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The map label for this gene is pyrD [H]

Identifier: 82703819

GI number: 82703819

Start: 3108544

End: 3109593

Strand: Reverse

Name: pyrD [H]

Synonym: Nmul_A2706

Alternate gene names: 82703819

Gene position: 3109593-3108544 (Counterclockwise)

Preceding gene: 82703821

Following gene: 82703818

Centisome position: 97.66

GC content: 57.05

Gene sequence:

>1050_bases
ATGATGCTTTACTCATTGCTCCGTCCCCTGGTATTTGCCCTCGAACCGGAAACCGCGCATGGTATTGCCTTCAACGCGAT
GGAGACGGCCCATCGGCTTGGGCTCTACCGTGCGCGTCCTGCGCCCTGCCGTTCTCGCAGCATAATGGGGCTGACCTTTC
CCAACCCTGTCGGCTTGGCAGCGGGATTGGACAAGAATGGCGAACATATAGACGCGCTGGCGGCCCTTGGATTCGGATTT
ATCGAAATTGGCACGGTCACGCCGCGGCCACAGCCGGGAAATCCCAAGCCCCGATTGTTTCGCCTGCCGCAGGCAAATTC
CATTATCAACCGCATGGGCTTCAATAATAACGGTATCGAGGGTCTTGTCGCAAACGTGAAGGCGATGGACTACAAAGGTA
TTCTGGGGATCAACATCGGGAAAAACTTCGATACGCCGGTAGAAAAAGCCGTGGATGACTATCTGATATGCCTGCGCAAG
GCGTATCGCTACGCCAGCTATATCACCGTCAACATTTCTTCTCCAAATACCCCTAATCTTCGGCAACTGCAACAGGCCAC
CGAACTGGATTCCCTGCTTGGCACGCTGAAACTGAATCAGCAGCGTCTGGCTGACGAACATGGAAAATACACCCCACTTC
TGGTGAAGATCGCTCCTGACCTGGAGTTGCCGGAAATCGATTCCATCGCCGCACTGTTGATGAAGCATCGTGTTGACGGC
GTTATTGCCACCAATACCACCCTCTCCCGCGCAGGGGTGGAAACACTTCCCCATGCGCGGGAAGCGGGCGGATTGAGCGG
GGCGCCGCTTGCAAAACGCGCGACCTCAGTCGTCGCGCGCCTCCACCATGCCCTGCAAGGGGCGCTGCCTATTATCGGGG
TGGGCGGCATCATGGATGCGGCCGGCGCTACCGAAAAAATCGCAGCCGGCGCCAGCCTGATCCAGGTATACAGCGGCCTC
GTTTATCGCGGTCCTCATCTCGTGGGTGAGATTGCACAGGTGTTGTGCAATGCAAATGGGGGGGGCCTCGATGGTGCCAG
TTCAACATGA

Upstream 100 bases:

>100_bases
GACATGGCGTCTGAACCCCGCCTGCCGCCGGTTATCATGGAGACTCCGTATAGACCGGATCAGGGAACAAGCGTTCACCC
CGGCGGCAATGGTAGAATGA

Downstream 100 bases:

>100_bases
AAGATATTTCTCTGGCAGAGAAAATTGATGCCATTCTTCCGCAAACCCAATGCCGCCAGTGCGGGTTTTCGGGTTGCAGG
CCTTACGCCGAAGCAATTGC

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 349; Mature: 349

Protein sequence:

>349_residues
MMLYSLLRPLVFALEPETAHGIAFNAMETAHRLGLYRARPAPCRSRSIMGLTFPNPVGLAAGLDKNGEHIDALAALGFGF
IEIGTVTPRPQPGNPKPRLFRLPQANSIINRMGFNNNGIEGLVANVKAMDYKGILGINIGKNFDTPVEKAVDDYLICLRK
AYRYASYITVNISSPNTPNLRQLQQATELDSLLGTLKLNQQRLADEHGKYTPLLVKIAPDLELPEIDSIAALLMKHRVDG
VIATNTTLSRAGVETLPHAREAGGLSGAPLAKRATSVVARLHHALQGALPIIGVGGIMDAAGATEKIAAGASLIQVYSGL
VYRGPHLVGEIAQVLCNANGGGLDGASST

Sequences:

>Translated_349_residues
MMLYSLLRPLVFALEPETAHGIAFNAMETAHRLGLYRARPAPCRSRSIMGLTFPNPVGLAAGLDKNGEHIDALAALGFGF
IEIGTVTPRPQPGNPKPRLFRLPQANSIINRMGFNNNGIEGLVANVKAMDYKGILGINIGKNFDTPVEKAVDDYLICLRK
AYRYASYITVNISSPNTPNLRQLQQATELDSLLGTLKLNQQRLADEHGKYTPLLVKIAPDLELPEIDSIAALLMKHRVDG
VIATNTTLSRAGVETLPHAREAGGLSGAPLAKRATSVVARLHHALQGALPIIGVGGIMDAAGATEKIAAGASLIQVYSGL
VYRGPHLVGEIAQVLCNANGGGLDGASST
>Mature_349_residues
MMLYSLLRPLVFALEPETAHGIAFNAMETAHRLGLYRARPAPCRSRSIMGLTFPNPVGLAAGLDKNGEHIDALAALGFGF
IEIGTVTPRPQPGNPKPRLFRLPQANSIINRMGFNNNGIEGLVANVKAMDYKGILGINIGKNFDTPVEKAVDDYLICLRK
AYRYASYITVNISSPNTPNLRQLQQATELDSLLGTLKLNQQRLADEHGKYTPLLVKIAPDLELPEIDSIAALLMKHRVDG
VIATNTTLSRAGVETLPHAREAGGLSGAPLAKRATSVVARLHHALQGALPIIGVGGIMDAAGATEKIAAGASLIQVYSGL
VYRGPHLVGEIAQVLCNANGGGLDGASST

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=334, Percent_Identity=42.814371257485, Blast_Score=238, Evalue=6e-63,
Organism=Escherichia coli, GI1787177, Length=333, Percent_Identity=55.8558558558559, Blast_Score=366, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI17509475, Length=317, Percent_Identity=40.3785488958991, Blast_Score=217, Evalue=9e-57,
Organism=Saccharomyces cerevisiae, GI6322633, Length=302, Percent_Identity=25.4966887417219, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI281361352, Length=347, Percent_Identity=40.0576368876081, Blast_Score=248, Evalue=3e-66,
Organism=Drosophila melanogaster, GI17137316, Length=347, Percent_Identity=40.0576368876081, Blast_Score=248, Evalue=3e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.5.2 [H]

Molecular weight: Translated: 37060; Mature: 37060

Theoretical pI: Translated: 9.26; Mature: 9.26

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMLYSLLRPLVFALEPETAHGIAFNAMETAHRLGLYRARPAPCRSRSIMGLTFPNPVGLA
CHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCC
AGLDKNGEHIDALAALGFGFIEIGTVTPRPQPGNPKPRLFRLPQANSIINRMGFNNNGIE
CCCCCCCCHHHHHHHHCCCEEEECCCCCCCCCCCCCCCEEECCCHHHHHHHCCCCCCCCH
GLVANVKAMDYKGILGINIGKNFDTPVEKAVDDYLICLRKAYRYASYITVNISSPNTPNL
HHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCCH
RQLQQATELDSLLGTLKLNQQRLADEHGKYTPLLVKIAPDLELPEIDSIAALLMKHRVDG
HHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCC
VIATNTTLSRAGVETLPHAREAGGLSGAPLAKRATSVVARLHHALQGALPIIGVGGIMDA
EEEECCCHHHCCHHHCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEECCCHHHC
AGATEKIAAGASLIQVYSGLVYRGPHLVGEIAQVLCNANGGGLDGASST
CCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MMLYSLLRPLVFALEPETAHGIAFNAMETAHRLGLYRARPAPCRSRSIMGLTFPNPVGLA
CHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCC
AGLDKNGEHIDALAALGFGFIEIGTVTPRPQPGNPKPRLFRLPQANSIINRMGFNNNGIE
CCCCCCCCHHHHHHHHCCCEEEECCCCCCCCCCCCCCCEEECCCHHHHHHHCCCCCCCCH
GLVANVKAMDYKGILGINIGKNFDTPVEKAVDDYLICLRKAYRYASYITVNISSPNTPNL
HHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCCH
RQLQQATELDSLLGTLKLNQQRLADEHGKYTPLLVKIAPDLELPEIDSIAALLMKHRVDG
HHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCC
VIATNTTLSRAGVETLPHAREAGGLSGAPLAKRATSVVARLHHALQGALPIIGVGGIMDA
EEEECCCHHHCCHHHCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEECCCHHHC
AGATEKIAAGASLIQVYSGLVYRGPHLVGEIAQVLCNANGGGLDGASST
CCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA