGLKDNNTLTFIQLLTPFVVYFLAEEVHA
HHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
SGIIAVVIAGLIHGLERDRLIRAQTELQMNYHQIWNTFSYALNGFVFVVLGFMIPTVVID
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IFQTEPDNFSFLIVITILIAIAIYACRFVWVYFWYKDFYFPKNIQSYLDEEHDSHETPPS
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCHH
RVRYAFIMTMCGIHGTISLSMALTLPFIITKGQAFEYRNDLLFIASFMVLISLILAQIVL
HHHHHHHHHHHCCCHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
PLITPSAEDTTFKGMTYQSAKIFIVQKVIQHFKNESKKDKNDTNYRPVLNQYYGELLFLL
HHHCCCCCCCEECCCEECCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHEEEE
NSEPDNQNTKELKRLEDIAKVIETSTLERLIDKGKATYQDINNYRNIVELTETHRTASFV
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
EKFANFFKMLWLRLKAMKHYKALNKESKKQEFENSFKDVQKIMRIVNHNIILRLKEEQNS
HHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCC
TNVLEVSLVINHYYDMSRSLKWRAQRRKERQENSNQIIPQAMFHNHKLEALYLQRHLLDE
CCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCHHHHHHHHHHHHH
LIRKNKINNIVAAQIRENINYNEIVLSLQSKH
HHHHHCCCHHHHHHHHHCCCHHHEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA