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The map label for this gene is purC

Identifier: 82750677

GI number: 82750677

Start: 1012522

End: 1013226

Strand: Direct

Name: purC

Synonym: SAB0933

Alternate gene names: 82750677

Gene position: 1012522-1013226 (Clockwise)

Preceding gene: 82750676

Following gene: 82750678

Centisome position: 36.92

GC content: 29.08

Gene sequence:

>705_bases
ATGACATTATTATATGAAGGAAAAGCGAAGCGCATTTTCTCAACAAATCAAGAAAATGAATTAAGAGTTGAATATAAAGA
TGAAGTTACTGCTGGAAACGGGGCTAAGAAAGACACGATGGCAGGTAAGGGGCGATTAAATAATCAAATTACTTCTATTA
TATTTAAATATTTACAAGAAAATGGAATAGAAAGTCACTTTATTAAGCAATTATCTGAAACAGAACAATTAGTTAAGCCT
GTGAAAATAATTCCATTAGAAGTAGTTGTTCGTAATATTGCTAGTGGATCTATTACAAAGCGTTTAGGTTTTGAAAATGG
TGAAGTTTTTAGAGAATCACTTGTGGAATTTTTCTATAAAAATGATGCATTAAATGATCCGTTGATAACGGATGATCACA
TCAAATTACTGAATATTGCGACAGATAAAGATATTGAAACATTAAAAACGAAAGCGCTAGAAATTAATCAAGTATTAAAA
AAATTAATGGATGCTATGAATTTAAAATTAGTAGATTTTAAAATCGAATTTGGAAAGACTGAGACTGGTCAAATTTTGTT
AGCGGATGAAATATCTCCAGATACATGCCGAATTTGGGATAAAGCTACCAATGCAAACTTTGATAAAGATGTATATAGAA
ATAACACTGGATCACTGATTGAAACATATCAAATATTTTTAAACAAATTGGAGGATTTAAAATAA

Upstream 100 bases:

>100_bases
TAAAGATAGCAGAAAAATGGGGCATATGACTGTACTAACGAATGATGTATACCAAACTGAACAAGATATGTACGCTAAAT
TTGAGGGGAGTAATTAAAGC

Downstream 100 bases:

>100_bases
TGAAAACAATTGAACTACATATCACATTACAACCACAAGTATTAGATACGCAAGGACAAACGCTTACTCGAGCTGTACAT
GATTTAGGTTATGCACAAGT

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase [H]

Number of amino acids: Translated: 234; Mature: 233

Protein sequence:

>234_residues
MTLLYEGKAKRIFSTNQENELRVEYKDEVTAGNGAKKDTMAGKGRLNNQITSIIFKYLQENGIESHFIKQLSETEQLVKP
VKIIPLEVVVRNIASGSITKRLGFENGEVFRESLVEFFYKNDALNDPLITDDHIKLLNIATDKDIETLKTKALEINQVLK
KLMDAMNLKLVDFKIEFGKTETGQILLADEISPDTCRIWDKATNANFDKDVYRNNTGSLIETYQIFLNKLEDLK

Sequences:

>Translated_234_residues
MTLLYEGKAKRIFSTNQENELRVEYKDEVTAGNGAKKDTMAGKGRLNNQITSIIFKYLQENGIESHFIKQLSETEQLVKP
VKIIPLEVVVRNIASGSITKRLGFENGEVFRESLVEFFYKNDALNDPLITDDHIKLLNIATDKDIETLKTKALEINQVLK
KLMDAMNLKLVDFKIEFGKTETGQILLADEISPDTCRIWDKATNANFDKDVYRNNTGSLIETYQIFLNKLEDLK
>Mature_233_residues
TLLYEGKAKRIFSTNQENELRVEYKDEVTAGNGAKKDTMAGKGRLNNQITSIIFKYLQENGIESHFIKQLSETEQLVKPV
KIIPLEVVVRNIASGSITKRLGFENGEVFRESLVEFFYKNDALNDPLITDDHIKLLNIATDKDIETLKTKALEINQVLKK
LMDAMNLKLVDFKIEFGKTETGQILLADEISPDTCRIWDKATNANFDKDVYRNNTGSLIETYQIFLNKLEDLK

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family [H]

Homologues:

Organism=Homo sapiens, GI119220557, Length=223, Percent_Identity=38.1165919282511, Blast_Score=136, Evalue=2e-32,
Organism=Homo sapiens, GI5453539, Length=223, Percent_Identity=38.1165919282511, Blast_Score=136, Evalue=2e-32,
Organism=Homo sapiens, GI119220559, Length=230, Percent_Identity=36.9565217391304, Blast_Score=128, Evalue=5e-30,
Organism=Escherichia coli, GI1788820, Length=227, Percent_Identity=40.5286343612335, Blast_Score=181, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI17531275, Length=223, Percent_Identity=37.6681614349776, Blast_Score=133, Evalue=9e-32,
Organism=Drosophila melanogaster, GI18860083, Length=221, Percent_Identity=31.6742081447964, Blast_Score=120, Evalue=6e-28,
Organism=Drosophila melanogaster, GI24583917, Length=222, Percent_Identity=31.5315315315315, Blast_Score=103, Evalue=9e-23,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236 [H]

Pfam domain/function: PF01259 SAICAR_synt [H]

EC number: =6.3.2.6 [H]

Molecular weight: Translated: 26727; Mature: 26596

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: PS01057 SAICAR_SYNTHETASE_1 ; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLLYEGKAKRIFSTNQENELRVEYKDEVTAGNGAKKDTMAGKGRLNNQITSIIFKYLQE
CCEEECCCCCCEECCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
NGIESHFIKQLSETEQLVKPVKIIPLEVVVRNIASGSITKRLGFENGEVFRESLVEFFYK
CCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHHHHH
NDALNDPLITDDHIKLLNIATDKDIETLKTKALEINQVLKKLMDAMNLKLVDFKIEFGKT
CCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEECCCC
ETGQILLADEISPDTCRIWDKATNANFDKDVYRNNTGSLIETYQIFLNKLEDLK
CCCCEEEECCCCCCCEEEECCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TLLYEGKAKRIFSTNQENELRVEYKDEVTAGNGAKKDTMAGKGRLNNQITSIIFKYLQE
CEEECCCCCCEECCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
NGIESHFIKQLSETEQLVKPVKIIPLEVVVRNIASGSITKRLGFENGEVFRESLVEFFYK
CCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHHHHH
NDALNDPLITDDHIKLLNIATDKDIETLKTKALEINQVLKKLMDAMNLKLVDFKIEFGKT
CCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEECCCC
ETGQILLADEISPDTCRIWDKATNANFDKDVYRNNTGSLIETYQIFLNKLEDLK
CCCCEEEECCCCCCCEEEECCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA