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The map label for this gene is purK

Identifier: 82750676

GI number: 82750676

Start: 1011394

End: 1012518

Strand: Direct

Name: purK

Synonym: SAB0932

Alternate gene names: 82750676

Gene position: 1011394-1012518 (Clockwise)

Preceding gene: 82750675

Following gene: 82750677

Centisome position: 36.88

GC content: 32.98

Gene sequence:

>1125_bases
ATGAACTTCAATAAATTAAAGTTTGGTGCGACTATTGGCATTATTGGTGGCGGTCAGCTTGGAAAGATGATGGCACAATC
AGCTCAAAAAATGGGTTATAAAGTGGCTGTTTTGGATCCTGCTGAAGATTGTCCATGTAGATACGTTGCACACGAATTTT
TACAAGCCAAGTATGACGATGAAAAGGCACTCAATCAATTAGGACAAAAATGTGATGTGATTACTTATGAATTTGAAAAC
ATTTCAGCCCAACAATTAAAACTATTATGTGAAAAGTACAATATTCCGCAAGGTTACCAAGCTATACAGTTATTACAAGA
CCGCTTAACTGAAAAAGAAACATTAAAAAGTGCTGGTACCAAGGTTGTCCCATTCATTTCAGTAAAAGAATCTACAGATA
TGGACAAAGCAATTGAAACATTAGGATATCCTTTTATTGTAAAAACTAGATTTGGTGGCTACGATGGCAAAGGTCAAGTT
TTAATTAACAACGAAAAAGACTTAAAAGAAGGTTTTAAATTAATTGAAACTAGTGAATGCGTAGCTGAAAAATATTTGAA
TATTAAGAAAGAAGTATCACTTACTGTTACAAGAGGAAACAACAATCAAATCACTTATTTCCCATTACAAGAAAATGAGC
ATAGAAATCAAATACTTTTCAAAACAATTGTTCCAGCGAGAATAGATAAAACAGCTGAGGCGAAAGAGCAAGTTAATAAA
ATTATCCAATCGATTCATTTCATTGGAACATTTACAGTTGAATTTTTTATAGATAGTAACAACCAATTGTATGTGAACGA
GATTGCACCAAGGCCTCACAATTCCGGACATTATTCAATTGAAGCATGTGATTATTCACAATTTGATACTCATATTTTAG
CAGTTACCGGACAATCATTACCAAATTCAATTGAATTATTAAAGCCTGCAGTCATGATGAACTTACTAGGTAAAGACTTA
GATTTATTGGAAAATGAATTTAATGAACATCCAGAGTGGCACTTACATATTTATGGTAAGTCTGAGCGTAAAGATAGCAG
AAAAATGGGGCATATGACTGTACTAACGAATGATGTATACCAAACTGAACAAGATATGTACGCTAAATTTGAGGGGAGTA
ATTAA

Upstream 100 bases:

>100_bases
ATACTTGCAGCAAGAATGTTAAGTATTCAAAATCCTTCTTTAGTTGAAAAACTAAATCAGTATGAATCTTCGTTAATTCA
AAAAGTGGAGGACATGCAAA

Downstream 100 bases:

>100_bases
AGCATGACATTATTATATGAAGGAAAAGCGAAGCGCATTTTCTCAACAAATCAAGAAAATGAATTAAGAGTTGAATATAA
AGATGAAGTTACTGCTGGAA

Product: phosphoribosylaminoimidazole carboxylase ATPase subunit

Products: NA

Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]

Number of amino acids: Translated: 374; Mature: 374

Protein sequence:

>374_residues
MNFNKLKFGATIGIIGGGQLGKMMAQSAQKMGYKVAVLDPAEDCPCRYVAHEFLQAKYDDEKALNQLGQKCDVITYEFEN
ISAQQLKLLCEKYNIPQGYQAIQLLQDRLTEKETLKSAGTKVVPFISVKESTDMDKAIETLGYPFIVKTRFGGYDGKGQV
LINNEKDLKEGFKLIETSECVAEKYLNIKKEVSLTVTRGNNNQITYFPLQENEHRNQILFKTIVPARIDKTAEAKEQVNK
IIQSIHFIGTFTVEFFIDSNNQLYVNEIAPRPHNSGHYSIEACDYSQFDTHILAVTGQSLPNSIELLKPAVMMNLLGKDL
DLLENEFNEHPEWHLHIYGKSERKDSRKMGHMTVLTNDVYQTEQDMYAKFEGSN

Sequences:

>Translated_374_residues
MNFNKLKFGATIGIIGGGQLGKMMAQSAQKMGYKVAVLDPAEDCPCRYVAHEFLQAKYDDEKALNQLGQKCDVITYEFEN
ISAQQLKLLCEKYNIPQGYQAIQLLQDRLTEKETLKSAGTKVVPFISVKESTDMDKAIETLGYPFIVKTRFGGYDGKGQV
LINNEKDLKEGFKLIETSECVAEKYLNIKKEVSLTVTRGNNNQITYFPLQENEHRNQILFKTIVPARIDKTAEAKEQVNK
IIQSIHFIGTFTVEFFIDSNNQLYVNEIAPRPHNSGHYSIEACDYSQFDTHILAVTGQSLPNSIELLKPAVMMNLLGKDL
DLLENEFNEHPEWHLHIYGKSERKDSRKMGHMTVLTNDVYQTEQDMYAKFEGSN
>Mature_374_residues
MNFNKLKFGATIGIIGGGQLGKMMAQSAQKMGYKVAVLDPAEDCPCRYVAHEFLQAKYDDEKALNQLGQKCDVITYEFEN
ISAQQLKLLCEKYNIPQGYQAIQLLQDRLTEKETLKSAGTKVVPFISVKESTDMDKAIETLGYPFIVKTRFGGYDGKGQV
LINNEKDLKEGFKLIETSECVAEKYLNIKKEVSLTVTRGNNNQITYFPLQENEHRNQILFKTIVPARIDKTAEAKEQVNK
IIQSIHFIGTFTVEFFIDSNNQLYVNEIAPRPHNSGHYSIEACDYSQFDTHILAVTGQSLPNSIELLKPAVMMNLLGKDL
DLLENEFNEHPEWHLHIYGKSERKDSRKMGHMTVLTNDVYQTEQDMYAKFEGSN

Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]

COG id: COG0026

COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786733, Length=349, Percent_Identity=28.9398280802292, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI1788155, Length=373, Percent_Identity=24.1286863270777, Blast_Score=89, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6324702, Length=381, Percent_Identity=31.2335958005249, Blast_Score=207, Evalue=3e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005875
- InterPro:   IPR011761
- InterPro:   IPR003135
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR006140
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02826 2-Hacid_dh_C; PF02222 ATP-grasp [H]

EC number: =6.3.4.18 [H]

Molecular weight: Translated: 42533; Mature: 42533

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFNKLKFGATIGIIGGGQLGKMMAQSAQKMGYKVAVLDPAEDCPCRYVAHEFLQAKYDD
CCCCEEEECEEEEEECCCHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHCCCH
EKALNQLGQKCDVITYEFENISAQQLKLLCEKYNIPQGYQAIQLLQDRLTEKETLKSAGT
HHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCC
KVVPFISVKESTDMDKAIETLGYPFIVKTRFGGYDGKGQVLINNEKDLKEGFKLIETSEC
EEEEEEEECCCCCHHHHHHHCCCCEEEEEECCCCCCCCCEEECCCHHHHHHHHHHHHHHH
VAEKYLNIKKEVSLTVTRGNNNQITYFPLQENEHRNQILFKTIVPARIDKTAEAKEQVNK
HHHHHHCCCEEEEEEEEECCCCEEEEEECCCCCCCCEEEEEECCCHHCCCHHHHHHHHHH
IIQSIHFIGTFTVEFFIDSNNQLYVNEIAPRPHNSGHYSIEACDYSQFDTHILAVTGQSL
HHHHHHHHEEEEEEEEECCCCEEEEEECCCCCCCCCCEEEEECCCCCCCCEEEEEECCCC
PNSIELLKPAVMMNLLGKDLDLLENEFNEHPEWHLHIYGKSERKDSRKMGHMTVLTNDVY
CCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCEEEEEEECCCCCHHHHCCCEEEEECHHH
QTEQDMYAKFEGSN
HCCHHHHEEECCCC
>Mature Secondary Structure
MNFNKLKFGATIGIIGGGQLGKMMAQSAQKMGYKVAVLDPAEDCPCRYVAHEFLQAKYDD
CCCCEEEECEEEEEECCCHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHCCCH
EKALNQLGQKCDVITYEFENISAQQLKLLCEKYNIPQGYQAIQLLQDRLTEKETLKSAGT
HHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCC
KVVPFISVKESTDMDKAIETLGYPFIVKTRFGGYDGKGQVLINNEKDLKEGFKLIETSEC
EEEEEEEECCCCCHHHHHHHCCCCEEEEEECCCCCCCCCEEECCCHHHHHHHHHHHHHHH
VAEKYLNIKKEVSLTVTRGNNNQITYFPLQENEHRNQILFKTIVPARIDKTAEAKEQVNK
HHHHHHCCCEEEEEEEEECCCCEEEEEECCCCCCCCEEEEEECCCHHCCCHHHHHHHHHH
IIQSIHFIGTFTVEFFIDSNNQLYVNEIAPRPHNSGHYSIEACDYSQFDTHILAVTGQSL
HHHHHHHHEEEEEEEEECCCCEEEEEECCCCCCCCCCEEEEECCCCCCCCEEEEEECCCC
PNSIELLKPAVMMNLLGKDLDLLENEFNEHPEWHLHIYGKSERKDSRKMGHMTVLTNDVY
CCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCEEEEEEECCCCCHHHHCCCEEEEECHHH
QTEQDMYAKFEGSN
HCCHHHHEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA