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The map label for this gene is pyn

Identifier: 82751737

GI number: 82751737

Start: 2151492

End: 2152793

Strand: Reverse

Name: pyn

Synonym: SAB2020c

Alternate gene names: 82751737

Gene position: 2152793-2151492 (Counterclockwise)

Preceding gene: 82751738

Following gene: 82751736

Centisome position: 78.5

GC content: 36.41

Gene sequence:

>1302_bases
ATGAGAATGATAGACATTATTGAGAAAAAGCGTGACGGTCATACACTAACAACGGAAGAAATTAATTTCTTTATTGACGG
CTATGTTAAAGGGGATATTCCTGATTACCAAGCATCAAGTTTAGCAATGGCGATTTATTTCCAAGATATGAATGATGATG
AGCGTGCAGCATTAACGATGGCTATGGTTAATTCTGGTGATATGATAGATTTGAGTGATATTAAAGGTGTCAAAGTAGAT
AAGCACTCAACAGGTGGTGTAGGAGATACAACTACATTGGTTTTAGCACCATTAGTAGCAGCTGTAGATGTTCCTGTTGC
AAAAATGAGTGGGCGTGGATTAGGTCATACAGGTGGTACGATTGATAAATTAGAAGCAATTGATGGTTTTCATGTTGAAA
TAGATGAAGCAACATTTGTGAAATTGGTTAATGAAAATAAAGTGGCAGTTGTAGGACAATCAGGAAATTTAACTCCTGCA
GACAAAAAAATATATGCCTTAAGGGATGTTACTGGTACTGTCAATTCAATACCATTAATTGCCTCTTCAATTATGAGTAA
AAAGATTGCCGCTGGTGCAGATGCAATTGTATTAGATGTAAAAACTGGTAGCGGTGCATTTATGAAAACATTAGAAGATG
CTGAAGCATTAGCGCACGCAATGGTACGTATTGGTAATAATGTGGGACGTAATACGATGGCGATTATTTCTGATATGAAT
CAGCCACTTGGACGTGCGATTGGCAATGCGCTTGAGTTACAAGAAGCAATTGATACGTTGAAAGGACAAGGTCCGAAAGA
TTTAACAGAACTTGTATTAACATTAGGTTCTCAAATGGTTGTACTTGCAAACAAAGCTGAAACGCTTGAAGAAGCGAGAG
CGTTGCTAATTGAGGCAATTGATTCAGGTGCAGCATTAGAAAAATTCAAAACATTTATTAAAAACCAAGGTGGCGACGAA
ACAGTTATTGACCATCCAGAGCGTTTGCCACAAGCTCAATATCAAATCGAATATAAAGCTAAAAAATCAGGTTATGTGAC
TGAGTTAGTCTCTAACGATATAGGTGTCGCTTCGATGATGTTAGGAGCGGGACGTTTAACAAAAGAGGATGATATTGATT
TAGCGGTTGGTATTGTTTTAAATAAAAAAATTGGTGATAAAGTAGAAGAAGGAGAATCATTATTAACGATTCACAGTAAT
CGCCAAGATGTAGACGATGTTGTTAAAAAATTAGATTCAAGCATAACAATTGCTGATCATGTTGTATCGCCTACATTAAT
TCATAAAATCATTACAGAGTAG

Upstream 100 bases:

>100_bases
TCGATAGCTTGCTATAATAATTTTCGCTTGTGCTTTTAAAAATGGACTAGAGAAAGCGCAGATGCTTTGTCCTAAGCTTT
TTAAGAAAAGGATGATAAAA

Downstream 100 bases:

>100_bases
GAGTTGAAGCTGATTGAACATACTAAGATATTTATTAGGAATAGGTTTTAGTGTAATAGGTGTATTGCATTTTACACGAG
AACGACAATTTAGAAATATC

Product: pyrimidine-nucleoside phosphorylase

Products: NA

Alternate protein names: PYNP [H]

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MRMIDIIEKKRDGHTLTTEEINFFIDGYVKGDIPDYQASSLAMAIYFQDMNDDERAALTMAMVNSGDMIDLSDIKGVKVD
KHSTGGVGDTTTLVLAPLVAAVDVPVAKMSGRGLGHTGGTIDKLEAIDGFHVEIDEATFVKLVNENKVAVVGQSGNLTPA
DKKIYALRDVTGTVNSIPLIASSIMSKKIAAGADAIVLDVKTGSGAFMKTLEDAEALAHAMVRIGNNVGRNTMAIISDMN
QPLGRAIGNALELQEAIDTLKGQGPKDLTELVLTLGSQMVVLANKAETLEEARALLIEAIDSGAALEKFKTFIKNQGGDE
TVIDHPERLPQAQYQIEYKAKKSGYVTELVSNDIGVASMMLGAGRLTKEDDIDLAVGIVLNKKIGDKVEEGESLLTIHSN
RQDVDDVVKKLDSSITIADHVVSPTLIHKIITE

Sequences:

>Translated_433_residues
MRMIDIIEKKRDGHTLTTEEINFFIDGYVKGDIPDYQASSLAMAIYFQDMNDDERAALTMAMVNSGDMIDLSDIKGVKVD
KHSTGGVGDTTTLVLAPLVAAVDVPVAKMSGRGLGHTGGTIDKLEAIDGFHVEIDEATFVKLVNENKVAVVGQSGNLTPA
DKKIYALRDVTGTVNSIPLIASSIMSKKIAAGADAIVLDVKTGSGAFMKTLEDAEALAHAMVRIGNNVGRNTMAIISDMN
QPLGRAIGNALELQEAIDTLKGQGPKDLTELVLTLGSQMVVLANKAETLEEARALLIEAIDSGAALEKFKTFIKNQGGDE
TVIDHPERLPQAQYQIEYKAKKSGYVTELVSNDIGVASMMLGAGRLTKEDDIDLAVGIVLNKKIGDKVEEGESLLTIHSN
RQDVDDVVKKLDSSITIADHVVSPTLIHKIITE
>Mature_433_residues
MRMIDIIEKKRDGHTLTTEEINFFIDGYVKGDIPDYQASSLAMAIYFQDMNDDERAALTMAMVNSGDMIDLSDIKGVKVD
KHSTGGVGDTTTLVLAPLVAAVDVPVAKMSGRGLGHTGGTIDKLEAIDGFHVEIDEATFVKLVNENKVAVVGQSGNLTPA
DKKIYALRDVTGTVNSIPLIASSIMSKKIAAGADAIVLDVKTGSGAFMKTLEDAEALAHAMVRIGNNVGRNTMAIISDMN
QPLGRAIGNALELQEAIDTLKGQGPKDLTELVLTLGSQMVVLANKAETLEEARALLIEAIDSGAALEKFKTFIKNQGGDE
TVIDHPERLPQAQYQIEYKAKKSGYVTELVSNDIGVASMMLGAGRLTKEDDIDLAVGIVLNKKIGDKVEEGESLLTIHSN
RQDVDDVVKKLDSSITIADHVVSPTLIHKIITE

Specific function: The Enzymes Which Catalyze The Reversible Phosphorolysis Of Pyrimidine Nucleosides Are Involved In The Degradation Of These Compounds And In Their Utilization As Carbon And Energy Sources, Or In The Rescue Of Pyrimidine Bases For Nucleotide Synthesis. [C

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI166158925, Length=409, Percent_Identity=38.1418092909535, Blast_Score=266, Evalue=4e-71,
Organism=Homo sapiens, GI4503445, Length=409, Percent_Identity=38.1418092909535, Blast_Score=266, Evalue=4e-71,
Organism=Homo sapiens, GI166158922, Length=409, Percent_Identity=38.1418092909535, Blast_Score=266, Evalue=4e-71,
Organism=Escherichia coli, GI1790842, Length=404, Percent_Identity=44.3069306930693, Blast_Score=326, Evalue=2e-90,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR018090
- InterPro:   IPR000053
- InterPro:   IPR017872 [H]

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C [H]

EC number: =2.4.2.2 [H]

Molecular weight: Translated: 46368; Mature: 46368

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRMIDIIEKKRDGHTLTTEEINFFIDGYVKGDIPDYQASSLAMAIYFQDMNDDERAALTM
CCCHHHHHHCCCCCEEECCCEEEEEEEEEECCCCCCCCCCEEEEEEEECCCCCHHHEEEE
AMVNSGDMIDLSDIKGVKVDKHSTGGVGDTTTLVLAPLVAAVDVPVAKMSGRGLGHTGGT
EEECCCCEEECCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCC
IDKLEAIDGFHVEIDEATFVKLVNENKVAVVGQSGNLTPADKKIYALRDVTGTVNSIPLI
HHHHHHCCCCEEEECCCEEEEEECCCEEEEEECCCCCCCCCCEEEEEECCCCCCHHHHHH
ASSIMSKKIAAGADAIVLDVKTGSGAFMKTLEDAEALAHAMVRIGNNVGRNTMAIISDMN
HHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCC
QPLGRAIGNALELQEAIDTLKGQGPKDLTELVLTLGSQMVVLANKAETLEEARALLIEAI
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHH
DSGAALEKFKTFIKNQGGDETVIDHPERLPQAQYQIEYKAKKSGYVTELVSNDIGVASMM
CCCHHHHHHHHHHHCCCCCCCCCCCHHHCCCCEEEEEEEECCCCCHHHHHHCCCCHHHHH
LGAGRLTKEDDIDLAVGIVLNKKIGDKVEEGESLLTIHSNRQDVDDVVKKLDSSITIADH
HCCCCCCCCCCCCEEEEEEEECHHCCHHHCCCEEEEEECCCCCHHHHHHHHCCCEEEHHH
VVSPTLIHKIITE
HCCHHHHHHHHCC
>Mature Secondary Structure
MRMIDIIEKKRDGHTLTTEEINFFIDGYVKGDIPDYQASSLAMAIYFQDMNDDERAALTM
CCCHHHHHHCCCCCEEECCCEEEEEEEEEECCCCCCCCCCEEEEEEEECCCCCHHHEEEE
AMVNSGDMIDLSDIKGVKVDKHSTGGVGDTTTLVLAPLVAAVDVPVAKMSGRGLGHTGGT
EEECCCCEEECCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCC
IDKLEAIDGFHVEIDEATFVKLVNENKVAVVGQSGNLTPADKKIYALRDVTGTVNSIPLI
HHHHHHCCCCEEEECCCEEEEEECCCEEEEEECCCCCCCCCCEEEEEECCCCCCHHHHHH
ASSIMSKKIAAGADAIVLDVKTGSGAFMKTLEDAEALAHAMVRIGNNVGRNTMAIISDMN
HHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCC
QPLGRAIGNALELQEAIDTLKGQGPKDLTELVLTLGSQMVVLANKAETLEEARALLIEAI
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHH
DSGAALEKFKTFIKNQGGDETVIDHPERLPQAQYQIEYKAKKSGYVTELVSNDIGVASMM
CCCHHHHHHHHHHHCCCCCCCCCCCHHHCCCCEEEEEEEECCCCCHHHHHHCCCCHHHHH
LGAGRLTKEDDIDLAVGIVLNKKIGDKVEEGESLLTIHSNRQDVDDVVKKLDSSITIADH
HCCCCCCCCCCCCEEEEEEEECHHCCHHHCCCEEEEEECCCCCHHHHHHHHCCCEEEHHH
VVSPTLIHKIITE
HCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA