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The map label for this gene is gluP [H]

Identifier: 82703577

GI number: 82703577

Start: 2810976

End: 2812091

Strand: Direct

Name: gluP [H]

Synonym: Nmul_A2462

Alternate gene names: 82703577

Gene position: 2810976-2812091 (Clockwise)

Preceding gene: 82703566

Following gene: 82703578

Centisome position: 88.28

GC content: 59.32

Gene sequence:

>1116_bases
ATGCTTTCACTCCATGATCTTCTTCACCGGCAGGTTCCTCGAGTTCCGGTAACGAAGCTGCTGGTGTCGACCAACCTGCT
GATCTTTGTAGCCATGCTTGCCAGCGGAGCAGGCTTGTGGCACTCATCCAATGGCGTACAACTCGCCTGGGGCGCCAACT
TCGGTCCCGCTACCCAGGATGGGGAGTGGTGGCGCCTCGGGACCGCCATGTTCCTTCATTTTGGCCTGGTCCATCTCACC
TTGAACCTCTGGGCGCTCTGGGATGCAGGCCAACTGGTTGAGCGCATGTACGGGCACGCGCGCTTTACCGCCCTCTACTT
TGCCAGCGGTCTTGCCGGCAATCTGCTCTCGCTGGTTGCCCATAAAGGCTTGGCCATTTCCGGCGGCGCTTCGGGCGCCA
TTTTCGGCCTATATGGCGCCCTGCTGGTATTTCTCTGGCGCGAGCGCGGCAGGCTGCATCCCCACGAGTTCCGATGGTTT
TTCTGGGGCGCCACGGCTTTTGCAATTGTCAGCCTTGGGCTGGGCCTCGCAATTACCGGTATCGATAACGCTGCTCATAT
CGGCGGTTTCGTGACCGGTCTGCTCGGCGGAATAGTATTTGCAAACCCAAGGATGAACGAAAAGCCTTCTCATGTATTCA
GCAGCCGCCTTTCCGCTATAAGCATTCTTGCACTGGCCGTCTTCATGCTGATCGTTCGGATTCCCCCTCCCGCCTATAAG
TGGAGCGAGGAAGTATTGGCGCGCAAGGAAATCGGCAATTTTCTGCGCGATGACCGGGCGATCACCCAGGCTTGGCAGCA
TATACTCGATGAGGCCAGGCGAGGAGGAATCTCCTTTGACGAACTGGCGGGGCAAATCGATACTGCGGTGGGTAATCCCT
ATGAAGAAAGCTTCGAGCAGCTTTCGGAACTTCCCCCTGATCCCGCATTGCCTTCTGCCGCTACGGTAGAAATGCTGCGA
GACTACGCCGAACGCCGGAGGGATGCGTCCCGCGCCCTTGCGGAAGGTCTGCGCACTCACAATCCCGCGCAAATCCGCCA
CGCGCTGGAAATGGCGAGGGAGCCGCTCCAGCTGCCCAAGCTCTCCCCGCCAACCCCGTCCGCCCTACCCCGCTGA

Upstream 100 bases:

>100_bases
TCCCGAAAAGGGGATCAGAGAGGGATTATTATTCCTTATTGCATCCATACGTTTCATCCTTATGCATCATAATGATTCGA
GAAGAACAGGTCTACCTTCC

Downstream 100 bases:

>100_bases
CGCCGCCCGATCCCGCATTTCGCGGAGATATCTTCTCTGGTTATCCTCCCGGCCATTTGTCATGCAACTCGTCTGGCACG
TCCTTTCTTGACATGCGCAG

Product: rhomboid-like protein

Products: NA

Alternate protein names: Intramembrane serine protease [H]

Number of amino acids: Translated: 371; Mature: 371

Protein sequence:

>371_residues
MLSLHDLLHRQVPRVPVTKLLVSTNLLIFVAMLASGAGLWHSSNGVQLAWGANFGPATQDGEWWRLGTAMFLHFGLVHLT
LNLWALWDAGQLVERMYGHARFTALYFASGLAGNLLSLVAHKGLAISGGASGAIFGLYGALLVFLWRERGRLHPHEFRWF
FWGATAFAIVSLGLGLAITGIDNAAHIGGFVTGLLGGIVFANPRMNEKPSHVFSSRLSAISILALAVFMLIVRIPPPAYK
WSEEVLARKEIGNFLRDDRAITQAWQHILDEARRGGISFDELAGQIDTAVGNPYEESFEQLSELPPDPALPSAATVEMLR
DYAERRRDASRALAEGLRTHNPAQIRHALEMAREPLQLPKLSPPTPSALPR

Sequences:

>Translated_371_residues
MLSLHDLLHRQVPRVPVTKLLVSTNLLIFVAMLASGAGLWHSSNGVQLAWGANFGPATQDGEWWRLGTAMFLHFGLVHLT
LNLWALWDAGQLVERMYGHARFTALYFASGLAGNLLSLVAHKGLAISGGASGAIFGLYGALLVFLWRERGRLHPHEFRWF
FWGATAFAIVSLGLGLAITGIDNAAHIGGFVTGLLGGIVFANPRMNEKPSHVFSSRLSAISILALAVFMLIVRIPPPAYK
WSEEVLARKEIGNFLRDDRAITQAWQHILDEARRGGISFDELAGQIDTAVGNPYEESFEQLSELPPDPALPSAATVEMLR
DYAERRRDASRALAEGLRTHNPAQIRHALEMAREPLQLPKLSPPTPSALPR
>Mature_371_residues
MLSLHDLLHRQVPRVPVTKLLVSTNLLIFVAMLASGAGLWHSSNGVQLAWGANFGPATQDGEWWRLGTAMFLHFGLVHLT
LNLWALWDAGQLVERMYGHARFTALYFASGLAGNLLSLVAHKGLAISGGASGAIFGLYGALLVFLWRERGRLHPHEFRWF
FWGATAFAIVSLGLGLAITGIDNAAHIGGFVTGLLGGIVFANPRMNEKPSHVFSSRLSAISILALAVFMLIVRIPPPAYK
WSEEVLARKEIGNFLRDDRAITQAWQHILDEARRGGISFDELAGQIDTAVGNPYEESFEQLSELPPDPALPSAATVEMLR
DYAERRRDASRALAEGLRTHNPAQIRHALEMAREPLQLPKLSPPTPSALPR

Specific function: Rhomboid-type serine protease that catalyzes intramembrane proteolysis. Important for normal cell division and sporulation. May act as a glucose exporter [H]

COG id: COG0705

COG function: function code R; Uncharacterized membrane protein (homolog of Drosophila rhomboid)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 TPR repeats [H]

Homologues:

Organism=Caenorhabditis elegans, GI115534507, Length=136, Percent_Identity=33.0882352941176, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002610
- InterPro:   IPR022764
- InterPro:   IPR001440
- InterPro:   IPR013026
- InterPro:   IPR011990
- InterPro:   IPR019734 [H]

Pfam domain/function: PF01694 Rhomboid; PF00515 TPR_1 [H]

EC number: =3.4.21.105 [H]

Molecular weight: Translated: 40711; Mature: 40711

Theoretical pI: Translated: 8.87; Mature: 8.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSLHDLLHRQVPRVPVTKLLVSTNLLIFVAMLASGAGLWHSSNGVQLAWGANFGPATQD
CCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCEECCCCEEEEECCCCCCCCCC
GEWWRLGTAMFLHFGLVHLTLNLWALWDAGQLVERMYGHARFTALYFASGLAGNLLSLVA
CCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HKGLAISGGASGAIFGLYGALLVFLWRERGRLHPHEFRWFFWGATAFAIVSLGLGLAITG
HCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHEEHHHHHHHHHHHHHHHEEEC
IDNAAHIGGFVTGLLGGIVFANPRMNEKPSHVFSSRLSAISILALAVFMLIVRIPPPAYK
CCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
WSEEVLARKEIGNFLRDDRAITQAWQHILDEARRGGISFDELAGQIDTAVGNPYEESFEQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHH
LSELPPDPALPSAATVEMLRDYAERRRDASRALAEGLRTHNPAQIRHALEMAREPLQLPK
HHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCC
LSPPTPSALPR
CCCCCCCCCCC
>Mature Secondary Structure
MLSLHDLLHRQVPRVPVTKLLVSTNLLIFVAMLASGAGLWHSSNGVQLAWGANFGPATQD
CCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCEECCCCEEEEECCCCCCCCCC
GEWWRLGTAMFLHFGLVHLTLNLWALWDAGQLVERMYGHARFTALYFASGLAGNLLSLVA
CCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HKGLAISGGASGAIFGLYGALLVFLWRERGRLHPHEFRWFFWGATAFAIVSLGLGLAITG
HCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHEEHHHHHHHHHHHHHHHEEEC
IDNAAHIGGFVTGLLGGIVFANPRMNEKPSHVFSSRLSAISILALAVFMLIVRIPPPAYK
CCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
WSEEVLARKEIGNFLRDDRAITQAWQHILDEARRGGISFDELAGQIDTAVGNPYEESFEQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHH
LSELPPDPALPSAATVEMLRDYAERRRDASRALAEGLRTHNPAQIRHALEMAREPLQLPK
HHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCC
LSPPTPSALPR
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]