Click here to switch to the map view.

The map label for this gene is coaBC [H]

Identifier: 82750816

GI number: 82750816

Start: 1159692

End: 1160891

Strand: Direct

Name: coaBC [H]

Synonym: SAB1075

Alternate gene names: 82750816

Gene position: 1159692-1160891 (Clockwise)

Preceding gene: 82750815

Following gene: 82750817

Centisome position: 42.29

GC content: 35.17

Gene sequence:

>1200_bases
ATGAAGAAAATATTGTTAGCCGTTACAGGTGGCATTGCGGCATATAAAGCGATTGATTTGACAAGTAAGTTAACACAATC
TGGGTATGAAGTTCGCGTTATGTTAACGAATCACGCGCAAAAATTTGTGACACCATTAGTATTTCAAGCAATAAGTCGAA
ATGCTGTTTATACAGATACTTTTATAGAAGAAAATCCTTCAGAAATACAGCATATTGCATTAGGTGATTGGGCAGATGCA
ATCATTGTTGCACCTGCAACGGCAAATACAATTGCAAAATTGAGTGTAGGTATTGCTGATGATTTGGTGACATCAACGTT
GCTAGCAACAGAGACACCGAAATTTATTGCGCCTGCCATGAATGTACATATGTATGAAAATAAGCGTACGCAGCAAAATA
TTAATATTTTAAAAGAAGATGGGTATCATTTTATCGAACCAGGAAGCGGATTTCTAGCATGTGGTTATGTTGCTAAAGGA
CGTATGGAAGAACCGCTTCAAATCGTTTCTGTTATTGATGCTCATTTTCAAAATAGTAATCGTTTAGCTAATAGTTCATT
TCAAGATAAACGCGCATTGGTTACAGCCGGACCAACTATTGAAGTTATCGATCCAGTCAGATTTGTATCCAATCGTTCTT
CTGGAAAAATGGGTTATGCAATAGCTGAAGCATTGCGAAATCGAGGAGCTATCGTGACGTTAGTTGCGGGTCCTACAACA
CTAGAGGATCCAAAAGATATTGAAGTTATTCATGTTCAAAGTGCTGAAGAAATGTTTGAACAAGTGACAAGCCGATTTGA
CGAACAAGATATTGTTGTAAAAGCAGCAGCCGTATCTGACTATACACCGGTTGATGTATTAGAACATAAGATGAAAAAGC
AGGATGGTGATTTGTCAGTATCTTTTAAACGTACTAAAGACATTCTTAAATATTTAGGTGAACATAAAACATCACAGTAT
TTAATAGGCTTTGCAGCAGAGACTGAAGATATTGAAAATTATGCACAACAAAAATTACGCAAGAAAAATGCAGATGTGAT
TATTTCAAATAATGTTGGGGATATGTCTATCGGATTTAGTTCTGATGATAATGAATTGACAATGCATTTTAAAAATAATG
AAAAAGTAAATATCAAGAAAGGAAAAAAAGTAGTATTAGCTGCACAAATTTTAGATGAACTAGAAACTAGGTGGCAATAA

Upstream 100 bases:

>100_bases
AATAATACTAAATTTGTATCTATAAAAAAGTAATGAGCATTTGTGCGCATATGATGATGTAAAGCGTAAATGTCATAGTG
ATATTTAAGGGAGATTGAAT

Downstream 100 bases:

>100_bases
TGATAGCGAAAGTCATAGTCGATGTCGCGTCGAAGAGCGTTGACTATAAATTTGATTATATAATTCCCGAACAACTCGAA
TCTGTCATCCAACCTGGTGT

Product: pantothenate metabolism flavoprotein

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MKKILLAVTGGIAAYKAIDLTSKLTQSGYEVRVMLTNHAQKFVTPLVFQAISRNAVYTDTFIEENPSEIQHIALGDWADA
IIVAPATANTIAKLSVGIADDLVTSTLLATETPKFIAPAMNVHMYENKRTQQNINILKEDGYHFIEPGSGFLACGYVAKG
RMEEPLQIVSVIDAHFQNSNRLANSSFQDKRALVTAGPTIEVIDPVRFVSNRSSGKMGYAIAEALRNRGAIVTLVAGPTT
LEDPKDIEVIHVQSAEEMFEQVTSRFDEQDIVVKAAAVSDYTPVDVLEHKMKKQDGDLSVSFKRTKDILKYLGEHKTSQY
LIGFAAETEDIENYAQQKLRKKNADVIISNNVGDMSIGFSSDDNELTMHFKNNEKVNIKKGKKVVLAAQILDELETRWQ

Sequences:

