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The map label for this gene is tcyB [H]

Identifier: 82752008

GI number: 82752008

Start: 2422915

End: 2423634

Strand: Reverse

Name: tcyB [H]

Synonym: SAB2293c

Alternate gene names: 82752008

Gene position: 2423634-2422915 (Counterclockwise)

Preceding gene: 82752009

Following gene: 82752007

Centisome position: 88.37

GC content: 33.75

Gene sequence:

>720_bases
ATGTTTCTAAATCTAAATAGCGAACAACAACATGCGCTAGATGCTGCAAAACAAGCTTTTGGACCTATGCTAGAAGGTTT
GGTCAAATATTCAATTCCTATTACATTAGTTACATTTGTTTTAGGATTGATTATTGCATTATTTACAGCATTAATGCGAA
TTTCAACGAGTAAAATTTTAAGAAGTATTTCACGTGTCTATGTATCTATTATTCGAGGAACACCAATGATAGTACAACTA
TTTATCATATTTTATGGTATTCCAGAATTAGGTAGATTATTAACAAATGACGCTGACAACCAATGGACATTGGCACCTGT
AGTGGCTGCTATTATTGGTTTATCATTAAATGTAGGTGCGTATGCTTCGGAAATTATTCGTGGCGGTATTATTTCTATAC
CGAAAGGACAAACAGAAGCTGCATATTCTATCGGTATGACGTATGGTCAAACGATCCAACGTATCATTTTACCGCAGGCA
ATTCGAGTGTCGATTCCTGCACTGGGTAATACATTTTTAAGTTTAATCAAAGATACATCATTATTAGGATTTATTTTAGT
GGCTGAAATGTTTAGAAAAGCTCAAGAAGTTGCGTCTACAACATATGAATATTTAACAATTTATGTGTTAGTTGCGCTAA
TGTACTGGGTGGTATGCTTTATTATGTCAATTATCCAAGGTATCTATGAATCTTATATTGAAAGAGGGTATCGCTCATGA

Upstream 100 bases:

>100_bases
AAAGTAGATGATGAAACAGTTCAAAAATTCAATGATGGCTTGAAAAAAATCGAGGAAAACGGTGAATTAGCTAAAATAGG
TAAGAAATGGTTTGGTCAAG

Downstream 100 bases:

>100_bases
TTCAATTGAACAATATCCATAAATCATTTAATGATGTTGAAGTCATCAAAGGTATTGATTTATCTGTTGAACAAGGTGAG
GTTGTAACCTTAATCGGTCG

Product: ABC transporter permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 239; Mature: 239

Protein sequence:

>239_residues
MFLNLNSEQQHALDAAKQAFGPMLEGLVKYSIPITLVTFVLGLIIALFTALMRISTSKILRSISRVYVSIIRGTPMIVQL
FIIFYGIPELGRLLTNDADNQWTLAPVVAAIIGLSLNVGAYASEIIRGGIISIPKGQTEAAYSIGMTYGQTIQRIILPQA
IRVSIPALGNTFLSLIKDTSLLGFILVAEMFRKAQEVASTTYEYLTIYVLVALMYWVVCFIMSIIQGIYESYIERGYRS

Sequences:

>Translated_239_residues
MFLNLNSEQQHALDAAKQAFGPMLEGLVKYSIPITLVTFVLGLIIALFTALMRISTSKILRSISRVYVSIIRGTPMIVQL
FIIFYGIPELGRLLTNDADNQWTLAPVVAAIIGLSLNVGAYASEIIRGGIISIPKGQTEAAYSIGMTYGQTIQRIILPQA
IRVSIPALGNTFLSLIKDTSLLGFILVAEMFRKAQEVASTTYEYLTIYVLVALMYWVVCFIMSIIQGIYESYIERGYRS
>Mature_239_residues
MFLNLNSEQQHALDAAKQAFGPMLEGLVKYSIPITLVTFVLGLIIALFTALMRISTSKILRSISRVYVSIIRGTPMIVQL
FIIFYGIPELGRLLTNDADNQWTLAPVVAAIIGLSLNVGAYASEIIRGGIISIPKGQTEAAYSIGMTYGQTIQRIILPQA
IRVSIPALGNTFLSLIKDTSLLGFILVAEMFRKAQEVASTTYEYLTIYVLVALMYWVVCFIMSIIQGIYESYIERGYRS

Specific function: Part of the ABC transporter complex tcyABC involved in L-cystine import. Probably responsible for the translocation of the substrate across the membrane (Probable) [H]

COG id: COG0765

COG function: function code E; ABC-type amino acid transport system, permease component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1788226, Length=218, Percent_Identity=44.4954128440367, Blast_Score=186, Evalue=9e-49,
Organism=Escherichia coli, GI1787030, Length=204, Percent_Identity=34.8039215686275, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI87082239, Length=194, Percent_Identity=35.0515463917526, Blast_Score=107, Evalue=5e-25,
Organism=Escherichia coli, GI1788646, Length=199, Percent_Identity=32.1608040201005, Blast_Score=101, Evalue=4e-23,
Organism=Escherichia coli, GI1788645, Length=187, Percent_Identity=28.8770053475936, Blast_Score=100, Evalue=8e-23,
Organism=Escherichia coli, GI1787087, Length=206, Percent_Identity=27.6699029126214, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1786873, Length=214, Percent_Identity=31.3084112149533, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1787086, Length=182, Percent_Identity=31.8681318681319, Blast_Score=87, Evalue=9e-19,
Organism=Escherichia coli, GI1786874, Length=216, Percent_Identity=25, Blast_Score=81, Evalue=5e-17,
Organism=Escherichia coli, GI48994930, Length=213, Percent_Identity=28.169014084507, Blast_Score=74, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010065
- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 26461; Mature: 26461

Theoretical pI: Translated: 9.14; Mature: 9.14

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFLNLNSEQQHALDAAKQAFGPMLEGLVKYSIPITLVTFVLGLIIALFTALMRISTSKIL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RSISRVYVSIIRGTPMIVQLFIIFYGIPELGRLLTNDADNQWTLAPVVAAIIGLSLNVGA
HHHHHHHHHHHHCCHHHHHHHHHHHCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCHHH
YASEIIRGGIISIPKGQTEAAYSIGMTYGQTIQRIILPQAIRVSIPALGNTFLSLIKDTS
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
LLGFILVAEMFRKAQEVASTTYEYLTIYVLVALMYWVVCFIMSIIQGIYESYIERGYRS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MFLNLNSEQQHALDAAKQAFGPMLEGLVKYSIPITLVTFVLGLIIALFTALMRISTSKIL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RSISRVYVSIIRGTPMIVQLFIIFYGIPELGRLLTNDADNQWTLAPVVAAIIGLSLNVGA
HHHHHHHHHHHHCCHHHHHHHHHHHCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCHHH
YASEIIRGGIISIPKGQTEAAYSIGMTYGQTIQRIILPQAIRVSIPALGNTFLSLIKDTS
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
LLGFILVAEMFRKAQEVASTTYEYLTIYVLVALMYWVVCFIMSIIQGIYESYIERGYRS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7551042; 8969502; 9384377 [H]