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The map label for this gene is ascD [H]

Identifier: 82703799

GI number: 82703799

Start: 3085915

End: 3086964

Strand: Direct

Name: ascD [H]

Synonym: Nmul_A2686

Alternate gene names: 82703799

Gene position: 3085915-3086964 (Clockwise)

Preceding gene: 82703794

Following gene: 82703804

Centisome position: 96.91

GC content: 55.71

Gene sequence:

>1050_bases
ATGTCTCATCAAATTACTATCCAGCCGAGCGGACACAGGTTTTTCGCCCAGCCTGGCGAGACTGTTCTCCAGGCCGCGCT
CCGGGAAGGTTTTCCGCTCCCCTATGGGTGCCGCAATGGCGCTTGCGGGACCTGCAAGGGCAAAATCATACAGGGAACAG
TGGATTTCGGCAGCTATAACGAGAACGCTCTGACGGAAACGGAAAAACAGGCGGGAATGGCATTGTTTTGCCGGGCCGTA
CCCCTCTCGGAACTTGTCATTGAATGCCGCGAAATCGGCGCCATAAAGGACATCAAGATCAAAACCCTTCCATGCCGGGT
GCAGAAGCTCGAACGGGTCGCACCCGATGTGATGATCATCTCCCTCAAGCTTCCCACCAACGAACGGCTGCAATTTCTGG
CGGGGCAGTATATCGACATCCTGATGAAAAATGGCAAGCGCCGTAGTTTTTCACTGGCCAACGCGCCCCATGACGATGAG
CTGCTTCAGTTACATGTGCGTAATTATCCGGGCGGCGCGTTCGCCGAGCATGTGTTCATGCAGATGAAAGAGAGGGATAT
TCTCCGCTTTGAAGGACCGCTCGGCACGTTCTTTCTGCGCGAAGACTCGGACAAGCCGATCATCTTTGTCGCCAGCGGCA
CGGGATTTGCACCGGTCAAGAGCATCCTCGAGGATGTATTTCACGGGCCCAATCCCCGCGGCCATGAGCGGCAGATCGTG
CTCTATTGGGGAAACCGTACCAGAGCTGACCTGTATGCCCCTGAATTGGCAGGAAGCTGGCAACAGGAACATGACAATTT
TACTTTTATTCCTGTGCTGTCGGAGCCGCTACCCTCTGACAACTGGAACGGAAGGACCGGCCTGGTGCATCAGGCTGTGC
TGGAGGATTTCGACGATCTCAGCGGCTATCAGGTGTATGCGTGCGGCACGCCGCCCATGGTCGAAGCCGCTCACAGGGAT
TTCACGCGCCTGCGCGGCCTTCCGGAAGAAGAATTCTTTTCGGATGCATTCATCACTTCAGCCACTTCAGCCAGTCCGCC
AAAAGCATGA

Upstream 100 bases:

>100_bases
TCACCGCAACCGACGATCAAGAGTGTTCGCTTTATCGTTTTCATGTTAGTTACCGACATTCCATTTTTATTTTTGCTGGC
TCATCCGTAATCGTAATCAG

Downstream 100 bases:

>100_bases
TGTTTTCTTCCTTGCGCCCCTCTTCCCAGCTCTGCGAAACGACATCGGGAATGGAACAGAGTCTGAAGGACTTCCGGCAC
TACTCCATCCATTATTCGGC

Product: CDP-6-deoxy-delta-3,4-glucoseen reductase

Products: NAD(P); FMNH2; 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: CDP-6-deoxy-delta-3,4-glucoseen reductase; E3 [H]

Number of amino acids: Translated: 349; Mature: 348

Protein sequence:

>349_residues
MSHQITIQPSGHRFFAQPGETVLQAALREGFPLPYGCRNGACGTCKGKIIQGTVDFGSYNENALTETEKQAGMALFCRAV
PLSELVIECREIGAIKDIKIKTLPCRVQKLERVAPDVMIISLKLPTNERLQFLAGQYIDILMKNGKRRSFSLANAPHDDE
LLQLHVRNYPGGAFAEHVFMQMKERDILRFEGPLGTFFLREDSDKPIIFVASGTGFAPVKSILEDVFHGPNPRGHERQIV
LYWGNRTRADLYAPELAGSWQQEHDNFTFIPVLSEPLPSDNWNGRTGLVHQAVLEDFDDLSGYQVYACGTPPMVEAAHRD
FTRLRGLPEEEFFSDAFITSATSASPPKA

Sequences:

>Translated_349_residues
MSHQITIQPSGHRFFAQPGETVLQAALREGFPLPYGCRNGACGTCKGKIIQGTVDFGSYNENALTETEKQAGMALFCRAV
PLSELVIECREIGAIKDIKIKTLPCRVQKLERVAPDVMIISLKLPTNERLQFLAGQYIDILMKNGKRRSFSLANAPHDDE
LLQLHVRNYPGGAFAEHVFMQMKERDILRFEGPLGTFFLREDSDKPIIFVASGTGFAPVKSILEDVFHGPNPRGHERQIV
LYWGNRTRADLYAPELAGSWQQEHDNFTFIPVLSEPLPSDNWNGRTGLVHQAVLEDFDDLSGYQVYACGTPPMVEAAHRD
FTRLRGLPEEEFFSDAFITSATSASPPKA
>Mature_348_residues
SHQITIQPSGHRFFAQPGETVLQAALREGFPLPYGCRNGACGTCKGKIIQGTVDFGSYNENALTETEKQAGMALFCRAVP
LSELVIECREIGAIKDIKIKTLPCRVQKLERVAPDVMIISLKLPTNERLQFLAGQYIDILMKNGKRRSFSLANAPHDDEL
LQLHVRNYPGGAFAEHVFMQMKERDILRFEGPLGTFFLREDSDKPIIFVASGTGFAPVKSILEDVFHGPNPRGHERQIVL
YWGNRTRADLYAPELAGSWQQEHDNFTFIPVLSEPLPSDNWNGRTGLVHQAVLEDFDDLSGYQVYACGTPPMVEAAHRDF
TRLRGLPEEEFFSDAFITSATSASPPKA

Specific function: Participates in the conversion of CDP-6-deoxy-D-glycero- L-threo-4-hexulose to 3,6-dideoxy-D-glycero-D-glycero-4-hexulose together with CDP-6-deoxy-D-glycero-L-threo-4-hexulose-3-dehydrase (E1) in two consecutive steps. The detailed mechanism of E3 is not

COG id: COG0543

COG function: function code HC; 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding FR-type domain [H]

Homologues:

Organism=Escherichia coli, GI2367314, Length=238, Percent_Identity=29.8319327731092, Blast_Score=118, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6323552, Length=217, Percent_Identity=25.3456221198157, Blast_Score=72, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006058
- InterPro:   IPR012675
- InterPro:   IPR017927
- InterPro:   IPR001041
- InterPro:   IPR008333
- InterPro:   IPR001433
- InterPro:   IPR001221
- InterPro:   IPR017938 [H]

Pfam domain/function: PF00970 FAD_binding_6; PF00111 Fer2; PF00175 NAD_binding_1 [H]

EC number: 1.5.1.29 [C]

Molecular weight: Translated: 38955; Mature: 38824

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHQITIQPSGHRFFAQPGETVLQAALREGFPLPYGCRNGACGTCKGKIIQGTVDFGSYN
CCCEEEEECCCCEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCC
ENALTETEKQAGMALFCRAVPLSELVIECREIGAIKDIKIKTLPCRVQKLERVAPDVMII
CCHHHHHHHHCCEEEEEECCCHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHCCCCEEEE
SLKLPTNERLQFLAGQYIDILMKNGKRRSFSLANAPHDDELLQLHVRNYPGGAFAEHVFM
EEECCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCEEEEEECCCCCHHHHHHHHH
QMKERDILRFEGPLGTFFLREDSDKPIIFVASGTGFAPVKSILEDVFHGPNPRGHERQIV
HHHHCCCEEECCCCEEEEEEECCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCEEEE
LYWGNRTRADLYAPELAGSWQQEHDNFTFIPVLSEPLPSDNWNGRTGLVHQAVLEDFDDL
EEECCCCCCCCCCHHHCCCHHHHCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCC
SGYQVYACGTPPMVEAAHRDFTRLRGLPEEEFFSDAFITSATSASPPKA
CCEEEEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
SHQITIQPSGHRFFAQPGETVLQAALREGFPLPYGCRNGACGTCKGKIIQGTVDFGSYN
CCEEEEECCCCEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCC
ENALTETEKQAGMALFCRAVPLSELVIECREIGAIKDIKIKTLPCRVQKLERVAPDVMII
CCHHHHHHHHCCEEEEEECCCHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHCCCCEEEE
SLKLPTNERLQFLAGQYIDILMKNGKRRSFSLANAPHDDELLQLHVRNYPGGAFAEHVFM
EEECCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCEEEEEECCCCCHHHHHHHHH
QMKERDILRFEGPLGTFFLREDSDKPIIFVASGTGFAPVKSILEDVFHGPNPRGHERQIV
HHHHCCCEEECCCCEEEEEEECCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCEEEE
LYWGNRTRADLYAPELAGSWQQEHDNFTFIPVLSEPLPSDNWNGRTGLVHQAVLEDFDDL
EEECCCCCCCCCCHHHCCCHHHHCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCC
SGYQVYACGTPPMVEAAHRDFTRLRGLPEEEFFSDAFITSATSASPPKA
CCEEEEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NAD(P)H2; FMN [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NAD(P)H2; FMN; 2 2-octaprenylphenol; O2 [C]

Specific reaction: NAD(P)H2 + FMN = NAD(P) + FMNH2 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: Oxidoreductases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10931327; 11586360; 12142430 [H]