Click here to switch to the map view.

The map label for this gene is yrkH [H]

Identifier: 82749808

GI number: 82749808

Start: 41106

End: 42440

Strand: Direct

Name: yrkH [H]

Synonym: SAB0031

Alternate gene names: 82749808

Gene position: 41106-42440 (Clockwise)

Preceding gene: 82749807

Following gene: 82749809

Centisome position: 1.5

GC content: 33.18

Gene sequence:

>1335_bases
ATGTTTTTTAAACAGTTTTACGATAATCATTTATCTCAAGCATCATATTTAGTGGGTTGTCAACGTACAGGAGAGGCAAT
AATAATAGACCCTGTTCGTGATTTATCGAAATATATAGAAGTTGCAGATTCTGAAGGTTTAACAATTACACAAGCTACAG
AACCACATATTCATGCTGATTTTGCTTTAGGAATTCGTGATGTGGCTAAACGCTTAAATGCAAATATATATGTGTCTGGC
GAAGGTGAAGATGCATTAGGGTATAAAAATATGCCATCAAAAACACAATTTGTTAAACATGGAGATATCATTCAAGTAGG
CAATGTTAAATTAGAAGTTCTGCATACTCCAGGACACACGCCTGAAAGTATTAGCTTTTTACTCACTGATTTAGGTGGTG
GTTCAAGTGTTCCGATGGGATTATTTAGTGGTGACTTTATTTTTGTTGGTGATATAGGTAGACCTGATTTATTAGAAAAA
TCTGTTCAAATAAAAGGTTCTACAGAAATTAGCGCGAAACAAATGTATGAGTCCGTTCAAAATATTAAAAATTTACCTGA
CTATGTTCAAATCTGGCCGGGTCATGGTGCTGGAAGCCCTTGTGGTAAAGCATTAGGTGCCATACCTATATCTACAATAG
GTTATGAGAAAATTAATAACTGGGCATTTAATGAAATTGATGAGACTAAATTTATTGAATCATTAACATCAAATCAACCA
GCACCACCGCATCATTTTGCACAAATGAAACAAGTTAATCAGTTTGATATGAATTTATATCAATCATACGATGTTTATCC
TAGTTTAGATAATAAAAGAGTAGCATTTGATCTTCGTAGCAAAGAGGCCTTTCACGGTGGCCACACAAAAGGAACAATCA
ATATACCATACAACAAAAACTTTATTAATCAAATTGGTTGGTACTTAGATTTTGAAAAAGATATAGATTTAATTGGAGAT
AAATCTACTGTTGAGAAAGCGAAACACACTTTACAATTAATTGGGTTTGATAAGGTAGCAGGCTATCGTTTGCCAAAATC
AGACATTTCAACCCAGTCCGTTCATAGCGCTTATATGACAGGTAAAGAAGAACATGTATTAGACGTACGTAATGATGAAG
AGTGGAATAATGGACACTTATACCAAGCTGTTAATATTGCACATGGTAAATTATTAAATGAAAATATTCCTTTTAATAAA
GAGGATAAAATATATGTACATTGTCAGTCAGGTGTTAGAAGTTCAATTGCAGTGGGTATATTGGAAAGCAAAGGTTTTGA
AAATGTGGTGAATATTAGAGAAGGCTATCAAGATTTTCCAGAATCATTAAAATAA

Upstream 100 bases:

>100_bases
AGTTGAGTACGGTGGTGTAGGCACTTATATTGGTGCTACTGAAAATGCGAATCATAATTTATTTATCTAATTAAATCTAT
TAATAAAAGGAGTTGTTATC

Downstream 100 bases:

>100_bases
TTTAAGGATGTGGAAAAAATGAATAAGCATTATCAAATTGTTATTATTGGTGGCGGTACAGCAGGTGTTACCGTAGCATC
AAGACTATTAAGAAAAAATC

Product: hydroxyacylglutathione hydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 444; Mature: 444

Protein sequence:

>444_residues
MFFKQFYDNHLSQASYLVGCQRTGEAIIIDPVRDLSKYIEVADSEGLTITQATEPHIHADFALGIRDVAKRLNANIYVSG
EGEDALGYKNMPSKTQFVKHGDIIQVGNVKLEVLHTPGHTPESISFLLTDLGGGSSVPMGLFSGDFIFVGDIGRPDLLEK
SVQIKGSTEISAKQMYESVQNIKNLPDYVQIWPGHGAGSPCGKALGAIPISTIGYEKINNWAFNEIDETKFIESLTSNQP
APPHHFAQMKQVNQFDMNLYQSYDVYPSLDNKRVAFDLRSKEAFHGGHTKGTINIPYNKNFINQIGWYLDFEKDIDLIGD
KSTVEKAKHTLQLIGFDKVAGYRLPKSDISTQSVHSAYMTGKEEHVLDVRNDEEWNNGHLYQAVNIAHGKLLNENIPFNK
EDKIYVHCQSGVRSSIAVGILESKGFENVVNIREGYQDFPESLK

Sequences:

>Translated_444_residues
MFFKQFYDNHLSQASYLVGCQRTGEAIIIDPVRDLSKYIEVADSEGLTITQATEPHIHADFALGIRDVAKRLNANIYVSG
EGEDALGYKNMPSKTQFVKHGDIIQVGNVKLEVLHTPGHTPESISFLLTDLGGGSSVPMGLFSGDFIFVGDIGRPDLLEK
SVQIKGSTEISAKQMYESVQNIKNLPDYVQIWPGHGAGSPCGKALGAIPISTIGYEKINNWAFNEIDETKFIESLTSNQP
APPHHFAQMKQVNQFDMNLYQSYDVYPSLDNKRVAFDLRSKEAFHGGHTKGTINIPYNKNFINQIGWYLDFEKDIDLIGD
KSTVEKAKHTLQLIGFDKVAGYRLPKSDISTQSVHSAYMTGKEEHVLDVRNDEEWNNGHLYQAVNIAHGKLLNENIPFNK
EDKIYVHCQSGVRSSIAVGILESKGFENVVNIREGYQDFPESLK
>Mature_444_residues
MFFKQFYDNHLSQASYLVGCQRTGEAIIIDPVRDLSKYIEVADSEGLTITQATEPHIHADFALGIRDVAKRLNANIYVSG
EGEDALGYKNMPSKTQFVKHGDIIQVGNVKLEVLHTPGHTPESISFLLTDLGGGSSVPMGLFSGDFIFVGDIGRPDLLEK
SVQIKGSTEISAKQMYESVQNIKNLPDYVQIWPGHGAGSPCGKALGAIPISTIGYEKINNWAFNEIDETKFIESLTSNQP
APPHHFAQMKQVNQFDMNLYQSYDVYPSLDNKRVAFDLRSKEAFHGGHTKGTINIPYNKNFINQIGWYLDFEKDIDLIGD
KSTVEKAKHTLQLIGFDKVAGYRLPKSDISTQSVHSAYMTGKEEHVLDVRNDEEWNNGHLYQAVNIAHGKLLNENIPFNK
EDKIYVHCQSGVRSSIAVGILESKGFENVVNIREGYQDFPESLK

Specific function: Unknown

COG id: COG0491

COG function: function code R; Zn-dependent hydrolases, including glyoxylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 rhodanese domain [H]

Homologues:

Organism=Homo sapiens, GI21703352, Length=218, Percent_Identity=27.9816513761468, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI116642887, Length=218, Percent_Identity=27.9816513761468, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI14150041, Length=188, Percent_Identity=30.3191489361702, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI46361987, Length=188, Percent_Identity=30.3191489361702, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI94538320, Length=188, Percent_Identity=29.7872340425532, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI94538322, Length=190, Percent_Identity=29.4736842105263, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI1787158, Length=226, Percent_Identity=29.646017699115, Blast_Score=87, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17538952, Length=196, Percent_Identity=28.0612244897959, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17536925, Length=171, Percent_Identity=30.9941520467836, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI221330176, Length=200, Percent_Identity=27.5, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR001763 [H]

