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The map label for this gene is hemB

Identifier: 82751257

GI number: 82751257

Start: 1647985

End: 1648959

Strand: Reverse

Name: hemB

Synonym: SAB1528c

Alternate gene names: 82751257

Gene position: 1648959-1647985 (Counterclockwise)

Preceding gene: 82751258

Following gene: 82751256

Centisome position: 60.13

GC content: 35.38

Gene sequence:

>975_bases
ATGAAATTTGATAGACATAGAAGATTGAGATCATCAGCGACAATGAGAGATATGGTTAGAGAGAATCATGTAAGAAAAGA
AGATTTAATATATCCAATTTTTGTAGTTGAAAAAGACGATGTGAAAAAAGAAATTAAGTCATTGCCAGGTGTATACCAAA
TCAGTTTGAATTTACTTGAAAGTGAATTAAAAGAAACTTATGACTTAGGCATACGTGCCATTATGTTTTTCGGTGTTCCA
AACTCAAAAGATGATATAGGTACTGGTGCATACATTCACGATGGTGTTATTCAACAGGCAACACGTATTGCTAAAAAAAT
GTATGATGACTTATTAATTGTTGCAGACACTTGTTTGTGTGAATATACTGATCATGGTCATTGTGGTGTGATTGATGACC
ATACACATGACGTTGACAATGATAAATCATTGCCACTACTTGTTAAAACAGCAATTTCTCAAGTGGAAGCTGGTGCTGAT
ATTATTGCACCAAGTAATATGATGGATGGTTTTGTTGCTGAAATTCGTCGTGGACTAGATGAAGTCGGCTATTACAATAT
TCCTATAATGAGTTATGGTGTCAAGTATGCATCTAGTTTCTTTGGACCTTTTAGAGATGCAGCAGATTCAGCGCCATCAT
TTGGTGATAGAAAAACGTATCAGATGGACCCTGCTAACCGTTTGGAAGCACTTCGTGAATTAGAAAGTGATCTTAAAGAA
GGGTGCGACATGATGATTGTTAAACCTGCTCTAAGTTATTTAGACATAGTTCGAGATGTTAAAAATCATACGAATGTTCC
AGTTGTTGCATATAATGTGAGTGGAGAATATAGTATGACTAAAGCAGCGGCACAAAATGGTTGGATAGATGAAGAACGTG
TCGTTATGGAACAAATGGTTTCAATGAAACGCGCAGGTGCTGATATGATTATTACGTATTTTGCAAAGGACATTTGTCGC
TATTTAGATAAATAA

Upstream 100 bases:

>100_bases
CAGCACGGACCATTAAATCATATCAACAACCAGTAACAATTGCAGAAATTCAAACACTTGAATCACTAATTGAAAAGATT
TTAGAAAGTAGGGGCTAAAA

Downstream 100 bases:

>100_bases
GGTTTTATATGTATGATTTTCCATAAACTATAGGAGGAATTTACTTTATGAGATATACGAAGTCAGAAGAAGCAATGAAG
GTTGCTGAAACTTTAATGCC

Product: delta-aminolevulinic acid dehydratase

Products: NA

Alternate protein names: ALAD; ALADH; Porphobilinogen synthase [H]

Number of amino acids: Translated: 324; Mature: 324

Protein sequence:

>324_residues
MKFDRHRRLRSSATMRDMVRENHVRKEDLIYPIFVVEKDDVKKEIKSLPGVYQISLNLLESELKETYDLGIRAIMFFGVP
NSKDDIGTGAYIHDGVIQQATRIAKKMYDDLLIVADTCLCEYTDHGHCGVIDDHTHDVDNDKSLPLLVKTAISQVEAGAD
IIAPSNMMDGFVAEIRRGLDEVGYYNIPIMSYGVKYASSFFGPFRDAADSAPSFGDRKTYQMDPANRLEALRELESDLKE
GCDMMIVKPALSYLDIVRDVKNHTNVPVVAYNVSGEYSMTKAAAQNGWIDEERVVMEQMVSMKRAGADMIITYFAKDICR
YLDK

Sequences:

>Translated_324_residues
MKFDRHRRLRSSATMRDMVRENHVRKEDLIYPIFVVEKDDVKKEIKSLPGVYQISLNLLESELKETYDLGIRAIMFFGVP
NSKDDIGTGAYIHDGVIQQATRIAKKMYDDLLIVADTCLCEYTDHGHCGVIDDHTHDVDNDKSLPLLVKTAISQVEAGAD
IIAPSNMMDGFVAEIRRGLDEVGYYNIPIMSYGVKYASSFFGPFRDAADSAPSFGDRKTYQMDPANRLEALRELESDLKE
GCDMMIVKPALSYLDIVRDVKNHTNVPVVAYNVSGEYSMTKAAAQNGWIDEERVVMEQMVSMKRAGADMIITYFAKDICR
YLDK
>Mature_324_residues
MKFDRHRRLRSSATMRDMVRENHVRKEDLIYPIFVVEKDDVKKEIKSLPGVYQISLNLLESELKETYDLGIRAIMFFGVP
NSKDDIGTGAYIHDGVIQQATRIAKKMYDDLLIVADTCLCEYTDHGHCGVIDDHTHDVDNDKSLPLLVKTAISQVEAGAD
IIAPSNMMDGFVAEIRRGLDEVGYYNIPIMSYGVKYASSFFGPFRDAADSAPSFGDRKTYQMDPANRLEALRELESDLKE
GCDMMIVKPALSYLDIVRDVKNHTNVPVVAYNVSGEYSMTKAAAQNGWIDEERVVMEQMVSMKRAGADMIITYFAKDICR
YLDK

Specific function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen [H]

COG id: COG0113

COG function: function code H; Delta-aminolevulinic acid dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ALADH family [H]

Homologues:

Organism=Homo sapiens, GI189083849, Length=301, Percent_Identity=42.1926910299003, Blast_Score=258, Evalue=6e-69,
Organism=Escherichia coli, GI87081728, Length=314, Percent_Identity=49.0445859872611, Blast_Score=301, Evalue=5e-83,
Organism=Saccharomyces cerevisiae, GI6321398, Length=316, Percent_Identity=41.7721518987342, Blast_Score=250, Evalue=2e-67,
Organism=Drosophila melanogaster, GI21358291, Length=318, Percent_Identity=37.4213836477987, Blast_Score=230, Evalue=1e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001731
- InterPro:   IPR013785 [H]

Pfam domain/function: PF00490 ALAD [H]

EC number: =4.2.1.24 [H]

Molecular weight: Translated: 36641; Mature: 36641

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS00169 D_ALA_DEHYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFDRHRRLRSSATMRDMVRENHVRKEDLIYPIFVVEKDDVKKEIKSLPGVYQISLNLLE
CCCHHHHHHHHHHHHHHHHHHHCCCHHHCEEEEEEEECHHHHHHHHHCCCEEEHHHHHHH
SELKETYDLGIRAIMFFGVPNSKDDIGTGAYIHDGVIQQATRIAKKMYDDLLIVADTCLC
HHHHHHHHHHHHEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EYTDHGHCGVIDDHTHDVDNDKSLPLLVKTAISQVEAGADIIAPSNMMDGFVAEIRRGLD
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHHHH
EVGYYNIPIMSYGVKYASSFFGPFRDAADSAPSFGDRKTYQMDPANRLEALRELESDLKE
HCCCCCCHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCEECCHHHHHHHHHHHHHHHHC
GCDMMIVKPALSYLDIVRDVKNHTNVPVVAYNVSGEYSMTKAAAQNGWIDEERVVMEQMV
CCCEEEHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHCCCCCHHHHHHHHHH
SMKRAGADMIITYFAKDICRYLDK
HHHHCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKFDRHRRLRSSATMRDMVRENHVRKEDLIYPIFVVEKDDVKKEIKSLPGVYQISLNLLE
CCCHHHHHHHHHHHHHHHHHHHCCCHHHCEEEEEEEECHHHHHHHHHCCCEEEHHHHHHH
SELKETYDLGIRAIMFFGVPNSKDDIGTGAYIHDGVIQQATRIAKKMYDDLLIVADTCLC
HHHHHHHHHHHHEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EYTDHGHCGVIDDHTHDVDNDKSLPLLVKTAISQVEAGADIIAPSNMMDGFVAEIRRGLD
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHHHH
EVGYYNIPIMSYGVKYASSFFGPFRDAADSAPSFGDRKTYQMDPANRLEALRELESDLKE
HCCCCCCHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCEECCHHHHHHHHHHHHHHHHC
GCDMMIVKPALSYLDIVRDVKNHTNVPVVAYNVSGEYSMTKAAAQNGWIDEERVVMEQMV
CCCEEEHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHCCCCCHHHHHHHHHH
SMKRAGADMIITYFAKDICRYLDK
HHHHCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9358061 [H]