>Translated_399_residues
MKKILLAVTGGIAAYKAIDLTSKLTQSGYEVRVMLTNHAQKFVTPLVFQAISRNAVYTDTFIEENPSEIQHIALGDWADA
IIVAPATANTIAKLSVGIADDLVTSTLLATETPKFIAPAMNVHMYENKRTQQNINILKEDGYHFIEPGSGFLACGYVAKG
RMEEPLQIVSVIDAHFQNSNRLANSSFQDKRALVTAGPTIEVIDPVRFVSNRSSGKMGYAIAEALRNRGAIVTLVAGPTT
LEDPKDIEVIHVQSAEEMFEQVTSRFDEQDIVVKAAAVSDYTPVDVLEHKMKKQDGDLSVSFKRTKDILKYLGEHKTSQY
LIGFAAETEDIENYAQQKLRKKNADVIISNNVGDMSIGFSSDDNELTMHFKNNEKVNIKKGKKVVLAAQILDELETRWQ
>Mature_399_residues
MKKILLAVTGGIAAYKAIDLTSKLTQSGYEVRVMLTNHAQKFVTPLVFQAISRNAVYTDTFIEENPSEIQHIALGDWADA
IIVAPATANTIAKLSVGIADDLVTSTLLATETPKFIAPAMNVHMYENKRTQQNINILKEDGYHFIEPGSGFLACGYVAKG
RMEEPLQIVSVIDAHFQNSNRLANSSFQDKRALVTAGPTIEVIDPVRFVSNRSSGKMGYAIAEALRNRGAIVTLVAGPTT
LEDPKDIEVIHVQSAEEMFEQVTSRFDEQDIVVKAAAVSDYTPVDVLEHKMKKQDGDLSVSFKRTKDILKYLGEHKTSQY
LIGFAAETEDIENYAQQKLRKKNADVIISNNVGDMSIGFSSDDNELTMHFKNNEKVNIKKGKKVVLAAQILDELETRWQ

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=185, Percent_Identity=36.7567567567568, Blast_Score=92, Evalue=1e-18,
Organism=Escherichia coli, GI87082301, Length=401, Percent_Identity=42.3940149625935, Blast_Score=293, Evalue=1e-80,
Organism=Caenorhabditis elegans, GI17560194, Length=184, Percent_Identity=37.5, Blast_Score=97, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6322762, Length=193, Percent_Identity=34.1968911917098, Blast_Score=86, Evalue=8e-18,
Organism=Drosophila melanogaster, GI24657262, Length=187, Percent_Identity=32.0855614973262, Blast_Score=93, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 44169; Mature: 44169

Theoretical pI: Translated: 5.87; Mature: 5.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKILLAVTGGIAAYKAIDLTSKLTQSGYEVRVMLTNHAQKFVTPLVFQAISRNAVYTDT
CCEEEEEEECCHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHCCCCEEEEH
FIEENPSEIQHIALGDWADAIIVAPATANTIAKLSVGIADDLVTSTLLATETPKFIAPAM
HHCCCHHHHHEEEECCCCCEEEECCCCCCCHHHEECCHHHHHHHHHHHHCCCCCHHCCCC
NVHMYENKRTQQNINILKEDGYHFIEPGSGFLACGYVAKGRMEEPLQIVSVIDAHFQNSN
EEEEECCCCCCCCCCEEECCCCEEECCCCCEEEECEECCCCCCCHHHHHHHHHHHHCCCC
RLANSSFQDKRALVTAGPTIEVIDPVRFVSNRSSGKMGYAIAEALRNRGAIVTLVAGPTT
CCCCCCCCCCCEEEECCCEEEEECHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEECCCC
LEDPKDIEVIHVQSAEEMFEQVTSRFDEQDIVVKAAAVSDYTPVDVLEHKMKKQDGDLSV
CCCCCCEEEEEECCHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHCCCCCEEE
SFKRTKDILKYLGEHKTSQYLIGFAAETEDIENYAQQKLRKKNADVIISNNVGDMSIGFS
EHHHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHHHCCCCEEEECCCCCEEECCC
SDDNELTMHFKNNEKVNIKKGKKVVLAAQILDELETRWQ
CCCCEEEEEECCCCEEEECCCCEEEHHHHHHHHHHHCCC
>Mature Secondary Structure
MKKILLAVTGGIAAYKAIDLTSKLTQSGYEVRVMLTNHAQKFVTPLVFQAISRNAVYTDT
CCEEEEEEECCHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHCCCCEEEEH
FIEENPSEIQHIALGDWADAIIVAPATANTIAKLSVGIADDLVTSTLLATETPKFIAPAM
HHCCCHHHHHEEEECCCCCEEEECCCCCCCHHHEECCHHHHHHHHHHHHCCCCCHHCCCC
NVHMYENKRTQQNINILKEDGYHFIEPGSGFLACGYVAKGRMEEPLQIVSVIDAHFQNSN
EEEEECCCCCCCCCCEEECCCCEEECCCCCEEEECEECCCCCCCHHHHHHHHHHHHCCCC
RLANSSFQDKRALVTAGPTIEVIDPVRFVSNRSSGKMGYAIAEALRNRGAIVTLVAGPTT
CCCCCCCCCCCEEEECCCEEEEECHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEECCCC
LEDPKDIEVIHVQSAEEMFEQVTSRFDEQDIVVKAAAVSDYTPVDVLEHKMKKQDGDLSV
CCCCCCEEEEEECCHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHCCCCCEEE
SFKRTKDILKYLGEHKTSQYLIGFAAETEDIENYAQQKLRKKNADVIISNNVGDMSIGFS
EHHHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHHHCCCCEEEECCCCCEEECCC
SDDNELTMHFKNNEKVNIKKGKKVVLAAQILDELETRWQ
CCCCEEEEEECCCCEEEECCCCEEEHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9534248; 9384377 [H]