Pfam domain/function: PF00753 Lactamase_B; PF00581 Rhodanese [H]

EC number: NA

Molecular weight: Translated: 49560; Mature: 49560

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: PS50206 RHODANESE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFFKQFYDNHLSQASYLVGCQRTGEAIIIDPVRDLSKYIEVADSEGLTITQATEPHIHAD
CCHHHHHHHHHHHHHHEEEECCCCCEEEECCHHHHHHHHHHCCCCCCEEEECCCCCEEEH
FALGIRDVAKRLNANIYVSGEGEDALGYKNMPSKTQFVKHGDIIQVGNVKLEVLHTPGHT
HHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCHHHHHCCCCEEEECCEEEEEEECCCCC
PESISFLLTDLGGGSSVPMGLFSGDFIFVGDIGRPDLLEKSVQIKGSTEISAKQMYESVQ
CHHHEEEEEECCCCCCCCCEEECCCEEEEECCCCCHHHHCCEEECCCCCHHHHHHHHHHH
NIKNLPDYVQIWPGHGAGSPCGKALGAIPISTIGYEKINNWAFNEIDETKFIESLTSNQP
HHHCCCCEEEEECCCCCCCHHHHHHCCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHCCCC
APPHHFAQMKQVNQFDMNLYQSYDVYPSLDNKRVAFDLRSKEAFHGGHTKGTINIPYNKN
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCHHHCCCCCCEEEECCCCCC
FINQIGWYLDFEKDIDLIGDKSTVEKAKHTLQLIGFDKVAGYRLPKSDISTQSVHSAYMT
HHHHHCCEEEECCCCCCCCCHHHHHHHHHHEEEEEEHHHCCCCCCCCCCCHHHHHHHHHC
GKEEHVLDVRNDEEWNNGHLYQAVNIAHGKLLNENIPFNKEDKIYVHCQSGVRSSIAVGI
CCCCEEEECCCCCCCCCCEEEEEEEECCCEEECCCCCCCCCCEEEEEECCCCCCEEEEEE
LESKGFENVVNIREGYQDFPESLK
CCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MFFKQFYDNHLSQASYLVGCQRTGEAIIIDPVRDLSKYIEVADSEGLTITQATEPHIHAD
CCHHHHHHHHHHHHHHEEEECCCCCEEEECCHHHHHHHHHHCCCCCCEEEECCCCCEEEH
FALGIRDVAKRLNANIYVSGEGEDALGYKNMPSKTQFVKHGDIIQVGNVKLEVLHTPGHT
HHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCHHHHHCCCCEEEECCEEEEEEECCCCC
PESISFLLTDLGGGSSVPMGLFSGDFIFVGDIGRPDLLEKSVQIKGSTEISAKQMYESVQ
CHHHEEEEEECCCCCCCCCEEECCCEEEEECCCCCHHHHCCEEECCCCCHHHHHHHHHHH
NIKNLPDYVQIWPGHGAGSPCGKALGAIPISTIGYEKINNWAFNEIDETKFIESLTSNQP
HHHCCCCEEEEECCCCCCCHHHHHHCCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHCCCC
APPHHFAQMKQVNQFDMNLYQSYDVYPSLDNKRVAFDLRSKEAFHGGHTKGTINIPYNKN
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCHHHCCCCCCEEEECCCCCC
FINQIGWYLDFEKDIDLIGDKSTVEKAKHTLQLIGFDKVAGYRLPKSDISTQSVHSAYMT
HHHHHCCEEEECCCCCCCCCHHHHHHHHHHEEEEEEHHHCCCCCCCCCCCHHHHHHHHHC
GKEEHVLDVRNDEEWNNGHLYQAVNIAHGKLLNENIPFNKEDKIYVHCQSGVRSSIAVGI
CCCCEEEECCCCCCCCCCEEEEEEEECCCEEECCCCCCCCCCEEEEEECCCCCCEEEEEE
LESKGFENVVNIREGYQDFPESLK
CCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]