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The map label for this gene is trpC [H]

Identifier: 82703677

GI number: 82703677

Start: 2934965

End: 2935804

Strand: Reverse

Name: trpC [H]

Synonym: Nmul_A2562

Alternate gene names: 82703677

Gene position: 2935804-2934965 (Counterclockwise)

Preceding gene: 82703678

Following gene: 82703676

Centisome position: 92.2

GC content: 60.36

Gene sequence:

>840_bases
TTGATCATGGCTAATATTCTTCAGGAGATTGTGGCGACAAAGCGACAGGAGATTGCGGCATTGAAAGCGCAGGGTTCTCT
CGCCGTGCTTCGCCGCCAGGCGGAAGCGTTACCGCCGCCAAGGGATTTCATTGGGGCGCTTCGCAAGAAGCTCGCCCTGG
GATTACCGGCCGTCATTGCGGAAATAAAGAAGGCCAGTCCCAGCAAGGGCGTGTTGCGTGAGCAGTTCGACCCTGCCGCC
ATCGCCGTGAGCTATGGCCAGCATGGCGCGGCCTGTCTGTCGGTTCTGACGGACCAGCAGTATTTCGGTGGCAGCGCGGA
ATATCTGAAGCAGGCCAGAAGCGCCTGCGACCTGCCGGTCCTGCGCAAGGATTTCATGCTGGACGAATATCAGGTCGCCG
AGGCAAGGCTCATGGGTGCGGATTGCATCCTCATCATTGTCGCCGCCTTCCGCGATCCTTTCATTTCGGCCGGGAGCCAC
CGGCAGCAGGAAGAAGCGGTAGTGGAAATGCGCAAGCTGGAGTCGTTGGCTCATGCGCTCGGGATGGCCGTTCTGGTGGA
GGTTCATGATGGGGCGGAACTCGAGCTGGCGCTGGAGTTGGCGTCTCCCCTGATCGGCATCAATAACCGCAACCTGCATA
CGTTTGAAACCCGCCTGGATACGACCCTGCATCTGCTAGACCGCATTCCCCCAGACCGTATGGCCATCACCGAAAGCGGG
GTACTCACACCTGACGATGTTGCGCTGATGCGCGGGCACGGGGTAGGCATCTTCCTCGTGGGCGAAGCCTTCATGCGGGC
TCCCGATCCCGGGACCGAGCTGGCGAGGTTGTTCGGGTAA

Upstream 100 bases:

>100_bases
AAAAAGCGCATGCCGCCATAGAAAGCGGCGCCGCGAGGAAAAAATTGCAGGAGCTGGTGGAATTCTCGAACCGGCAGAAC
CGCGGTGAGGTTTCTCTTGT

Downstream 100 bases:

>100_bases
TTCATCAATCCGTCCGGGTTGCATTCAACTCAAAGGCTTCCGAAGGTTCCCCTGCTTTGTTGCAAAAAAGCAACACATAT
CCCTGCCCACCTCCTAAACT

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS [H]

Number of amino acids: Translated: 279; Mature: 279

Protein sequence:

>279_residues
MIMANILQEIVATKRQEIAALKAQGSLAVLRRQAEALPPPRDFIGALRKKLALGLPAVIAEIKKASPSKGVLREQFDPAA
IAVSYGQHGAACLSVLTDQQYFGGSAEYLKQARSACDLPVLRKDFMLDEYQVAEARLMGADCILIIVAAFRDPFISAGSH
RQQEEAVVEMRKLESLAHALGMAVLVEVHDGAELELALELASPLIGINNRNLHTFETRLDTTLHLLDRIPPDRMAITESG
VLTPDDVALMRGHGVGIFLVGEAFMRAPDPGTELARLFG

Sequences:

>Translated_279_residues
MIMANILQEIVATKRQEIAALKAQGSLAVLRRQAEALPPPRDFIGALRKKLALGLPAVIAEIKKASPSKGVLREQFDPAA
IAVSYGQHGAACLSVLTDQQYFGGSAEYLKQARSACDLPVLRKDFMLDEYQVAEARLMGADCILIIVAAFRDPFISAGSH
RQQEEAVVEMRKLESLAHALGMAVLVEVHDGAELELALELASPLIGINNRNLHTFETRLDTTLHLLDRIPPDRMAITESG
VLTPDDVALMRGHGVGIFLVGEAFMRAPDPGTELARLFG
>Mature_279_residues
MIMANILQEIVATKRQEIAALKAQGSLAVLRRQAEALPPPRDFIGALRKKLALGLPAVIAEIKKASPSKGVLREQFDPAA
IAVSYGQHGAACLSVLTDQQYFGGSAEYLKQARSACDLPVLRKDFMLDEYQVAEARLMGADCILIIVAAFRDPFISAGSH
RQQEEAVVEMRKLESLAHALGMAVLVEVHDGAELELALELASPLIGINNRNLHTFETRLDTTLHLLDRIPPDRMAITESG
VLTPDDVALMRGHGVGIFLVGEAFMRAPDPGTELARLFG

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=267, Percent_Identity=37.4531835205993, Blast_Score=146, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6322638, Length=240, Percent_Identity=38.3333333333333, Blast_Score=153, Evalue=2e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS [H]

EC number: =4.1.1.48 [H]

Molecular weight: Translated: 30268; Mature: 30268

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIMANILQEIVATKRQEIAALKAQGSLAVLRRQAEALPPPRDFIGALRKKLALGLPAVIA
CCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCHHHHHH
EIKKASPSKGVLREQFDPAAIAVSYGQHGAACLSVLTDQQYFGGSAEYLKQARSACDLPV
HHHHCCCCCCHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHH
LRKDFMLDEYQVAEARLMGADCILIIVAAFRDPFISAGSHRQQEEAVVEMRKLESLAHAL
HHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
GMAVLVEVHDGAELELALELASPLIGINNRNLHTFETRLDTTLHLLDRIPPDRMAITESG
HHHEEEEECCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEECCCC
VLTPDDVALMRGHGVGIFLVGEAFMRAPDPGTELARLFG
CCCCCHHHHCCCCCCEEEEECHHHHCCCCCHHHHHHHCC
>Mature Secondary Structure
MIMANILQEIVATKRQEIAALKAQGSLAVLRRQAEALPPPRDFIGALRKKLALGLPAVIA
CCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCHHHHHH
EIKKASPSKGVLREQFDPAAIAVSYGQHGAACLSVLTDQQYFGGSAEYLKQARSACDLPV
HHHHCCCCCCHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHH
LRKDFMLDEYQVAEARLMGADCILIIVAAFRDPFISAGSHRQQEEAVVEMRKLESLAHAL
HHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
GMAVLVEVHDGAELELALELASPLIGINNRNLHTFETRLDTTLHLLDRIPPDRMAITESG
HHHEEEEECCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEECCCC
VLTPDDVALMRGHGVGIFLVGEAFMRAPDPGTELARLFG
CCCCCHHHHCCCCCCEEEEECHHHHCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA