Click here to switch to the map view.

The map label for this gene is kbl [C]

Identifier: 82752020

GI number: 82752020

Start: 2435350

End: 2436465

Strand: Reverse

Name: kbl [C]

Synonym: SAB2305c

Alternate gene names: 82752020

Gene position: 2436465-2435350 (Counterclockwise)

Preceding gene: 82752021

Following gene: 82752019

Centisome position: 88.84

GC content: 30.65

Gene sequence:

>1116_bases
ATGATGTTTCAAGAGCAAATTGATTTATTACAACAGAAAGGGTTATATCGGTCGCTTAAATCGGTAGGGTATATAGATAG
ACAGTATATTGAAGTAGAAAATAAGCGATGTACGAATTATACATCTAATGATTATTTAGGATTAGGACAAATAGCGTTTG
ATAAGGATGATTTCGAAAGATTTATGCGGAAGTATAGTTATCACTTATCAAGTTCAAGATTAATTAGTGGAAGTTCGACA
GCTTATGAAGAAATTGAAACAATGTTAGCAGGTTGGCTCGGATATAGTGCATGTACTATCTTAAATAGTGGTTATGATGC
TAATTTGGCGTTATTTAATATTTTCAAAAATACAAATTGTGTCGTGTTTTCAGATCAAGAAAATCATGCGAGTATTATTG
ACGGTATTAAGTTAAGTGGTTTAGAAAAAGTGATATATAAGCATTTAGATATTGCTGATTTAGAAAAAAGGTTAGCGGAA
TGCCCTAATCAAAATATACAAAAAATAATCATATCTGATAGTGTATTTTCAACGAATGGCGACGTTGTGGATATTGGTCA
ATTAGTCTCATTAAAGCATAAATATAACGCAACACTGATACTCGATGTTTCACATAGTTTTGGAATAGAGAATTACTCGA
ATTATCAAGGCATAGATATACTCACTTCTAGTTTATCTAAAGCATGTGGTGCATACGGGGGTGTGATTTTAAGTTCAAAT
GATGTGAAGGATATGTTAATTAATCACGGTAGACCACTCATCTACTCAAGTAGTTTGCCAATTTATAATTTGTATTTTAT
AAAAAGAAATATTGAAAAGTTAATAAATGCTGATGATAGACGCACTAAATTAAATAGTTTGAGTAAATATTTTAACCAAA
AGTTACAAGCACTCAATGTTAATTATAATAGTTCAAACTCGCCGATTAAGTTTATTGAGTTTGATGACATAGAAGCGGCT
GAGAACATTCATCAAACATTATTAAAGCATCATGTGTTTACAAGTTATTTAAGGTATCCAACTGTGACTAAGCCAATGTT
AAGAATATCATTGTCGTATTTTCATACTGAACAAGATGTAGATAGGTTGTTTGAAATTTTGCATCAAGAAGATTGA

Upstream 100 bases:

>100_bases
CTAATTACTGGTGGGCAACCGAACCAATTGGACTACGATATGATTAATGATTTGGGCTTTGAAATTGATTATGACACTTG
TGAAAATAAGGAAAACAAGA

Downstream 100 bases:

>100_bases
GGTGATCGTCATGTATAGTATAAAAATGCGTTCTAGCAATCAAGATGTTCATATTAGTGGTGCTGAAACGATTTGTGAGT
TTGACAAAATAGAACAGACG

Product: hypothetical protein

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 371; Mature: 371

Protein sequence:

>371_residues
MMFQEQIDLLQQKGLYRSLKSVGYIDRQYIEVENKRCTNYTSNDYLGLGQIAFDKDDFERFMRKYSYHLSSSRLISGSST
AYEEIETMLAGWLGYSACTILNSGYDANLALFNIFKNTNCVVFSDQENHASIIDGIKLSGLEKVIYKHLDIADLEKRLAE
CPNQNIQKIIISDSVFSTNGDVVDIGQLVSLKHKYNATLILDVSHSFGIENYSNYQGIDILTSSLSKACGAYGGVILSSN
DVKDMLINHGRPLIYSSSLPIYNLYFIKRNIEKLINADDRRTKLNSLSKYFNQKLQALNVNYNSSNSPIKFIEFDDIEAA
ENIHQTLLKHHVFTSYLRYPTVTKPMLRISLSYFHTEQDVDRLFEILHQED

Sequences:

>Translated_371_residues
MMFQEQIDLLQQKGLYRSLKSVGYIDRQYIEVENKRCTNYTSNDYLGLGQIAFDKDDFERFMRKYSYHLSSSRLISGSST
AYEEIETMLAGWLGYSACTILNSGYDANLALFNIFKNTNCVVFSDQENHASIIDGIKLSGLEKVIYKHLDIADLEKRLAE
CPNQNIQKIIISDSVFSTNGDVVDIGQLVSLKHKYNATLILDVSHSFGIENYSNYQGIDILTSSLSKACGAYGGVILSSN
DVKDMLINHGRPLIYSSSLPIYNLYFIKRNIEKLINADDRRTKLNSLSKYFNQKLQALNVNYNSSNSPIKFIEFDDIEAA
ENIHQTLLKHHVFTSYLRYPTVTKPMLRISLSYFHTEQDVDRLFEILHQED
>Mature_371_residues
MMFQEQIDLLQQKGLYRSLKSVGYIDRQYIEVENKRCTNYTSNDYLGLGQIAFDKDDFERFMRKYSYHLSSSRLISGSST
AYEEIETMLAGWLGYSACTILNSGYDANLALFNIFKNTNCVVFSDQENHASIIDGIKLSGLEKVIYKHLDIADLEKRLAE
CPNQNIQKIIISDSVFSTNGDVVDIGQLVSLKHKYNATLILDVSHSFGIENYSNYQGIDILTSSLSKACGAYGGVILSSN
DVKDMLINHGRPLIYSSSLPIYNLYFIKRNIEKLINADDRRTKLNSLSKYFNQKLQALNVNYNSSNSPIKFIEFDDIEAA
ENIHQTLLKHHVFTSYLRYPTVTKPMLRISLSYFHTEQDVDRLFEILHQED

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=379, Percent_Identity=26.6490765171504, Blast_Score=159, Evalue=4e-39,
Organism=Homo sapiens, GI284448556, Length=340, Percent_Identity=28.5294117647059, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI83977440, Length=391, Percent_Identity=27.6214833759591, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI83977442, Length=391, Percent_Identity=27.6214833759591, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI83977444, Length=391, Percent_Identity=27.6214833759591, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI4502025, Length=393, Percent_Identity=25.9541984732824, Blast_Score=122, Evalue=7e-28,
Organism=Homo sapiens, GI40316939, Length=393, Percent_Identity=25.9541984732824, Blast_Score=122, Evalue=7e-28,
Organism=Homo sapiens, GI119220554, Length=369, Percent_Identity=25.7452574525745, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI4758668, Length=357, Percent_Identity=24.0896358543417, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI5454084, Length=251, Percent_Identity=25.4980079681275, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI1790046, Length=377, Percent_Identity=27.5862068965517, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1786993, Length=355, Percent_Identity=28.169014084507, Blast_Score=146, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI71994529, Length=355, Percent_Identity=29.5774647887324, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI32566772, Length=335, Percent_Identity=25.3731343283582, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17560914, Length=322, Percent_Identity=26.0869565217391, Blast_Score=95, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI17560912, Length=322, Percent_Identity=26.0869565217391, Blast_Score=94, Evalue=8e-20,
Organism=Saccharomyces cerevisiae, GI6320267, Length=357, Percent_Identity=26.3305322128852, Blast_Score=116, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6320438, Length=394, Percent_Identity=27.1573604060914, Blast_Score=115, Evalue=8e-27,
Organism=Saccharomyces cerevisiae, GI6323954, Length=274, Percent_Identity=21.8978102189781, Blast_Score=66, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24662918, Length=345, Percent_Identity=29.2753623188406, Blast_Score=165, Evalue=6e-41,
Organism=Drosophila melanogaster, GI17136286, Length=369, Percent_Identity=28.7262872628726, Blast_Score=125, Evalue=4e-29,
Organism=Drosophila melanogaster, GI17137420, Length=400, Percent_Identity=27, Blast_Score=121, Evalue=9e-28,
Organism=Drosophila melanogaster, GI24653280, Length=377, Percent_Identity=20.9549071618037, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24653276, Length=377, Percent_Identity=20.9549071618037, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24653278, Length=377, Percent_Identity=20.9549071618037, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR010962
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 42479; Mature: 42479

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMFQEQIDLLQQKGLYRSLKSVGYIDRQYIEVENKRCTNYTSNDYLGLGQIAFDKDDFER
CCCHHHHHHHHHCCHHHHHHHCCCCCHHHEEECCCCCCCCCCCCCCCCCEEEECHHHHHH
FMRKYSYHLSSSRLISGSSTAYEEIETMLAGWLGYSACTILNSGYDANLALFNIFKNTNC
HHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCE
VVFSDQENHASIIDGIKLSGLEKVIYKHLDIADLEKRLAECPNQNIQKIIISDSVFSTNG
EEEECCCCCHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCEEEEEECCEECCCC
DVVDIGQLVSLKHKYNATLILDVSHSFGIENYSNYQGIDILTSSLSKACGAYGGVILSSN
CEEEHHHHHHHHHCCCEEEEEEECHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCEEECCC
DVKDMLINHGRPLIYSSSLPIYNLYFIKRNIEKLINADDRRTKLNSLSKYFNQKLQALNV
CHHHHHHHCCCCEEEECCCCEEEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHEEEC
NYNSSNSPIKFIEFDDIEAAENIHQTLLKHHVFTSYLRYPTVTKPMLRISLSYFHTEQDV
CCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCHHHH
DRLFEILHQED
HHHHHHHHCCC
>Mature Secondary Structure
MMFQEQIDLLQQKGLYRSLKSVGYIDRQYIEVENKRCTNYTSNDYLGLGQIAFDKDDFER
CCCHHHHHHHHHCCHHHHHHHCCCCCHHHEEECCCCCCCCCCCCCCCCCEEEECHHHHHH
FMRKYSYHLSSSRLISGSSTAYEEIETMLAGWLGYSACTILNSGYDANLALFNIFKNTNC
HHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCE
VVFSDQENHASIIDGIKLSGLEKVIYKHLDIADLEKRLAECPNQNIQKIIISDSVFSTNG
EEEECCCCCHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCEEEEEECCEECCCC
DVVDIGQLVSLKHKYNATLILDVSHSFGIENYSNYQGIDILTSSLSKACGAYGGVILSSN
CEEEHHHHHHHHHCCCEEEEEEECHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCEEECCC
DVKDMLINHGRPLIYSSSLPIYNLYFIKRNIEKLINADDRRTKLNSLSKYFNQKLQALNV
CHHHHHHHCCCCEEEECCCCEEEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHEEEC
NYNSSNSPIKFIEFDDIEAAENIHQTLLKHHVFTSYLRYPTVTKPMLRISLSYFHTEQDV
CCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCHHHH
DRLFEILHQED
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA