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The map label for this gene is ispD1

Identifier: 82749957

GI number: 82749957

Start: 237280

End: 237996

Strand: Direct

Name: ispD1

Synonym: SAB0190

Alternate gene names: 82749957

Gene position: 237280-237996 (Clockwise)

Preceding gene: 82749956

Following gene: 82749958

Centisome position: 8.65

GC content: 32.78

Gene sequence:

>717_bases
ATGATTTATGCAGGTATTTTAGCAGGAGGTATTGGTTCAAGAATGGGGAACGTGCCATTACCAAAACAATTTTTAGATAT
TGATAATAAACCGATTTTAATCCATACAATTGAGAAGTTCATTTTAGTGAGTGAATTTAATGAGATTATTATCGCAACGC
CAGCACAGTGGATTTCCCATACACAGGATATTTTAAAAAAATATAATATTACAGATCAACGTGTCAAAGTAGTTGCAGGT
GGTACGGATCGAAACGAAACAATTATGAACATTATCGACCATATTCGCAATGTAAATGGAATTAATAATAATGATGTGAT
TGTAACTCATGATGCCGTAAGACCATTTTTAACTCAACGTATTATTAAAGAGAATATTGAAGTAGCAGCAAAATATGGTG
CAGTAGATACAGTCATTGAAGCAATTGATACGATTGTAATGTCTAAAGATAAACAGAACATACACAGTATCCCTGTAAGG
AATGAAATGTATCAAGGCCAAACACCACAATCATTTAATATTAAATTATTACAAGATAGTTATCGCGCCTTGAGTAGTGA
ACAAAAAGAAATCTTATCAGATGCATGTAAAATCATTGTCGAATCTGGACATGCAGTTAAATTGGTACGTGGAGAACTCT
ACAACATTAAAGTGACAACACCGTATGATTTAAAAGTAGCAAATGCCATTATTCAAGGTGATATTGCCGATGATTAA

Upstream 100 bases:

>100_bases
CTTAATAAAAGAGGCAAGTGAGCAATAGGTTAGGCTTATGTTCGGACATAGGTCAGTAATGTATAAATGGAAACGATGTA
ATGACAGAATGGAGGACAAC

Downstream 100 bases:

>100_bases
TCAAGTATATCAACTCGTTGCACCGAGACAGTTCGACGTCACATATAATAATGTTGATATTTATGGTAATCATGTCATCG
TAAGACCTTTTATACTTGTC

Product: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase

Products: NA

Alternate protein names: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase 1; MEP cytidylyltransferase 1; MCT 1

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MIYAGILAGGIGSRMGNVPLPKQFLDIDNKPILIHTIEKFILVSEFNEIIIATPAQWISHTQDILKKYNITDQRVKVVAG
GTDRNETIMNIIDHIRNVNGINNNDVIVTHDAVRPFLTQRIIKENIEVAAKYGAVDTVIEAIDTIVMSKDKQNIHSIPVR
NEMYQGQTPQSFNIKLLQDSYRALSSEQKEILSDACKIIVESGHAVKLVRGELYNIKVTTPYDLKVANAIIQGDIADD

Sequences:

>Translated_238_residues
MIYAGILAGGIGSRMGNVPLPKQFLDIDNKPILIHTIEKFILVSEFNEIIIATPAQWISHTQDILKKYNITDQRVKVVAG
GTDRNETIMNIIDHIRNVNGINNNDVIVTHDAVRPFLTQRIIKENIEVAAKYGAVDTVIEAIDTIVMSKDKQNIHSIPVR
NEMYQGQTPQSFNIKLLQDSYRALSSEQKEILSDACKIIVESGHAVKLVRGELYNIKVTTPYDLKVANAIIQGDIADD
>Mature_238_residues
MIYAGILAGGIGSRMGNVPLPKQFLDIDNKPILIHTIEKFILVSEFNEIIIATPAQWISHTQDILKKYNITDQRVKVVAG
GTDRNETIMNIIDHIRNVNGINNNDVIVTHDAVRPFLTQRIIKENIEVAAKYGAVDTVIEAIDTIVMSKDKQNIHSIPVR
NEMYQGQTPQSFNIKLLQDSYRALSSEQKEILSDACKIIVESGHAVKLVRGELYNIKVTTPYDLKVANAIIQGDIADD

Specific function: Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)

COG id: COG1211

COG function: function code I; 4-diphosphocytidyl-2-methyl-D-erithritol synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ispD family

Homologues:

Organism=Homo sapiens, GI157412259, Length=241, Percent_Identity=26.1410788381743, Blast_Score=94, Evalue=9e-20,
Organism=Homo sapiens, GI157671913, Length=230, Percent_Identity=24.7826086956522, Blast_Score=79, Evalue=3e-15,
Organism=Escherichia coli, GI1789104, Length=232, Percent_Identity=26.7241379310345, Blast_Score=73, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ISPD1_STAAB (Q2YV76)

Other databases:

- EMBL:   AJ938182
- RefSeq:   YP_415698.1
- ProteinModelPortal:   Q2YV76
- STRING:   Q2YV76
- EnsemblBacteria:   EBSTAT00000012421
- GeneID:   3793574
- GenomeReviews:   AJ938182_GR
- KEGG:   sab:SAB0190
- NMPDR:   fig|273036.3.peg.408
- eggNOG:   COG1211
- GeneTree:   EBGT00050000024510
- HOGENOM:   HBG672839
- OMA:   GELFNIK
- ProtClustDB:   PRK13385
- BioCyc:   SAUR273036:SAB0190-MONOMER
- HAMAP:   MF_00108
- InterPro:   IPR001228
- InterPro:   IPR018294

Pfam domain/function: PF01128 IspD

EC number: =2.7.7.60

Molecular weight: Translated: 26574; Mature: 26574

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS01295 ISPD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIYAGILAGGIGSRMGNVPLPKQFLDIDNKPILIHTIEKFILVSEFNEIIIATPAQWISH
CEEEEEECCCHHHHCCCCCCCHHHHCCCCCCEEHHHHHHHHHHHCCCCEEEECCHHHHHH
TQDILKKYNITDQRVKVVAGGTDRNETIMNIIDHIRNVNGINNNDVIVTHDAVRPFLTQR
HHHHHHHCCCCCHHEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHHH
IIKENIEVAAKYGAVDTVIEAIDTIVMSKDKQNIHSIPVRNEMYQGQTPQSFNIKLLQDS
HHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCHHCCCCCHHHHCCCCCCCCEEEEHHHH
YRALSSEQKEILSDACKIIVESGHAVKLVRGELYNIKVTTPYDLKVANAIIQGDIADD
HHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCEEEEEEECCCCHHHHHHHHCCCCCCC
>Mature Secondary Structure
MIYAGILAGGIGSRMGNVPLPKQFLDIDNKPILIHTIEKFILVSEFNEIIIATPAQWISH
CEEEEEECCCHHHHCCCCCCCHHHHCCCCCCEEHHHHHHHHHHHCCCCEEEECCHHHHHH
TQDILKKYNITDQRVKVVAGGTDRNETIMNIIDHIRNVNGINNNDVIVTHDAVRPFLTQR
HHHHHHHCCCCCHHEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHHH
IIKENIEVAAKYGAVDTVIEAIDTIVMSKDKQNIHSIPVRNEMYQGQTPQSFNIKLLQDS
HHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCHHCCCCCHHHHCCCCCCCCEEEEHHHH
YRALSSEQKEILSDACKIIVESGHAVKLVRGELYNIKVTTPYDLKVANAIIQGDIADD
HHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCEEEEEEECCCCHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA