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The map label for this gene is hlb [H]

Identifier: 82751595

GI number: 82751595

Start: 2010354

End: 2011346

Strand: Direct

Name: hlb [H]

Synonym: SAB1874

Alternate gene names: 82751595

Gene position: 2010354-2011346 (Clockwise)

Preceding gene: 82751593

Following gene: 82751598

Centisome position: 73.3

GC content: 33.23

Gene sequence:

>993_bases
ATGGTGAAAAAAACAAAATCCAATTCACTAAAAAAAGTTGCAACACTTGCATTAGCAAATTTATTATTAGTTGGTGCACT
TACTGACAATAGTGCCAAAGCCGAATCTAAGAAAGATGATACTGATTTGAAGTTAGTTAGTCATAACGTTTATATGTTAT
CGACGGTTTTGTATCCAAACTGGGGGCAATATAAACGCGCTGATTTAATCGGACAATCTTCTTATATTAAAAATAATGAT
GTCGTAATATTCAATGAAGCATTTGATAATGGTGCATCAGACAAATTATTAAGTAATGTAAAAAAAGAATATCCTTACCA
AACACCTGTACTCGGTCGTTCTCAATCAGGTTGGGACAAAACTGAAGGTAGCTACTCATCAACTGTTGCTGAAGATGGTG
GCGTAGCGATTGTAAGTAAATATCCTATTAAAGAGAAAATCCAGCATGTTTTCAAAAGCGGTTGTGGATTCGATAATGAT
AGCAACAAAGGCTTTATTTATACAAAAATAGAGAAAAATGGTAAGAACGTTCACGTTATCGGTACACATACACAATCTGA
AGATTCTCGTTGTGGTGCTGGACATGATCGAAAAATTAGAGCTGAACAAATGAAAGAAATCAGTGACTTTGTTAAAAAGA
AAAATATCCCTAAAGATGAAACGGTATATATAGGTGGCGACCTTAATGTTAATAAAGGCACTCCAGAGTTCAAAGATATG
CTTAAAAACTTGAATGTAAATGATGTTCTATATGCAGGTCATAATAGCACATGGGACCCTCAATCAAATTCAATTGCGAA
ATATAATTACCCTAATGGTAAACCAGAACATTTAGACTATATATTTACAGATAAAGATCATAAACAACCAAAACAATTAG
TCAATGAAGTTGTGACTGAAAAACCTAAGCCATGGGATGTATATGCGTTCCCATATTACTATGTTTACAATGATTTTTCA
GATCATTACCCAATCAAAGCCTATAGTAAATAG

Upstream 100 bases:

>100_bases
ATTTGCTTAAAAATATAAATTCGATTTAATAATTAATTTAAATTTAGTTAATCAATTTTGCATCTATTTTGTTGTAAGGT
ATATAAAAGGAGTGATAATC

Downstream 100 bases:

>100_bases
TGCTCAACTAACTAATAACTCGCTTCGTTCTAAAAAGTCGAAGCGAGTTATATTGTTAAAATTTGAATTGACTGAGTCTA
GGACATAAATCAAGTTCTAG

Product: beta-hemolysin

Products: NA

Alternate protein names: Beta-hemolysin; Beta-toxin; Sphingomyelinase; SMase [H]

Number of amino acids: Translated: 330; Mature: 330

Protein sequence:

>330_residues
MVKKTKSNSLKKVATLALANLLLVGALTDNSAKAESKKDDTDLKLVSHNVYMLSTVLYPNWGQYKRADLIGQSSYIKNND
VVIFNEAFDNGASDKLLSNVKKEYPYQTPVLGRSQSGWDKTEGSYSSTVAEDGGVAIVSKYPIKEKIQHVFKSGCGFDND
SNKGFIYTKIEKNGKNVHVIGTHTQSEDSRCGAGHDRKIRAEQMKEISDFVKKKNIPKDETVYIGGDLNVNKGTPEFKDM
LKNLNVNDVLYAGHNSTWDPQSNSIAKYNYPNGKPEHLDYIFTDKDHKQPKQLVNEVVTEKPKPWDVYAFPYYYVYNDFS
DHYPIKAYSK

Sequences:

>Translated_330_residues
MVKKTKSNSLKKVATLALANLLLVGALTDNSAKAESKKDDTDLKLVSHNVYMLSTVLYPNWGQYKRADLIGQSSYIKNND
VVIFNEAFDNGASDKLLSNVKKEYPYQTPVLGRSQSGWDKTEGSYSSTVAEDGGVAIVSKYPIKEKIQHVFKSGCGFDND
SNKGFIYTKIEKNGKNVHVIGTHTQSEDSRCGAGHDRKIRAEQMKEISDFVKKKNIPKDETVYIGGDLNVNKGTPEFKDM
LKNLNVNDVLYAGHNSTWDPQSNSIAKYNYPNGKPEHLDYIFTDKDHKQPKQLVNEVVTEKPKPWDVYAFPYYYVYNDFS
DHYPIKAYSK
>Mature_330_residues
MVKKTKSNSLKKVATLALANLLLVGALTDNSAKAESKKDDTDLKLVSHNVYMLSTVLYPNWGQYKRADLIGQSSYIKNND
VVIFNEAFDNGASDKLLSNVKKEYPYQTPVLGRSQSGWDKTEGSYSSTVAEDGGVAIVSKYPIKEKIQHVFKSGCGFDND
SNKGFIYTKIEKNGKNVHVIGTHTQSEDSRCGAGHDRKIRAEQMKEISDFVKKKNIPKDETVYIGGDLNVNKGTPEFKDM
LKNLNVNDVLYAGHNSTWDPQSNSIAKYNYPNGKPEHLDYIFTDKDHKQPKQLVNEVVTEKPKPWDVYAFPYYYVYNDFS
DHYPIKAYSK

Specific function: Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the neutral sphingomyelinase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005135
- InterPro:   IPR017766 [H]

Pfam domain/function: PF03372 Exo_endo_phos [H]

EC number: =3.1.4.3 [H]

Molecular weight: Translated: 37252; Mature: 37252

Theoretical pI: Translated: 9.09; Mature: 9.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKKTKSNSLKKVATLALANLLLVGALTDNSAKAESKKDDTDLKLVSHNVYMLSTVLYPN
CCCCCCCCHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCEEEEECCEEEEEEEECCC
WGQYKRADLIGQSSYIKNNDVVIFNEAFDNGASDKLLSNVKKEYPYQTPVLGRSQSGWDK
CCCCHHHHHCCCCCEECCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCC
TEGSYSSTVAEDGGVAIVSKYPIKEKIQHVFKSGCGFDNDSNKGFIYTKIEKNGKNVHVI
CCCCCCHHCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCEEEEE
GTHTQSEDSRCGAGHDRKIRAEQMKEISDFVKKKNIPKDETVYIGGDLNVNKGTPEFKDM
ECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEECCEEECCCCCHHHHHH
LKNLNVNDVLYAGHNSTWDPQSNSIAKYNYPNGKPEHLDYIFTDKDHKQPKQLVNEVVTE
HHCCCCCEEEEECCCCCCCCCCCCEEEECCCCCCCCCEEEEECCCCCCCHHHHHHHHHHC
KPKPWDVYAFPYYYVYNDFSDHYPIKAYSK
CCCCCEEEECEEEEEECCCCCCCCEEECCC
>Mature Secondary Structure
MVKKTKSNSLKKVATLALANLLLVGALTDNSAKAESKKDDTDLKLVSHNVYMLSTVLYPN
CCCCCCCCHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCEEEEECCEEEEEEEECCC
WGQYKRADLIGQSSYIKNNDVVIFNEAFDNGASDKLLSNVKKEYPYQTPVLGRSQSGWDK
CCCCHHHHHCCCCCEECCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCC
TEGSYSSTVAEDGGVAIVSKYPIKEKIQHVFKSGCGFDNDSNKGFIYTKIEKNGKNVHVI
CCCCCCHHCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCEEEEE
GTHTQSEDSRCGAGHDRKIRAEQMKEISDFVKKKNIPKDETVYIGGDLNVNKGTPEFKDM
ECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEECCEEECCCCCHHHHHH
LKNLNVNDVLYAGHNSTWDPQSNSIAKYNYPNGKPEHLDYIFTDKDHKQPKQLVNEVVTE
HHCCCCCEEEEECCCCCCCCCCCCEEEECCCCCCCCCEEEEECCCCCCCHHHHHHHHHHC
KPKPWDVYAFPYYYVYNDFSDHYPIKAYSK
CCCCCEEEECEEEEEECCCCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8914839 [H]